NO20006251D0 - Benzotiepin-1,1-dioksidderivater, fremgangsmåte for deres fremstilling, legemidler som inneholder disse forbindelsene og deres anvendelse - Google Patents

Benzotiepin-1,1-dioksidderivater, fremgangsmåte for deres fremstilling, legemidler som inneholder disse forbindelsene og deres anvendelse

Info

Publication number
NO20006251D0
NO20006251D0 NO20006251A NO20006251A NO20006251D0 NO 20006251 D0 NO20006251 D0 NO 20006251D0 NO 20006251 A NO20006251 A NO 20006251A NO 20006251 A NO20006251 A NO 20006251A NO 20006251 D0 NO20006251 D0 NO 20006251D0
Authority
NO
Norway
Prior art keywords
benzothiepine
compounds
preparation
medicaments containing
dioxide derivatives
Prior art date
Application number
NO20006251A
Other languages
English (en)
Other versions
NO20006251L (no
NO327075B1 (no
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20006251D0 publication Critical patent/NO20006251D0/no
Publication of NO20006251L publication Critical patent/NO20006251L/no
Publication of NO327075B1 publication Critical patent/NO327075B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
NO20006251A 1998-06-10 2000-12-08 Benzotiepin-1,1-dioksidderivater, fremgangsmate for deres fremstilling, legemidler som inneholder disse forbindelsene samt deres anvendelse NO327075B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP1999/003743 WO1999064409A2 (de) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Publications (3)

Publication Number Publication Date
NO20006251D0 true NO20006251D0 (no) 2000-12-08
NO20006251L NO20006251L (no) 2001-02-07
NO327075B1 NO327075B1 (no) 2009-04-20

Family

ID=7870440

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006251A NO327075B1 (no) 1998-06-10 2000-12-08 Benzotiepin-1,1-dioksidderivater, fremgangsmate for deres fremstilling, legemidler som inneholder disse forbindelsene samt deres anvendelse

Country Status (26)

Country Link
US (1) US6387944B1 (no)
EP (2) EP1086092B1 (no)
JP (2) JP4374426B2 (no)
KR (2) KR100681721B1 (no)
CN (2) CN1127497C (no)
AR (2) AR018634A1 (no)
AT (2) ATE227715T1 (no)
AU (2) AU753275B2 (no)
BR (2) BR9912188B1 (no)
CA (2) CA2334775C (no)
CZ (2) CZ297989B6 (no)
DE (3) DE19825804C2 (no)
DK (2) DK1086092T3 (no)
ES (2) ES2182535T3 (no)
HK (2) HK1036799A1 (no)
HU (2) HU229761B1 (no)
ID (2) ID28695A (no)
IL (1) IL140078A (no)
NO (1) NO327075B1 (no)
NZ (1) NZ508681A (no)
PL (2) PL196074B1 (no)
PT (2) PT1086092E (no)
RU (2) RU2215001C2 (no)
TR (2) TR200003634T2 (no)
WO (2) WO1999064410A1 (no)
ZA (2) ZA200007060B (no)

Families Citing this family (65)

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SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
PT1345895E (pt) * 2000-12-21 2007-02-28 Sanofi Aventis Deutschland Novas difenilazetidinonas, processo para a sua preparação, fármacos contendo estes compostos e sua utilização para o tratamento de distúrbios do metabolismo lipídico
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
CA2457976A1 (en) * 2001-08-22 2003-03-06 Aventis Pharma Deutschland Gmbh Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
JP3616635B2 (ja) 2001-09-08 2005-02-02 アストラゼネカ アクチボラグ 高脂質血症の治療のための回腸胆汁酸運搬(ibat)阻害活性を持つベンゾチアゼピン及びベンゾチアジアゼピン誘導体
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
SE0201937D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
US20040138145A1 (en) * 2002-12-12 2004-07-15 Aventis Pharma S.A. Application of intestinal biliary acid reuptake inhibitors for the prevention and treatment of alzheimer's disease
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
DE102006053636B4 (de) * 2006-11-14 2008-09-18 Sanofi-Aventis Deutschland Gmbh Neue mit Cyclohexylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate und deren Verwendung
DE102006053635B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US20100221513A1 (en) * 2008-09-05 2010-09-02 Wisconsin Alumni Research Foundation Self sintering transparent nanoporous thin-films for use in self-cleaning, anti-fogging, anti-corrosion, anti-erosion electronic and optical applications
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
PT2637646T (pt) 2010-11-08 2016-08-17 Albireo Ab Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar
DK2637668T3 (en) 2010-11-08 2016-08-29 Albireo Ab Ibat inhibitors for the treatment of liver diseases
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EA030839B1 (ru) 2011-10-28 2018-10-31 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей
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AU2014228850A1 (en) 2013-03-15 2015-10-29 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
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US10709755B2 (en) 2014-06-25 2020-07-14 Elobix Ab Solid formulation and method for preventing or reducing coloration thereof
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US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
EP3413877B1 (en) 2016-02-09 2021-04-07 Albireo AB Oral cholestyramine formulation and use thereof
CA3011619C (en) 2016-02-09 2024-01-02 Albireo Ab Oral cholestyramine formulation and use thereof
EP3664782A1 (en) 2017-08-09 2020-06-17 Albireo AB Cholestyramine pellets, oral cholestyramine formulations and use thereof
EP3664781A1 (en) 2017-08-09 2020-06-17 Albireo AB Cholestyramine granules, oral cholestyramine formulations and use thereof
WO2019234077A1 (en) 2018-06-05 2019-12-12 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
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JP3304093B2 (ja) * 1994-09-13 2002-07-22 モンサント カンパニー 回腸の胆汁酸輸送及びタウロコール酸塩吸収の阻害活性を有する新規ベンゾチエピン類
RU2202549C2 (ru) * 1996-03-11 2003-04-20 Джи. Ди. Сирл Энд Ко. Бензотиепины, фармацевтическая композиция на их основе, способ профилактики или лечения гиперлипидемического состояния
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CA2337307A1 (en) * 1998-08-20 2000-03-02 Osamu Nishimura Quaternary ammonium salts and their use

Also Published As

Publication number Publication date
TR200003634T2 (tr) 2001-06-21
ATE259372T1 (de) 2004-02-15
CA2334773C (en) 2009-05-26
PL344827A1 (en) 2001-11-19
CA2334775A1 (en) 1999-12-16
AR018633A1 (es) 2001-11-28
WO1999064409A2 (de) 1999-12-16
WO1999064409A3 (de) 2000-03-02
DE59908522D1 (de) 2004-03-18
AR018634A1 (es) 2001-11-28
JP2002517490A (ja) 2002-06-18
DK1086113T3 (da) 2004-05-24
PL196074B1 (pl) 2007-12-31
DE19825804A1 (de) 1999-12-16
CZ297989B6 (cs) 2007-05-16
JP3374129B2 (ja) 2003-02-04
HU229761B1 (hu) 2014-06-30
AU4503199A (en) 1999-12-30
ID26876A (id) 2001-02-15
HU228570B1 (en) 2013-04-29
ZA200007060B (en) 2001-07-18
WO1999064410A1 (de) 1999-12-16
HK1036799A1 (en) 2002-01-18
NO20006251L (no) 2001-02-07
BR9912188A (pt) 2001-04-10
EP1086113B1 (de) 2004-02-11
CN1305469A (zh) 2001-07-25
JP2002517491A (ja) 2002-06-18
CA2334773A1 (en) 1999-12-16
KR100681721B1 (ko) 2007-02-15
CN1305487A (zh) 2001-07-25
AU752633B2 (en) 2002-09-26
CN1127497C (zh) 2003-11-12
TR200003632T2 (tr) 2001-04-20
NZ508681A (en) 2002-06-28
ZA200007061B (en) 2001-07-18
PL196057B1 (pl) 2007-11-30
AU4501999A (en) 1999-12-30
ATE227715T1 (de) 2002-11-15
IL140078A (en) 2004-08-31
HK1039490A1 (en) 2002-04-26
BR9911123A (pt) 2006-01-03
ES2182535T3 (es) 2003-03-01
CZ20004592A3 (cs) 2001-04-11
BR9911123B1 (pt) 2010-12-14
ES2215387T3 (es) 2004-10-01
HUP0102256A3 (en) 2002-04-29
EP1086092A1 (de) 2001-03-28
CA2334775C (en) 2009-10-13
US6387944B1 (en) 2002-05-14
HUP0102554A3 (en) 2002-12-28
NO327075B1 (no) 2009-04-20
HUP0102256A1 (hu) 2001-12-28
RU2220141C2 (ru) 2003-12-27
RU2215001C2 (ru) 2003-10-27
PT1086113E (pt) 2004-06-30
PT1086092E (pt) 2003-03-31
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
IL140078A0 (en) 2002-02-10
DE19825804C2 (de) 2000-08-24
AU753275B2 (en) 2002-10-10
CZ297925B6 (cs) 2007-05-02
KR20010052701A (ko) 2001-06-25
KR20010052682A (ko) 2001-06-25
EP1086113A2 (de) 2001-03-28
HUP0102554A1 (hu) 2001-10-28
JP4374426B2 (ja) 2009-12-02
CN1152039C (zh) 2004-06-02
DE59903411D1 (de) 2002-12-19
DK1086092T3 (da) 2003-03-10
EP1086092B1 (de) 2002-11-13
ID28695A (id) 2001-06-28
CZ20004591A3 (cs) 2001-04-11
BR9912188B1 (pt) 2010-12-14

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