NO20014792L - Med sukkerrester substituerte 1,4-benzotiazepin-1,1-dioksid- derivater, fremgangsmåte for deres fremstilling, legemidler sominneholder disse og forbindelser og deres anvendelse - Google Patents
Med sukkerrester substituerte 1,4-benzotiazepin-1,1-dioksid- derivater, fremgangsmåte for deres fremstilling, legemidler sominneholder disse og forbindelser og deres anvendelseInfo
- Publication number
- NO20014792L NO20014792L NO20014792A NO20014792A NO20014792L NO 20014792 L NO20014792 L NO 20014792L NO 20014792 A NO20014792 A NO 20014792A NO 20014792 A NO20014792 A NO 20014792A NO 20014792 L NO20014792 L NO 20014792L
- Authority
- NO
- Norway
- Prior art keywords
- benzothiazepine
- compounds
- preparation
- sugar residues
- drugs containing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19916108A DE19916108C1 (de) | 1999-04-09 | 1999-04-09 | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
PCT/EP2000/002570 WO2000061568A2 (de) | 1999-04-09 | 2000-03-23 | Mit zuckerresten substituierte 1,4-benzothiazepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20014792L true NO20014792L (no) | 2001-10-02 |
NO20014792D0 NO20014792D0 (no) | 2001-10-02 |
NO319836B1 NO319836B1 (no) | 2005-09-19 |
Family
ID=7904060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20014792A NO319836B1 (no) | 1999-04-09 | 2001-10-02 | Med sukkerrester substituerte 1,4-benzotiazepin-1,1-dioksid-derivater, fremgangsmate for deres fremstilling, legemidler som inneholder disse og forbindelser og deres anvendelse |
Country Status (32)
Country | Link |
---|---|
US (1) | US6277831B1 (no) |
EP (1) | EP1169313B1 (no) |
JP (1) | JP2002541248A (no) |
KR (1) | KR100686905B1 (no) |
CN (1) | CN1145619C (no) |
AR (1) | AR023401A1 (no) |
AT (1) | ATE243686T1 (no) |
AU (1) | AU765199B2 (no) |
BR (1) | BR0009641A (no) |
CA (1) | CA2369070C (no) |
CZ (1) | CZ300410B6 (no) |
DE (2) | DE19916108C1 (no) |
DK (1) | DK1169313T3 (no) |
EE (1) | EE04613B1 (no) |
ES (1) | ES2200860T3 (no) |
HK (1) | HK1044537B (no) |
HR (1) | HRP20010725A2 (no) |
HU (1) | HUP0200644A3 (no) |
IL (2) | IL145647A0 (no) |
MY (1) | MY120842A (no) |
NO (1) | NO319836B1 (no) |
NZ (1) | NZ514656A (no) |
PL (1) | PL203806B1 (no) |
PT (1) | PT1169313E (no) |
RS (1) | RS49850B (no) |
RU (1) | RU2232155C2 (no) |
SI (1) | SI1169313T1 (no) |
SK (1) | SK286744B6 (no) |
TR (1) | TR200102910T2 (no) |
TW (1) | TWI254045B (no) |
WO (1) | WO2000061568A2 (no) |
ZA (1) | ZA200107989B (no) |
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US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
HUP0104593A3 (en) * | 1998-12-23 | 2004-10-28 | G D Searle Llc Chicago | Combinations of benzothiepine ileal bile acid transport inhibitor and nicotinic acid derivatives for cardiovascular indications |
DK1140189T3 (da) * | 1998-12-23 | 2003-09-15 | Searle Llc | Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer |
EA005815B1 (ru) * | 1998-12-23 | 2005-06-30 | Джи.Ди.Сирл Ллс | Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний |
PL348609A1 (en) * | 1998-12-23 | 2002-06-03 | Searle Llc | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications |
US6489366B1 (en) * | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
US6462091B1 (en) * | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
CA2356157C (en) * | 1998-12-23 | 2008-04-01 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
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US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
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AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
JP2023504643A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
PE20230234A1 (es) | 2019-12-04 | 2023-02-07 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar |
JP2023504644A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
HUE065571T2 (hu) | 2019-12-04 | 2024-06-28 | Albireo Ab | Benzotia(di)azepin vegyületek és alkalmazásuk epesav modulátorként |
JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
KR20230117393A (ko) | 2020-12-04 | 2023-08-08 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의용도 |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK406686D0 (da) * | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
IL108634A0 (en) * | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
ZA941003B (en) * | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
US5723589A (en) * | 1995-12-21 | 1998-03-03 | Icn Pharmaceuticals | Carbohydrate conjugated bio-active compounds |
DK0864582T3 (da) * | 1997-03-14 | 2003-09-29 | Aventis Pharma Gmbh | Hypolidemiske 1,4-benzothiazepin-1,1-dioxider |
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1999
- 1999-04-09 DE DE19916108A patent/DE19916108C1/de not_active Expired - Fee Related
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2000
- 2000-03-23 CA CA002369070A patent/CA2369070C/en not_active Expired - Fee Related
- 2000-03-23 DE DE50002646T patent/DE50002646D1/de not_active Expired - Lifetime
- 2000-03-23 SI SI200030186T patent/SI1169313T1/xx unknown
- 2000-03-23 RU RU2001129936/04A patent/RU2232155C2/ru not_active IP Right Cessation
- 2000-03-23 CZ CZ20013610A patent/CZ300410B6/cs not_active IP Right Cessation
- 2000-03-23 ES ES00920550T patent/ES2200860T3/es not_active Expired - Lifetime
- 2000-03-23 PL PL350984A patent/PL203806B1/pl not_active IP Right Cessation
- 2000-03-23 KR KR1020017012822A patent/KR100686905B1/ko not_active IP Right Cessation
- 2000-03-23 EP EP00920550A patent/EP1169313B1/de not_active Expired - Lifetime
- 2000-03-23 IL IL14564700A patent/IL145647A0/xx active IP Right Grant
- 2000-03-23 JP JP2000610842A patent/JP2002541248A/ja not_active Abandoned
- 2000-03-23 AT AT00920550T patent/ATE243686T1/de not_active IP Right Cessation
- 2000-03-23 EE EEP200100495A patent/EE04613B1/xx not_active IP Right Cessation
- 2000-03-23 HU HU0200644A patent/HUP0200644A3/hu unknown
- 2000-03-23 WO PCT/EP2000/002570 patent/WO2000061568A2/de active IP Right Grant
- 2000-03-23 AU AU41087/00A patent/AU765199B2/en not_active Ceased
- 2000-03-23 BR BR0009641-5A patent/BR0009641A/pt not_active Application Discontinuation
- 2000-03-23 TR TR2001/02910T patent/TR200102910T2/xx unknown
- 2000-03-23 NZ NZ514656A patent/NZ514656A/en not_active IP Right Cessation
- 2000-03-23 RS YUP-709/01A patent/RS49850B/sr unknown
- 2000-03-23 DK DK00920550T patent/DK1169313T3/da active
- 2000-03-23 SK SK1416-2001A patent/SK286744B6/sk not_active IP Right Cessation
- 2000-03-23 PT PT00920550T patent/PT1169313E/pt unknown
- 2000-03-23 CN CNB008060738A patent/CN1145619C/zh not_active Expired - Fee Related
- 2000-04-06 AR ARP000101577A patent/AR023401A1/es unknown
- 2000-04-07 US US09/545,456 patent/US6277831B1/en not_active Expired - Lifetime
- 2000-04-07 MY MYPI20001448A patent/MY120842A/en unknown
- 2000-04-21 TW TW089106263A patent/TWI254045B/zh not_active IP Right Cessation
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2001
- 2001-09-25 IL IL145647A patent/IL145647A/en not_active IP Right Cessation
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- 2001-10-02 NO NO20014792A patent/NO319836B1/no not_active IP Right Cessation
- 2001-10-08 HR HR20010725A patent/HRP20010725A2/hr not_active Application Discontinuation
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