RU2215001C2 - Производные бензо(b)тиепин-1,1-диоксидов, способ их получения, лекарственное средство и способ его получения - Google Patents

Производные бензо(b)тиепин-1,1-диоксидов, способ их получения, лекарственное средство и способ его получения Download PDF

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RU2215001C2
RU2215001C2 RU2001101491/04A RU2001101491A RU2215001C2 RU 2215001 C2 RU2215001 C2 RU 2215001C2 RU 2001101491/04 A RU2001101491/04 A RU 2001101491/04A RU 2001101491 A RU2001101491 A RU 2001101491A RU 2215001 C2 RU2215001 C2 RU 2215001C2
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formula
compounds
ethyl
methyl
butyl
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RU2001101491/04A
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RU2001101491A (ru
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Венделин ФРИК (DE)
Венделин Фрик
Альфонс ЭНЗЕН (DE)
Альфонс ЭНЗЕН
Хайнер ГЛОМБИК (DE)
Хайнер Гломбик
Хуберт ХОЙЕР (DE)
Хуберт Хойер
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Авентис Фарма Дойчланд Гмбх
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2001101491/04A 1998-06-10 1999-05-28 Производные бензо(b)тиепин-1,1-диоксидов, способ их получения, лекарственное средство и способ его получения RU2215001C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19825804.6 1998-06-10

Publications (2)

Publication Number Publication Date
RU2001101491A RU2001101491A (ru) 2003-01-20
RU2215001C2 true RU2215001C2 (ru) 2003-10-27

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Family Applications (2)

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RU2001101491/04A RU2215001C2 (ru) 1998-06-10 1999-05-28 Производные бензо(b)тиепин-1,1-диоксидов, способ их получения, лекарственное средство и способ его получения
RU2001101499/04A RU2220141C2 (ru) 1998-06-10 1999-05-29 Производные бензотиепин-1,1-диоксидов, способ их получения и лекарственное средство

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RU2001101499/04A RU2220141C2 (ru) 1998-06-10 1999-05-29 Производные бензотиепин-1,1-диоксидов, способ их получения и лекарственное средство

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US (1) US6387944B1 (enExample)
EP (2) EP1086092B1 (enExample)
JP (2) JP4374426B2 (enExample)
KR (2) KR100681721B1 (enExample)
CN (2) CN1127497C (enExample)
AR (2) AR018633A1 (enExample)
AT (2) ATE227715T1 (enExample)
AU (2) AU753275B2 (enExample)
BR (2) BR9912188B1 (enExample)
CA (2) CA2334775C (enExample)
CZ (2) CZ297989B6 (enExample)
DE (3) DE19825804C2 (enExample)
DK (2) DK1086092T3 (enExample)
ES (2) ES2182535T3 (enExample)
HU (2) HU229761B1 (enExample)
ID (2) ID28695A (enExample)
IL (1) IL140078A (enExample)
NO (1) NO327075B1 (enExample)
NZ (1) NZ508681A (enExample)
PL (2) PL196074B1 (enExample)
PT (2) PT1086092E (enExample)
RU (2) RU2215001C2 (enExample)
TR (2) TR200003634T2 (enExample)
WO (2) WO1999064410A1 (enExample)
ZA (2) ZA200007061B (enExample)

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JP7748451B2 (ja) 2020-08-03 2025-10-02 アルビレオ・アクチボラグ ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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WO1996008484A1 (en) * 1994-09-13 1996-03-21 Monsanto Company Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1996008484A1 (en) * 1994-09-13 1996-03-21 Monsanto Company Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
WO1997033882A1 (en) * 1996-03-11 1997-09-18 G.D. Searle And Co. Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

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ZA200007060B (en) 2001-07-18
DE19825804A1 (de) 1999-12-16
HK1036799A1 (en) 2002-01-18
NZ508681A (en) 2002-06-28
HU228570B1 (en) 2013-04-29
ID26876A (id) 2001-02-15
CZ297989B6 (cs) 2007-05-16
CN1152039C (zh) 2004-06-02
BR9911123B1 (pt) 2010-12-14
CA2334773C (en) 2009-05-26
ATE259372T1 (de) 2004-02-15
JP2002517491A (ja) 2002-06-18
AU4501999A (en) 1999-12-30
TR200003632T2 (tr) 2001-04-20
KR100681721B1 (ko) 2007-02-15
ID28695A (id) 2001-06-28
CZ297925B6 (cs) 2007-05-02
AR018633A1 (es) 2001-11-28
NO327075B1 (no) 2009-04-20
CZ20004592A3 (cs) 2001-04-11
US6387944B1 (en) 2002-05-14
PL196074B1 (pl) 2007-12-31
HUP0102256A1 (hu) 2001-12-28
PL344827A1 (en) 2001-11-19
CZ20004591A3 (cs) 2001-04-11
DE19825804C2 (de) 2000-08-24
KR20010052701A (ko) 2001-06-25
WO1999064409A2 (de) 1999-12-16
PT1086092E (pt) 2003-03-31
BR9911123A (pt) 2006-01-03
DE59903411D1 (de) 2002-12-19
HUP0102554A1 (hu) 2001-10-28
DK1086092T3 (da) 2003-03-10
CN1305487A (zh) 2001-07-25
EP1086113B1 (de) 2004-02-11
KR20010052682A (ko) 2001-06-25
EP1086113A2 (de) 2001-03-28
HU229761B1 (hu) 2014-06-30
JP2002517490A (ja) 2002-06-18
BR9912188A (pt) 2001-04-10
DK1086113T3 (da) 2004-05-24
ES2215387T3 (es) 2004-10-01
HUP0102256A3 (en) 2002-04-29
ES2182535T3 (es) 2003-03-01
DE59908522D1 (de) 2004-03-18
RU2220141C2 (ru) 2003-12-27
WO1999064409A3 (de) 2000-03-02
AU4503199A (en) 1999-12-30
PT1086113E (pt) 2004-06-30
CN1127497C (zh) 2003-11-12
JP3374129B2 (ja) 2003-02-04
JP4374426B2 (ja) 2009-12-02
AU753275B2 (en) 2002-10-10
IL140078A0 (en) 2002-02-10
AU752633B2 (en) 2002-09-26
WO1999064410A1 (de) 1999-12-16
BR9912188B1 (pt) 2010-12-14
HUP0102554A3 (en) 2002-12-28
TR200003634T2 (tr) 2001-06-21
EP1086092B1 (de) 2002-11-13
EP1086092A1 (de) 2001-03-28
CA2334775C (en) 2009-10-13
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
HK1039490A1 (en) 2002-04-26
NO20006251D0 (no) 2000-12-08
CN1305469A (zh) 2001-07-25
AR018634A1 (es) 2001-11-28
CA2334773A1 (en) 1999-12-16
ATE227715T1 (de) 2002-11-15
NO20006251L (no) 2001-02-07
IL140078A (en) 2004-08-31
CA2334775A1 (en) 1999-12-16
PL196057B1 (pl) 2007-11-30
ZA200007061B (en) 2001-07-18

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