JP2003520208A5 - - Google Patents
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- JP2003520208A5 JP2003520208A5 JP2001543559A JP2001543559A JP2003520208A5 JP 2003520208 A5 JP2003520208 A5 JP 2003520208A5 JP 2001543559 A JP2001543559 A JP 2001543559A JP 2001543559 A JP2001543559 A JP 2001543559A JP 2003520208 A5 JP2003520208 A5 JP 2003520208A5
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- JP
- Japan
- Prior art keywords
- compound according
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- atoms
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 5
- 0 C*C[C@]([C@@]1O)OC(C)=C[C@@]1C=O Chemical compound C*C[C@]([C@@]1O)OC(C)=C[C@@]1C=O 0.000 description 4
- PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical group O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 description 1
- MPCRDMGAPFBKFH-UHFFFAOYSA-N CC(C(NC(Cc(cc1)ccc1C(C)=C)C(N1CCCCC1)=O)=O)NC Chemical compound CC(C(NC(Cc(cc1)ccc1C(C)=C)C(N1CCCCC1)=O)=O)NC MPCRDMGAPFBKFH-UHFFFAOYSA-N 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204172 | 1999-12-07 | ||
| EP99204172.3 | 1999-12-07 | ||
| PCT/EP2000/012155 WO2001042262A2 (en) | 1999-12-07 | 2000-12-01 | Antithrombotic compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520208A JP2003520208A (ja) | 2003-07-02 |
| JP2003520208A5 true JP2003520208A5 (enExample) | 2008-01-10 |
| JP4820517B2 JP4820517B2 (ja) | 2011-11-24 |
Family
ID=8240976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001543559A Expired - Lifetime JP4820517B2 (ja) | 1999-12-07 | 2000-12-01 | 抗血栓性化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6875755B2 (enExample) |
| EP (1) | EP1237897B1 (enExample) |
| JP (1) | JP4820517B2 (enExample) |
| KR (1) | KR100776607B1 (enExample) |
| CN (1) | CN1195767C (enExample) |
| AR (1) | AR026726A1 (enExample) |
| AU (1) | AU781846B2 (enExample) |
| BR (1) | BR0016217A (enExample) |
| CA (1) | CA2393042C (enExample) |
| CO (1) | CO5251449A1 (enExample) |
| CZ (1) | CZ303385B6 (enExample) |
| HK (1) | HK1047593A1 (enExample) |
| HU (1) | HUP0203471A3 (enExample) |
| IL (2) | IL149628A0 (enExample) |
| NO (1) | NO323059B1 (enExample) |
| NZ (1) | NZ519100A (enExample) |
| PE (1) | PE20010935A1 (enExample) |
| PL (1) | PL202840B1 (enExample) |
| RU (1) | RU2266913C2 (enExample) |
| SK (1) | SK287682B6 (enExample) |
| TW (1) | TWI289566B (enExample) |
| WO (1) | WO2001042262A2 (enExample) |
| ZA (1) | ZA200203799B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2557086A3 (en) * | 2001-09-07 | 2014-11-05 | Alchemia Limited | Synthetic heparin pentasaccharides |
| WO2004007468A1 (en) | 2002-07-15 | 2004-01-22 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| WO2004032836A2 (en) | 2002-10-07 | 2004-04-22 | Merck & Co., Inc. | Antidiabetic beta-amino heterocylcic dipeptidyl peptidase inhibitors |
| JP4413863B2 (ja) | 2002-11-07 | 2010-02-10 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体 |
| CA2512546A1 (en) | 2003-01-17 | 2004-08-05 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| JP2006516573A (ja) | 2003-01-31 | 2006-07-06 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体 |
| WO2004103276A2 (en) | 2003-05-14 | 2004-12-02 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004110436A1 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| US7456204B2 (en) | 2003-06-17 | 2008-11-25 | Merck & Co., Inc. | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CN1882551A (zh) | 2003-07-31 | 2006-12-20 | 麦克公司 | 用作用于治疗或预防糖尿病的二肽基肽酶－iv酶抑制剂的六氢二氮杂吖庚因酮 |
| EP1574516A1 (en) | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Antithrombotic compound |
| TW200621794A (en) * | 2004-10-06 | 2006-07-01 | Akzo Nobel Nv | Pulmonary administration of an antithrombotic compound |
| TWI403334B (zh) * | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| HRP20110331T1 (hr) * | 2005-10-10 | 2011-06-30 | N.V. Organon | Antikoagulantno-antitrombotski dvojni inhibitori, koji sadrže biotinski biljeg |
| CN102892411B (zh) | 2009-12-18 | 2015-01-21 | 恩多提斯药业公司 | 含有合成的低聚糖的药物口服剂型 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
| DE4206858A1 (de) * | 1992-03-05 | 1993-09-09 | Behringwerke Ag | Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| ES2147216T3 (es) * | 1993-09-01 | 2000-09-01 | Akzo Nobel Nv | Bisconjugados que comprenden dos sacaridos y un grupo de union. |
| IL126893A (en) * | 1997-11-19 | 2003-05-29 | Akzo Nobel Nv | Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them |
| NZ508623A (en) * | 1998-06-17 | 2002-11-26 | Akzo Nobel Nv | Antithrombotic peptide compounds with saccharide radicals |
-
2000
- 2000-11-21 TW TW089124693A patent/TWI289566B/zh not_active IP Right Cessation
- 2000-12-01 NZ NZ519100A patent/NZ519100A/en not_active IP Right Cessation
- 2000-12-01 HU HU0203471A patent/HUP0203471A3/hu unknown
- 2000-12-01 US US10/148,868 patent/US6875755B2/en not_active Expired - Lifetime
- 2000-12-01 PL PL355484A patent/PL202840B1/pl not_active IP Right Cessation
- 2000-12-01 AU AU20038/01A patent/AU781846B2/en not_active Expired
- 2000-12-01 CA CA2393042A patent/CA2393042C/en not_active Expired - Lifetime
- 2000-12-01 JP JP2001543559A patent/JP4820517B2/ja not_active Expired - Lifetime
- 2000-12-01 KR KR1020027007186A patent/KR100776607B1/ko not_active Expired - Fee Related
- 2000-12-01 WO PCT/EP2000/012155 patent/WO2001042262A2/en not_active Ceased
- 2000-12-01 RU RU2002118117/04A patent/RU2266913C2/ru not_active IP Right Cessation
- 2000-12-01 BR BR0016217-5A patent/BR0016217A/pt active Search and Examination
- 2000-12-01 CN CNB008167753A patent/CN1195767C/zh not_active Expired - Fee Related
- 2000-12-01 EP EP00983209.8A patent/EP1237897B1/en not_active Expired - Lifetime
- 2000-12-01 HK HK02109170.1A patent/HK1047593A1/zh unknown
- 2000-12-01 IL IL14962800A patent/IL149628A0/xx unknown
- 2000-12-01 CZ CZ20021958A patent/CZ303385B6/cs not_active IP Right Cessation
- 2000-12-01 SK SK794-2002A patent/SK287682B6/sk not_active IP Right Cessation
- 2000-12-06 AR ARP000106443A patent/AR026726A1/es active IP Right Grant
- 2000-12-06 CO CO00093231A patent/CO5251449A1/es not_active Application Discontinuation
- 2000-12-06 PE PE2000001308A patent/PE20010935A1/es not_active Application Discontinuation
-
2002
- 2002-05-13 ZA ZA200203799A patent/ZA200203799B/xx unknown
- 2002-05-14 IL IL149628A patent/IL149628A/en not_active IP Right Cessation
- 2002-06-06 NO NO20022689A patent/NO323059B1/no not_active IP Right Cessation
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