JP2005537268A5 - - Google Patents
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- Publication number
- JP2005537268A5 JP2005537268A5 JP2004521935A JP2004521935A JP2005537268A5 JP 2005537268 A5 JP2005537268 A5 JP 2005537268A5 JP 2004521935 A JP2004521935 A JP 2004521935A JP 2004521935 A JP2004521935 A JP 2004521935A JP 2005537268 A5 JP2005537268 A5 JP 2005537268A5
- Authority
- JP
- Japan
- Prior art keywords
- quinidine
- dextromethorphan
- salt
- day
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 claims 106
- 239000003814 drug Substances 0.000 claims 55
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims 53
- 229960001404 quinidine Drugs 0.000 claims 53
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims 52
- 229960001985 dextromethorphan Drugs 0.000 claims 52
- 229940124597 therapeutic agent Drugs 0.000 claims 38
- 230000004770 neurodegeneration Effects 0.000 claims 18
- 208000015122 neurodegenerative disease Diseases 0.000 claims 18
- 229940079593 drug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 239000002775 capsule Substances 0.000 claims 10
- 208000029028 brain injury Diseases 0.000 claims 9
- 206010054196 Affect lability Diseases 0.000 claims 7
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 claims 6
- GJHKWLSRHNWTAN-UHFFFAOYSA-N 1-ethoxy-4-(4-pentylcyclohexyl)benzene Chemical compound C1CC(CCCCC)CCC1C1=CC=C(OCC)C=C1 GJHKWLSRHNWTAN-UHFFFAOYSA-N 0.000 claims 6
- -1 alkali metal salt Chemical class 0.000 claims 6
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 claims 6
- 201000006417 multiple sclerosis Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229960004482 quinidine sulfate Drugs 0.000 claims 6
- 239000000890 drug combination Substances 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 229940126585 therapeutic drug Drugs 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 239000004381 Choline salt Chemical class 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical class NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 3
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 239000007983 Tris buffer Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical class C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 3
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 claims 3
- 235000019417 choline salt Nutrition 0.000 claims 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 3
- 239000012458 free base Chemical class 0.000 claims 3
- 230000001146 hypoxic effect Effects 0.000 claims 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims 3
- 229910003002 lithium salt Inorganic materials 0.000 claims 3
- 159000000002 lithium salts Chemical class 0.000 claims 3
- 159000000003 magnesium salts Chemical class 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 230000016273 neuron death Effects 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 3
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 3
- 150000003248 quinolines Chemical class 0.000 claims 3
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- 230000008451 emotion Effects 0.000 claims 2
- 201000000196 pseudobulbar palsy Diseases 0.000 claims 2
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39666102P | 2002-07-17 | 2002-07-17 | |
| US60/396,661 | 2002-07-17 | ||
| PCT/US2003/022303 WO2004006930A1 (en) | 2002-07-17 | 2003-07-17 | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011157054A Division JP2011225601A (ja) | 2002-07-17 | 2011-07-15 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2012024387A Division JP2012116858A (ja) | 2002-07-17 | 2012-02-07 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005537268A JP2005537268A (ja) | 2005-12-08 |
| JP2005537268A5 true JP2005537268A5 (enExample) | 2006-08-31 |
| JP5082032B2 JP5082032B2 (ja) | 2012-11-28 |
Family
ID=30116047
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521935A Expired - Lifetime JP5082032B2 (ja) | 2002-07-17 | 2003-07-17 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2011157054A Pending JP2011225601A (ja) | 2002-07-17 | 2011-07-15 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2012024387A Pending JP2012116858A (ja) | 2002-07-17 | 2012-02-07 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2013272584A Pending JP2014058575A (ja) | 2002-07-17 | 2013-12-27 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2014035209A Pending JP2014129384A (ja) | 2002-07-17 | 2014-02-26 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2015182769A Expired - Lifetime JP6074000B2 (ja) | 2002-07-17 | 2015-09-16 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2016051838A Expired - Lifetime JP6097859B2 (ja) | 2002-07-17 | 2016-03-16 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2016225766A Expired - Lifetime JP6332651B2 (ja) | 2002-07-17 | 2016-11-21 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2017027686A Pending JP2017088620A (ja) | 2002-07-17 | 2017-02-17 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2018106910A Pending JP2018150368A (ja) | 2002-07-17 | 2018-06-04 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2019191618A Pending JP2020063248A (ja) | 2002-07-17 | 2019-10-21 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2021039908A Withdrawn JP2021098743A (ja) | 2002-07-17 | 2021-03-12 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
Family Applications After (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011157054A Pending JP2011225601A (ja) | 2002-07-17 | 2011-07-15 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2012024387A Pending JP2012116858A (ja) | 2002-07-17 | 2012-02-07 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2013272584A Pending JP2014058575A (ja) | 2002-07-17 | 2013-12-27 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2014035209A Pending JP2014129384A (ja) | 2002-07-17 | 2014-02-26 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2015182769A Expired - Lifetime JP6074000B2 (ja) | 2002-07-17 | 2015-09-16 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2016051838A Expired - Lifetime JP6097859B2 (ja) | 2002-07-17 | 2016-03-16 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2016225766A Expired - Lifetime JP6332651B2 (ja) | 2002-07-17 | 2016-11-21 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2017027686A Pending JP2017088620A (ja) | 2002-07-17 | 2017-02-17 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2018106910A Pending JP2018150368A (ja) | 2002-07-17 | 2018-06-04 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2019191618A Pending JP2020063248A (ja) | 2002-07-17 | 2019-10-21 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
| JP2021039908A Withdrawn JP2021098743A (ja) | 2002-07-17 | 2021-03-12 | 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (12) | US7659282B2 (enExample) |
| EP (6) | EP1539166B1 (enExample) |
| JP (12) | JP5082032B2 (enExample) |
| KR (7) | KR20050043893A (enExample) |
| AT (1) | ATE399553T1 (enExample) |
| AU (3) | AU2003251971B9 (enExample) |
| BE (1) | BE2013C064I2 (enExample) |
| CA (1) | CA2492081C (enExample) |
| CY (2) | CY1110405T1 (enExample) |
| DE (1) | DE60321929D1 (enExample) |
| DK (2) | DK1980252T3 (enExample) |
| ES (2) | ES2553654T3 (enExample) |
| FR (1) | FR13C0062I2 (enExample) |
| HU (2) | HUE028100T2 (enExample) |
| IL (7) | IL166166A0 (enExample) |
| LU (1) | LU92323I2 (enExample) |
| NO (2) | NO330626B1 (enExample) |
| PL (2) | PL398445A1 (enExample) |
| PT (2) | PT1539166E (enExample) |
| RU (1) | RU2341265C2 (enExample) |
| SI (2) | SI1980252T1 (enExample) |
| TW (1) | TWI326214B (enExample) |
| WO (1) | WO2004006930A1 (enExample) |
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3405058B2 (ja) | 1996-03-29 | 2003-05-12 | スズキ株式会社 | トランスファの潤滑構造 |
| TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| US7754767B2 (en) * | 2002-11-06 | 2010-07-13 | Trinity Laboratories, Inc. | Method for treatment of premature ejaculation in humans |
| US20070004680A1 (en) * | 2004-03-30 | 2007-01-04 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| US20070191411A1 (en) * | 2004-10-07 | 2007-08-16 | Smith Richard A | Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| AU2007212586A1 (en) * | 2006-02-03 | 2007-08-16 | Avanir Pharmaceuticals | Pharmaceutical compositions for treating depression, anxiety and neurodegenerative disorders |
| US20160143901A1 (en) * | 2006-02-03 | 2016-05-26 | Avanir Pharmaceuticals, Inc. | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of agitation in dementia |
| CN102718710B (zh) | 2007-05-01 | 2014-11-05 | 康塞特医药品公司 | 吗啡烷化合物 |
| EP3632916B1 (en) | 2007-05-01 | 2022-06-08 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| PT2522668E (pt) | 2007-05-01 | 2015-06-09 | Concert Pharmaceuticals Inc | Compostos de morfinano |
| WO2009006194A1 (en) * | 2007-06-28 | 2009-01-08 | Avanir Pharmaceuticals | Pharmaceutical compositions for the treatment of involuntary emotional expression disorder |
| ES2575086T3 (es) | 2008-09-19 | 2016-06-24 | Concert Pharmaceuticals Inc. | Compuestos de morfinano deuterados |
| US20120122848A1 (en) * | 2009-07-29 | 2012-05-17 | Green Cross Corporation | (+)-3-hydroxymorphinan derivatives as neuroprotectants |
| US20110212987A1 (en) * | 2009-08-28 | 2011-09-01 | Avanir Pharmaceuticals, Inc. | Method of reducing cns and gastrointestinal side affects associated with long-term dextromethorphan/low-dose quinidine combination therapy |
| KR20130061148A (ko) * | 2010-05-03 | 2013-06-10 | 티에스에이치 바이오팜 코포레이션 리미티드 | 고혈압 치료용 약학 조성물 및 방법 |
| JP5935154B2 (ja) * | 2011-03-14 | 2016-06-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ１１９モジュレーターとしてのｎ−シクロプロピル−ｎ−ピペリジニルベンズアミド |
| US8569328B1 (en) * | 2011-05-24 | 2013-10-29 | Antecip Bioventures Ii Llc | Compositions and methods comprising tilidine or related compounds and dextromethorphan |
| WO2012168315A1 (en) | 2011-06-09 | 2012-12-13 | Boehringer Ingelheim International Gmbh | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
| US20130274282A1 (en) * | 2012-04-16 | 2013-10-17 | Herriot Tabuteau | Compositions and methods comprising celecoxib or related compounds and dextromethorphan |
| WO2014078435A1 (en) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
| WO2014138669A1 (en) * | 2013-03-07 | 2014-09-12 | Mindlab LLC | Pain medicine combination and uses thereof |
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2019
- 2019-06-16 IL IL267381A patent/IL267381A/en unknown
- 2019-10-03 US US16/591,879 patent/US20200276185A1/en not_active Abandoned
- 2019-10-21 JP JP2019191618A patent/JP2020063248A/ja active Pending
-
2021
- 2021-03-12 JP JP2021039908A patent/JP2021098743A/ja not_active Withdrawn
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