AU2003251971B9 - Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders - Google Patents

Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders Download PDF

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Publication number
AU2003251971B9
AU2003251971B9 AU2003251971A AU2003251971A AU2003251971B9 AU 2003251971 B9 AU2003251971 B9 AU 2003251971B9 AU 2003251971 A AU2003251971 A AU 2003251971A AU 2003251971 A AU2003251971 A AU 2003251971A AU 2003251971 B9 AU2003251971 B9 AU 2003251971B9
Authority
AU
Australia
Prior art keywords
dextromethorphan
quinidine
day
administered
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2003251971A
Other languages
English (en)
Other versions
AU2003251971B2 (en
AU2003251971A1 (en
Inventor
James Berg
Laura E. Pope
Richard A. Smith
Gerald Yakatan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avanir Pharmaceuticals Inc
Original Assignee
Avanir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30116047&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2003251971(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Publication of AU2003251971A1 publication Critical patent/AU2003251971A1/en
Publication of AU2003251971B2 publication Critical patent/AU2003251971B2/en
Priority to AU2008201775A priority Critical patent/AU2008201775B2/en
Application granted granted Critical
Publication of AU2003251971B9 publication Critical patent/AU2003251971B9/en
Priority to AU2010212348A priority patent/AU2010212348B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AU2003251971A 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders Expired AU2003251971B9 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2008201775A AU2008201775B2 (en) 2002-07-17 2008-04-22 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2010212348A AU2010212348B2 (en) 2002-07-17 2010-08-13 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39666102P 2002-07-17 2002-07-17
US60/396,661 2002-07-17
PCT/US2003/022303 WO2004006930A1 (en) 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008201775A Division AU2008201775B2 (en) 2002-07-17 2008-04-22 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Publications (3)

Publication Number Publication Date
AU2003251971A1 AU2003251971A1 (en) 2004-02-02
AU2003251971B2 AU2003251971B2 (en) 2008-02-21
AU2003251971B9 true AU2003251971B9 (en) 2008-04-24

Family

ID=30116047

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2003251971A Expired AU2003251971B9 (en) 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2008201775A Expired AU2008201775B2 (en) 2002-07-17 2008-04-22 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2010212348A Expired AU2010212348B2 (en) 2002-07-17 2010-08-13 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2008201775A Expired AU2008201775B2 (en) 2002-07-17 2008-04-22 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2010212348A Expired AU2010212348B2 (en) 2002-07-17 2010-08-13 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Country Status (23)

Country Link
US (12) US7659282B2 (enExample)
EP (6) EP3281630A1 (enExample)
JP (12) JP5082032B2 (enExample)
KR (7) KR101622446B1 (enExample)
AT (1) ATE399553T1 (enExample)
AU (3) AU2003251971B9 (enExample)
BE (1) BE2013C064I2 (enExample)
CA (1) CA2492081C (enExample)
CY (2) CY1110405T1 (enExample)
DE (1) DE60321929D1 (enExample)
DK (2) DK1980252T3 (enExample)
ES (2) ES2553654T3 (enExample)
FR (1) FR13C0062I2 (enExample)
HU (2) HUE028100T2 (enExample)
IL (7) IL166166A0 (enExample)
LU (1) LU92323I2 (enExample)
NO (2) NO330626B1 (enExample)
PL (2) PL213552B1 (enExample)
PT (2) PT1539166E (enExample)
RU (1) RU2341265C2 (enExample)
SI (2) SI1980252T1 (enExample)
TW (1) TWI326214B (enExample)
WO (1) WO2004006930A1 (enExample)

Families Citing this family (143)

* Cited by examiner, † Cited by third party
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JP3405058B2 (ja) 1996-03-29 2003-05-12 スズキ株式会社 トランスファの潤滑構造
TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2003291302A1 (en) * 2002-11-06 2004-06-03 Azaya Therapeutics, Inc. Method for treatment of premature ejaculation in humans
EP1734962A4 (en) * 2004-03-30 2010-07-14 Painceptor Pharma Corp COMPOSITIONS AND METHOD FOR MODULATING CONTROLLED ION CHANNELS
US20070191411A1 (en) * 2004-10-07 2007-08-16 Smith Richard A Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
KR20080097443A (ko) * 2006-02-03 2008-11-05 아바니르 파마슈티컬스 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물
US20160143901A1 (en) * 2006-02-03 2016-05-26 Avanir Pharmaceuticals, Inc. Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of agitation in dementia
MX341177B (es) 2007-05-01 2016-08-10 Concert Pharmaceuticals Inc Compuestos de morfina.
EP2522668B1 (en) * 2007-05-01 2015-02-25 Concert Pharmaceuticals, Inc. Morphinan compounds
ES2536984T3 (es) 2007-05-01 2015-06-01 Concert Pharmaceuticals, Inc. Compuestos de morfina
WO2009006194A1 (en) * 2007-06-28 2009-01-08 Avanir Pharmaceuticals Pharmaceutical compositions for the treatment of involuntary emotional expression disorder
CA2737811C (en) 2008-09-19 2019-07-09 Concert Pharmaceuticals Inc. Morphinan compounds
KR101401386B1 (ko) * 2009-07-29 2014-05-29 주식회사 녹십자 신경보호제로서의 (+)-3-하이드록시모르피난 유도체
US20110212987A1 (en) * 2009-08-28 2011-09-01 Avanir Pharmaceuticals, Inc. Method of reducing cns and gastrointestinal side affects associated with long-term dextromethorphan/low-dose quinidine combination therapy
JP5847162B2 (ja) * 2010-05-03 2016-01-20 ティーエスエイチ バイオファーム コーポレーション リミテッド 高血圧治療用医薬組成物及び方法
JP5935154B2 (ja) * 2011-03-14 2016-06-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇｐｒ１１９モジュレーターとしてのｎ−シクロプロピル−ｎ−ピペリジニルベンズアミド
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US10716784B2 (en) 2013-03-07 2020-07-21 Mindlab LLC Pain medicine combination and uses thereof
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