CN1195767C - 抗血栓形成化合物 - Google Patents

抗血栓形成化合物 Download PDF

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Publication number
CN1195767C
CN1195767C CNB008167753A CN00816775A CN1195767C CN 1195767 C CN1195767 C CN 1195767C CN B008167753 A CNB008167753 A CN B008167753A CN 00816775 A CN00816775 A CN 00816775A CN 1195767 C CN1195767 C CN 1195767C
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CN
China
Prior art keywords
compound
formula
group
solution
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008167753A
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English (en)
Chinese (zh)
Other versions
CN1407989A (zh
Inventor
C·A·A·范伯伊克尔
C·M·特罗姆普
T·T·M·吉尔特森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme BV
Original Assignee
Sanofi Synthelabo SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA, Akzo Nobel NV filed Critical Sanofi Synthelabo SA
Publication of CN1407989A publication Critical patent/CN1407989A/zh
Application granted granted Critical
Publication of CN1195767C publication Critical patent/CN1195767C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CNB008167753A 1999-12-07 2000-12-01 抗血栓形成化合物 Expired - Fee Related CN1195767C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204172 1999-12-07
EP99204172.3 1999-12-07

Publications (2)

Publication Number Publication Date
CN1407989A CN1407989A (zh) 2003-04-02
CN1195767C true CN1195767C (zh) 2005-04-06

Family

ID=8240976

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008167753A Expired - Fee Related CN1195767C (zh) 1999-12-07 2000-12-01 抗血栓形成化合物

Country Status (23)

Country Link
US (1) US6875755B2 (enExample)
EP (1) EP1237897B1 (enExample)
JP (1) JP4820517B2 (enExample)
KR (1) KR100776607B1 (enExample)
CN (1) CN1195767C (enExample)
AR (1) AR026726A1 (enExample)
AU (1) AU781846B2 (enExample)
BR (1) BR0016217A (enExample)
CA (1) CA2393042C (enExample)
CO (1) CO5251449A1 (enExample)
CZ (1) CZ303385B6 (enExample)
HK (1) HK1047593A1 (enExample)
HU (1) HUP0203471A3 (enExample)
IL (2) IL149628A0 (enExample)
NO (1) NO323059B1 (enExample)
NZ (1) NZ519100A (enExample)
PE (1) PE20010935A1 (enExample)
PL (1) PL202840B1 (enExample)
RU (1) RU2266913C2 (enExample)
SK (1) SK287682B6 (enExample)
TW (1) TWI289566B (enExample)
WO (1) WO2001042262A2 (enExample)
ZA (1) ZA200203799B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2557086A3 (en) * 2001-09-07 2014-11-05 Alchemia Limited Synthetic heparin pentasaccharides
WO2004007468A1 (en) 2002-07-15 2004-01-22 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004032836A2 (en) 2002-10-07 2004-04-22 Merck & Co., Inc. Antidiabetic beta-amino heterocylcic dipeptidyl peptidase inhibitors
JP4413863B2 (ja) 2002-11-07 2010-02-10 メルク エンド カムパニー インコーポレーテッド 糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
CA2512546A1 (en) 2003-01-17 2004-08-05 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2006516573A (ja) 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
WO2004103276A2 (en) 2003-05-14 2004-12-02 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004110436A1 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7456204B2 (en) 2003-06-17 2008-11-25 Merck & Co., Inc. Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CN1882551A (zh) 2003-07-31 2006-12-20 麦克公司 用作用于治疗或预防糖尿病的二肽基肽酶－iv酶抑制剂的六氢二氮杂吖庚因酮
EP1574516A1 (en) 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
TW200621794A (en) * 2004-10-06 2006-07-01 Akzo Nobel Nv Pulmonary administration of an antithrombotic compound
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
HRP20110331T1 (hr) * 2005-10-10 2011-06-30 N.V. Organon Antikoagulantno-antitrombotski dvojni inhibitori, koji sadrže biotinski biljeg
CN102892411B (zh) 2009-12-18 2015-01-21 恩多提斯药业公司 含有合成的低聚糖的药物口服剂型

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2147216T3 (es) * 1993-09-01 2000-09-01 Akzo Nobel Nv Bisconjugados que comprenden dos sacaridos y un grupo de union.
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
NZ508623A (en) * 1998-06-17 2002-11-26 Akzo Nobel Nv Antithrombotic peptide compounds with saccharide radicals

Also Published As

Publication number Publication date
KR20020070988A (ko) 2002-09-11
NO20022689D0 (no) 2002-06-06
RU2266913C2 (ru) 2005-12-27
US20030114361A1 (en) 2003-06-19
PL202840B1 (pl) 2009-07-31
JP4820517B2 (ja) 2011-11-24
EP1237897B1 (en) 2015-01-14
NO20022689L (no) 2002-06-06
KR100776607B1 (ko) 2007-11-16
CA2393042C (en) 2011-06-28
CZ303385B6 (cs) 2012-08-29
BR0016217A (pt) 2002-09-10
PL355484A1 (en) 2004-05-04
CZ20021958A3 (cs) 2002-08-14
WO2001042262A3 (en) 2001-12-13
ZA200203799B (en) 2003-10-29
AU2003801A (en) 2001-06-18
CA2393042A1 (en) 2001-06-14
AR026726A1 (es) 2003-02-26
EP1237897A2 (en) 2002-09-11
SK287682B6 (sk) 2011-06-06
SK7942002A3 (en) 2002-09-10
NZ519100A (en) 2004-09-24
PE20010935A1 (es) 2001-09-20
WO2001042262A2 (en) 2001-06-14
AU781846B2 (en) 2005-06-16
HUP0203471A3 (en) 2003-03-28
CO5251449A1 (es) 2003-02-28
IL149628A0 (en) 2002-11-10
TWI289566B (en) 2007-11-11
HK1047593A1 (zh) 2003-02-28
US6875755B2 (en) 2005-04-05
NO323059B1 (no) 2006-12-27
CN1407989A (zh) 2003-04-02
JP2003520208A (ja) 2003-07-02
HUP0203471A2 (hu) 2003-02-28
IL149628A (en) 2010-04-29

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