JP2008540687A5 - - Google Patents

Download PDF

Info

Publication number
JP2008540687A5
JP2008540687A5 JP2008512617A JP2008512617A JP2008540687A5 JP 2008540687 A5 JP2008540687 A5 JP 2008540687A5 JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008540687 A5 JP2008540687 A5 JP 2008540687A5
Authority
JP
Japan
Prior art keywords
alkyl
group
aryl
heteroaryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008512617A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008540687A (ja
JP5463034B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/020970 external-priority patent/WO2006128184A2/en
Publication of JP2008540687A publication Critical patent/JP2008540687A/ja
Publication of JP2008540687A5 publication Critical patent/JP2008540687A5/ja
Application granted granted Critical
Publication of JP5463034B2 publication Critical patent/JP5463034B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008512617A 2005-05-20 2006-05-22 ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 Expired - Fee Related JP5463034B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68347005P 2005-05-20 2005-05-20
US60/683,470 2005-05-20
US70646505P 2005-08-08 2005-08-08
US60/706,465 2005-08-08
US73499105P 2005-11-09 2005-11-09
US60/734,991 2005-11-09
PCT/US2006/020970 WO2006128184A2 (en) 2005-05-20 2006-05-22 Pyrimidine or triazine fused bicyclic metalloprotease inhibitors

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013089076A Division JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Division JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Publications (3)

Publication Number Publication Date
JP2008540687A JP2008540687A (ja) 2008-11-20
JP2008540687A5 true JP2008540687A5 (enExample) 2009-07-30
JP5463034B2 JP5463034B2 (ja) 2014-04-09

Family

ID=37239216

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008512617A Expired - Fee Related JP5463034B2 (ja) 2005-05-20 2006-05-22 ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
JP2013089076A Expired - Fee Related JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Withdrawn JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013089076A Expired - Fee Related JP5391351B2 (ja) 2005-05-20 2013-04-22 ヘテロ二環式メタロプロテアーゼ阻害薬
JP2013254709A Withdrawn JP2014088396A (ja) 2005-05-20 2013-12-10 ヘテロ二環式メタロプロテアーゼ阻害薬

Country Status (13)

Country Link
US (2) US20060293345A1 (enExample)
EP (1) EP1910367A2 (enExample)
JP (3) JP5463034B2 (enExample)
KR (1) KR20080087070A (enExample)
CN (1) CN101238127A (enExample)
AU (1) AU2006251989B2 (enExample)
BR (1) BRPI0609802A2 (enExample)
CA (1) CA2608890C (enExample)
CR (1) CR9614A (enExample)
EA (1) EA013525B1 (enExample)
IL (1) IL187495A0 (enExample)
NO (1) NO20076554L (enExample)
WO (1) WO2006128184A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155737A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
WO2008063669A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic matrix metalloprotease inhibitors
CA2670083A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
CA2680173A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
KR20210103586A (ko) * 2007-06-04 2021-08-23 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
WO2009075790A1 (en) * 2007-12-07 2009-06-18 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors for intra-articular application
CN105418450A (zh) 2008-05-05 2016-03-23 赛诺菲-安万特 酰基氨基取代的稠合环戊烷羧酸衍生物及它们作为药物的用途
RU2630577C2 (ru) 2008-12-04 2017-09-11 Чунси ЮЙ Композиции интенсивного проникновения и их применение
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
CN101709034B (zh) * 2009-12-14 2017-05-31 大连九信精细化工有限公司 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法
WO2011082271A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted triazolo-pyrimidine compounds
EP2649075B1 (en) 2010-12-08 2018-04-25 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Substituted pyrazolopyrimidines as glucocerebrosidase activators
US9309250B2 (en) 2011-06-22 2016-04-12 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
KR101935868B1 (ko) 2011-12-30 2019-04-03 에스케이이노베이션 주식회사 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품
CN116898848A (zh) 2012-01-18 2023-10-20 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
WO2014089379A1 (en) 2012-12-07 2014-06-12 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
US9663519B2 (en) 2013-03-15 2017-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2970289A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
EP2970288A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2015085132A1 (en) 2013-12-06 2015-06-11 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
HRP20200186T1 (hr) 2014-06-05 2020-05-29 Vertex Pharmaceuticals Inc. Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici
JP6936007B2 (ja) 2014-06-17 2021-09-15 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｃｈｋ１阻害剤とａｔｒ阻害剤との組み合わせを使用してがんを処置する方法
CN104326914A (zh) * 2014-11-18 2015-02-04 江苏恒祥化工有限责任公司 一种反式-4-甲酸甲酯环己烷甲酸的制备方法
CN104560997B (zh) * 2014-12-25 2018-05-04 中国科学院广州生物医药与健康研究院 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用
DK3237619T3 (da) 2014-12-25 2020-11-09 Guangzhou Ribobio Co Ltd Sammensætninger og fremgangsmåder til at inhibere ekspression af adamts-5 og adam17
EP3355926B1 (en) 2015-09-30 2025-12-24 Vertex Pharmaceuticals Inc. Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using
EP3529230B1 (en) 2016-10-19 2020-09-30 Eastman Chemical Company Synthesis of bicyclo(2.2.2)octanes
WO2019075004A1 (en) * 2017-10-11 2019-04-18 Eastman Chemical Company SYNTHESIS OF BICYCLO [2.2.2] OCTANE DERIVATIVES
MD3740481T3 (ro) * 2018-01-19 2025-06-30 Cytokinetics Inc Analogi de dihidrobenzofuran și inden în calitate de inhibitori ai sarcomerului cardiac
CN108558672B (zh) * 2018-06-21 2021-04-30 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸及其异构体的制备方法
CN110950868B (zh) * 2018-09-27 2022-05-13 苏州锐明新药研发有限公司 吡唑并嘧啶化合物及制备方法与制备抗癌症药物的应用
US10836899B2 (en) 2018-12-13 2020-11-17 Eastman Chemical Company Polyesters with specified crystallization half-times
CN116283995B (zh) * 2022-09-08 2023-12-29 华中科技大学同济医学院附属同济医院 一种脂酰辅酶a合成酶短链家族成员3的激动剂及其应用
CN116969831B (zh) * 2023-08-01 2025-09-23 菏泽皓元医药科技有限公司 一种莫奈太尔的中间体及其制备方法

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497814A (en) * 1982-08-16 1985-02-05 Schering Corporation 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility
JPH0750322B2 (ja) * 1986-06-25 1995-05-31 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料の処理方
DE3704203A1 (de) * 1987-02-11 1988-08-25 Boehringer Ingelheim Kg Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie
FI883320L (fi) * 1987-08-07 1989-02-08 Sankei Yakuhin Kk --laktam, dess framstaellning och mellanprodukter foer dess framstaellning.
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
DE3942357A1 (de) * 1989-12-21 1991-06-27 Boehringer Mannheim Gmbh 3-aminopyrazolo-heterocyclen, deren verwendung zur bestimmung von wasserstoffperoxid, wasserstoffperoxid-bildenden systemen, peroxidase, peroxidatisch wirksamen substanzen oder von elektronenreichen aromatischen verbindungen, entsprechende bestimmungsverfahren und hierfuer geeignete mittel
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
JPH06509576A (ja) * 1991-07-29 1994-10-27 ワーナー−ランバート・コンパニー アセチルコリンエステラーゼ阻害剤としてのキナゾリン誘導体
WO1993002711A1 (en) * 1991-08-09 1993-02-18 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
US5302586A (en) * 1991-12-19 1994-04-12 G. D. Searle & Co. Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury
FR2687675B1 (fr) * 1992-01-31 1997-04-18 Roussel Uclaf Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
JP2794510B2 (ja) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
MX9304801A (es) * 1992-08-06 1997-06-28 Warner Lambert Co 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
DE4327027A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Imidazoazine
DE4311460A1 (de) * 1993-04-08 1994-10-13 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen Bestimmung eines Analyten mittels Benzylalkoholdehydrogenase und einem chromogenen Redoxindikator
DE4311464A1 (de) * 1993-04-08 1994-10-13 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
DE59608203D1 (de) * 1995-05-09 2001-12-20 Basf Ag PYRAZOLO- 1,5a]-PYRIMIDINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
IT1286545B1 (it) * 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
AR015104A1 (es) * 1996-11-13 2001-04-18 Dowelanco Compuestos de n-arilsulfilimina sustituidos, utiles como catalizadores en la preparacion de compuestos de n-arilarilsulfonamida; proceso para preparar dichos compuestos y su uso para catalizar dicha preparacion.
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6110944A (en) * 1997-03-12 2000-08-29 G. D. Searle & Co. LTA4, hydrolase inhibitors
US6214834B1 (en) * 1997-03-28 2001-04-10 Dupont Pharmaceuticals Company Integrin inhibitor prodrugs
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
JP3773227B2 (ja) * 1997-10-16 2006-05-10 東京応化工業株式会社 レジスト用剥離液組成物およびこれを用いたレジスト剥離方法
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
AUPP278498A0 (en) * 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6319660B1 (en) * 1998-12-28 2001-11-20 Eastman Kodak Company Color photographic element containing speed improving compound
US6190848B1 (en) * 1999-07-21 2001-02-20 Eastman Kodak Company Color photographic element containing ballasted triazole derivative and inhibitor releasing coupler
GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
FR2801308B1 (fr) * 1999-11-19 2003-05-09 Oreal COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
US6461538B2 (en) * 1999-12-16 2002-10-08 Fuji Photo Film Co., Ltd. Production process for indolizine compounds and their use in organic light-emitting devices
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
FR2805539B1 (fr) * 2000-02-25 2005-06-10 Oreal Compositions de teinture des fibres keratiniques contenant des derives d'indolizine et procede de teinture
JP2001348520A (ja) * 2000-04-03 2001-12-18 Fuji Photo Film Co Ltd メチン化合物、固体微粒子分散物、インクジェット用記録液、およびインクジェット記録方法
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
PL358877A1 (en) * 2000-04-28 2004-08-23 Baxter Healthcare Sa 2-acyl indol derivatives and their use as anti-tumour agents
CA2413802A1 (en) * 2000-06-30 2002-01-10 Mark R. Schmitt Substituted-triazolopyrimidines as anticancer agents
US20020041880A1 (en) * 2000-07-05 2002-04-11 Defeo-Jones Deborah Method of treating cancer
AUPQ969800A0 (en) * 2000-08-28 2000-09-21 Fujisawa Pharmaceutical Co., Ltd. Pyrazolopyridine compound and pharmaceutical use thereof
TWI243019B (en) * 2000-08-31 2005-11-11 Basf Ag Process for the preparation of a solid herbicidal formulation
JP2002205992A (ja) * 2000-11-08 2002-07-23 Takeda Chem Ind Ltd 二環式トリアゾロン誘導体およびそれを含有する除草剤
DE60112609T2 (de) * 2000-12-15 2006-01-19 Glaxo Group Ltd., Greenford Pyrazolopyridine
PA8539501A1 (es) * 2001-02-14 2002-09-30 Warner Lambert Co Compuestos triazolo como inhibidores de mmp
WO2002064571A1 (en) * 2001-02-14 2002-08-22 Warner-Lambert Company Llc Pyrimidine matrix metalloproteinase inhibitors
ES2316546T3 (es) * 2001-02-20 2009-04-16 Astrazeneca Ab 2-arilamino-pirimidinas para el tratamiento de trastornos asociados a gsk3.
JP4237497B2 (ja) * 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
US6756498B2 (en) * 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
WO2002096363A2 (en) * 2001-05-30 2002-12-05 Alteon, Inc. Method for treating fibrotic diseases or other indications
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US6861436B2 (en) * 2001-09-13 2005-03-01 Synta Pharmaceuticals Corp. 1-glyoxylamide indolizines for treating cancer
US20040116462A1 (en) * 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
US6740649B2 (en) * 2001-09-17 2004-05-25 Bristol-Myers Squibb Company Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
DE10160357A1 (de) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
TW200306822A (en) * 2002-01-31 2003-12-01 Daiichi Seiyaku Co Imidazo[1, 2-a]pyridine derivative
CA2484631A1 (en) * 2002-05-13 2003-11-27 Merck & Co., Inc. Phenyl substituted imidazopyridines and phenyl substituted benzimidazoles
AU2003240488A1 (en) * 2002-06-04 2003-12-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
AU2003249535A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors
AU2003253165A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
ATE388941T1 (de) * 2002-11-02 2008-03-15 Sanofi Aventis Deutschland Neue pyrimidin-4,6-dicarbons urediamide zur selektiven inhibierung von kollagenasen
US7824851B2 (en) * 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
WO2004052315A2 (en) * 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2004222387A1 (en) * 2003-03-13 2004-09-30 Synta Pharmaceuticals Corp. Fused pyrrole compounds
ES2423800T3 (es) * 2003-03-28 2013-09-24 Novartis Vaccines And Diagnostics, Inc. Uso de compuestos orgánicos para la inmunopotenciación
US7235569B2 (en) * 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
EP2236131A3 (en) * 2003-07-01 2011-03-02 President and Fellows of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
HRP20110180T1 (hr) * 2003-07-23 2011-04-30 Synta Pharmaceuticals Corporation Spojevi za upotrebu kod upala i upotrebe vezane uz imunitet
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7144907B2 (en) * 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US20060173183A1 (en) * 2004-12-31 2006-08-03 Alantos Pharmaceuticals, Inc., Multicyclic bis-amide MMP inhibitors
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155737A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
CA2635580A1 (en) * 2005-12-30 2007-07-12 Alantos Pharmaceuticals Holding, Inc. Substituted bis-amide metalloprotease inhibitors

Similar Documents

Publication Publication Date Title
JP2008540687A5 (enExample)
RU2353616C2 (ru) Производные 2-пиридона в качестве ингибиторов эластазы нейтрофилов и их применение
RU2370495C2 (ru) Дополнительные гетероциклические соединения и их применение в качестве антагонистов метаботропного глутаматного рецептора
JP2008513498A5 (enExample)
RU2007120454A (ru) Производные хинуклидина и их применение в качестве антагонистов мускариновых рецепторов м3
JP2006500394A5 (enExample)
JP2018524339A5 (enExample)
JP2004530641A5 (enExample)
JP2009522295A5 (enExample)
JP2012511588A5 (enExample)
JP2006506352A5 (enExample)
MY145465A (en) Diaminopyrimidines as p2x3 and p2x2/3 antagonists.
JP2007530577A5 (enExample)
JP2007517006A5 (enExample)
DE60309829D1 (de) Glucocorticoid mimetika, verfahren zu ihrer herstellung, pharmazeutische formulierungen sie enthaltend und verwendungen davon
JP2010526079A5 (enExample)
KR960705795A (ko) 항염증제로서의 이속사졸린 화합물(isoxazoline compounds as antinflammatiory agents)
CA2652834A1 (en) Substituted arylimidazolones and -triazolones and the use thereof
JP2003506491A5 (enExample)
JP2005508967A5 (enExample)
JP2006512293A5 (enExample)
JP2008514650A5 (enExample)
JP2004529145A5 (enExample)
JP2007538031A5 (enExample)
RU2007108863A (ru) Производные пиразола для лечения состояний, опосредованных активацией рецептора аденозина а2в или а3