CN101238127A - 嘧啶或三嗪稠合的二环金属蛋白酶抑制剂 - Google Patents

嘧啶或三嗪稠合的二环金属蛋白酶抑制剂 Download PDF

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Publication number
CN101238127A
CN101238127A CNA2006800262633A CN200680026263A CN101238127A CN 101238127 A CN101238127 A CN 101238127A CN A2006800262633 A CNA2006800262633 A CN A2006800262633A CN 200680026263 A CN200680026263 A CN 200680026263A CN 101238127 A CN101238127 A CN 101238127A
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alkyl
aryl
cycloalkyl
heteroaryl
heterocycloalkyl
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CNA2006800262633A
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Chinese (zh)
Inventor
C·施蒂内克
C·格格
F·里希特
M·霍赫格尔特尔
T·富伊尔施泰因
H·布卢姆
I·苏霍莱基
J·贝尔
X·吴
M·施奈德
B·诺尔特
B·加拉赫尔
J·范韦尔德惠岑
H·邓
M·埃泽尔斯
H·克罗特
A·基利
T·鲍威尔斯
A·G·塔夫拉斯
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Alantos Pharmaceuticals Holding Inc
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Alantos Pharmaceuticals Inc
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Publication of CN101238127A publication Critical patent/CN101238127A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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CNA2006800262633A 2005-05-20 2006-05-22 嘧啶或三嗪稠合的二环金属蛋白酶抑制剂 Pending CN101238127A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68347005P 2005-05-20 2005-05-20
US60/683,470 2005-05-20
US70646505P 2005-08-08 2005-08-08
US60/706,465 2005-08-08
US73499105P 2005-11-09 2005-11-09
US60/734,991 2005-11-09

Publications (1)

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CN101238127A true CN101238127A (zh) 2008-08-06

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CNA2006800262633A Pending CN101238127A (zh) 2005-05-20 2006-05-22 嘧啶或三嗪稠合的二环金属蛋白酶抑制剂

Country Status (13)

Country Link
US (2) US20060293345A1 (enExample)
EP (1) EP1910367A2 (enExample)
JP (3) JP5463034B2 (enExample)
KR (1) KR20080087070A (enExample)
CN (1) CN101238127A (enExample)
AU (1) AU2006251989B2 (enExample)
BR (1) BRPI0609802A2 (enExample)
CA (1) CA2608890C (enExample)
CR (1) CR9614A (enExample)
EA (1) EA013525B1 (enExample)
IL (1) IL187495A0 (enExample)
NO (1) NO20076554L (enExample)
WO (1) WO2006128184A2 (enExample)

Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN104326914A (zh) * 2014-11-18 2015-02-04 江苏恒祥化工有限责任公司 一种反式-4-甲酸甲酯环己烷甲酸的制备方法
CN104560997A (zh) * 2014-12-25 2015-04-29 中国科学院广州生物医药与健康研究院 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用
CN108558672A (zh) * 2018-06-21 2018-09-21 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸及其异构体的制备方法
CN110950868A (zh) * 2018-09-27 2020-04-03 苏州锐明新药研发有限公司 吡唑并嘧啶化合物及制备方法与制备抗癌症药物的应用
US10709729B2 (en) 2014-12-25 2020-07-14 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Compositions and methods for inhibiting expression of ADAMTS-5 and ADAM17
CN116283995A (zh) * 2022-09-08 2023-06-23 华中科技大学同济医学院附属同济医院 一种脂酰辅酶a合成酶短链家族成员3的激动剂及其应用
CN116969831A (zh) * 2023-08-01 2023-10-31 山东成武泽大泛科化工有限公司 一种莫奈太尔的中间体及其制备方法

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US20070155737A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
AU2007321923A1 (en) * 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic matrix metalloprotease inhibitors
EP2102211A2 (en) * 2006-11-20 2009-09-23 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
US7691851B2 (en) 2007-03-07 2010-04-06 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
CA2691446C (en) 2007-06-04 2021-07-06 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
WO2009075790A1 (en) * 2007-12-07 2009-06-18 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors for intra-articular application
ES2637805T3 (es) 2008-05-05 2017-10-17 Sanofi Derivados de ácido ciclopentanocarboxílico fusionados sustituidos por acilamino y su uso como productos farmacéuticos
KR20200022525A (ko) 2008-12-04 2020-03-03 충시 위 고투과력을 가진 조성물 및 이의 적용
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
CN101709034B (zh) * 2009-12-14 2017-05-31 大连九信精细化工有限公司 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法
US8343977B2 (en) 2009-12-30 2013-01-01 Arqule, Inc. Substituted triazolo-pyrimidine compounds
RS63320B1 (sr) 2010-12-08 2022-07-29 The U S A As Represented By The Secretary Department Of Health And Human Services Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze
EP2723746A1 (en) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
KR101935868B1 (ko) 2011-12-30 2019-04-03 에스케이이노베이션 주식회사 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품
KR102332837B1 (ko) 2012-01-18 2021-12-01 테크필즈 파마 코., 엘티디. 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물
BR112015012454B1 (pt) 2012-12-07 2022-07-05 Vertex Pharmaceuticals Incorporated Compostos inibidores de atr quinase, seu uso e composição farmacêutica compreendendo os mesmos
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
WO2014143240A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
WO2014143242A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2014143241A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
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ES2777608T3 (es) 2014-06-05 2020-08-05 Vertex Pharma Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
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