CA2608890C - Heterobicyclic metalloprotease inhibitors - Google Patents
Heterobicyclic metalloprotease inhibitors Download PDFInfo
- Publication number
- CA2608890C CA2608890C CA2608890A CA2608890A CA2608890C CA 2608890 C CA2608890 C CA 2608890C CA 2608890 A CA2608890 A CA 2608890A CA 2608890 A CA2608890 A CA 2608890A CA 2608890 C CA2608890 C CA 2608890C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- nr10r11
- group
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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| US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
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| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| CA2670044A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic matrix metalloprotease inhibitors |
| US20080176870A1 (en) * | 2006-11-20 | 2008-07-24 | Bert Nolte | Heterobicyclic metalloprotease inhibitors |
| US20080221093A1 (en) * | 2007-03-07 | 2008-09-11 | Christian Gege | Metalloprotease inhibitors containing a heterocyclic moiety |
| KR20220107078A (ko) | 2007-06-04 | 2022-08-01 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| WO2009075790A1 (en) * | 2007-12-07 | 2009-06-18 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors for intra-articular application |
| CA2723302C (en) | 2008-05-05 | 2013-08-20 | Sanofi-Aventis | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals |
| MX379054B (es) | 2008-12-04 | 2025-03-11 | Chongxi Yu | Composiciones de alta penetracion y sus aplicaciones. |
| AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
| CN101709034B (zh) * | 2009-12-14 | 2017-05-31 | 大连九信精细化工有限公司 | 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法 |
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| BR112013014242B1 (pt) | 2010-12-08 | 2022-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Composição farmacêutica e composto ou seu sal farmaceuticamente aceitável |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| KR101935868B1 (ko) | 2011-12-30 | 2019-04-03 | 에스케이이노베이션 주식회사 | 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품 |
| CN107929743B (zh) | 2012-01-18 | 2023-09-01 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| PL3808749T3 (pl) | 2012-12-07 | 2023-07-10 | Vertex Pharmaceuticals Incorporated | Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych |
| WO2014100779A1 (en) | 2012-12-21 | 2014-06-26 | Advanced Cell Technology, Inc. | Methods ofr production of platelets from pluripotent stem cells and compositions thereof |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| JP2016512239A (ja) | 2013-03-15 | 2016-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
| PL3077397T3 (pl) | 2013-12-06 | 2020-04-30 | Vertex Pharmaceuticals Inc. | Związek 2-amino-6-fluoro-n-[5-fluoro-pirydyn-3-ylo]pyrazolo [1,5-a]pirymidino-3-karboksamidu przydatny jako inhibitor kinazy atr, jego wytwarzanie, różne postacie stałe i ich radioznakowane pochodne |
| SG10201902206QA (en) | 2014-06-05 | 2019-04-29 | Vertex Pharma | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
| PT3157566T (pt) | 2014-06-17 | 2019-07-11 | Vertex Pharma | Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr |
| CN104326914A (zh) * | 2014-11-18 | 2015-02-04 | 江苏恒祥化工有限责任公司 | 一种反式-4-甲酸甲酯环己烷甲酸的制备方法 |
| CN104560997B (zh) * | 2014-12-25 | 2018-05-04 | 中国科学院广州生物医药与健康研究院 | 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用 |
| WO2016103042A1 (en) | 2014-12-25 | 2016-06-30 | Guangzhou Ribobio Co., Ltd. | Compositions and methods for inhibiting expression of adamts-5 and adam17 |
| RU2768621C1 (ru) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr |
| EP3529230B1 (en) | 2016-10-19 | 2020-09-30 | Eastman Chemical Company | Synthesis of bicyclo(2.2.2)octanes |
| EP3694831A1 (en) | 2017-10-11 | 2020-08-19 | Eastman Chemical Company | Synthesis of bicyclo[2.2.2]octane derivatives |
| TWI835770B (zh) * | 2018-01-19 | 2024-03-21 | 美商胞質動力學公司 | 心肌節抑制劑 |
| CN108558672B (zh) * | 2018-06-21 | 2021-04-30 | 利尔化学股份有限公司 | 2-硝基-4-三氟甲基苯甲酸及其异构体的制备方法 |
| CN110950868B (zh) * | 2018-09-27 | 2022-05-13 | 苏州锐明新药研发有限公司 | 吡唑并嘧啶化合物及制备方法与制备抗癌症药物的应用 |
| US10836899B2 (en) | 2018-12-13 | 2020-11-17 | Eastman Chemical Company | Polyesters with specified crystallization half-times |
| CN116283995B (zh) * | 2022-09-08 | 2023-12-29 | 华中科技大学同济医学院附属同济医院 | 一种脂酰辅酶a合成酶短链家族成员3的激动剂及其应用 |
| CN116969831B (zh) * | 2023-08-01 | 2025-09-23 | 菏泽皓元医药科技有限公司 | 一种莫奈太尔的中间体及其制备方法 |
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| DE3704203A1 (de) * | 1987-02-11 | 1988-08-25 | Boehringer Ingelheim Kg | Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie |
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-
2006
- 2006-05-22 WO PCT/US2006/020970 patent/WO2006128184A2/en not_active Ceased
- 2006-05-22 AU AU2006251989A patent/AU2006251989B2/en not_active Ceased
- 2006-05-22 JP JP2008512617A patent/JP5463034B2/ja not_active Expired - Fee Related
- 2006-05-22 CA CA2608890A patent/CA2608890C/en not_active Expired - Fee Related
- 2006-05-22 US US11/440,087 patent/US20060293345A1/en not_active Abandoned
- 2006-05-22 EA EA200702568A patent/EA013525B1/ru not_active IP Right Cessation
- 2006-05-22 BR BRPI0609802A patent/BRPI0609802A2/pt not_active IP Right Cessation
- 2006-05-22 KR KR1020077029688A patent/KR20080087070A/ko not_active Abandoned
- 2006-05-22 EP EP20060760560 patent/EP1910367A2/en not_active Withdrawn
- 2006-05-22 CN CNA2006800262633A patent/CN101238127A/zh active Pending
-
2007
- 2007-11-19 IL IL187495A patent/IL187495A0/en unknown
- 2007-12-07 US US12/001,041 patent/US20080161300A1/en not_active Abandoned
- 2007-12-19 CR CR9614A patent/CR9614A/es not_active Application Discontinuation
- 2007-12-19 NO NO20076554A patent/NO20076554L/no not_active Application Discontinuation
-
2013
- 2013-04-22 JP JP2013089076A patent/JP5391351B2/ja not_active Expired - Fee Related
- 2013-12-10 JP JP2013254709A patent/JP2014088396A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CR9614A (es) | 2008-04-28 |
| US20060293345A1 (en) | 2006-12-28 |
| JP5391351B2 (ja) | 2014-01-15 |
| EA200702568A1 (ru) | 2008-06-30 |
| JP2008540687A (ja) | 2008-11-20 |
| WO2006128184A2 (en) | 2006-11-30 |
| EA013525B1 (ru) | 2010-06-30 |
| WO2006128184A3 (en) | 2007-03-08 |
| EP1910367A2 (en) | 2008-04-16 |
| AU2006251989B2 (en) | 2010-05-27 |
| JP5463034B2 (ja) | 2014-04-09 |
| NO20076554L (no) | 2008-02-19 |
| CN101238127A (zh) | 2008-08-06 |
| JP2013181033A (ja) | 2013-09-12 |
| JP2014088396A (ja) | 2014-05-15 |
| IL187495A0 (en) | 2008-02-09 |
| US20080161300A1 (en) | 2008-07-03 |
| AU2006251989A1 (en) | 2006-11-30 |
| KR20080087070A (ko) | 2008-09-30 |
| CA2608890A1 (en) | 2006-11-30 |
| BRPI0609802A2 (pt) | 2017-05-02 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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