JP5463034B2 - ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 - Google Patents
ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 Download PDFInfo
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- JP5463034B2 JP5463034B2 JP2008512617A JP2008512617A JP5463034B2 JP 5463034 B2 JP5463034 B2 JP 5463034B2 JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008512617 A JP2008512617 A JP 2008512617A JP 5463034 B2 JP5463034 B2 JP 5463034B2
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- 125000002619 bicyclic group Chemical group 0.000 title description 13
- 239000003475 metalloproteinase inhibitor Substances 0.000 title description 3
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- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
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- 125000004446 heteroarylalkyl group Chemical group 0.000 description 15
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 14
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Landscapes
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Applications Claiming Priority (7)
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| US68347005P | 2005-05-20 | 2005-05-20 | |
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| US70646505P | 2005-08-08 | 2005-08-08 | |
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| US73499105P | 2005-11-09 | 2005-11-09 | |
| US60/734,991 | 2005-11-09 | ||
| PCT/US2006/020970 WO2006128184A2 (en) | 2005-05-20 | 2006-05-22 | Pyrimidine or triazine fused bicyclic metalloprotease inhibitors |
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| JP2013089076A Division JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Division JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
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| JP2008540687A JP2008540687A (ja) | 2008-11-20 |
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| JP2013089076A Expired - Fee Related JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Withdrawn JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
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| JP2013089076A Expired - Fee Related JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Withdrawn JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
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Families Citing this family (38)
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| US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| CA2670044A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic matrix metalloprotease inhibitors |
| US20080176870A1 (en) * | 2006-11-20 | 2008-07-24 | Bert Nolte | Heterobicyclic metalloprotease inhibitors |
| US20080221093A1 (en) * | 2007-03-07 | 2008-09-11 | Christian Gege | Metalloprotease inhibitors containing a heterocyclic moiety |
| KR20220107078A (ko) | 2007-06-04 | 2022-08-01 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| WO2009075790A1 (en) * | 2007-12-07 | 2009-06-18 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors for intra-articular application |
| CA2723302C (en) | 2008-05-05 | 2013-08-20 | Sanofi-Aventis | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals |
| MX379054B (es) | 2008-12-04 | 2025-03-11 | Chongxi Yu | Composiciones de alta penetracion y sus aplicaciones. |
| AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
| CN101709034B (zh) * | 2009-12-14 | 2017-05-31 | 大连九信精细化工有限公司 | 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法 |
| US8343977B2 (en) | 2009-12-30 | 2013-01-01 | Arqule, Inc. | Substituted triazolo-pyrimidine compounds |
| BR112013014242B1 (pt) | 2010-12-08 | 2022-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Composição farmacêutica e composto ou seu sal farmaceuticamente aceitável |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| KR101935868B1 (ko) | 2011-12-30 | 2019-04-03 | 에스케이이노베이션 주식회사 | 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품 |
| CN107929743B (zh) | 2012-01-18 | 2023-09-01 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| PL3808749T3 (pl) | 2012-12-07 | 2023-07-10 | Vertex Pharmaceuticals Incorporated | Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych |
| WO2014100779A1 (en) | 2012-12-21 | 2014-06-26 | Advanced Cell Technology, Inc. | Methods ofr production of platelets from pluripotent stem cells and compositions thereof |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| JP2016512239A (ja) | 2013-03-15 | 2016-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
| PL3077397T3 (pl) | 2013-12-06 | 2020-04-30 | Vertex Pharmaceuticals Inc. | Związek 2-amino-6-fluoro-n-[5-fluoro-pirydyn-3-ylo]pyrazolo [1,5-a]pirymidino-3-karboksamidu przydatny jako inhibitor kinazy atr, jego wytwarzanie, różne postacie stałe i ich radioznakowane pochodne |
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- 2006-05-22 US US11/440,087 patent/US20060293345A1/en not_active Abandoned
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- 2006-05-22 BR BRPI0609802A patent/BRPI0609802A2/pt not_active IP Right Cessation
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| CA2608890C (en) | 2011-08-02 |
| CR9614A (es) | 2008-04-28 |
| US20060293345A1 (en) | 2006-12-28 |
| JP5391351B2 (ja) | 2014-01-15 |
| EA200702568A1 (ru) | 2008-06-30 |
| JP2008540687A (ja) | 2008-11-20 |
| WO2006128184A2 (en) | 2006-11-30 |
| EA013525B1 (ru) | 2010-06-30 |
| WO2006128184A3 (en) | 2007-03-08 |
| EP1910367A2 (en) | 2008-04-16 |
| AU2006251989B2 (en) | 2010-05-27 |
| NO20076554L (no) | 2008-02-19 |
| CN101238127A (zh) | 2008-08-06 |
| JP2013181033A (ja) | 2013-09-12 |
| JP2014088396A (ja) | 2014-05-15 |
| IL187495A0 (en) | 2008-02-09 |
| US20080161300A1 (en) | 2008-07-03 |
| AU2006251989A1 (en) | 2006-11-30 |
| KR20080087070A (ko) | 2008-09-30 |
| CA2608890A1 (en) | 2006-11-30 |
| BRPI0609802A2 (pt) | 2017-05-02 |
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