JP2007517006A5 - - Google Patents

Info

Publication number

JP2007517006A5

JP2007517006A5 JP2006546305A JP2006546305A JP2007517006A5 JP 2007517006 A5 JP2007517006 A5 JP 2007517006A5 JP 2006546305 A JP2006546305 A JP 2006546305A JP 2006546305 A JP2006546305 A JP 2006546305A JP 2007517006 A5 JP2007517006 A5 JP 2007517006A5

Authority

JP

Japan

Prior art keywords

alkyl

alkoxy

formula

amino

saturated

Prior art date

2004-12-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000217 alkyl group Chemical group 0.000 claims 82
• 125000003545 alkoxy group Chemical group 0.000 claims 49
• 229920006395 saturated elastomer Polymers 0.000 claims 48
• 150000001875 compounds Chemical class 0.000 claims 28
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 24
• 125000003282 alkyl amino group Chemical group 0.000 claims 22
• 229910052739 hydrogen Inorganic materials 0.000 claims 21
• 239000001257 hydrogen Substances 0.000 claims 21
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
• 125000000753 cycloalkyl group Chemical group 0.000 claims 15
• 125000000524 functional group Chemical group 0.000 claims 14
• 125000001153 fluoro group Chemical group F* 0.000 claims 13
• 125000005843 halogen group Chemical group 0.000 claims 13
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 12
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 11
• -1 Amino, carbamoyl Chemical group 0.000 claims 11
• 125000004093 cyano group Chemical group *C#N 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 8
• 125000004076 pyridyl group Chemical group 0.000 claims 6
• 125000001113 thiadiazolyl group Chemical group 0.000 claims 6
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
• 125000001786 isothiazolyl group Chemical group 0.000 claims 5
• 125000000842 isoxazolyl group Chemical group 0.000 claims 5
• 125000003226 pyrazolyl group Chemical group 0.000 claims 5
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
• 125000000335 thiazolyl group Chemical group 0.000 claims 5
• 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims 4
• 241001465754 Metazoa Species 0.000 claims 4
• 125000001246 bromo group Chemical group Br* 0.000 claims 4
• 125000001589 carboacyl group Chemical group 0.000 claims 4
• 125000001309 chloro group Chemical group Cl* 0.000 claims 4
• 125000002541 furyl group Chemical group 0.000 claims 4
• 125000001072 heteroaryl group Chemical group 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 125000002883 imidazolyl group Chemical group 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 125000001715 oxadiazolyl group Chemical group 0.000 claims 4
• 125000002971 oxazolyl group Chemical group 0.000 claims 4
• 125000003373 pyrazinyl group Chemical group 0.000 claims 4
• 125000002098 pyridazinyl group Chemical group 0.000 claims 4
• 125000000168 pyrrolyl group Chemical group 0.000 claims 4
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
• 125000003831 tetrazolyl group Chemical group 0.000 claims 4
• 125000001544 thienyl group Chemical group 0.000 claims 4
• 125000001425 triazolyl group Chemical group 0.000 claims 4
• 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
• 150000001412 amines Chemical class 0.000 claims 3
• 125000002619 bicyclic group Chemical group 0.000 claims 3
• 125000004432 carbon atom Chemical group C* 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 125000005842 heteroatom Chemical group 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 108010090091 TIE-2 Receptor Proteins 0.000 claims 2
• 125000005236 alkanoylamino group Chemical group 0.000 claims 2
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
• 150000002431 hydrogen Chemical group 0.000 claims 2
• 125000002346 iodo group Chemical group I* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 125000004043 oxo group Chemical group O=* 0.000 claims 2
• UPQQXPKAYZYUKO-UHFFFAOYSA-N 2,2,2-trichloroacetamide Chemical compound OC(=N)C(Cl)(Cl)Cl UPQQXPKAYZYUKO-UHFFFAOYSA-N 0.000 claims 1
• 241001024304 Mino Species 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 150000001345 alkine derivatives Chemical class 0.000 claims 1
• 230000001772 anti-angiogenic effect Effects 0.000 claims 1
• 125000004104 aryloxy group Chemical group 0.000 claims 1
• 125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 claims 1
• 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000012948 isocyanate Substances 0.000 claims 1
• 150000002513 isocyanates Chemical class 0.000 claims 1
• 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
• 125000003386 piperidinyl group Chemical group 0.000 claims 1
• 125000006239 protecting group Chemical group 0.000 claims 1
• 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
• WTVXIBRMWGUIMI-UHFFFAOYSA-N trifluoro($l^{1}-oxidanylsulfonyl)methane Chemical group [O]S(=O)(=O)C(F)(F)F WTVXIBRMWGUIMI-UHFFFAOYSA-N 0.000 claims 1