JP2007517007A5 - - Google Patents
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- Publication number
- JP2007517007A5 JP2007517007A5 JP2006546306A JP2006546306A JP2007517007A5 JP 2007517007 A5 JP2007517007 A5 JP 2007517007A5 JP 2006546306 A JP2006546306 A JP 2006546306A JP 2006546306 A JP2006546306 A JP 2006546306A JP 2007517007 A5 JP2007517007 A5 JP 2007517007A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- amino
- saturated
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 80
- 229920006395 saturated elastomer Polymers 0.000 claims 49
- 125000003545 alkoxy group Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 26
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 21
- 125000003282 alkyl amino group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- -1 amino, carbamoyl Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000000524 functional group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000001786 isothiazolyl group Chemical group 0.000 claims 6
- 125000000842 isoxazolyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000002883 imidazolyl group Chemical group 0.000 claims 5
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 5
- 125000002971 oxazolyl group Chemical group 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims 5
- 125000000168 pyrrolyl group Chemical group 0.000 claims 5
- 125000003831 tetrazolyl group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000001425 triazolyl group Chemical group 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010090091 TIE-2 Receptor Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 claims 1
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0330000A GB0330000D0 (en) | 2003-12-24 | 2003-12-24 | Compounds |
| GB0416849A GB0416849D0 (en) | 2004-07-29 | 2004-07-29 | Compounds |
| PCT/GB2004/005337 WO2005060970A1 (en) | 2003-12-24 | 2004-12-20 | Pyrimidines with tie2 (tek) activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517007A JP2007517007A (ja) | 2007-06-28 |
| JP2007517007A5 true JP2007517007A5 (enExample) | 2008-02-14 |
Family
ID=34712715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546306A Pending JP2007517007A (ja) | 2003-12-24 | 2004-12-20 | Ｔｉｅ２（ＴＥＫ）活性を持つピリミジン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080108608A1 (enExample) |
| EP (1) | EP1737463B1 (enExample) |
| JP (1) | JP2007517007A (enExample) |
| AR (1) | AR046795A1 (enExample) |
| AT (1) | ATE415970T1 (enExample) |
| DE (1) | DE602004018193D1 (enExample) |
| ES (1) | ES2317079T3 (enExample) |
| TW (1) | TW200526597A (enExample) |
| UY (1) | UY28701A1 (enExample) |
| WO (1) | WO2005060970A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| US20080146599A1 (en) * | 2005-02-01 | 2008-06-19 | Astrazeneca Ab | Pyrimidine Compounds Having Tie-2 (Tek) Inhibitory Activity |
| EP1863805A1 (en) * | 2005-02-01 | 2007-12-12 | AstraZeneca AB | Pyrimidine compounds having tie2 (tek) inhibitory activity |
| GB0502418D0 (en) * | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| JP2008534565A (ja) * | 2005-03-31 | 2008-08-28 | アストラゼネカ アクチボラグ | Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体 |
| JP5200939B2 (ja) * | 2005-12-23 | 2013-06-05 | アリアド・ファーマシューティカルズ・インコーポレイテッド | 二環式ヘテロアリール化合物 |
| KR20090018104A (ko) | 2006-05-08 | 2009-02-19 | 어리어드 파마슈티칼스, 인코포레이티드 | 아세틸렌계 헤테로아릴 화합물 |
| EP2024366B1 (en) | 2006-05-08 | 2015-09-16 | Ariad Pharmaceuticals, Inc. | Monocyclic heteroaryl compounds |
| US8558002B2 (en) * | 2006-11-16 | 2013-10-15 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| EP2070929A1 (en) * | 2007-12-11 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| JP5590040B2 (ja) | 2008-11-12 | 2014-09-17 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのピラジノピラジンおよび誘導体 |
| ES2444433T3 (es) * | 2008-11-14 | 2014-02-25 | Concert Pharmaceuticals, Inc. | Derivados de dioxopiperidinil-ftalimida sustituidos |
| US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| EP2922838B1 (en) | 2012-10-22 | 2018-03-14 | Concert Pharmaceuticals Inc. | Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} . |
| CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| ES2747249T3 (es) * | 2014-07-17 | 2020-03-10 | Sunshine Lake Pharma Co Ltd | Derivados de 1-(5-(terc-butil)isoxazol-3-il)-3-(4-((fenil)etinil)fenil)urea y compuestos relacionados como inhibidores de FLT3 para el tratamiento de cáncer |
| AU2018299536B2 (en) * | 2017-07-13 | 2022-06-02 | Sunshine Lake Pharma Co., Ltd. | Salt of substituted urea derivative and use thereof in medicine |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5154728B2 (ja) * | 2000-07-24 | 2013-02-27 | クレニツキー・ファーマシューティカルズ，インコーポレイテッド | 神経栄養活性を有する置換５−アルキニルピリミジン |
| WO2003029209A2 (en) * | 2001-10-02 | 2003-04-10 | Smithkline Beecham Corporation | Chemical compounds |
| US20030225273A1 (en) * | 2002-03-21 | 2003-12-04 | Michaelides Michael R. | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors |
| DE602004015509D1 (de) * | 2003-12-24 | 2008-09-11 | Astrazeneca Ab | Pyrimidine mit tie2 (tek) aktivität |
-
2004
- 2004-12-20 JP JP2006546306A patent/JP2007517007A/ja active Pending
- 2004-12-20 ES ES04806139T patent/ES2317079T3/es not_active Expired - Lifetime
- 2004-12-20 AT AT04806139T patent/ATE415970T1/de not_active IP Right Cessation
- 2004-12-20 US US10/596,745 patent/US20080108608A1/en not_active Abandoned
- 2004-12-20 WO PCT/GB2004/005337 patent/WO2005060970A1/en not_active Ceased
- 2004-12-20 DE DE602004018193T patent/DE602004018193D1/de not_active Expired - Fee Related
- 2004-12-20 EP EP04806139A patent/EP1737463B1/en not_active Expired - Lifetime
- 2004-12-23 UY UY28701A patent/UY28701A1/es not_active Application Discontinuation
- 2004-12-24 TW TW093140578A patent/TW200526597A/zh unknown
- 2004-12-27 AR ARP040104906A patent/AR046795A1/es unknown
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