JP2018536678A5 - - Google Patents
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- Publication number
- JP2018536678A5 JP2018536678A5 JP2018529261A JP2018529261A JP2018536678A5 JP 2018536678 A5 JP2018536678 A5 JP 2018536678A5 JP 2018529261 A JP2018529261 A JP 2018529261A JP 2018529261 A JP2018529261 A JP 2018529261A JP 2018536678 A5 JP2018536678 A5 JP 2018536678A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- membered
- substitution
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 238000000034 method Methods 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- -1 chloro, fluoro, cyano, hydroxy, amino, carboxy, acetyl Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 2
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 150000001409 amidines Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical group I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000005556 thienylene group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 COC(C1=C(CN2C=C(C=**3Cc(cc4)cc*4C(*C4CNCCC4)=N)C3=CC2)CSC2N1C([*+])[C@]2N)=* Chemical compound COC(C1=C(CN2C=C(C=**3Cc(cc4)cc*4C(*C4CNCCC4)=N)C3=CC2)CSC2N1C([*+])[C@]2N)=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562265625P | 2015-12-10 | 2015-12-10 | |
| US62/265,625 | 2015-12-10 | ||
| PCT/CA2016/051428 WO2017096472A1 (en) | 2015-12-10 | 2016-12-05 | Cephem compounds, their production and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536678A JP2018536678A (ja) | 2018-12-13 |
| JP2018536678A5 true JP2018536678A5 (enExample) | 2019-12-05 |
| JP6967000B2 JP6967000B2 (ja) | 2021-11-17 |
Family
ID=59012429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529261A Active JP6967000B2 (ja) | 2015-12-10 | 2016-12-05 | セフェム系化合物、それらの生成および使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9751894B2 (enExample) |
| EP (1) | EP3386977A4 (enExample) |
| JP (1) | JP6967000B2 (enExample) |
| KR (2) | KR102135230B1 (enExample) |
| CN (1) | CN108463461B (enExample) |
| AU (1) | AU2016367284C1 (enExample) |
| BR (1) | BR112018009725A8 (enExample) |
| CA (1) | CA3005779C (enExample) |
| EA (1) | EA039648B1 (enExample) |
| HK (1) | HK1254209A1 (enExample) |
| IL (1) | IL259234B (enExample) |
| WO (1) | WO2017096472A1 (enExample) |
| ZA (1) | ZA201802654B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102135230B1 (ko) | 2015-12-10 | 2020-07-17 | 나에자-알지엠 파마슈티칼스 유엘씨 | 세펨 화합물, 그의 제조 및 용도 |
| EP3687992A1 (en) * | 2017-09-27 | 2020-08-05 | Meiji Seika Pharma Co., Ltd. | Crystalline forms of diazabicyclooctane derivatives and production process thereof |
| TWI795549B (zh) * | 2018-04-06 | 2023-03-11 | 日商富士軟片股份有限公司 | 新穎青黴烷衍生物或其鹽、醫藥組成物及其應用 |
| KR102484880B1 (ko) | 2018-06-08 | 2023-01-05 | 엘지디스플레이 주식회사 | 신축 가능한 표시장치, 패널 구동회로 및 구동방법 |
| DK3833665T3 (da) | 2018-08-09 | 2023-10-09 | Antabio Sas | Diazabicyclooctanoner som hæmmere af serin-beta-lactamaser |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| WO2020263975A1 (en) | 2019-06-24 | 2020-12-30 | Diverse Biotech, Inc. | Beta-lactam-cannabinoid conjugate molecules |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3118732A1 (de) | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| US4406899A (en) | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
| IL77458A (en) * | 1985-01-14 | 1990-07-26 | Eisai Co Ltd | Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor |
| ATE89826T1 (de) * | 1985-03-01 | 1993-06-15 | Takeda Chemical Industries Ltd | Antibakterielle verbindungen, ihre herstellung und verwendung. |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US4777128A (en) | 1986-05-27 | 1988-10-11 | Ethigen Corporation | Fluorescence immunoassay involving energy transfer between two fluorophores |
| US5173485A (en) | 1988-03-09 | 1992-12-22 | Fujisawa Pharmaceutical Company, Ltd. | Cephem compounds |
| GB8805642D0 (en) | 1988-03-09 | 1988-04-07 | Fujisawa Pharmaceutical Co | New cephem compounds & processes for preparation thereof |
| US5215982A (en) | 1989-11-10 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| CA2216259A1 (en) | 1996-09-25 | 1998-03-25 | Eisai Chemical Co., Ltd. | Production process of cephem compound |
| TW526202B (en) | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
| JP2003026679A (ja) * | 2001-07-10 | 2003-01-29 | Banyu Pharmaceut Co Ltd | 新規カルバペネム誘導体 |
| TW200305422A (en) * | 2002-03-18 | 2003-11-01 | Shionogi & Co | Broad spectrum cefem compounds |
| JP4448821B2 (ja) | 2002-10-30 | 2010-04-14 | アステラス製薬株式会社 | セフェム化合物 |
| JP2009530228A (ja) | 2006-03-16 | 2009-08-27 | アステラス製薬株式会社 | セフェム化合物および抗菌薬としての利用 |
| CN101343281A (zh) * | 2007-04-20 | 2009-01-14 | 山东轩竹医药科技有限公司 | 新型脒基吡啶基头孢菌素类化合物 |
| MX2011004636A (es) * | 2008-10-31 | 2011-06-20 | Shionogi & Co | Cefarosporinas que tienen un grupo catecol. |
| MX2012011521A (es) * | 2010-04-05 | 2013-03-08 | Shionogi & Co | Compuestos cefem que tienen un grupo catecol. |
| US8883773B2 (en) | 2010-04-05 | 2014-11-11 | Shionogi & Co., Ltd. | Cephem compound having pseudo-catechol group |
| JP5852562B2 (ja) | 2010-04-28 | 2016-02-03 | 塩野義製薬株式会社 | 新規なセフェム誘導体 |
| WO2011160020A2 (en) * | 2010-06-18 | 2011-12-22 | Fob Synthesis | Carbapenem antibacterials with gram-negative activity |
| KR101719556B1 (ko) | 2011-03-30 | 2017-03-24 | 주식회사 레고켐 바이오사이언스 | 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 |
| CA2833121A1 (en) | 2011-04-28 | 2012-11-01 | Shionogi & Co., Ltd. | Novel cephem compound having catechol or pseudo-catechol structure |
| JP2013012630A (ja) | 2011-06-30 | 2013-01-17 | Toyota Industries Corp | 熱電変換モジュール |
| TWI547496B (zh) | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
| WO2013051597A1 (ja) | 2011-10-04 | 2013-04-11 | 塩野義製薬株式会社 | カテコール基を有するセフェム誘導体 |
| US8809314B1 (en) * | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| UY35103A (es) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
| WO2014087165A1 (en) | 2012-12-06 | 2014-06-12 | University Of Bath | Tankyrase inhibitors |
| US20150344502A1 (en) | 2012-12-26 | 2015-12-03 | Shionogi & Co., Ltd. | Cephem compound |
| KR102135230B1 (ko) | 2015-12-10 | 2020-07-17 | 나에자-알지엠 파마슈티칼스 유엘씨 | 세펨 화합물, 그의 제조 및 용도 |
-
2016
- 2016-12-05 KR KR1020197010752A patent/KR102135230B1/ko not_active Expired - Fee Related
- 2016-12-05 CN CN201680072172.7A patent/CN108463461B/zh not_active Expired - Fee Related
- 2016-12-05 EA EA201891381A patent/EA039648B1/ru unknown
- 2016-12-05 AU AU2016367284A patent/AU2016367284C1/en not_active Ceased
- 2016-12-05 BR BR112018009725A patent/BR112018009725A8/pt not_active IP Right Cessation
- 2016-12-05 US US15/369,181 patent/US9751894B2/en not_active Ceased
- 2016-12-05 JP JP2018529261A patent/JP6967000B2/ja active Active
- 2016-12-05 KR KR1020187015784A patent/KR20180066264A/ko not_active Ceased
- 2016-12-05 CA CA3005779A patent/CA3005779C/en active Active
- 2016-12-05 EP EP16871861.7A patent/EP3386977A4/en active Pending
- 2016-12-05 WO PCT/CA2016/051428 patent/WO2017096472A1/en not_active Ceased
- 2016-12-05 HK HK18113349.1A patent/HK1254209A1/zh unknown
-
2018
- 2018-04-20 ZA ZA2018/02654A patent/ZA201802654B/en unknown
- 2018-05-09 IL IL259234A patent/IL259234B/en active IP Right Grant
- 2018-12-19 US US16/225,892 patent/USRE48097E1/en active Active
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