EA039648B1 - Соединения цефема, их получение и применение - Google Patents

Соединения цефема, их получение и применение Download PDF

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Publication number
EA039648B1
EA039648B1 EA201891381A EA201891381A EA039648B1 EA 039648 B1 EA039648 B1 EA 039648B1 EA 201891381 A EA201891381 A EA 201891381A EA 201891381 A EA201891381 A EA 201891381A EA 039648 B1 EA039648 B1 EA 039648B1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
methyl
pyrrolo
pyridin
acetyl
Prior art date
Application number
EA201891381A
Other languages
English (en)
Russian (ru)
Other versions
EA201891381A1 (ru
Inventor
Самарендра Нат Маити
Дай Куок Нгуйен
Андхе В. Н. Редди
Джуди Йип
Чан Минь Ха
Ронг Линг
Рудонг Шан
Мадхава Редди Мадала
Original Assignee
НАЕДЖА-АрДжиЭм ФАРМАСЬЮТИКАЛЗ ЮЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by НАЕДЖА-АрДжиЭм ФАРМАСЬЮТИКАЛЗ ЮЭлСи filed Critical НАЕДЖА-АрДжиЭм ФАРМАСЬЮТИКАЛЗ ЮЭлСи
Publication of EA201891381A1 publication Critical patent/EA201891381A1/ru
Publication of EA039648B1 publication Critical patent/EA039648B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201891381A 2015-12-10 2016-12-05 Соединения цефема, их получение и применение EA039648B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562265625P 2015-12-10 2015-12-10
PCT/CA2016/051428 WO2017096472A1 (en) 2015-12-10 2016-12-05 Cephem compounds, their production and use

Publications (2)

Publication Number Publication Date
EA201891381A1 EA201891381A1 (ru) 2019-01-31
EA039648B1 true EA039648B1 (ru) 2022-02-21

Family

ID=59012429

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891381A EA039648B1 (ru) 2015-12-10 2016-12-05 Соединения цефема, их получение и применение

Country Status (13)

Country Link
US (2) US9751894B2 (enExample)
EP (1) EP3386977A4 (enExample)
JP (1) JP6967000B2 (enExample)
KR (2) KR20180066264A (enExample)
CN (1) CN108463461B (enExample)
AU (1) AU2016367284C1 (enExample)
BR (1) BR112018009725A8 (enExample)
CA (1) CA3005779C (enExample)
EA (1) EA039648B1 (enExample)
HK (1) HK1254209A1 (enExample)
IL (1) IL259234B (enExample)
WO (1) WO2017096472A1 (enExample)
ZA (1) ZA201802654B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9751894B2 (en) 2015-12-10 2017-09-05 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use
KR20200091395A (ko) * 2017-09-27 2020-07-30 페도라 파마슈티칼스 인코포레이티드 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법
TWI795549B (zh) * 2018-04-06 2023-03-11 日商富士軟片股份有限公司 新穎青黴烷衍生物或其鹽、醫藥組成物及其應用
KR102484880B1 (ko) 2018-06-08 2023-01-05 엘지디스플레이 주식회사 신축 가능한 표시장치, 패널 구동회로 및 구동방법
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP4272831A3 (en) 2018-08-09 2024-02-21 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
US12257307B2 (en) 2019-06-24 2025-03-25 Diverse Biotech, Inc. β-lactam-cannabinoid conjugate molecules

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350905A1 (en) * 1998-11-27 2000-06-08 Shionogi & Co., Ltd. Imidazo[4,5-b]pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum
CA2479354A1 (en) * 2002-03-18 2003-09-25 Shionogi & Co., Ltd. Broad-spectrum cephem compounds
CN101343281A (zh) * 2007-04-20 2009-01-14 山东轩竹医药科技有限公司 新型脒基吡啶基头孢菌素类化合物
EP2341053A1 (en) * 2008-10-31 2011-07-06 Shionogi & Co., Ltd. Cephalosporin having catechol group
CA2833121A1 (en) * 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
US20130096299A1 (en) * 2010-04-28 2013-04-18 Shionogi & Co., Ltd. Novel cephem derivative
WO2014068388A1 (en) * 2012-10-29 2014-05-08 Glaxo Group Limited 2 substituted cephem compounds
US20150344502A1 (en) * 2012-12-26 2015-12-03 Shionogi & Co., Ltd. Cephem compound

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DE3118732A1 (de) 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4910301A (en) 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
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US5173485A (en) 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
GB8805642D0 (en) 1988-03-09 1988-04-07 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5215982A (en) 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA2216259A1 (en) 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
JP2003026679A (ja) * 2001-07-10 2003-01-29 Banyu Pharmaceut Co Ltd 新規カルバペネム誘導体
ATE368042T1 (de) 2002-10-30 2007-08-15 Astellas Pharma Inc Cephemverbindungen
WO2007119511A1 (en) 2006-03-16 2007-10-25 Astellas Pharma Inc. Cephem compounds and use as antimicrobial agents
CN102918047A (zh) 2010-04-05 2013-02-06 盐野义制药株式会社 具有假儿茶酚基团的头孢烯类化合物
AU2011236933A1 (en) 2010-04-05 2013-05-02 Shionogi & Co., Ltd. Cephem compound having catechol group
WO2011160020A2 (en) * 2010-06-18 2011-12-22 Fob Synthesis Carbapenem antibacterials with gram-negative activity
KR101719556B1 (ko) 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
JP2013012630A (ja) 2011-06-30 2013-01-17 Toyota Industries Corp 熱電変換モジュール
WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
US8809314B1 (en) * 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
WO2014087165A1 (en) 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors
US9751894B2 (en) 2015-12-10 2017-09-05 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350905A1 (en) * 1998-11-27 2000-06-08 Shionogi & Co., Ltd. Imidazo[4,5-b]pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum
CA2479354A1 (en) * 2002-03-18 2003-09-25 Shionogi & Co., Ltd. Broad-spectrum cephem compounds
CN101343281A (zh) * 2007-04-20 2009-01-14 山东轩竹医药科技有限公司 新型脒基吡啶基头孢菌素类化合物
EP2341053A1 (en) * 2008-10-31 2011-07-06 Shionogi & Co., Ltd. Cephalosporin having catechol group
US20130096299A1 (en) * 2010-04-28 2013-04-18 Shionogi & Co., Ltd. Novel cephem derivative
CA2833121A1 (en) * 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
WO2014068388A1 (en) * 2012-10-29 2014-05-08 Glaxo Group Limited 2 substituted cephem compounds
US20150344502A1 (en) * 2012-12-26 2015-12-03 Shionogi & Co., Ltd. Cephem compound

Also Published As

Publication number Publication date
KR20180066264A (ko) 2018-06-18
EP3386977A1 (en) 2018-10-17
EA201891381A1 (ru) 2019-01-31
JP2018536678A (ja) 2018-12-13
CN108463461A (zh) 2018-08-28
KR102135230B1 (ko) 2020-07-17
CA3005779A1 (en) 2017-06-15
US20170166587A1 (en) 2017-06-15
CA3005779C (en) 2020-04-07
HK1254209A1 (zh) 2019-07-12
WO2017096472A1 (en) 2017-06-15
AU2016367284B2 (en) 2018-05-17
US9751894B2 (en) 2017-09-05
USRE48097E1 (en) 2020-07-14
ZA201802654B (en) 2019-07-31
IL259234B (en) 2018-12-31
EP3386977A4 (en) 2019-05-22
KR20190042752A (ko) 2019-04-24
AU2016367284A1 (en) 2018-05-10
BR112018009725A8 (pt) 2019-02-26
AU2016367284C1 (en) 2018-09-20
CN108463461B (zh) 2021-11-19
JP6967000B2 (ja) 2021-11-17
BR112018009725A2 (en) 2018-11-06

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