HK1254209A1 - 頭孢烯化合物、其製備和用途 - Google Patents

頭孢烯化合物、其製備和用途

Info

Publication number
HK1254209A1
HK1254209A1 HK18113349.1A HK18113349A HK1254209A1 HK 1254209 A1 HK1254209 A1 HK 1254209A1 HK 18113349 A HK18113349 A HK 18113349A HK 1254209 A1 HK1254209 A1 HK 1254209A1
Authority
HK
Hong Kong
Prior art keywords
production
cephem compounds
cephem
compounds
Prior art date
Application number
HK18113349.1A
Other languages
English (en)
Inventor
Samarendra Nath Maiti
Dai Quoc Nguyen
Andhe V N Reddy
Judy Yip
Chan Minh Ha
Rong Ling
Rudong Shan
Madhava Reddy Madala
Original Assignee
Naeja Rgm Pharmaceuticals Ulc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naeja Rgm Pharmaceuticals Ulc filed Critical Naeja Rgm Pharmaceuticals Ulc
Publication of HK1254209A1 publication Critical patent/HK1254209A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
HK18113349.1A 2015-12-10 2018-10-18 頭孢烯化合物、其製備和用途 HK1254209A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562265625P 2015-12-10 2015-12-10
PCT/CA2016/051428 WO2017096472A1 (en) 2015-12-10 2016-12-05 Cephem compounds, their production and use

Publications (1)

Publication Number Publication Date
HK1254209A1 true HK1254209A1 (zh) 2019-07-12

Family

ID=59012429

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18113349.1A HK1254209A1 (zh) 2015-12-10 2018-10-18 頭孢烯化合物、其製備和用途

Country Status (13)

Country Link
US (2) US9751894B2 (zh)
EP (1) EP3386977A4 (zh)
JP (1) JP6967000B2 (zh)
KR (2) KR102135230B1 (zh)
CN (1) CN108463461B (zh)
AU (1) AU2016367284C1 (zh)
BR (1) BR112018009725A8 (zh)
CA (1) CA3005779C (zh)
EA (1) EA039648B1 (zh)
HK (1) HK1254209A1 (zh)
IL (1) IL259234B (zh)
WO (1) WO2017096472A1 (zh)
ZA (1) ZA201802654B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA039648B1 (ru) 2015-12-10 2022-02-21 НАЕДЖА-АрДжиЭм ФАРМАСЬЮТИКАЛЗ ЮЭлСи Соединения цефема, их получение и применение
EP3687992A1 (en) * 2017-09-27 2020-08-05 Meiji Seika Pharma Co., Ltd. Crystalline forms of diazabicyclooctane derivatives and production process thereof
TWI795549B (zh) * 2018-04-06 2023-03-11 日商富士軟片股份有限公司 新穎青黴烷衍生物或其鹽、醫藥組成物及其應用
KR102484880B1 (ko) 2018-06-08 2023-01-05 엘지디스플레이 주식회사 신축 가능한 표시장치, 패널 구동회로 및 구동방법
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases

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* Cited by examiner, † Cited by third party
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DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US5173485A (en) * 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
GB8805642D0 (en) 1988-03-09 1988-04-07 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5215982A (en) * 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA2216259A1 (en) 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
JP2003026679A (ja) * 2001-07-10 2003-01-29 Banyu Pharmaceut Co Ltd 新規カルバペネム誘導体
TW200305422A (en) * 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
ATE368042T1 (de) 2002-10-30 2007-08-15 Astellas Pharma Inc Cephemverbindungen
US20090012054A1 (en) 2006-03-16 2009-01-08 Astellas Pharma Inc. Cephem Compounds and Use as Antimicrobial Agents
CN101343281A (zh) * 2007-04-20 2009-01-14 山东轩竹医药科技有限公司 新型脒基吡啶基头孢菌素类化合物
US9238657B2 (en) 2008-10-31 2016-01-19 Shionogi & Co., Ltd. Cephalosporin having catechol group
WO2011125966A1 (ja) 2010-04-05 2011-10-13 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
RU2012146986A (ru) * 2010-04-05 2014-05-20 Сионоги Энд Ко., Лтд. Цефемовые соединения, содержащие катехольную группу
US9085589B2 (en) * 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
JP5922110B2 (ja) * 2010-06-18 2016-05-24 フオブ・シンセシス グラム陰性活性を有するカルバペネム系抗菌薬
KR101719556B1 (ko) 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
EP2703406A4 (en) 2011-04-28 2015-08-05 Shionogi & Co NOVEL CEPHEM COMPOUND HAVING THE CATÉCHOL STRUCTURE OR A STRUCTURE CLOSE TO CATÉCHOL
WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
US8809314B1 (en) * 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
UY35103A (es) * 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
WO2014087165A1 (en) 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors
WO2014104148A1 (ja) * 2012-12-26 2014-07-03 塩野義製薬株式会社 セフェム化合物
EA039648B1 (ru) 2015-12-10 2022-02-21 НАЕДЖА-АрДжиЭм ФАРМАСЬЮТИКАЛЗ ЮЭлСи Соединения цефема, их получение и применение

Also Published As

Publication number Publication date
AU2016367284C1 (en) 2018-09-20
USRE48097E1 (en) 2020-07-14
JP6967000B2 (ja) 2021-11-17
IL259234B (en) 2018-12-31
EP3386977A1 (en) 2018-10-17
AU2016367284A1 (en) 2018-05-10
US9751894B2 (en) 2017-09-05
US20170166587A1 (en) 2017-06-15
ZA201802654B (en) 2019-07-31
CN108463461B (zh) 2021-11-19
JP2018536678A (ja) 2018-12-13
KR20190042752A (ko) 2019-04-24
CN108463461A (zh) 2018-08-28
KR20180066264A (ko) 2018-06-18
EP3386977A4 (en) 2019-05-22
WO2017096472A1 (en) 2017-06-15
CA3005779C (en) 2020-04-07
EA039648B1 (ru) 2022-02-21
KR102135230B1 (ko) 2020-07-17
BR112018009725A2 (pt) 2018-11-06
EA201891381A1 (ru) 2019-01-31
BR112018009725A8 (pt) 2019-02-26
CA3005779A1 (en) 2017-06-15
AU2016367284B2 (en) 2018-05-17

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