JP2009530281A5 - - Google Patents

Download PDF

Info

Publication number
JP2009530281A5
JP2009530281A5 JP2009500426A JP2009500426A JP2009530281A5 JP 2009530281 A5 JP2009530281 A5 JP 2009530281A5 JP 2009500426 A JP2009500426 A JP 2009500426A JP 2009500426 A JP2009500426 A JP 2009500426A JP 2009530281 A5 JP2009530281 A5 JP 2009530281A5
Authority
JP
Japan
Prior art keywords
group
alkyl
compound
halo
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009500426A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009530281A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/006279 external-priority patent/WO2007106469A2/en
Publication of JP2009530281A publication Critical patent/JP2009530281A/ja
Publication of JP2009530281A5 publication Critical patent/JP2009530281A5/ja
Withdrawn legal-status Critical Current

Links

JP2009500426A 2006-03-14 2007-03-12 代謝障害の治療に有用である二環式カルボン酸誘導体 Withdrawn JP2009530281A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78270606P 2006-03-14 2006-03-14
US90520707P 2007-03-05 2007-03-05
PCT/US2007/006279 WO2007106469A2 (en) 2006-03-14 2007-03-12 Bicyclic carboxylic acid derivatives useful for treating metabolic disorders

Publications (2)

Publication Number Publication Date
JP2009530281A JP2009530281A (ja) 2009-08-27
JP2009530281A5 true JP2009530281A5 (enExample) 2010-04-22

Family

ID=38326178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009500426A Withdrawn JP2009530281A (ja) 2006-03-14 2007-03-12 代謝障害の治療に有用である二環式カルボン酸誘導体

Country Status (9)

Country Link
US (1) US20070244155A1 (enExample)
EP (1) EP2001844A2 (enExample)
JP (1) JP2009530281A (enExample)
AR (1) AR059895A1 (enExample)
AU (1) AU2007225208A1 (enExample)
CA (1) CA2646430A1 (enExample)
MX (1) MX2008011615A (enExample)
TW (1) TW200804333A (enExample)
WO (1) WO2007106469A2 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100130737A1 (en) * 2005-02-18 2010-05-27 Takeda Pharmaceutical Company Limited Regulating Agent of GPR34 Receptor Function
WO2008030618A1 (en) * 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
EP2064193A1 (en) * 2006-09-07 2009-06-03 Amgen, Inc Heterocyclic gpr40 modulators
WO2008130514A1 (en) * 2007-04-16 2008-10-30 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR20100090249A (ko) 2007-10-10 2010-08-13 암젠 인크 치환된 비페닐 grp40 조절제
EP2215068B1 (en) * 2007-10-29 2012-06-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2260017A1 (en) * 2008-03-06 2010-12-15 Amgen, Inc Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
KR20220084423A (ko) 2008-07-23 2022-06-21 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체
JP2012503595A (ja) * 2008-07-28 2012-02-09 シダンスク ユニバーシティ 代謝病の治療用の化合物
BRPI0917923B1 (pt) * 2008-08-27 2022-04-05 Arena Pharmaceuticals Inc Derivado de ácido tricíclico substituído, sua composição, seu uso e processo para preparar a referida composição
CA2739888C (en) * 2008-10-15 2013-11-19 Amgen Inc. Spirocyclic gpr40 modulators
EP2690095A1 (en) * 2008-10-21 2014-01-29 Camabay Therapeutics, Inc. Aryl gpr120 receptor agonists and uses thereof
AR074760A1 (es) * 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2389226B1 (en) * 2009-01-23 2013-11-20 Merck Sharp & Dohme Corp. Bridged and fused heterocyclic antidiabetic compounds
AU2010240142A1 (en) * 2009-04-22 2011-11-10 Astellas Pharma Inc. Carboxylic acid compound
JP5856980B2 (ja) 2010-01-27 2016-02-10 アリーナ ファーマシューティカルズ, インコーポレイテッド (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
EP2582674B1 (en) * 2010-06-16 2014-10-01 Cymabay Therapeutics, Inc. Gpr120 receptor agonists and uses thereof
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2511273B8 (en) * 2011-04-15 2019-06-26 Hivih Inhibitors of viral replication, their process of preparation and their therapeutical uses
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
AU2012365706B2 (en) * 2012-01-12 2015-08-20 Jiangsu Hengrui Medicine Co., Ltd. Polycyclic derivatives, preparation method and medical uses thereof
MX2014012741A (es) 2012-04-26 2015-04-13 Bristol Myers Squibb Co Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activado de proteasa (par4) para tratamiento de agregacion plaquetaria.
SI3243826T1 (sl) 2012-04-26 2020-03-31 Bristol-Myers Squibb Company Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov
US9862730B2 (en) 2012-04-26 2018-01-09 Bristol-Myers Squibb Company Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
EP2880028B1 (en) 2012-08-02 2020-09-30 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
CN104812748B (zh) 2012-11-16 2017-10-24 百时美施贵宝公司 二氢吡唑gpr40调节剂
WO2014122067A1 (en) * 2013-02-06 2014-08-14 Boehringer Ingelheim International Gmbh New indanyloxydihydrobenzofuranylacetic acids
EP2958562B1 (en) 2013-02-22 2025-09-10 Merck Sharp & Dohme LLC Antidiabetic bicyclic compounds
US9643946B2 (en) * 2013-02-28 2017-05-09 Sk Chemicals Co., Ltd. Tricyclic compound and use thereof
CN104109115B (zh) * 2013-04-16 2016-11-23 中国科学院上海药物研究所 一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途
EP2821104A1 (en) 2013-07-05 2015-01-07 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
CN105246875A (zh) * 2013-09-03 2016-01-13 四川海思科制药有限公司 茚满衍生物及其制备方法和在医药上的应用
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015073342A1 (en) * 2013-11-15 2015-05-21 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015084692A1 (en) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
EP3102198B1 (en) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Antidiabetic compounds
WO2015176267A1 (en) 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2016022446A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [5,6]-fused bicyclic antidiabetic compounds
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
EP3177282B1 (en) 2014-08-08 2021-10-06 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
EP3177287B1 (en) 2014-08-08 2022-02-23 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
ES2805743T3 (es) 2015-03-24 2021-02-15 Inst Nat Sante Rech Med Método y composición farmacéutica para uso en el tratamiento de la diabetes
EP3310760B8 (en) 2015-06-22 2022-10-19 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in s1p1 receptor-associated disorders
LT3344248T (lt) 2015-09-02 2022-06-27 Trevena, Inc. 6-narių azaheterociklinių junginių, kurių sudėtyje yra deltaopioidų receptorius moduliuojančių junginių, panaudojimo ir gamybos būdai
US10676458B2 (en) 2016-03-29 2020-06-09 Merch Sharp & Dohne Corp. Rahway Antidiabetic bicyclic compounds
KR102364344B1 (ko) 2016-05-23 2022-02-18 인스티튜드 오브 머테리아 메디카, 차이니스 아케데미 오브 메디컬 싸이언시스 니코티닐 알콜 에테르 유도체, 그의 제조 방법, 및 그의 약학적 조성물 및 용도
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. ANTIDIABETIC SPIROCHROMAN COMPOUNDS
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
EP3582779B1 (en) 2017-02-17 2024-04-17 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
WO2018152286A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
AR111199A1 (es) * 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
CN109320483A (zh) * 2017-08-01 2019-02-12 南京大学 香豆素衍生物、其制备方法及其作为药物的用途
PL3684767T3 (pl) 2017-09-22 2024-10-14 Jubilant Epipad LLC Związki heterocykliczne jako inhibitory pad
PL3697785T3 (pl) 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
EP3709995A4 (en) 2017-11-16 2021-04-14 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
SI3704120T1 (sl) 2017-11-24 2024-07-31 Jubilant Episcribe Llc Heterociklične spojine kot inhibitorji prmt5
MX2020008404A (es) 2018-02-13 2020-09-25 Gilead Sciences Inc Inhibidores de molecula de muerte programada 1 (pd-1)/ligando de molecula de muerte programada 1 (pd-l1).
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
ES3035911T3 (en) 2018-04-19 2025-09-11 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
SI3820572T1 (sl) 2018-07-13 2023-12-29 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
KR102836433B1 (ko) 2018-09-06 2025-07-21 아레나 파마슈티칼스, 인크. 자가면역 및 염증성 장애의 치료에 유용한 화합물
JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ, インコーポレイテッド Pd-1/pd-l1阻害剤
CN113185446A (zh) * 2018-12-06 2021-07-30 上海济煜医药科技有限公司 作为免疫调节的芳环衍生物及其制备方法和应用
CN110156761B (zh) * 2019-06-18 2022-08-09 郑州大学 含香豆素-联苯骨架化合物、制备方法及其应用
CN113880747B (zh) * 2020-07-03 2023-05-26 上海美迪西生物医药股份有限公司 一种吲哚衍生物及其应用
CN114163426B (zh) 2020-09-10 2024-03-19 上海爱博医药科技有限公司 苯并含氧杂环类化合物及其医药应用
CN115340484A (zh) * 2021-05-13 2022-11-15 上海美迪西生物医药股份有限公司 苄氧基吲哚类支链酸类衍生物及其制备方法和应用
EP4556465A4 (en) * 2022-11-22 2025-10-29 Xian Xintong Pharmaceutical Res Co Ltd NEW BICYCLIC PD-L1 INHIBITORS, THEIR PREPARATION PROCESSES AND MEDICINAL USES
WO2025141118A1 (en) * 2023-12-27 2025-07-03 Institut National de la Santé et de la Recherche Médicale Arylalkyloxyindole compounds and derivatives and their use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE305216B (enExample) * 1965-09-17 1968-10-21 Astra Apotekarnes Kem Fab
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors
AU6490396A (en) * 1995-07-14 1997-02-18 Smithkline Beecham Corporation Substituted-pent-4-ynoic acids
US6645939B1 (en) * 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
WO1999046232A1 (en) * 1998-03-10 1999-09-16 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
CA2433573A1 (en) * 2000-12-28 2002-07-11 Takeda Chemical Industries, Ltd. Alkanoic acid derivatives, process for their production and use thereof
CN1293042C (zh) * 2002-02-07 2007-01-03 远藤仁 芳香族氨基酸衍生物及其药物组合物
DE60332320D1 (de) * 2002-02-14 2010-06-10 Takeda Pharmaceutical Neues screening-verfahren
US6875780B2 (en) * 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
GB0214149D0 (en) * 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
CA2527691C (en) * 2003-05-30 2013-01-22 Takeda Pharmaceutical Company Limited Condensed ring compound
BRPI0508098A (pt) * 2004-02-27 2007-07-17 Amgen Inc compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos
US20060003344A1 (en) * 2004-06-30 2006-01-05 Pfizer Inc. Methods related to a single nucleotide polymorphism of the G protein coupled receptor, GPR40
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
CA2621949A1 (en) * 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
JP5271895B2 (ja) * 2006-05-15 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション 抗糖尿病性の二環式化合物

Similar Documents

Publication Publication Date Title
JP2009530281A5 (enExample)
JP2011515341A5 (enExample)
Momose et al. Novel 5-substituted 2, 4-thiazolidinedione and 2, 4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities
CN115244056A (zh) 稠合咪唑类衍生物、其制备方法及其在医药上的应用
NZ631569A (en) Phenyl alkanoic acid derivatives as gpr agonists
RU2419624C2 (ru) Сульфонамидные производные как активаторы гликокиназы, применимые для лечения диабета типа 2
JP2020033357A5 (enExample)
JP2009533410A5 (enExample)
JP2013538802A5 (enExample)
JP2010510242A5 (enExample)
WO2001016123A1 (en) Benzylidene-thiazolidinediones and analogues and their use in the treatment of inflammation
JP2016506960A5 (enExample)
RU2481330C2 (ru) Азотсодержащее ароматическое гетероциклическое соединение
CA2404384A1 (en) Substituted 1,3-thiazole compounds, their production and use
JP5786034B2 (ja) 脂質異常症の治療に適したヘテロ環式化合物
CA2486399A1 (en) Calcium receptor modulating agents
RU2009133259A (ru) Производные пиразола в качестве ингибиторов 11-бета-hsd1
JP2005513026A5 (enExample)
JP2010530438A5 (enExample)
CA2558585A1 (en) Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
JP2012505896A5 (enExample)
JP2007519695A5 (enExample)
RU2010134411A (ru) Фенилацетамидное производное
PE20080360A1 (es) Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3
IL287159B1 (en) Small molecules agonists for FXR (farnesoid X receptor) and method for their preparation and use