|
JPWO2006088246A1
(ja)
*
|
2005-02-18 |
2008-07-10 |
武田薬品工業株式会社 |
Ｇｐｒ３４受容体機能調節剤
|
|
US7687526B2
(en)
*
|
2006-09-07 |
2010-03-30 |
Amgen Inc. |
Benzo-fused compounds for use in treating metabolic disorders
|
|
AU2007293028B2
(en)
*
|
2006-09-07 |
2012-05-31 |
Amgen Inc. |
Heterocyclic GPR40 modulators
|
|
CA2683751C
(en)
*
|
2007-04-16 |
2013-01-08 |
Amgen Inc. |
Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
KR20100090249A
(ko)
|
2007-10-10 |
2010-08-13 |
암젠 인크 |
치환된 비페닐 ｇｒｐ４０ 조절제
|
|
WO2009058237A1
(en)
*
|
2007-10-29 |
2009-05-07 |
Merck & Co., Inc. |
Antidiabetic tricyclic compounds
|
|
US8450522B2
(en)
*
|
2008-03-06 |
2013-05-28 |
Amgen Inc. |
Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
|
|
HRP20161133T1
(hr)
|
2008-07-23 |
2016-12-02 |
Arena Pharmaceuticals, Inc. |
DERIVATI SUSPSTITUIRANE 1,2,3,4-TETRAHIDROCIKLOPENTA[b]INDOL-3-IL-OCTENE KISELINE KORISNI U LIJEČENJU AUTOIMUNIH I UPALNIH POREMEĆAJA
|
|
WO2010012650A1
(en)
*
|
2008-07-28 |
2010-02-04 |
Syddansk Universitet |
Compounds for the treatment of metabolic diseases
|
|
CN105816453B
(zh)
|
2008-08-27 |
2021-03-05 |
艾尼纳制药公司 |
用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
|
|
US8748462B2
(en)
*
|
2008-10-15 |
2014-06-10 |
Amgen Inc. |
Spirocyclic GPR40 modulators
|
|
JP2012506386A
(ja)
*
|
2008-10-21 |
2012-03-15 |
メタボレックス， インコーポレイテッド |
アリールｇｐｒ１２０受容体アゴニストおよびその使用
|
|
AR074760A1
(es)
*
|
2008-12-18 |
2011-02-09 |
Metabolex Inc |
Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
|
|
CA2749930A1
(en)
*
|
2009-01-23 |
2010-07-29 |
Schering Corporation |
Bridged and fused heterocyclic antidiabetic compounds
|
|
US20120035196A1
(en)
*
|
2009-04-22 |
2012-02-09 |
Kenji Negoro |
Carboxylic acid compound
|
|
CA2786994C
(en)
|
2010-01-27 |
2018-01-16 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
|
|
WO2011107494A1
(de)
|
2010-03-03 |
2011-09-09 |
Sanofi |
Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
CN105503882B
(zh)
|
2010-03-03 |
2019-07-05 |
艾尼纳制药公司 |
制备s1p1受体调节剂及其晶体形式的方法
|
|
CA2801182A1
(en)
*
|
2010-06-16 |
2011-12-22 |
Metabolex, Inc. |
Gpr120 receptor agonists and uses thereof
|
|
US8933024B2
(en)
|
2010-06-18 |
2015-01-13 |
Sanofi |
Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8710050B2
(en)
|
2011-03-08 |
2014-04-29 |
Sanofi |
Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
WO2012120054A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2511273B8
(en)
*
|
2011-04-15 |
2019-06-26 |
Hivih |
Inhibitors of viral replication, their process of preparation and their therapeutical uses
|
|
WO2013037390A1
(en)
|
2011-09-12 |
2013-03-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
WO2013045413A1
(en)
|
2011-09-27 |
2013-04-04 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
JP6122871B2
(ja)
*
|
2012-01-12 |
2017-04-26 |
ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． |
多環式化合物誘導体、それらの製造方法および医薬用途
|
|
EA201491967A1
(ru)
|
2012-04-26 |
2015-03-31 |
Бристол-Майерс Сквибб Компани |
Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов
|
|
SMT201700457T1
(it)
|
2012-04-26 |
2017-11-15 |
Bristol Myers Squibb Co |
DERlVATI IMIDAZOTIADIAZOLICI E IMIDAZOPIRAZINICI COME INIBITORI DEL RECETTORE ATTIVATO DA PROTEASI 4 (PAR4) PER IL TRATTAMENTO DELL'AGGREGAZIONE PIASTRINICA
|
|
EP2855489B1
(en)
|
2012-04-26 |
2017-01-04 |
Bristol-Myers Squibb Company |
Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
|
|
WO2014022528A1
(en)
|
2012-08-02 |
2014-02-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014064215A1
(en)
|
2012-10-24 |
2014-05-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
|
|
HUE032401T2
(en)
|
2012-11-16 |
2017-09-28 |
Bristol Myers Squibb Co |
Dihydropyrazole GPR40 modulators
|
|
WO2014122067A1
(en)
*
|
2013-02-06 |
2014-08-14 |
Boehringer Ingelheim International Gmbh |
New indanyloxydihydrobenzofuranylacetic acids
|
|
WO2014130608A1
(en)
|
2013-02-22 |
2014-08-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
KR101735787B1
(ko)
*
|
2013-02-28 |
2017-05-16 |
주식회사 티움바이오 |
삼환식 화합물 및 이의 용도
|
|
CN104109115B
(zh)
*
|
2013-04-16 |
2016-11-23 |
中国科学院上海药物研究所 |
一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途
|
|
EP2821104A1
(en)
|
2013-07-05 |
2015-01-07 |
Laboratoire Biodim |
Inhibitors of viral replication, their process of preparation and their therapeutical uses
|
|
WO2015032328A1
(zh)
*
|
2013-09-03 |
2015-03-12 |
四川海思科制药有限公司 |
茚满衍生物及其制备方法和在医药上的应用
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
US10519115B2
(en)
|
2013-11-15 |
2019-12-31 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
EP3076959B1
(en)
|
2013-12-04 |
2018-07-04 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2015089809A1
(en)
|
2013-12-19 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Antidiabetic substituted heteroaryl compounds
|
|
US10059667B2
(en)
|
2014-02-06 |
2018-08-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic compounds
|
|
WO2015176267A1
(en)
|
2014-05-22 |
2015-11-26 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2016019587A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
[7, 6]-fused bicyclic antidiabetic compounds
|
|
WO2016022446A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
[5,6]-fused bicyclic antidiabetic compounds
|
|
EP3177287B1
(en)
|
2014-08-08 |
2022-02-23 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
EP3177282B1
(en)
|
2014-08-08 |
2021-10-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
AU2016205361C1
(en)
|
2015-01-06 |
2021-04-08 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
WO2016151018A1
(en)
|
2015-03-24 |
2016-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method and pharmaceutical composition for use in the treatment of diabetes
|
|
PL3310760T3
(pl)
|
2015-06-22 |
2023-03-06 |
Arena Pharmaceuticals, Inc. |
Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
|
|
CA3015702A1
(en)
|
2015-09-02 |
2017-03-09 |
Trevena, Inc. |
6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
|
|
WO2017172505A1
(en)
|
2016-03-29 |
2017-10-05 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
RU2735541C2
(ru)
*
|
2016-05-23 |
2020-11-03 |
Инститьют Оф Материя Медика, Чайниз Экедеми Оф Медикал Сайенсез |
Простое эфирное производное никотинилового спирта, получение и фармацевтическая композиция и применения
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298B1
(en)
|
2016-12-20 |
2026-03-11 |
Merck Sharp & Dohme LLC |
Antidiabetic spirochroman compounds
|
|
KR20190116416A
(ko)
|
2017-02-16 |
2019-10-14 |
아레나 파마슈티칼스, 인크. |
원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
|
|
JP2020507610A
(ja)
|
2017-02-16 |
2020-03-12 |
アリーナ ファーマシューティカルズ， インコーポレイテッド |
腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
|
|
BR112019016827A2
(pt)
|
2017-02-17 |
2020-04-07 |
Trevena Inc |
compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
|
|
JP7185633B2
(ja)
|
2017-02-17 |
2022-12-07 |
トレベナ・インコーポレイテッド |
７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法
|
|
AR111199A1
(es)
*
|
2017-03-31 |
2019-06-12 |
Takeda Pharmaceuticals Co |
Compuesto aromático agonista de gpr40
|
|
BR102018007822A2
(pt)
|
2017-04-20 |
2018-11-06 |
Gilead Sciences, Inc. |
composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
|
|
CN109320483A
(zh)
*
|
2017-08-01 |
2019-02-12 |
南京大学 |
香豆素衍生物、其制备方法及其作为药物的用途
|
|
SG11202002032SA
(en)
|
2017-09-22 |
2020-04-29 |
Jubilant Epipad LLC |
Heterocyclic compounds as pad inhibitors
|
|
CA3076476A1
(en)
|
2017-10-18 |
2019-04-25 |
Jubilant Epipad LLC |
Imidazo-pyridine compounds as pad inhibitors
|
|
BR112020008851A2
(pt)
|
2017-11-06 |
2020-10-20 |
Jubilant Prodel LLC |
composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
|
|
US11225471B2
(en)
|
2017-11-16 |
2022-01-18 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
PL3704120T3
(pl)
|
2017-11-24 |
2024-09-16 |
Jubilant Episcribe Llc |
Związki heterocykliczne jako inhibitory prmt5
|
|
KR102708681B1
(ko)
|
2018-02-13 |
2024-09-26 |
길리애드 사이언시즈, 인코포레이티드 |
Pd-1/pd-l1 억제제
|
|
SG11202008950PA
(en)
|
2018-03-13 |
2020-10-29 |
Jubilant Prodel LLC |
Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
|
|
EP4600247A3
(en)
|
2018-04-19 |
2025-11-19 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
AU2019280822A1
(en)
|
2018-06-06 |
2021-01-07 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
UA126421C2
(uk)
|
2018-07-13 |
2022-09-28 |
Гіліад Сайєнсіз, Інк. |
Інгібітори pd-1/pd-l1
|
|
EP3847158A1
(en)
|
2018-09-06 |
2021-07-14 |
Arena Pharmaceuticals, Inc. |
Compounds useful in the treatment of autoimmune and inflammatory disorders
|
|
US11236085B2
(en)
|
2018-10-24 |
2022-02-01 |
Gilead Sciences, Inc. |
PD-1/PD-L1 inhibitors
|
|
JP7464920B2
(ja)
*
|
2018-12-06 |
2024-04-10 |
シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド |
免疫調節としての芳香環誘導体及びその製造方法と使用
|
|
CN110156761B
(zh)
*
|
2019-06-18 |
2022-08-09 |
郑州大学 |
含香豆素-联苯骨架化合物、制备方法及其应用
|
|
WO2022002225A1
(zh)
*
|
2020-07-03 |
2022-01-06 |
上海美迪西生物医药股份有限公司 |
一种吲哚衍生物及其应用
|
|
CN114163426B
(zh)
|
2020-09-10 |
2024-03-19 |
上海爱博医药科技有限公司 |
苯并含氧杂环类化合物及其医药应用
|
|
CN115340484A
(zh)
*
|
2021-05-13 |
2022-11-15 |
上海美迪西生物医药股份有限公司 |
苄氧基吲哚类支链酸类衍生物及其制备方法和应用
|
|
AU2023383986A1
(en)
*
|
2022-11-22 |
2025-03-13 |
Xi'an Xintong Pharmaceutical Research Co., Ltd. |
Novel bicyclic pd-l1 inhibitors, preparation methods therefor and medicinal uses thereof
|
|
CN116283560A
(zh)
*
|
2023-02-27 |
2023-06-23 |
南通大学 |
一种基于水溶性柱芳烃的纳米诊疗材料
|
|
WO2025141118A1
(en)
*
|
2023-12-27 |
2025-07-03 |
Institut National de la Santé et de la Recherche Médicale |
Arylalkyloxyindole compounds and derivatives and their use
|