DE602004018193D1 - Pyrimidine mit tie2 (tek) aktivität - Google Patents
Pyrimidine mit tie2 (tek) aktivitätInfo
- Publication number
- DE602004018193D1 DE602004018193D1 DE602004018193T DE602004018193T DE602004018193D1 DE 602004018193 D1 DE602004018193 D1 DE 602004018193D1 DE 602004018193 T DE602004018193 T DE 602004018193T DE 602004018193 T DE602004018193 T DE 602004018193T DE 602004018193 D1 DE602004018193 D1 DE 602004018193D1
- Authority
- DE
- Germany
- Prior art keywords
- tie2
- tek
- pyrimidines
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102100022014 Angiopoietin-1 receptor Human genes 0.000 title 2
- 101000753291 Homo sapiens Angiopoietin-1 receptor Proteins 0.000 title 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0330000A GB0330000D0 (en) | 2003-12-24 | 2003-12-24 | Compounds |
| GB0416849A GB0416849D0 (en) | 2004-07-29 | 2004-07-29 | Compounds |
| PCT/GB2004/005337 WO2005060970A1 (en) | 2003-12-24 | 2004-12-20 | Pyrimidines with tie2 (tek) activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004018193D1 true DE602004018193D1 (de) | 2009-01-15 |
Family
ID=34712715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004018193T Expired - Fee Related DE602004018193D1 (de) | 2003-12-24 | 2004-12-20 | Pyrimidine mit tie2 (tek) aktivität |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080108608A1 (enExample) |
| EP (1) | EP1737463B1 (enExample) |
| JP (1) | JP2007517007A (enExample) |
| AR (1) | AR046795A1 (enExample) |
| AT (1) | ATE415970T1 (enExample) |
| DE (1) | DE602004018193D1 (enExample) |
| ES (1) | ES2317079T3 (enExample) |
| TW (1) | TW200526597A (enExample) |
| UY (1) | UY28701A1 (enExample) |
| WO (1) | WO2005060970A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| US20100048543A1 (en) * | 2005-02-01 | 2010-02-25 | Astrazeneca Ab | Pyrimidine compounds having ties (tek) inhibitory activity |
| US20080146599A1 (en) * | 2005-02-01 | 2008-06-19 | Astrazeneca Ab | Pyrimidine Compounds Having Tie-2 (Tek) Inhibitory Activity |
| GB0502418D0 (en) * | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| JP2008534565A (ja) * | 2005-03-31 | 2008-08-28 | アストラゼネカ アクチボラグ | Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体 |
| HUE047422T2 (hu) | 2005-12-23 | 2020-04-28 | Ariad Pharma Inc | Biciklusos heteroaril vegyületek |
| ES2555515T3 (es) * | 2006-05-08 | 2016-01-04 | Ariad Pharmaceuticals, Inc. | Compuestos de heteroarilo monocíclico |
| EA200870514A1 (ru) | 2006-05-08 | 2009-04-28 | Ариад Фармасьютикалз, Инк. | Ацетиленовые гетероарильные соединения |
| US8558002B2 (en) * | 2006-11-16 | 2013-10-15 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| EP2070929A1 (en) * | 2007-12-11 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| EP2671891A3 (en) | 2008-06-27 | 2014-03-05 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| AU2009314631B2 (en) | 2008-11-12 | 2014-07-31 | Takeda Pharmaceutical Company Limited | Pyrazinopyrazines and derivatives as kinase inhibitors |
| US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| JP5647615B2 (ja) * | 2008-11-14 | 2015-01-07 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換ジオキソピペリジニルフタルイミド誘導体 |
| EP2922838B1 (en) | 2012-10-22 | 2018-03-14 | Concert Pharmaceuticals Inc. | Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} . |
| CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| ES2747249T3 (es) * | 2014-07-17 | 2020-03-10 | Sunshine Lake Pharma Co Ltd | Derivados de 1-(5-(terc-butil)isoxazol-3-il)-3-(4-((fenil)etinil)fenil)urea y compuestos relacionados como inhibidores de FLT3 para el tratamiento de cáncer |
| US11213529B2 (en) | 2017-07-13 | 2022-01-04 | Sunshine Lake Pharma Co., Ltd. | Salt of substituted urea derivative and use thereof in medicine |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5154728B2 (ja) * | 2000-07-24 | 2013-02-27 | クレニツキー・ファーマシューティカルズ，インコーポレイテッド | 神経栄養活性を有する置換５−アルキニルピリミジン |
| AU2002341920A1 (en) * | 2001-10-02 | 2003-04-14 | Smithkline Beecham Corporation | Chemical compounds |
| US20030225273A1 (en) * | 2002-03-21 | 2003-12-04 | Michaelides Michael R. | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors |
| ATE402705T1 (de) * | 2003-12-24 | 2008-08-15 | Astrazeneca Ab | Pyrimidine mit tie2 (tek) aktivität |
-
2004
- 2004-12-20 AT AT04806139T patent/ATE415970T1/de not_active IP Right Cessation
- 2004-12-20 JP JP2006546306A patent/JP2007517007A/ja active Pending
- 2004-12-20 ES ES04806139T patent/ES2317079T3/es not_active Expired - Lifetime
- 2004-12-20 EP EP04806139A patent/EP1737463B1/en not_active Expired - Lifetime
- 2004-12-20 US US10/596,745 patent/US20080108608A1/en not_active Abandoned
- 2004-12-20 WO PCT/GB2004/005337 patent/WO2005060970A1/en not_active Ceased
- 2004-12-20 DE DE602004018193T patent/DE602004018193D1/de not_active Expired - Fee Related
- 2004-12-23 UY UY28701A patent/UY28701A1/es not_active Application Discontinuation
- 2004-12-24 TW TW093140578A patent/TW200526597A/zh unknown
- 2004-12-27 AR ARP040104906A patent/AR046795A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1102425A1 (en) | 2007-11-23 |
| US20080108608A1 (en) | 2008-05-08 |
| WO2005060970A1 (en) | 2005-07-07 |
| EP1737463B1 (en) | 2008-12-03 |
| ATE415970T1 (de) | 2008-12-15 |
| JP2007517007A (ja) | 2007-06-28 |
| ES2317079T3 (es) | 2009-04-16 |
| AR046795A1 (es) | 2005-12-21 |
| EP1737463A1 (en) | 2007-01-03 |
| UY28701A1 (es) | 2005-07-29 |
| TW200526597A (en) | 2005-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE402705T1 (de) | Pyrimidine mit tie2 (tek) aktivität | |
| ATE415970T1 (de) | Pyrimidine mit tie2 (tek) aktivität | |
| ATE529412T1 (de) | Herbizide pyrimidine | |
| EP1546115A4 (en) | Substituted pyrimidines | |
| DK1487805T3 (da) | Pyrimidinderivater | |
| ATE520672T1 (de) | Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine | |
| ATE434610T1 (de) | Aryl substituierte pyrimidine und deren verwendung | |
| IS8006A (is) | Setin pýrimidínón | |
| HUS1500055I1 (hu) | HIV-gátló pirimidinszármazékok | |
| EP1724267A4 (en) | pyrimidine derivative | |
| DE50311783D1 (de) | Pyridazinderivate | |
| IS8406A (is) | 5,7-díamínópýrasóló [4,3-d] pýrimidín með PDE-5 hindrandi virkni | |
| MA28813B1 (fr) | Derives de pyrimidine | |
| DE602004014292D1 (de) | Verstärkersystem mit variabler versorgung | |
| NO20042742L (no) | Pyrimidinforbindelser | |
| DE60304718D1 (de) | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität | |
| ATE542802T1 (de) | Hiv-inhibierende 5-substituierte pyrimidine | |
| IL172848A0 (en) | 2-substituted pyrimidines | |
| ZA200707315B (en) | Substituted 5-phenyl pyrimidines I in therapy | |
| NO20054199D0 (no) | 6-substituerte imidazopyraziner | |
| DE50313605D1 (de) | Versorgungsleitungsstruktur | |
| DK1603910T3 (da) | Substituerede 2-(diazabicykloalkyl)-pyrimidon-derivater | |
| ZA200500863B (en) | Condensed pyridines and pyrimidines with Tie2 (tek) activity. | |
| DE50309332D1 (de) | Empfangsanordnung mit vorverstärkerschaltung | |
| FR2846209B1 (fr) | Structure de couchage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |