JP2005537323A5 - - Google Patents
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- Publication number
- JP2005537323A5 JP2005537323A5 JP2004532994A JP2004532994A JP2005537323A5 JP 2005537323 A5 JP2005537323 A5 JP 2005537323A5 JP 2004532994 A JP2004532994 A JP 2004532994A JP 2004532994 A JP2004532994 A JP 2004532994A JP 2005537323 A5 JP2005537323 A5 JP 2005537323A5
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- optionally substituted
- alkyl
- hydrogen
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004517 1,2,5-thiadiazolyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 *C(c(nc1)c(*)cc1-c1c(*=C=C)c(*)cc(*)c1)NC(C1(CCC1)NC(*)=O)=O Chemical compound *C(c(nc1)c(*)cc1-c1c(*=C=C)c(*)cc(*)c1)NC(C1(CCC1)NC(*)=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40674202P | 2002-08-29 | 2002-08-29 | |
| PCT/US2003/026628 WO2004019868A2 (en) | 2002-08-29 | 2003-08-25 | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005537323A JP2005537323A (ja) | 2005-12-08 |
| JP2005537323A5 true JP2005537323A5 (enExample) | 2006-06-22 |
Family
ID=31978351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532994A Pending JP2005537323A (ja) | 2002-08-29 | 2003-08-25 | Ｎ−ビアリールメチルアミノシクロアルカンカルボキサミド誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7163951B2 (enExample) |
| EP (1) | EP1545538A2 (enExample) |
| JP (1) | JP2005537323A (enExample) |
| KR (1) | KR20050033660A (enExample) |
| CN (1) | CN1678320A (enExample) |
| AU (1) | AU2003265674B2 (enExample) |
| BR (1) | BR0313239A (enExample) |
| CA (1) | CA2495914A1 (enExample) |
| IL (1) | IL166426A0 (enExample) |
| MX (1) | MXPA05002245A (enExample) |
| NO (1) | NO20051539L (enExample) |
| PL (1) | PL374529A1 (enExample) |
| RU (1) | RU2005108667A (enExample) |
| WO (1) | WO2004019868A2 (enExample) |
| ZA (1) | ZA200500471B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004265300A1 (en) * | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Sulfonyl substituted N-(biarylmethyl) aminocyclopropanecarboxamides |
| KR20070002006A (ko) | 2004-02-11 | 2007-01-04 | 스미스클라인 비참 코포레이션 | Ｈｉｖ 인테그라제 억제제 |
| ATE423114T1 (de) * | 2004-03-02 | 2009-03-15 | Merck & Co Inc | Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten |
| US7429604B2 (en) * | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
| ES2422197T3 (es) | 2005-06-03 | 2013-09-09 | Merck Sharp & Dohme | Derivados 1-hidroxicicloalcanocarboxamida como antagonistas de la bradiquinina |
| JP2009519966A (ja) | 2005-12-14 | 2009-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | セリンプロテアーゼ阻害剤として有用な６員ヘテロ環 |
| JP5238812B2 (ja) | 2007-08-29 | 2013-07-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ブラジキニンｂ１アンタゴニスト |
| WO2009132453A1 (en) * | 2008-04-28 | 2009-11-05 | Neuromed Pharmaceuticals Ltd. | Cyclylamine derivatives as calcium channel blockers |
| TW201024279A (en) * | 2008-09-18 | 2010-07-01 | Jerini Ag | Use of B1 receptor antagonists |
| MY153941A (en) * | 2009-02-26 | 2015-04-15 | Boehringer Ingelheim Int | Compounds as bradykinin b1 antagonists |
| WO2010097373A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
| ES2446352T3 (es) * | 2009-06-02 | 2014-03-07 | Boehringer Ingelheim International Gmbh | Derivados de amidas del ácido 6,7-dihidro-5H-imidazo[1,2-a]imidazol-3-carboxílico |
| KR101628132B1 (ko) * | 2010-01-25 | 2016-06-08 | 주식회사 바이오씨에스 | 신규한 바이아릴아미드 유도체 및 이를 유효성분으로 함유하는 조성물 |
| SI2539323T1 (sl) * | 2010-02-23 | 2015-03-31 | Boehringer Ingelheim International Gmbh | Spojine kot antagonisti bradikinina B1 |
| US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| HUP1000598A2 (en) * | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
| US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
| US8592426B2 (en) | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| NO2686520T3 (enExample) * | 2011-06-06 | 2018-03-17 | ||
| CN114404414A (zh) | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
| EP3247355A4 (en) | 2015-01-23 | 2018-06-13 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| EA036920B1 (ru) | 2015-04-01 | 2021-01-15 | Экебиа Терапьютикс, Инк. | Композиции и способы для лечения анемии |
| TW202406895A (zh) | 2018-05-09 | 2024-02-16 | 美商阿克比治療有限公司 | 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023265A (en) | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
| IL99372A0 (en) | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
| US6919343B2 (en) * | 2002-02-08 | 2005-07-19 | Merck & Co., Inc. | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives |
| AU2003217728B2 (en) * | 2002-02-08 | 2008-11-20 | Merck Sharp & Dohme Corp. | N-Biphenylmethyl aminocycloalkanecarboxamide derivatives |
-
2003
- 2003-08-25 WO PCT/US2003/026628 patent/WO2004019868A2/en not_active Ceased
- 2003-08-25 MX MXPA05002245A patent/MXPA05002245A/es not_active Application Discontinuation
- 2003-08-25 CA CA002495914A patent/CA2495914A1/en not_active Abandoned
- 2003-08-25 IL IL16642603A patent/IL166426A0/xx unknown
- 2003-08-25 AU AU2003265674A patent/AU2003265674B2/en not_active Ceased
- 2003-08-25 KR KR1020057003550A patent/KR20050033660A/ko not_active Withdrawn
- 2003-08-25 EP EP03791763A patent/EP1545538A2/en not_active Withdrawn
- 2003-08-25 US US10/523,911 patent/US7163951B2/en not_active Expired - Fee Related
- 2003-08-25 PL PL03374529A patent/PL374529A1/xx not_active Application Discontinuation
- 2003-08-25 BR BR0313239-0A patent/BR0313239A/pt not_active Application Discontinuation
- 2003-08-25 RU RU2005108667/04A patent/RU2005108667A/ru not_active Application Discontinuation
- 2003-08-25 CN CNA03820293XA patent/CN1678320A/zh active Pending
- 2003-08-25 JP JP2004532994A patent/JP2005537323A/ja active Pending
-
2005
- 2005-01-18 ZA ZA2005/00471A patent/ZA200500471B/en unknown
- 2005-03-23 NO NO20051539A patent/NO20051539L/no unknown
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