JP2005537323A - N−ビアリールメチルアミノシクロアルカンカルボキサミド誘導体 - Google Patents

N−ビアリールメチルアミノシクロアルカンカルボキサミド誘導体 Download PDF

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JP2005537323A
JP2005537323A JP2004532994A JP2004532994A JP2005537323A JP 2005537323 A JP2005537323 A JP 2005537323A JP 2004532994 A JP2004532994 A JP 2004532994A JP 2004532994 A JP2004532994 A JP 2004532994A JP 2005537323 A JP2005537323 A JP 2005537323A
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compound
optionally substituted
halogen
alkyl
hydrogen
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JP2005537323A5 (enExample
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クダツク,スコツト・デイ
ウツド,マイケル・アール
ボツク,マーク・ジー
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Merck and Co Inc
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Merck and Co Inc
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
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JP2004532994A 2002-08-29 2003-08-25 N−ビアリールメチルアミノシクロアルカンカルボキサミド誘導体 Pending JP2005537323A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40674202P 2002-08-29 2002-08-29
PCT/US2003/026628 WO2004019868A2 (en) 2002-08-29 2003-08-25 N-biarylmethyl aminocycloalkanecarboxamide derivatives

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JP2005537323A true JP2005537323A (ja) 2005-12-08
JP2005537323A5 JP2005537323A5 (enExample) 2006-06-22

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US (1) US7163951B2 (enExample)
EP (1) EP1545538A2 (enExample)
JP (1) JP2005537323A (enExample)
KR (1) KR20050033660A (enExample)
CN (1) CN1678320A (enExample)
AU (1) AU2003265674B2 (enExample)
BR (1) BR0313239A (enExample)
CA (1) CA2495914A1 (enExample)
IL (1) IL166426A0 (enExample)
MX (1) MXPA05002245A (enExample)
NO (1) NO20051539L (enExample)
PL (1) PL374529A1 (enExample)
RU (1) RU2005108667A (enExample)
WO (1) WO2004019868A2 (enExample)
ZA (1) ZA200500471B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
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JP2012518672A (ja) * 2009-02-26 2012-08-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ブラジキニンb1アンタゴニストとしての化合物
JP2012528859A (ja) * 2009-06-02 2012-11-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 6,7−ジヒドロ−5H−イミダゾ[1,2−a]イミダゾール−3−カルボン酸アミドの誘導体
JP2013534238A (ja) * 2010-08-20 2013-09-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ブラジキニンb1受容体のアンタゴニストとしての二置換テトラヒドロフラニル化合物
JP2013542951A (ja) * 2010-11-05 2013-11-28 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ インドール誘導体
JP2014511359A (ja) * 2011-01-24 2014-05-15 エフ.ホフマン−ラ ロシュ アーゲー 新しいアリール−ベンゾシクロアルキルアミド誘導体
JP2021059573A (ja) * 2011-06-06 2021-04-15 アケビア セラピューティクス インコーポレイテッドAkebia Therapeutics Inc. [(5−(ハロフェニル)−3−ヒドロキシピリジン−2−カルボニル)−アミノ]アルカン酸誘導体の調製における中間体としての5−((ハロフェニル)−3−ハロ−ピリジン−2−イル)−ニトリル誘導体

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332499B2 (en) * 2003-08-07 2008-02-19 Merck & Co., Inc. Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides
CN1976915A (zh) 2004-02-11 2007-06-06 史密丝克莱恩比彻姆公司 Hiv整合酶抑制剂
CA2557858A1 (en) * 2004-03-02 2005-09-15 Merck & Co., Inc. Amino cyclopropane carboxamide derivatives as bradykinin antagonists
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
US20060217362A1 (en) * 2004-12-29 2006-09-28 Tung Jay S Novel compounds useful for bradykinin B1 receptor antagonism
AU2006255642A1 (en) * 2005-06-03 2006-12-14 Merck Sharp & Dohme Corp. 1-Hydroxycycloalkanecarboxamide derivatives as bradykinin antagonists
AU2006325746A1 (en) * 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
CL2008002545A1 (es) 2007-08-29 2009-10-23 Boehringer Ingelheim Int Compuestos derivados de fenoxi-bencil-carbamoilo; composicion farmaceutica; procedimiento para preparar la composicion farmaceutica; y su uso en el tratamiento del dolor.
CA2722704A1 (en) * 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Cyclylamine derivatives as calcium channel blockers
TW201024279A (en) * 2008-09-18 2010-07-01 Jerini Ag Use of B1 receptor antagonists
WO2010097373A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin b1 antagonisten
KR101628132B1 (ko) * 2010-01-25 2016-06-08 주식회사 바이오씨에스 신규한 바이아릴아미드 유도체 및 이를 유효성분으로 함유하는 조성물
MA34008B1 (fr) 2010-02-23 2013-02-01 Boehringer Ingelheim Int Composes en tant qu'antagonistes de la bradykinine b1
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
HUE066123T2 (hu) 2013-06-13 2024-07-28 Akebia Therapeutics Inc Készítmények és módszerek anémia kezelésére
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
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US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
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WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023265A (en) * 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
IL99372A0 (en) 1990-09-10 1992-08-18 Ciba Geigy Ag Azacyclic compounds
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
DE60303441T2 (de) 2002-02-08 2006-09-21 Merck & Co., Inc. N-biphenylmethylaminocycloalkancarboxamid-derivative

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* Cited by examiner, † Cited by third party
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US7163951B2 (en) 2007-01-16
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US20050288305A1 (en) 2005-12-29
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AU2003265674B2 (en) 2008-12-11
CN1678320A (zh) 2005-10-05
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