ES2422197T3 - Derivados 1-hidroxicicloalcanocarboxamida como antagonistas de la bradiquinina - Google Patents

Derivados 1-hidroxicicloalcanocarboxamida como antagonistas de la bradiquinina

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Publication number
ES2422197T3
ES2422197T3 ES06771439T ES06771439T ES2422197T3 ES 2422197 T3 ES2422197 T3 ES 2422197T3 ES 06771439 T ES06771439 T ES 06771439T ES 06771439 T ES06771439 T ES 06771439T ES 2422197 T3 ES2422197 T3 ES 2422197T3
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Spain
Prior art keywords
oxadiazol
methyl
hydroxycycloalkanecarboxamide
derivatives
halomethyl
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ES06771439T
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English (en)
Inventor
Scott D Kuduk
Michael R Wood
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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Abstract

compuesto que tiene la fórmula (I): o una sal farmacéuticamente aceptable del mismo, en la que ----es un enlace sencillo o doble; R1, R2 y R3 está seleccionado cada uno independientemente de H, halógeno y OH y al menos uno de R1, R2 y R3 esun átomo de flúor; o R1 y R2 unidos al mismo átomo de carbono juntos representan oxo; R4 es H o metilo; R5 es Cl o F; R6 está seleccionado de -CO2-alquilo C1-4, -O-alquilo C1-4, -O-haloalquilo C1-4, 2-metiltetrazol-5-ilo, 5-metil-1,2,4-oxadiazol-3-ilo, 3-metil-1,2,4-oxadiazol-5-ilo, 5-halometil-1,2,4-oxadiazol-3-ilo, 3-halometil-1,2,4-oxadiazol-5-ilo,tetrazol-5-ilo, 5-halometil-1,2,3-triazolilo y 5-metil-1,2,3-triazolilo; R7y R8 son cada uno independientemente Cl o F; y n es 0 o 1.
ES06771439T 2005-06-03 2006-05-30 Derivados 1-hidroxicicloalcanocarboxamida como antagonistas de la bradiquinina Active ES2422197T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68746905P 2005-06-03 2005-06-03
PCT/US2006/020668 WO2006132837A1 (en) 2005-06-03 2006-05-30 l-HYDROXYCYCLOALKANECARBOXAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS

Publications (1)

Publication Number Publication Date
ES2422197T3 true ES2422197T3 (es) 2013-09-09

Family

ID=36997582

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06771439T Active ES2422197T3 (es) 2005-06-03 2006-05-30 Derivados 1-hidroxicicloalcanocarboxamida como antagonistas de la bradiquinina

Country Status (7)

Country Link
US (1) US7816380B2 (es)
EP (1) EP1893579B1 (es)
JP (1) JP2008542379A (es)
AU (1) AU2006255642A1 (es)
CA (1) CA2610059A1 (es)
ES (1) ES2422197T3 (es)
WO (1) WO2006132837A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010020556A1 (en) 2008-08-22 2010-02-25 Evotec Neurosciences Gmbh New bradykinin b1 antagonists
EP2396301A2 (en) 2009-02-13 2011-12-21 Jerini AG Small molecule bradykinin b1 receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005108667A (ru) * 2002-08-29 2005-08-27 Мерк энд Ко., Инк. (US) Производные n-биарилметиламиноциклоалканкарбоксамида
WO2005063690A1 (en) * 2003-12-22 2005-07-14 Merck & Co., Inc. Alpha-hydroxy amides as bradykinin antagonists or inverse agonists

Also Published As

Publication number Publication date
WO2006132837A1 (en) 2006-12-14
EP1893579B1 (en) 2013-05-01
US7816380B2 (en) 2010-10-19
JP2008542379A (ja) 2008-11-27
AU2006255642A1 (en) 2006-12-14
US20090062349A1 (en) 2009-03-05
EP1893579A1 (en) 2008-03-05
CA2610059A1 (en) 2006-12-14

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