JP2003506491A5 - - Google Patents
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- JP2003506491A5 JP2003506491A5 JP2001516532A JP2001516532A JP2003506491A5 JP 2003506491 A5 JP2003506491 A5 JP 2003506491A5 JP 2001516532 A JP2001516532 A JP 2001516532A JP 2001516532 A JP2001516532 A JP 2001516532A JP 2003506491 A5 JP2003506491 A5 JP 2003506491A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- alkenyl
- alkynyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 204
- 150000001875 compounds Chemical class 0.000 claims 103
- 125000003118 aryl group Chemical group 0.000 claims 84
- 125000000304 alkynyl group Chemical group 0.000 claims 77
- 125000001072 heteroaryl group Chemical group 0.000 claims 52
- 125000003342 alkenyl group Chemical group 0.000 claims 42
- 125000000623 heterocyclic group Chemical class 0.000 claims 33
- 125000001424 substituent group Chemical group 0.000 claims 31
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 30
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 229910052799 carbon Inorganic materials 0.000 claims 18
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 12
- 125000006323 alkenyl amino group Chemical group 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 125000006319 alkynyl amino group Chemical group 0.000 claims 12
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000004104 aryloxy group Chemical class 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 8
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 8
- 229960000310 isoleucine Drugs 0.000 claims 8
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 8
- 235000004279 alanine Nutrition 0.000 claims 7
- BXRLWGXPSRYJDZ-UHFFFAOYSA-N 3-cyanoalanine Chemical compound OC(=O)C(N)CC#N BXRLWGXPSRYJDZ-UHFFFAOYSA-N 0.000 claims 6
- 239000004215 Carbon black (E152) Substances 0.000 claims 6
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- AGPKZVBTJJNPAG-UHNVWZDZSA-N L-allo-Isoleucine Chemical compound CC[C@@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-UHNVWZDZSA-N 0.000 claims 6
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 6
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 6
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 6
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 6
- IDIDJDIHTAOVLG-VKHMYHEASA-N S-methylcysteine Chemical compound CSC[C@H](N)C(O)=O IDIDJDIHTAOVLG-VKHMYHEASA-N 0.000 claims 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 125000001374 aryl-fused-cycloalkyl group Chemical group 0.000 claims 6
- 125000005841 biaryl group Chemical group 0.000 claims 6
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 6
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 6
- 229930195733 hydrocarbon Natural products 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 claims 6
- 239000004474 valine Substances 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 125000001769 aryl amino group Chemical class 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- IDIDJDIHTAOVLG-UHFFFAOYSA-N S-methyl-L-cysteine Natural products CSCC(N)C(O)=O IDIDJDIHTAOVLG-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 3
- -1 cyclohexyl alanine Chemical compound 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 229960003104 ornithine Drugs 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 150000003457 sulfones Chemical class 0.000 claims 3
- 150000003462 sulfoxides Chemical class 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- 241001024304 Mino Species 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14884599P | 1999-08-13 | 1999-08-13 | |
| US60/148,845 | 1999-08-13 | ||
| PCT/US2000/022285 WO2001012186A1 (en) | 1999-08-13 | 2000-08-14 | Cell adhesion inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506491A JP2003506491A (ja) | 2003-02-18 |
| JP2003506491A5 true JP2003506491A5 (enExample) | 2005-10-27 |
Family
ID=22527673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001516532A Pending JP2003506491A (ja) | 1999-08-13 | 2000-08-14 | 細胞接着インヒビター |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6630503B1 (enExample) |
| EP (2) | EP1265606B9 (enExample) |
| JP (1) | JP2003506491A (enExample) |
| KR (1) | KR100720907B1 (enExample) |
| CN (1) | CN1377268A (enExample) |
| AT (1) | ATE343383T1 (enExample) |
| AU (1) | AU780610B2 (enExample) |
| BG (1) | BG65755B1 (enExample) |
| BR (1) | BR0013248A (enExample) |
| CA (1) | CA2380817A1 (enExample) |
| CY (1) | CY1105912T1 (enExample) |
| CZ (1) | CZ2002518A3 (enExample) |
| DE (1) | DE60031577T2 (enExample) |
| DK (1) | DK1265606T3 (enExample) |
| EA (1) | EA005578B1 (enExample) |
| EE (1) | EE200200070A (enExample) |
| ES (1) | ES2270868T3 (enExample) |
| GE (2) | GEP20063956B (enExample) |
| HU (1) | HUP0202469A3 (enExample) |
| IL (2) | IL148014A0 (enExample) |
| IS (1) | IS6257A (enExample) |
| MX (1) | MXPA02001449A (enExample) |
| NO (1) | NO324044B1 (enExample) |
| NZ (1) | NZ517011A (enExample) |
| PL (1) | PL354063A1 (enExample) |
| PT (1) | PT1265606E (enExample) |
| RS (1) | RS50470B (enExample) |
| SK (1) | SK287075B6 (enExample) |
| UA (1) | UA75581C2 (enExample) |
| WO (1) | WO2001012186A1 (enExample) |
| ZA (1) | ZA200201158B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618630B2 (en) | 1998-09-14 | 2009-11-17 | Board Of Regents, The University Of Texas System | Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists |
| EE200200070A (et) * | 1999-08-13 | 2003-04-15 | Biogen, Inc. | Raku adhesiooni inhibiitorid |
| DE10006453A1 (de) * | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| JP2002201168A (ja) * | 2000-12-28 | 2002-07-16 | Kaken Pharmaceut Co Ltd | シクロヘキサン誘導体 |
| US7157487B2 (en) | 2000-12-28 | 2007-01-02 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| JP2004526733A (ja) * | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | 強力な細胞接着阻害剤としての置換ｎ−アリールスルホニル−プロリン誘導体 |
| US6663489B2 (en) | 2001-08-24 | 2003-12-16 | Igt | Gaming device having an award distributor and an award accumulator bonus game |
| ES2197003B1 (es) * | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
| KR101051842B1 (ko) | 2003-07-24 | 2011-07-25 | 다이이찌 세이야꾸 가부시기가이샤 | 시클로헥산카르복실산류 |
| EP1706399A1 (en) * | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
| MX2007000228A (es) * | 2004-07-08 | 2007-03-30 | Elan Pharm Inc | Antagonistas de vla-4 multivalentes que comprenden porsiones de polietilenglicol. |
| US7196112B2 (en) * | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| US7915316B2 (en) * | 2005-08-22 | 2011-03-29 | Allergan, Inc | Sulfonamides |
| EP1939175B1 (en) | 2005-09-27 | 2017-03-01 | Shionogi&Co., Ltd. | Sulfonamide derivative having pgd2 receptor antagonistic activity |
| NZ595196A (en) * | 2005-11-09 | 2013-03-28 | Proteolix Inc | Peptide-based compounds for enzyme inhibition |
| AR063470A1 (es) * | 2006-08-02 | 2009-01-28 | Genzyme Corp | Terapia combinada |
| TW200817319A (en) | 2006-08-10 | 2008-04-16 | Astellas Pharma Inc | Sulfonamide compound or salt thereof |
| EP2124996A4 (en) | 2007-02-20 | 2010-03-24 | Merrimack Pharmaceuticals Inc | METHOD FOR TREATING MULTIPLE SCLEROSIS BY ADMINISTERING AN ALPHA FETOPROTEIN COMBINED WITH AN INTEGRINANT AGONIST |
| PL2288715T3 (pl) | 2008-04-11 | 2015-03-31 | Merrimack Pharmaceuticals Inc | Łączniki będące albuminą surowicy ludzkiej i ich koniugaty |
| KR20110112301A (ko) | 2008-11-18 | 2011-10-12 | 메리맥 파마슈티컬즈, 인크. | 인간 혈청 알부민 링커 및 그 콘쥬게이트 |
| US9345766B2 (en) | 2012-08-30 | 2016-05-24 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-ERBB3 agents |
| JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
| EP3209641A4 (en) | 2014-05-05 | 2018-06-06 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| EP3307738B1 (en) | 2015-06-11 | 2022-04-20 | The Regents of the University of Michigan | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| EP3436046A4 (en) * | 2016-04-01 | 2020-03-11 | The Regents of The University of California | INTEGRIN ALPHA 5 BETA 1 INHIBITORS AND METHODS OF USE |
| CN109721605B (zh) * | 2017-10-31 | 2022-03-11 | 维眸生物科技（上海）有限公司 | 一种免疫细胞迁徙抑制剂 |
| US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
| ES3003232T3 (en) | 2018-10-30 | 2025-03-10 | Gilead Sciences Inc | Compounds for inhibition of alpha4beta7 integrin |
| ES2987796T3 (es) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CN112969687B (zh) | 2018-10-30 | 2024-08-23 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
| AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (71)
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-
2000
- 2000-08-14 EE EEP200200070A patent/EE200200070A/xx unknown
- 2000-08-14 JP JP2001516532A patent/JP2003506491A/ja active Pending
- 2000-08-14 MX MXPA02001449A patent/MXPA02001449A/es active IP Right Grant
- 2000-08-14 DK DK00959232T patent/DK1265606T3/da active
- 2000-08-14 EP EP00959232A patent/EP1265606B9/en not_active Expired - Lifetime
- 2000-08-14 RS YUP-98/02A patent/RS50470B/sr unknown
- 2000-08-14 NZ NZ517011A patent/NZ517011A/en unknown
- 2000-08-14 IL IL14801400A patent/IL148014A0/xx unknown
- 2000-08-14 CA CA002380817A patent/CA2380817A1/en not_active Abandoned
- 2000-08-14 AT AT00959232T patent/ATE343383T1/de not_active IP Right Cessation
- 2000-08-14 PL PL00354063A patent/PL354063A1/xx not_active Application Discontinuation
- 2000-08-14 HU HU0202469A patent/HUP0202469A3/hu unknown
- 2000-08-14 EA EA200200253A patent/EA005578B1/ru not_active IP Right Cessation
- 2000-08-14 ES ES00959232T patent/ES2270868T3/es not_active Expired - Lifetime
- 2000-08-14 EP EP06021333A patent/EP1741428A3/en not_active Withdrawn
- 2000-08-14 UA UA2002032010A patent/UA75581C2/uk unknown
- 2000-08-14 DE DE60031577T patent/DE60031577T2/de not_active Expired - Lifetime
- 2000-08-14 WO PCT/US2000/022285 patent/WO2001012186A1/en not_active Ceased
- 2000-08-14 GE GE5468A patent/GEP20063956B/en unknown
- 2000-08-14 AU AU70586/00A patent/AU780610B2/en not_active Ceased
- 2000-08-14 PT PT00959232T patent/PT1265606E/pt unknown
- 2000-08-14 CN CN00813728A patent/CN1377268A/zh active Pending
- 2000-08-14 SK SK215-2002A patent/SK287075B6/sk not_active IP Right Cessation
- 2000-08-14 US US09/638,652 patent/US6630503B1/en not_active Expired - Fee Related
- 2000-08-14 GE GE4744A patent/GEP20053477B/en unknown
- 2000-08-14 KR KR1020027001850A patent/KR100720907B1/ko not_active Expired - Fee Related
- 2000-08-14 CZ CZ2002518A patent/CZ2002518A3/cs unknown
- 2000-08-14 BR BR0013248-9A patent/BR0013248A/pt not_active Application Discontinuation
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2002
- 2002-01-31 IS IS6257A patent/IS6257A/is unknown
- 2002-02-05 IL IL148014A patent/IL148014A/en not_active IP Right Cessation
- 2002-02-11 ZA ZA200201158A patent/ZA200201158B/en unknown
- 2002-02-13 NO NO20020725A patent/NO324044B1/no not_active IP Right Cessation
- 2002-03-11 BG BG106510A patent/BG65755B1/bg unknown
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2003
- 2003-10-03 US US10/677,756 patent/US7034043B2/en not_active Expired - Fee Related
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- 2006-02-27 US US11/362,043 patent/US20060166961A1/en not_active Abandoned
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- 2007-01-09 CY CY20071100027T patent/CY1105912T1/el unknown
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