JP2004529874A5 - - Google Patents
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- Publication number
- JP2004529874A5 JP2004529874A5 JP2002563877A JP2002563877A JP2004529874A5 JP 2004529874 A5 JP2004529874 A5 JP 2004529874A5 JP 2002563877 A JP2002563877 A JP 2002563877A JP 2002563877 A JP2002563877 A JP 2002563877A JP 2004529874 A5 JP2004529874 A5 JP 2004529874A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- hydrogen bond
- hydrophobic group
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 239000001257 hydrogen Substances 0.000 claims 37
- 239000000370 acceptor Substances 0.000 claims 33
- 125000001165 hydrophobic group Chemical group 0.000 claims 33
- 125000004429 atom Chemical group 0.000 claims 23
- 102100027995 Collagenase 3 Human genes 0.000 claims 16
- 108050005238 Collagenase 3 Proteins 0.000 claims 16
- 125000006413 ring segment Chemical group 0.000 claims 16
- 239000003446 ligand Substances 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000005647 linker group Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 230000007850 degeneration Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 208000028169 periodontal disease Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 230000008856 allosteric binding Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26882101P | 2001-02-14 | 2001-02-14 | |
| PCT/IB2002/000447 WO2002064080A2 (en) | 2001-02-14 | 2002-02-13 | Matrix metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004529874A JP2004529874A (ja) | 2004-09-30 |
| JP2004529874A5 true JP2004529874A5 (enExample) | 2005-07-21 |
Family
ID=23024626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563877A Abandoned JP2004529874A (ja) | 2001-02-14 | 2002-02-13 | マトリックスメタロプロテイナーゼ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20030078276A1 (enExample) |
| EP (1) | EP1361873A4 (enExample) |
| JP (1) | JP2004529874A (enExample) |
| AR (1) | AR033859A1 (enExample) |
| AU (1) | AU2002228302A1 (enExample) |
| BR (1) | BR0207864A (enExample) |
| CA (1) | CA2437643A1 (enExample) |
| HN (1) | HN2002000037A (enExample) |
| MX (1) | MXPA03007250A (enExample) |
| PA (1) | PA8539301A1 (enExample) |
| PE (1) | PE20020873A1 (enExample) |
| PY (1) | PY0202788A (enExample) |
| SV (1) | SV2002000874A (enExample) |
| UY (1) | UY27174A1 (enExample) |
| WO (1) | WO2002064080A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| DOP2002000334A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
| MXPA03005870A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
| JP2004518723A (ja) * | 2001-02-14 | 2004-06-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ピリミジンマトリックスメタロプロテイナーゼ阻害剤 |
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| MXPA04002537A (es) | 2001-10-12 | 2004-05-31 | Warner Lambert Co | Alquinos como inhibidores de metaloproteinasa de matriz. |
| WO2004007469A1 (en) * | 2002-07-12 | 2004-01-22 | Warner-Lambert Company Llc | New alkynylated quinazolin compounds as mmp-13 inhibitors |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| SV2003001289A (es) * | 2001-10-12 | 2003-06-24 | Warner Lambert Co | Compuestos pirimidina de anillo fusionado alquinilado |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| AU2002249275A1 (en) * | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
| BR0312708A (pt) * | 2002-07-17 | 2005-04-26 | Warner Lambert Co | Combinação de um inibidor alcina alostérico de metaloproteinase-13 de matriz com celecoxib ou valdecoxib |
| MXPA05000754A (es) * | 2002-07-17 | 2005-04-19 | Warner Lambert Co | Combinacion de un inhibidor carboxilico alosterico de la metaloproteinasa de matriz-13 con celecoxib o valdecoxib. |
| EP1531904A1 (en) * | 2002-07-17 | 2005-05-25 | Warner-Lambert Company LLC | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
| BR0312727A (pt) * | 2002-07-17 | 2005-04-19 | Warner Lambert Co | Combinação de um inibidor alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib |
| WO2004007025A1 (en) * | 2002-07-17 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
| WO2004014869A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors |
| AU2003249477A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
| WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
| AU2003249535A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors |
| MXPA05001786A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz. |
| MXPA05001784A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de isoquinolina como inhibidores de metaloproteinasa de matriz. |
| AU2003250470A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
| MXPA05001603A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados monociclicos como inhibidores de metaloproteinasa de matriz. |
| CA2497658A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
| WO2004014378A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
| WO2004014384A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors |
| AU2003253186A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
| WO2004014365A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
| MXPA05001783A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz. |
| US7166609B2 (en) | 2002-11-02 | 2007-01-23 | Sanofi-Aventis Deutschland Gmbh | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases |
| US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
| WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
| AU2004263900A1 (en) * | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
| WO2005019188A1 (ja) * | 2003-08-22 | 2005-03-03 | Takeda Pharmaceutical Company Limited | 縮合ピリミジン誘導体およびその用途 |
| PT1684719E (pt) * | 2003-11-14 | 2012-02-03 | Baxter Int | Composições de alfa-1-antitripsina e métodos de tratamento utilizando estas composições |
| US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
| US7914771B2 (en) | 2004-03-09 | 2011-03-29 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| US20070105768A1 (en) * | 2004-11-10 | 2007-05-10 | Rajiv Nayar | Dry recombinant human alpha 1-antitrypsin formulation |
| EP1820795A4 (en) | 2004-12-07 | 2010-10-20 | Toyama Chemical Co Ltd | NEW ANTHRANILIC ACID DERIVATIVE OR SALT FROM IT |
| EP1860098B1 (en) * | 2005-03-16 | 2012-11-14 | Toyama Chemical Co., Ltd. | Novel anthranilic acid derivative or salt thereof |
| CN101198614B (zh) | 2005-06-14 | 2011-07-06 | Aska制药株式会社 | 噻吩并嘧啶衍生物 |
| JP5324785B2 (ja) * | 2005-10-28 | 2013-10-23 | 武田薬品工業株式会社 | 複素環アミド化合物及びその用途 |
| WO2008138126A1 (en) * | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
| EP2240178A4 (en) * | 2007-12-19 | 2011-10-26 | Glaxosmithkline Llc | PROLYLHYDROXYLASEHEMMER |
| CN102105464A (zh) | 2008-05-27 | 2011-06-22 | 德克萨斯大学系统董事会 | Wnt蛋白信号转导抑制剂 |
| JP5657201B2 (ja) * | 2008-09-30 | 2015-01-21 | サンメディカル株式会社 | 酵素阻害作用または酵素阻害作用と抗菌作用とを有する歯科用組成物 |
| CN102627657B (zh) * | 2012-03-09 | 2015-01-07 | 苏州施亚生物科技有限公司 | 3-(4-甲氧基-苄基)-1h-嘧啶-2,4-二酮衍生物的合成方法 |
| CN103012189A (zh) * | 2012-12-20 | 2013-04-03 | 天津理工大学 | 具有抗血小板聚集作用的酰胺类化合物及其制备和应用 |
| EA201600318A1 (ru) * | 2013-10-07 | 2016-09-30 | Байер Фарма Акциенгезельшафт | Циклические тиеноурацилкарбоксамиды и их применение |
| EP3299371B1 (en) * | 2015-05-20 | 2021-08-25 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
| CN107614501B (zh) | 2015-05-20 | 2020-01-14 | 广东众生睿创生物科技有限公司 | 羟基嘌呤类化合物及其应用 |
| CN109593066B (zh) * | 2018-12-21 | 2020-06-19 | 上海交通大学 | 一种用于治疗肠道细菌感染的叶酸拮抗剂及其制备与应用 |
| US11919895B2 (en) * | 2019-10-25 | 2024-03-05 | Saint Louis University | GPR183 antagonists for the treatment of pain |
| CN115197225B (zh) * | 2021-09-03 | 2023-04-11 | 贵州大学 | 一种五元杂环并喹唑啉酮类化合物及其制备方法 |
| CN113773277B (zh) * | 2021-09-18 | 2023-12-05 | 兰州大学 | 一种4h-1,2,4-苯并噻二嗪-1,1-二氧化物衍生物的合成方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US193377A (en) * | 1877-07-24 | Improvement in bee-hives | ||
| US129672A (en) * | 1872-07-23 | Improvement in heating-stoves | ||
| US156069A (en) * | 1874-10-20 | Improvement in lithographic printing-presses | ||
| US144274A (en) * | 1873-11-04 | Improvement in self-closing telegraph-keys | ||
| US130278A (en) * | 1872-08-06 | Improvement in pipe-tongs | ||
| US161000A (en) * | 1875-03-23 | Improvement in millstone-bushes | ||
| US151558A (en) * | 1874-06-02 | Improvement in the modes of machine-sewing | ||
| US156061A (en) * | 1874-10-20 | Improvement in boot and shoe nails | ||
| US151555A (en) * | 1874-06-02 | Improvement in street-railway switches | ||
| US4172A (en) * | 1845-09-02 | Coal-breaker | ||
| US3655679A (en) * | 1969-06-25 | 1972-04-11 | Merck & Co Inc | Certain aryl pyridine carboxylic acid derivatives |
| US5521181A (en) * | 1995-01-27 | 1996-05-28 | Abbott Laboratories | Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists |
| US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| MXPA99001974A (es) * | 1996-12-09 | 2002-03-27 | Warner Lambert Co | Metodo para tratar y prevenir fallas cardiacas y dilatacion ventricular. |
| MXPA03005870A (es) * | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibirores de benzotiadiazina de metaloproteinasas de la matriz. |
-
2002
- 2002-02-08 PA PA20028539301A patent/PA8539301A1/es unknown
- 2002-02-13 CA CA002437643A patent/CA2437643A1/en not_active Abandoned
- 2002-02-13 PE PE2002000116A patent/PE20020873A1/es not_active Application Discontinuation
- 2002-02-13 MX MXPA03007250A patent/MXPA03007250A/es unknown
- 2002-02-13 WO PCT/IB2002/000447 patent/WO2002064080A2/en not_active Ceased
- 2002-02-13 AU AU2002228302A patent/AU2002228302A1/en not_active Abandoned
- 2002-02-13 SV SV2002000874A patent/SV2002000874A/es not_active Application Discontinuation
- 2002-02-13 UY UY27174A patent/UY27174A1/es not_active Application Discontinuation
- 2002-02-13 EP EP02710275A patent/EP1361873A4/en not_active Withdrawn
- 2002-02-13 US US10/075,069 patent/US20030078276A1/en not_active Abandoned
- 2002-02-13 PY PY200200202788A patent/PY0202788A/es unknown
- 2002-02-13 JP JP2002563877A patent/JP2004529874A/ja not_active Abandoned
- 2002-02-13 BR BR0207864-3A patent/BR0207864A/pt not_active IP Right Cessation
- 2002-02-13 HN HN2002000037A patent/HN2002000037A/es unknown
- 2002-02-13 AR ARP020100472A patent/AR033859A1/es not_active Application Discontinuation
-
2004
- 2004-04-29 US US10/835,619 patent/US20050004126A1/en not_active Abandoned
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