SV2002000874A - Inhibidores de la metaloproteinasa de la matriz - Google Patents

Inhibidores de la metaloproteinasa de la matriz

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Publication number
SV2002000874A
SV2002000874A SV2002000874A SV2002000874A SV2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A
Authority
SV
El Salvador
Prior art keywords
mmp
hydrophobic group
hydrogen link
metaloproteinase
matrix
Prior art date
Application number
SV2002000874A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of SV2002000874A publication Critical patent/SV2002000874A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D285/32—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 3
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  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PROVEEN COMPUESTOS QUE SE UNEN ALOSTERICAENTE CON EL DOMINIO CATALITICO DE LA MMP-13 Y QUE COMPRENDEN: UN GRUPO HIDROFOBICO; UN PRIMER Y UN SEGUNDO ACEPTORES DE ENLACE DE HIDROGENO; Y POR LO MENOS UNO Y, CON PREFERENCIA LOS DOS -ES DECIR, UN TERCER ACEPTOR DE ENLACE DE HIDROGENO Y UN SEGUDO GRUPO HIDROFOBICO. LAS COORDINADAS CARTESIANAS PARA LOS CENTROIDES CON LAS CARACTERISTICAS ANTERIORES SE DEFINEN EN LA MEMORIA DESCRIPTIVA. CUANDO EL LIGANDO SE UNE A LA MMP-13, EL PRIMER , EL SEGUDO Y EL TERCER (SI ESTA PRESENTE) ACEPTORES DE ENLACE DE HIDROGENO SE UNEN RESPECTIVAMENTE CON THR245, THR247 Y MET 253, EL PRIMER GRUPO HIDROFOBICO SE SITUA DENTRO DEL CANAL S1' DE LA MMP-13 Y EL SEGUNDO GRUPO HIROFOBICO (SI ESTA PRESENTE) ESTA RELATIVAMENTE ABIERTO AL SOLVENTE. LOS COMPUESTOS, ESPECIFICAMENTE INHIBEN LA ENZIMA DE LA METALOPROTEINASA DE LA MATRIZ-13 Y, POR LO TANTO, RESULTAN DE UTILIDAD EN EL TRATAMIENTO E ENFERMEDADES QUE RESULTAN DE LA ROTURA DE LOS TEJIDOS, TALES COMO POR EJEMPLO, LA ENFEMEDAD CARDIACA, LA ESCLEROSIS MULTIPLE, ARTRITIS, ARTEROSCLEROSIS Y OSTEOPOROSIS.
SV2002000874A 2001-02-14 2002-02-13 Inhibidores de la metaloproteinasa de la matriz SV2002000874A (es)

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MXPA03007250A (es) 2005-07-25
WO2002064080A3 (en) 2002-12-12
HN2002000037A (es) 2002-07-09
AU2002228302A1 (en) 2002-08-28
AR033859A1 (es) 2004-01-07
JP2004529874A (ja) 2004-09-30
PA8539301A1 (es) 2002-09-30
UY27174A1 (es) 2002-09-30
WO2002064080A2 (en) 2002-08-22
BR0207864A (pt) 2004-03-09
EP1361873A4 (en) 2005-10-26
PE20020873A1 (es) 2002-10-26
US20030078276A1 (en) 2003-04-24
CA2437643A1 (en) 2002-08-22
EP1361873A2 (en) 2003-11-19

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