SV2002000874A - Inhibidores de la metaloproteinasa de la matriz - Google Patents
Inhibidores de la metaloproteinasa de la matrizInfo
- Publication number
- SV2002000874A SV2002000874A SV2002000874A SV2002000874A SV2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A SV 2002000874 A SV2002000874 A SV 2002000874A
- Authority
- SV
- El Salvador
- Prior art keywords
- mmp
- hydrophobic group
- hydrogen link
- metaloproteinase
- matrix
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
- C07D285/32—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 3
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
SE PROVEEN COMPUESTOS QUE SE UNEN ALOSTERICAENTE CON EL DOMINIO CATALITICO DE LA MMP-13 Y QUE COMPRENDEN: UN GRUPO HIDROFOBICO; UN PRIMER Y UN SEGUNDO ACEPTORES DE ENLACE DE HIDROGENO; Y POR LO MENOS UNO Y, CON PREFERENCIA LOS DOS -ES DECIR, UN TERCER ACEPTOR DE ENLACE DE HIDROGENO Y UN SEGUDO GRUPO HIDROFOBICO. LAS COORDINADAS CARTESIANAS PARA LOS CENTROIDES CON LAS CARACTERISTICAS ANTERIORES SE DEFINEN EN LA MEMORIA DESCRIPTIVA. CUANDO EL LIGANDO SE UNE A LA MMP-13, EL PRIMER , EL SEGUDO Y EL TERCER (SI ESTA PRESENTE) ACEPTORES DE ENLACE DE HIDROGENO SE UNEN RESPECTIVAMENTE CON THR245, THR247 Y MET 253, EL PRIMER GRUPO HIDROFOBICO SE SITUA DENTRO DEL CANAL S1' DE LA MMP-13 Y EL SEGUNDO GRUPO HIROFOBICO (SI ESTA PRESENTE) ESTA RELATIVAMENTE ABIERTO AL SOLVENTE. LOS COMPUESTOS, ESPECIFICAMENTE INHIBEN LA ENZIMA DE LA METALOPROTEINASA DE LA MATRIZ-13 Y, POR LO TANTO, RESULTAN DE UTILIDAD EN EL TRATAMIENTO E ENFERMEDADES QUE RESULTAN DE LA ROTURA DE LOS TEJIDOS, TALES COMO POR EJEMPLO, LA ENFEMEDAD CARDIACA, LA ESCLEROSIS MULTIPLE, ARTRITIS, ARTEROSCLEROSIS Y OSTEOPOROSIS.
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US26882101P | 2001-02-14 | 2001-02-14 |
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EP (1) | EP1361873A4 (es) |
JP (1) | JP2004529874A (es) |
AR (1) | AR033859A1 (es) |
AU (1) | AU2002228302A1 (es) |
BR (1) | BR0207864A (es) |
CA (1) | CA2437643A1 (es) |
HN (1) | HN2002000037A (es) |
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PE (1) | PE20020873A1 (es) |
SV (1) | SV2002000874A (es) |
UY (1) | UY27174A1 (es) |
WO (1) | WO2002064080A2 (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
ES2231708T3 (es) | 2001-02-14 | 2005-05-16 | Warner-Lambert Company Llc | Benzotiadicinas inhibidoras de metaloproteinasa de matriz. |
DOP2002000334A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
CA2433772C (en) * | 2001-02-14 | 2008-10-07 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
MXPA04002537A (es) | 2001-10-12 | 2004-05-31 | Warner Lambert Co | Alquinos como inhibidores de metaloproteinasa de matriz. |
JP2005509626A (ja) * | 2001-10-12 | 2005-04-14 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテアーゼ−13阻害剤としてのアルキニル化縮合環ピリミジン化合物 |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2003076416A1 (en) * | 2002-03-08 | 2003-09-18 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
AU2002331362A1 (en) * | 2002-07-12 | 2004-02-02 | Warner-Lambert Company Llc | New alkynylated quinazolin compounds as mmp-13 inhibitors |
MXPA05000729A (es) * | 2002-07-17 | 2005-04-08 | Warner Lambert Co | Combinacion de un inhibidor alosterico de metaloproteinasa-13 de matriz con celecoxib o valdecoxib. |
WO2004007025A1 (en) * | 2002-07-17 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
AU2003281167A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
MXPA05000754A (es) * | 2002-07-17 | 2005-04-19 | Warner Lambert Co | Combinacion de un inhibidor carboxilico alosterico de la metaloproteinasa de matriz-13 con celecoxib o valdecoxib. |
CA2489722A1 (en) * | 2002-07-17 | 2004-01-22 | William Howard Roark | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
AU2003249535A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors |
PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
WO2004014365A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Phthalimide derivatives as matrix metalloproteinase inhibitors |
WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
MXPA05001784A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de isoquinolina como inhibidores de metaloproteinasa de matriz. |
WO2004014378A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
WO2004014869A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 5,6-fused 3,4-dihydropyrimidine-2-one derivatives as matrix metalloproteinase inhibitors |
BR0313724A (pt) | 2002-08-13 | 2005-06-28 | Warner Lambert Co | Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz |
WO2004014384A2 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors |
AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
WO2004014923A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
WO2004014908A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
AU2003253176A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Monocyclic derivatives as matrix metalloproteinase inhibitors |
WO2004014909A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
MXPA05001785A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de cromona como inhibidores de las metaloproteinasas de matriz. |
AU2003250471A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors |
US7166609B2 (en) | 2002-11-02 | 2007-01-23 | Sanofi-Aventis Deutschland Gmbh | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases |
US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
CA2572324A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
US7419801B2 (en) | 2003-08-08 | 2008-09-02 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
CA2536313A1 (en) * | 2003-08-22 | 2005-03-03 | Takeda Pharmaceutical Company Limited | Fused pyrimidine derivative and use thereof |
AU2004290587B2 (en) * | 2003-11-14 | 2010-08-12 | Arriva Pharmaceuticals, Inc. | Alpha 1-antitrypsin compositions and treatment methods using such compositions |
US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
WO2005086915A2 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
US20070105768A1 (en) * | 2004-11-10 | 2007-05-10 | Rajiv Nayar | Dry recombinant human alpha 1-antitrypsin formulation |
US7999132B2 (en) * | 2004-12-07 | 2011-08-16 | Toyama Chemical Co., Ltd. | Anthranilic acid derivative or salt thereof |
ES2395952T3 (es) | 2005-03-16 | 2013-02-18 | Toyama Chemical Co., Ltd. | Nuevo derivado del ácido antranílico o una sal del mismo |
CN101198614B (zh) | 2005-06-14 | 2011-07-06 | Aska制药株式会社 | 噻吩并嘧啶衍生物 |
EP1953148B1 (en) * | 2005-10-28 | 2012-02-29 | Takeda Pharmaceutical Company Limited | Heterocyclic amide compound and use thereof |
CA2685753A1 (en) * | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
US20100298324A1 (en) * | 2007-12-19 | 2010-11-25 | Smith Kline Beecham Corporation | Prolyl Hydroxylase Inhibitors |
CN102105464A (zh) | 2008-05-27 | 2011-06-22 | 德克萨斯大学系统董事会 | Wnt蛋白信号转导抑制剂 |
JP5657201B2 (ja) * | 2008-09-30 | 2015-01-21 | サンメディカル株式会社 | 酵素阻害作用または酵素阻害作用と抗菌作用とを有する歯科用組成物 |
CN102627657B (zh) * | 2012-03-09 | 2015-01-07 | 苏州施亚生物科技有限公司 | 3-(4-甲氧基-苄基)-1h-嘧啶-2,4-二酮衍生物的合成方法 |
CN103012189A (zh) * | 2012-12-20 | 2013-04-03 | 天津理工大学 | 具有抗血小板聚集作用的酰胺类化合物及其制备和应用 |
CN105793267B (zh) * | 2013-10-07 | 2018-02-06 | 拜耳制药股份公司 | 环状噻吩并尿嘧啶甲酰胺类及其用途 |
US10618898B2 (en) | 2015-05-20 | 2020-04-14 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
EP3299371B1 (en) * | 2015-05-20 | 2021-08-25 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
CN109593066B (zh) * | 2018-12-21 | 2020-06-19 | 上海交通大学 | 一种用于治疗肠道细菌感染的叶酸拮抗剂及其制备与应用 |
US11919895B2 (en) * | 2019-10-25 | 2024-03-05 | Saint Louis University | GPR183 antagonists for the treatment of pain |
CN115197225B (zh) * | 2021-09-03 | 2023-04-11 | 贵州大学 | 一种五元杂环并喹唑啉酮类化合物及其制备方法 |
CN113773277B (zh) * | 2021-09-18 | 2023-12-05 | 兰州大学 | 一种4h-1,2,4-苯并噻二嗪-1,1-二氧化物衍生物的合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US144274A (en) * | 1873-11-04 | Improvement in self-closing telegraph-keys | ||
US161000A (en) * | 1875-03-23 | Improvement in millstone-bushes | ||
US130278A (en) * | 1872-08-06 | Improvement in pipe-tongs | ||
US156061A (en) * | 1874-10-20 | Improvement in boot and shoe nails | ||
US129672A (en) * | 1872-07-23 | Improvement in heating-stoves | ||
US156069A (en) * | 1874-10-20 | Improvement in lithographic printing-presses | ||
US193377A (en) * | 1877-07-24 | Improvement in bee-hives | ||
US151555A (en) * | 1874-06-02 | Improvement in street-railway switches | ||
US151558A (en) * | 1874-06-02 | Improvement in the modes of machine-sewing | ||
US4172A (en) * | 1845-09-02 | Coal-breaker | ||
US3655679A (en) * | 1969-06-25 | 1972-04-11 | Merck & Co Inc | Certain aryl pyridine carboxylic acid derivatives |
US5521181A (en) * | 1995-01-27 | 1996-05-28 | Abbott Laboratories | Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists |
US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
IL128545A0 (en) * | 1996-12-09 | 2000-01-31 | Warner Lambert Co | Method for treating and preventing heart failure and ventricular dilatation |
ES2231708T3 (es) * | 2001-02-14 | 2005-05-16 | Warner-Lambert Company Llc | Benzotiadicinas inhibidoras de metaloproteinasa de matriz. |
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- 2002-02-13 SV SV2002000874A patent/SV2002000874A/es not_active Application Discontinuation
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WO2002064080A3 (en) | 2002-12-12 |
UY27174A1 (es) | 2002-09-30 |
AU2002228302A1 (en) | 2002-08-28 |
PE20020873A1 (es) | 2002-10-26 |
EP1361873A4 (en) | 2005-10-26 |
BR0207864A (pt) | 2004-03-09 |
WO2002064080A2 (en) | 2002-08-22 |
HN2002000037A (es) | 2002-07-09 |
CA2437643A1 (en) | 2002-08-22 |
PA8539301A1 (es) | 2002-09-30 |
US20050004126A1 (en) | 2005-01-06 |
AR033859A1 (es) | 2004-01-07 |
JP2004529874A (ja) | 2004-09-30 |
EP1361873A2 (en) | 2003-11-19 |
MXPA03007250A (es) | 2005-07-25 |
US20030078276A1 (en) | 2003-04-24 |
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