|
DE60234094D1
(de)
|
2001-05-11 |
2009-12-03 |
Ludwig Inst For Cancer Res Ltd |
Spezifische bindungsproteine und ihre verwendung
|
|
US20110313230A1
(en)
|
2001-05-11 |
2011-12-22 |
Terrance Grant Johns |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US7129261B2
(en)
*
|
2001-05-31 |
2006-10-31 |
Medarex, Inc. |
Cytotoxic agents
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
JP4703566B2
(ja)
*
|
2003-05-14 |
2011-06-15 |
イムノゲン インコーポレーティッド |
薬剤複合体組成物
|
|
WO2006002474A1
(en)
*
|
2004-07-02 |
2006-01-12 |
The Walter And Eliza Hall Institute Of Medical Research |
Alpha-helical mimetics
|
|
KR20070053214A
(ko)
*
|
2004-08-26 |
2007-05-23 |
니콜라스 피라말 인디아 리미티드 |
신규 생분해성 링커를 함유하는 프로드럭
|
|
AU2004224925C1
(en)
*
|
2004-08-30 |
2011-07-21 |
Biotest Ag |
Immunoconjugates targeting syndecan-1 expressing cells and use thereof
|
|
ES2503719T3
(es)
*
|
2005-02-11 |
2014-10-07 |
Immunogen, Inc. |
Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
|
|
US20110166319A1
(en)
*
|
2005-02-11 |
2011-07-07 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
|
US7714016B2
(en)
*
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
JP2009503105A
(ja)
*
|
2005-08-03 |
2009-01-29 |
イミュノジェン・インコーポレーテッド |
免疫複合体製剤
|
|
AU2006283726C1
(en)
|
2005-08-24 |
2015-05-07 |
Immunogen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
|
EP1940470B1
(en)
*
|
2005-09-26 |
2013-04-17 |
Medarex, Inc. |
Antibody-drug conjugates and their use
|
|
KR20080056167A
(ko)
*
|
2005-09-26 |
2008-06-20 |
메다렉스, 인코포레이티드 |
씨디70에 대한 인간 모노크로날 항체
|
|
EA015324B1
(ru)
*
|
2005-10-26 |
2011-06-30 |
Медарекс, Инк. |
Способы и соединения для получения аналогов сс-1065
|
|
AU2006316629A1
(en)
*
|
2005-11-17 |
2007-05-31 |
Millennium Pharmaceuticals, Inc. |
Humanized immunoglobulin reactive with alpha 4 beta 7 integrin
|
|
EP1806365A1
(en)
|
2006-01-05 |
2007-07-11 |
Boehringer Ingelheim International GmbH |
Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
EP1832577A1
(en)
*
|
2006-03-07 |
2007-09-12 |
Sanofi-Aventis |
Improved prodrugs of CC-1065 analogs
|
|
NZ574215A
(en)
|
2006-07-18 |
2012-07-27 |
Sanofi Aventis |
Antagonist antibody against epha2 for the treatment of cancer
|
|
EP1914242A1
(en)
*
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
JP2010513306A
(ja)
*
|
2006-12-14 |
2010-04-30 |
メダレックス インコーポレーティッド |
Ｃｄ７０に結合するヒト抗体およびその使用
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
CA2676244C
(en)
|
2007-01-25 |
2017-01-17 |
Kwok-Kin Wong |
Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
|
|
CA2678514A1
(en)
|
2007-02-21 |
2008-08-28 |
Medarex, Inc. |
Chemical linkers with single amino acids and conjugates thereof
|
|
CN101688229B
(zh)
|
2007-03-15 |
2013-06-12 |
路德维格癌症研究所 |
包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
|
|
PE20090309A1
(es)
*
|
2007-06-04 |
2009-04-18 |
Wyeth Corp |
Conjugado portador-caliqueamicina y un metodo de deteccion de caliqueamicina
|
|
SI2019104T1
(sl)
*
|
2007-07-19 |
2013-12-31 |
Sanofi |
Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
|
CA2696360C
(en)
|
2007-08-14 |
2018-11-20 |
Ludwig Institute For Cancer Research |
Monoclonal antibody targeting the egfr receptor and uses thereof
|
|
ES2441115T3
(es)
*
|
2007-11-13 |
2014-01-31 |
The Scripps Research Institute |
Derivados de CBI sujetos a activación reductora
|
|
CN101945892B
(zh)
*
|
2007-12-26 |
2017-11-24 |
生物测试股份公司 |
用于改进对表达cd138的肿瘤细胞的靶向的方法和试剂
|
|
DK2242772T3
(en)
*
|
2007-12-26 |
2015-01-05 |
Biotest Ag |
Immunoconjugates that targets CD138, and uses thereof
|
|
BRPI0821447A2
(pt)
*
|
2007-12-26 |
2015-06-16 |
Biotest Ag |
Anticorpo de alvejamento engenheirado, composição farmacêutica, hibridoma, ensaio com base em anticorpo, polipeptídeo isolado, e, método para ligação homogênea
|
|
WO2009080831A1
(en)
*
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
|
HUE034763T2
(en)
|
2008-04-30 |
2018-02-28 |
Immunogen Inc |
Crosslinkers and their use
|
|
CA2742568C
(en)
|
2008-11-03 |
2017-09-26 |
Syntarga B.V. |
Novel cc-1065 analogs and their conjugates
|
|
SG173152A1
(en)
|
2009-02-05 |
2011-08-29 |
Immunogen Inc |
Novel benzodiazepine derivatives
|
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
MX2011012794A
(es)
|
2009-06-03 |
2012-05-08 |
Immunogen Inc |
Metodos de conjugacion.
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
UY32914A
(es)
|
2009-10-02 |
2011-04-29 |
Sanofi Aventis |
Anticuerpos que se usan específicamente al receptor epha2
|
|
KR20120080611A
(ko)
|
2009-10-06 |
2012-07-17 |
이뮤노젠 아이엔씨 |
효능 있는 접합체 및 친수성 링커
|
|
US8330262B2
(en)
*
|
2010-02-02 |
2012-12-11 |
International Business Machines Corporation |
Processes for enhanced 3D integration and structures generated using the same
|
|
WO2011100403A1
(en)
|
2010-02-10 |
2011-08-18 |
Immunogen, Inc |
Cd20 antibodies and uses thereof
|
|
EP3108886B1
(en)
|
2010-04-21 |
2020-06-17 |
Syntarga B.V. |
Conjugates of cc-1065 analogs and bifunctional linkers
|
|
PL3153504T3
(pl)
|
2010-12-09 |
2019-04-30 |
Immunogen Inc |
Sposoby otrzymywania naładowanych środków sieciujących
|
|
US9540438B2
(en)
|
2011-01-14 |
2017-01-10 |
Redwood Bioscience, Inc. |
Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
|
|
KR20190089048A
(ko)
|
2011-02-15 |
2019-07-29 |
이뮤노젠 아이엔씨 |
컨쥬게이트의 제조방법
|
|
ME03353B
(me)
|
2011-03-29 |
2019-10-20 |
Immunogen Inc |
Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
|
|
WO2012135517A2
(en)
|
2011-03-29 |
2012-10-04 |
Immunogen, Inc. |
Preparation of maytansinoid antibody conjugates by a one-step process
|
|
US8852599B2
(en)
*
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
US20140196786A1
(en)
*
|
2011-06-06 |
2014-07-17 |
International Frontier Technology Laboratory, Inc. |
A composite glass plate
|
|
EP3228325A1
(en)
|
2011-06-10 |
2017-10-11 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
SG10201605041VA
(en)
|
2011-06-21 |
2016-08-30 |
Immunogen Inc |
Novel maytansinoid derivatives with peptide linker and conjugates thereof
|
|
CN104302324A
(zh)
|
2011-12-08 |
2015-01-21 |
生物测试股份公司 |
靶向cd138的免疫偶联物的用途
|
|
ES2755719T3
(es)
|
2012-04-05 |
2020-04-23 |
Nerviano Medical Sciences Srl |
Nuevos agentes alquilantes
|
|
EP2836493B1
(en)
*
|
2012-04-05 |
2018-06-20 |
Nerviano Medical Sciences S.r.l. |
Functionalized thieno-indole derivatives for the treatment of cancer
|
|
JP2015516980A
(ja)
|
2012-04-26 |
2015-06-18 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｃｄ３７抗体とベンダムスチンとの併用
|
|
JP2015517512A
(ja)
|
2012-05-16 |
2015-06-22 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｃｄ３７抗体の更なる薬剤との併用
|
|
WO2013171287A1
(en)
|
2012-05-16 |
2013-11-21 |
Boehringer Ingelheim International Gmbh |
Combination of cd37 antibodies with ice (ifosfamide, carboplatin, etoposide)
|
|
WO2014055877A1
(en)
|
2012-10-04 |
2014-04-10 |
Immunogen, Inc. |
Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
|
|
CA2891280C
(en)
|
2012-11-24 |
2018-03-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
WO2014093379A1
(en)
|
2012-12-10 |
2014-06-19 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
AU2013359506B2
(en)
|
2012-12-10 |
2018-05-24 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
EP2931316B1
(en)
|
2012-12-12 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
|
ES2738657T3
(es)
*
|
2013-09-25 |
2020-01-24 |
Nerviano Medical Sciences Srl |
Derivados de tieno[2,3-e]indol como nuevos antitumorales
|
|
CA2926586C
(en)
|
2013-10-11 |
2020-04-07 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
KR102572149B1
(ko)
|
2013-10-11 |
2023-08-30 |
아사나 바이오사이언시스 엘엘씨 |
단백질-폴리머-약물 접합체
|
|
TR201810856T4
(tr)
|
2014-01-10 |
2018-08-27 |
Synthon Biopharmaceuticals Bv |
CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
|
|
JP6342517B2
(ja)
|
2014-01-10 |
2018-06-13 |
シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． |
改善されたインビボ抗腫瘍活性を示すデュオカルマイシンａｄｃ
|
|
RU2686085C2
(ru)
|
2014-01-10 |
2019-04-24 |
Синтон Байофармасьютикалс Б. В. |
Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия
|
|
US9943606B2
(en)
|
2014-01-15 |
2018-04-17 |
Rutgers, The State University Of New Jersey |
Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
|
|
CN106414465B
(zh)
|
2014-02-28 |
2021-11-16 |
杭州多禧生物科技有限公司 |
带电荷链接体及其在共轭反应上的应用
|
|
US9381256B2
(en)
|
2014-09-03 |
2016-07-05 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
US9669102B2
(en)
|
2014-09-03 |
2017-06-06 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
ES2986970T3
(es)
|
2014-12-04 |
2024-11-13 |
Celgene Corp |
Conjugados de biomoléculas
|
|
SI3313845T1
(sl)
|
2015-06-29 |
2021-01-29 |
Immunogen, Inc. |
Konjugati spremenjenih protiteles cisteina
|
|
NZ739830A
(en)
|
2015-07-12 |
2021-12-24 |
Hangzhou Dac Biotech Co Ltd |
Bridge linkers for conjugation of cell-binding molecules
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
KR102660070B1
(ko)
|
2015-07-21 |
2024-04-24 |
이뮤노젠 아이엔씨 |
세포독성 벤조다이아제핀 유도체의 제조 방법
|
|
EP3331569A1
(en)
|
2015-08-07 |
2018-06-13 |
Gamamabs Pharma |
Antibodies, antibody drug conjugates and methods of use
|
|
EP3380525B1
(en)
|
2015-11-25 |
2023-11-08 |
Immunogen, Inc. |
Pharmaceutical formulations and methods of use thereof
|
|
CN109071634A
(zh)
|
2016-04-26 |
2018-12-21 |
R.P.谢勒技术有限责任公司 |
抗体偶联物及其制备和使用方法
|
|
TW201808336A
(zh)
|
2016-05-11 |
2018-03-16 |
賽諾菲公司 |
用抗ｍｕｃ１類美登素免疫綴合物抗體治療腫瘤的治療方案
|
|
US11617799B2
(en)
|
2016-06-27 |
2023-04-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
ES2902179T3
(es)
|
2016-08-19 |
2022-03-25 |
Bristol Myers Squibb Co |
Compuestos de seco-ciclopropapirroloindol, conjugados de anticuerpo-fármaco de los mismos y métodos de elaboración y uso
|
|
CN116143678A
(zh)
|
2016-11-14 |
2023-05-23 |
杭州多禧生物科技有限公司 |
偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
|
|
KR102576550B1
(ko)
|
2016-11-23 |
2023-09-07 |
이뮤노젠 아이엔씨 |
벤조다이아제핀 유도체의 선택적인 설폰화
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
RU2022101392A
(ru)
|
2017-02-28 |
2022-03-02 |
Иммуноджен, Инк. |
Производные майтанзиноида с саморасщепляющимися пептидными линкерами и их конъюгаты
|
|
WO2018195243A1
(en)
|
2017-04-20 |
2018-10-25 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives and conjugates thereof
|
|
CA3066754A1
(en)
|
2017-06-22 |
2018-12-27 |
Mersana Therapeutics, Inc. |
Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
|
|
TW202413360A
(zh)
|
2017-12-28 |
2024-04-01 |
美商伊繆諾金公司 |
苯二氮平衍生物
|
|
ES2975330T3
(es)
|
2018-05-04 |
2024-07-04 |
Tagworks Pharmaceuticals B V |
Compuestos que comprenden un enlazador para aumentar la estabilidad del trans-cicloocteno
|
|
US20210299286A1
(en)
|
2018-05-04 |
2021-09-30 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
|
KR20210084546A
(ko)
|
2018-10-29 |
2021-07-07 |
메르사나 테라퓨틱스, 인코포레이티드 |
펩티드 함유 링커를 갖는 시스테인 조작된 항체-약물 접합체
|
|
DK3941946T3
(da)
|
2019-03-20 |
2025-03-24 |
Univ California |
Claudin-6-antistoffer og lægemiddelkonjugater
|
|
EP3941944A4
(en)
|
2019-03-20 |
2022-11-30 |
The Regents of the University of California |
Claudin-6 bispecific antibodies
|
|
CN113661172A
(zh)
|
2019-03-29 |
2021-11-16 |
伊缪诺金公司 |
用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物
|
|
EP3958977B1
(en)
|
2019-04-26 |
2023-09-13 |
ImmunoGen, Inc. |
Camptothecin derivatives
|
|
IL289093B2
(en)
|
2019-06-17 |
2025-02-01 |
Tagworks Pharmaceuticals B V |
Compounds for a fast and efficient "click release" reaction
|
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
|
JP2023510349A
(ja)
|
2020-01-09 |
2023-03-13 |
メルサナ セラピューティクス インコーポレイテッド |
ペプチド含有リンカーとの部位特異的抗体－薬物コンジュゲート
|
|
BR112022017064A2
(pt)
|
2020-02-25 |
2022-11-16 |
Mediboston Inc |
Derivados da camptotecina e seus conjugados
|
|
EP4178624A2
(en)
|
2020-07-07 |
2023-05-17 |
Bionecure Therapeutics, Inc. |
Maytansinoids as adc payloads and their use for the treatment of cancer
|
|
US12521444B2
(en)
|
2021-02-25 |
2026-01-13 |
Fortvita Biologics Limited |
Anti-HER2 antibody-drug conjugates and uses thereof
|
|
CN118339280A
(zh)
|
2021-09-06 |
2024-07-12 |
维拉克萨生物技术有限责任公司 |
用于真核生物中遗传密码子扩展的新型氨酰tRNA合成酶变体
|
|
WO2022078524A2
(en)
|
2021-11-03 |
2022-04-21 |
Hangzhou Dac Biotech Co., Ltd. |
Specific conjugation of an antibody
|
|
KR20240105469A
(ko)
|
2021-11-25 |
2024-07-05 |
베락사 바이오테크 게엠베하 |
유전자 코드 확장을 이용하는 부위-특이적 접합에 의해 제조되는 개선된 항체-페이로드 접합체 (apc)
|
|
DK4186529T3
(da)
|
2021-11-25 |
2025-08-25 |
Veraxa Biotech Gmbh |
Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
|
|
WO2023104941A1
(en)
|
2021-12-08 |
2023-06-15 |
European Molecular Biology Laboratory |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
|
DK4314031T3
(da)
|
2022-02-15 |
2024-06-17 |
Tagworks Pharmaceuticals B V |
Maskeret il12-protein
|
|
CA3261603A1
(en)
|
2022-07-15 |
2024-01-18 |
Pheon Therapeutics Ltd |
ANTIBODY-DRUG CONJUGATES
|
|
TW202412762A
(zh)
|
2022-07-27 |
2024-04-01 |
香港商祐方有限公司 |
奧瑞他汀衍生物及其結合物
|
|
WO2024080872A1
(en)
|
2022-10-12 |
2024-04-18 |
Tagworks Pharmaceuticals B.V. |
Strained bicyclononenes
|
|
WO2024153789A1
(en)
|
2023-01-20 |
2024-07-25 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
KR20250169530A
(ko)
|
2023-03-10 |
2025-12-03 |
태그웍스 파마슈티컬스 비.브이. |
개선된 t-링커를 갖는 트랜스-사이클로옥텐
|
|
CN121646574A
(zh)
|
2023-07-27 |
2026-03-10 |
维拉克萨生物技术有限责任公司 |
亲水性反式环辛烯(hyTCO)化合物、含有该化合物的构建体和缀合物
|
|
WO2025056807A1
(en)
|
2023-09-15 |
2025-03-20 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|
|
WO2025174248A1
(en)
|
2024-02-16 |
2025-08-21 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctenes with "or gate" release
|
|
WO2026043376A1
(en)
|
2024-08-22 |
2026-02-26 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctene formulations
|