|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
PT1392359E
(pt)
|
2001-05-11 |
2010-01-27 |
Ludwig Inst For Cancer Res Ltd |
Proteínas de ligação específica e suas utilizações
|
|
US20110313230A1
(en)
|
2001-05-11 |
2011-12-22 |
Terrance Grant Johns |
Specific binding proteins and uses thereof
|
|
NZ529788A
(en)
*
|
2001-05-31 |
2003-12-19 |
Medarex Inc |
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
EP2281577B1
(en)
*
|
2003-05-14 |
2016-11-16 |
ImmunoGen, Inc. |
Drug conjugate composition
|
|
WO2006002474A1
(en)
*
|
2004-07-02 |
2006-01-12 |
The Walter And Eliza Hall Institute Of Medical Research |
Alpha-helical mimetics
|
|
EP2266622A3
(en)
*
|
2004-08-26 |
2012-06-20 |
Piramal Life Sciences Limited |
Prodrugs containing novel bio-cleavable linkers
|
|
AU2004224925C1
(en)
*
|
2004-08-30 |
2011-07-21 |
Biotest Ag |
Immunoconjugates targeting syndecan-1 expressing cells and use thereof
|
|
ES2503719T3
(es)
|
2005-02-11 |
2014-10-07 |
Immunogen, Inc. |
Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
|
|
US20110166319A1
(en)
*
|
2005-02-11 |
2011-07-07 |
Immunogen, Inc. |
Process for preparing purified drug conjugates
|
|
US7714016B2
(en)
*
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
NZ599176A
(en)
*
|
2005-08-03 |
2014-04-30 |
Immunogen Inc |
Immunoconjugate formulations
|
|
NZ565964A
(en)
*
|
2005-08-24 |
2011-11-25 |
Immunogen Inc |
Process for preparing maytansinoid antibody conjugates by purifying with tangential flow filtration
|
|
EP1940470B1
(en)
*
|
2005-09-26 |
2013-04-17 |
Medarex, Inc. |
Antibody-drug conjugates and their use
|
|
JP2009509510A
(ja)
*
|
2005-09-26 |
2009-03-12 |
メダレックス インコーポレーティッド |
Cd70に対するヒトモノクローナル抗体
|
|
EA015324B1
(ru)
*
|
2005-10-26 |
2011-06-30 |
Медарекс, Инк. |
Способы и соединения для получения аналогов сс-1065
|
|
JP2009515552A
(ja)
*
|
2005-11-17 |
2009-04-16 |
ミレニアム・ファーマシューティカルズ・インコーポレイテッド |
α4β7インテグリン反応性ヒト化免疫グロブリン
|
|
EP1806365A1
(en)
|
2006-01-05 |
2007-07-11 |
Boehringer Ingelheim International GmbH |
Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
EP1832577A1
(en)
*
|
2006-03-07 |
2007-09-12 |
Sanofi-Aventis |
Improved prodrugs of CC-1065 analogs
|
|
EP2044122B1
(en)
*
|
2006-07-18 |
2018-03-28 |
Sanofi |
Antagonist antibody against epha2 for the treatment of cancer
|
|
EP1914242A1
(en)
*
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
CA2672468A1
(en)
*
|
2006-12-14 |
2008-06-19 |
Medarex, Inc. |
Human antibodies that bind cd70 and uses thereof
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
ES2609094T3
(es)
|
2007-01-25 |
2017-04-18 |
Dana-Farber Cancer Institute, Inc. |
Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante
|
|
TW200900059A
(en)
|
2007-02-21 |
2009-01-01 |
Medarex Inc |
Chemical linkers with single amino acids and conjugates thereof
|
|
CA2680854C
(en)
|
2007-03-15 |
2017-02-14 |
Ludwig Institute For Cancer Research |
Treatment method using egfr antibodies and src inhibitors and related formulations
|
|
PE20090309A1
(es)
*
|
2007-06-04 |
2009-04-18 |
Wyeth Corp |
Conjugado portador-caliqueamicina y un metodo de deteccion de caliqueamicina
|
|
ES2435779T3
(es)
*
|
2007-07-19 |
2013-12-23 |
Sanofi |
Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
|
EP2188311B1
(en)
|
2007-08-14 |
2016-10-05 |
Ludwig Institute for Cancer Research Ltd. |
Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
|
|
ES2441115T3
(es)
*
|
2007-11-13 |
2014-01-31 |
The Scripps Research Institute |
Derivados de CBI sujetos a activación reductora
|
|
CA2710483C
(en)
*
|
2007-12-26 |
2018-05-08 |
Biotest Ag |
Methods and agents for improving targeting of cd138 expressing tumor cells
|
|
US9387261B2
(en)
*
|
2007-12-26 |
2016-07-12 |
Biotest Ag |
Immunoconjugates targeting CD138 and uses thereof
|
|
US9221914B2
(en)
|
2007-12-26 |
2015-12-29 |
Biotest Ag |
Agents targeting CD138 and uses thereof
|
|
WO2009080831A1
(en)
*
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
|
NO2281006T3
(enExample)
|
2008-04-30 |
2017-12-30 |
|
|
|
RU2562232C2
(ru)
*
|
2008-11-03 |
2015-09-10 |
Синтарга Б.В. |
Новые аналоги сс-1065 и их конъюгаты
|
|
EP3100745B1
(en)
|
2009-02-05 |
2018-04-18 |
Immunogen, Inc. |
Novel benzodiazepine derivatives
|
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
LT2437790T
(lt)
|
2009-06-03 |
2019-06-10 |
Immunogen, Inc. |
Konjugavimo būdai
|
|
US20110076232A1
(en)
*
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
UY32914A
(es)
|
2009-10-02 |
2011-04-29 |
Sanofi Aventis |
Anticuerpos que se usan específicamente al receptor epha2
|
|
JP2013506709A
(ja)
|
2009-10-06 |
2013-02-28 |
イミュノジェン・インコーポレーテッド |
有効なコンジュゲートおよび親水性リンカー
|
|
US8330262B2
(en)
*
|
2010-02-02 |
2012-12-11 |
International Business Machines Corporation |
Processes for enhanced 3D integration and structures generated using the same
|
|
AR080154A1
(es)
|
2010-02-10 |
2012-03-14 |
Immunogen Inc |
Anticuerpos cd20 y su utilizacion
|
|
HUE030846T2
(en)
|
2010-04-21 |
2017-06-28 |
Syntarga Bv |
Conjugates of cc-1065 analogs and bifunctional linkers
|
|
HUE041699T2
(hu)
|
2010-12-09 |
2019-05-28 |
Immunogen Inc |
Töltött térhálósítók elõállítására szolgáló eljárások
|
|
EP2663647A4
(en)
|
2011-01-14 |
2015-08-19 |
Redwood Bioscience Inc |
POLYPEPTIDE IMMUNOGLOBULINS WITH ALDEHYDIC MARKING AND THEIR USE METHOD
|
|
PT2675480T
(pt)
|
2011-02-15 |
2019-04-15 |
Immunogen Inc |
Métodos para preparação de conjugados
|
|
TR201902180T4
(tr)
|
2011-03-29 |
2019-03-21 |
Immunogen Inc |
Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi
|
|
SG193997A1
(en)
|
2011-03-29 |
2013-11-29 |
Immunogen Inc |
Process for manufacturing conjugates of improved homogeneity
|
|
US8852599B2
(en)
*
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
JP6049613B2
(ja)
*
|
2011-06-06 |
2016-12-21 |
inQs株式会社 |
複合ガラス板
|
|
MX2013014583A
(es)
|
2011-06-10 |
2014-03-31 |
Mersana Therapeutics Inc |
Conjugados de proteina-polimero-farmaco.
|
|
JP6209159B2
(ja)
|
2011-06-21 |
2017-10-04 |
イミュノジェン・インコーポレーテッド |
ペプチドリンカーを有する新規メイタンシノイド誘導体およびその結合体
|
|
AU2012372140B9
(en)
|
2011-12-08 |
2015-10-15 |
Biotest Ag |
Uses of immunoconjugates targeting CD138
|
|
ES2929759T3
(es)
|
2012-04-05 |
2022-12-01 |
Nerviano Medical Sciences Srl |
Nuevos agentes alquilantes
|
|
WO2013149946A1
(en)
*
|
2012-04-05 |
2013-10-10 |
Nerviano Medical Sciences S.R.L. |
Functionalized thieno-indole derivatives for the treatment of cancer
|
|
JP2015516980A
(ja)
|
2012-04-26 |
2015-06-18 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cd37抗体とベンダムスチンとの併用
|
|
WO2013171289A1
(en)
|
2012-05-16 |
2013-11-21 |
Boehringer Ingelheim International Gmbh |
Combination of cd37 antibodies with further agents
|
|
US8992915B2
(en)
|
2012-05-16 |
2015-03-31 |
Boehringer Ingelheim International Gmbh |
Combination of CD37 antibodies with ICE
|
|
IN2015DN03202A
(enExample)
|
2012-10-04 |
2015-10-02 |
Immunogen Inc |
|
|
WO2014080251A1
(en)
|
2012-11-24 |
2014-05-30 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
JP6334553B2
(ja)
|
2012-12-10 |
2018-05-30 |
メルサナ セラピューティクス,インコーポレイティド |
タンパク質−高分子−薬剤コンジュゲート
|
|
WO2014093379A1
(en)
|
2012-12-10 |
2014-06-19 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
JP6487422B2
(ja)
*
|
2013-09-25 |
2019-03-20 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
新しい抗腫瘍剤としてのチエノ[2,3−e]インドール誘導体
|
|
CN105979970B
(zh)
|
2013-10-11 |
2019-09-10 |
梅尔莎纳医疗公司 |
蛋白质-聚合物-药物共轭物
|
|
KR102355745B1
(ko)
|
2013-10-11 |
2022-01-26 |
아사나 바이오사이언시스 엘엘씨 |
단백질-폴리머-약물 접합체
|
|
PL3092010T3
(pl)
|
2014-01-10 |
2019-01-31 |
Synthon Biopharmaceuticals B.V. |
Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
|
|
JP6224268B2
(ja)
|
2014-01-10 |
2017-11-01 |
シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. |
子宮内膜癌の治療において使用するためのデュオカルマイシンadc
|
|
HRP20160697T1
(hr)
|
2014-01-10 |
2016-07-15 |
Synthon Biopharmaceuticals B.V. |
Duokarmicin adcs koji pokazuje poboljšanu antitumorsku aktivnost in vivo
|
|
US9943606B2
(en)
|
2014-01-15 |
2018-04-17 |
Rutgers, The State University Of New Jersey |
Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
|
|
AU2014384434B2
(en)
|
2014-02-28 |
2016-11-03 |
Hangzhou Dac Biotech Co., Ltd |
Charged linkers and their uses for conjugation
|
|
WO2016036804A1
(en)
|
2014-09-03 |
2016-03-10 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
CA2959630A1
(en)
|
2014-09-03 |
2016-03-10 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
ES2986970T3
(es)
|
2014-12-04 |
2024-11-13 |
Celgene Corp |
Conjugados de biomoléculas
|
|
SI3313845T1
(sl)
|
2015-06-29 |
2021-01-29 |
Immunogen, Inc. |
Konjugati spremenjenih protiteles cisteina
|
|
JP6759326B2
(ja)
|
2015-07-12 |
2020-09-23 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. |
細胞結合分子の共役のための架橋連結体
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
AU2016297607A1
(en)
|
2015-07-21 |
2018-02-08 |
Immunogen, Inc. |
Methods of preparing cytotoxic benzodiazepine derivatives
|
|
US10509035B2
(en)
|
2015-08-07 |
2019-12-17 |
Gamamabs Pharma Sa |
Antibodies, antibody drug conjugates and methods of use
|
|
DK3380525T3
(da)
|
2015-11-25 |
2024-01-29 |
Immunogen Inc |
Farmaceutiske formuleringer og fremgangsmåder til anvendelse deraf
|
|
US11208632B2
(en)
|
2016-04-26 |
2021-12-28 |
R.P. Scherer Technologies, Llc |
Antibody conjugates and methods of making and using the same
|
|
TW201808336A
(zh)
|
2016-05-11 |
2018-03-16 |
賽諾菲公司 |
用抗muc1類美登素免疫綴合物抗體治療腫瘤的治療方案
|
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
JP7023933B2
(ja)
|
2016-08-19 |
2022-02-22 |
ブリストル-マイヤーズ スクイブ カンパニー |
セコ-シクロプロパピロロインドール化合物、その抗体-薬物コンジュゲート、ならびに製造および使用方法
|
|
CN110099682B
(zh)
|
2016-11-14 |
2023-03-31 |
杭州多禧生物科技有限公司 |
偶联连接体,含有此连接体的细胞结合分子-药物偶联物及其制备和应用
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
WO2018098258A2
(en)
|
2016-11-23 |
2018-05-31 |
Immunogen, Inc. |
Selective sulfonation of benzodiazepine derivatives
|
|
KR102681168B1
(ko)
|
2017-02-28 |
2024-07-04 |
이뮤노젠 아이엔씨 |
자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
|
|
US20180346488A1
(en)
|
2017-04-20 |
2018-12-06 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives and conjugates thereof
|
|
AU2018290330A1
(en)
|
2017-06-22 |
2020-01-02 |
Mersana Therapeutics, Inc. |
Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
|
|
WO2019133652A1
(en)
|
2017-12-28 |
2019-07-04 |
Immunogen, Inc. |
Benzodiazepine derivatives
|
|
EP3787691A1
(en)
|
2018-05-04 |
2021-03-10 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
|
US20210308207A1
(en)
|
2018-05-04 |
2021-10-07 |
Tagworks Pharmaceuticals B.V. |
Compounds comprising a linker for increasing transcyclooctene stability
|
|
MX2021004906A
(es)
|
2018-10-29 |
2021-09-10 |
Mersana Therapeutics Inc |
Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos.
|
|
FI3941946T3
(fi)
|
2019-03-20 |
2025-03-28 |
Univ California |
Klaudiini-6-vasta-aineita ja klaudiini-6-vasta-ainelääkekonjugaatteja
|
|
CN114206934A
(zh)
|
2019-03-20 |
2022-03-18 |
加利福尼亚大学董事会 |
密封蛋白-6双特异性抗体
|
|
JP2022529583A
(ja)
|
2019-03-29 |
2022-06-23 |
イミュノジェン・インコーポレーテッド |
異常細胞増殖を阻害するまたは増殖性疾患を治療するための細胞毒性ビス-ベンゾジアゼピン誘導体及び細胞結合剤とのその複合体
|
|
HRP20231619T1
(hr)
|
2019-04-26 |
2024-04-26 |
Immunogen, Inc. |
Derivati kamptotecina
|
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
|
IL289093B2
(en)
|
2019-06-17 |
2025-02-01 |
Tagworks Pharmaceuticals B V |
Compounds for a fast and efficient "click release" reaction
|
|
BR112022013255A2
(pt)
|
2020-01-09 |
2022-09-06 |
Mersana Therapeutics Inc |
Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo
|
|
CN115551552A
(zh)
|
2020-02-25 |
2022-12-30 |
祐方有限公司 |
喜树碱衍生物及其缀合物
|
|
US20230256114A1
(en)
|
2020-07-07 |
2023-08-17 |
Bionecure Therapeutics, Inc. |
Novel maytansinoids as adc payloads and their use for the treatment of cancer
|
|
US12521444B2
(en)
|
2021-02-25 |
2026-01-13 |
Fortvita Biologics Limited |
Anti-HER2 antibody-drug conjugates and uses thereof
|
|
WO2023031445A2
(en)
|
2021-09-06 |
2023-03-09 |
Veraxa Biotech Gmbh |
Novel aminoacyl-trna synthetase variants for genetic code expansion in eukaryotes
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
EP4437005A1
(en)
|
2021-11-25 |
2024-10-02 |
Veraxa Biotech GmbH |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
|
EP4186529B1
(en)
|
2021-11-25 |
2025-07-09 |
Veraxa Biotech GmbH |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
|
CA3239713A1
(en)
|
2021-12-08 |
2023-06-15 |
Edward A. LEMKE |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
|
WO2023158305A1
(en)
|
2022-02-15 |
2023-08-24 |
Tagworks Pharmaceuticals B.V. |
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