|
US7087229B2
(en)
*
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7413738B2
(en)
*
|
2002-08-13 |
2008-08-19 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on biodegradable linkers
|
|
US7122189B2
(en)
*
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7332164B2
(en)
*
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
AU2004230927B9
(en)
*
|
2003-04-13 |
2011-12-01 |
Enzon Pharmaceuticals, Inc. |
Polymeric oligonucleotide prodrugs
|
|
PL1625156T3
(pl)
|
2003-05-12 |
2013-03-29 |
Affymax Inc |
Peptydy wiążące się do receptora erytropoetyny
|
|
CN1849141A
(zh)
*
|
2003-05-12 |
2006-10-18 |
阿费麦克斯公司 |
用于聚(乙二醇)修饰的肽的间隔臂部分
|
|
KR101163683B1
(ko)
|
2003-05-12 |
2012-07-10 |
아피맥스, 인크. |
에리스로포이에틴 수용체에 결합하는 신규의 펩티드
|
|
CZ294996B6
(cs)
*
|
2003-07-16 |
2005-04-13 |
Ústav Makromolekulární Chemie Av Čr |
Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
|
|
US8394365B2
(en)
|
2003-09-17 |
2013-03-12 |
Nektar Therapeutics |
Multi-arm polymer prodrugs
|
|
CN1852740B
(zh)
*
|
2003-09-17 |
2011-05-11 |
耐科塔医药公司 |
多支链聚合物的药物前体
|
|
CA2786794C
(en)
*
|
2004-03-23 |
2017-09-12 |
Complex Biosystems Gmbh |
Aromatic polymeric cascade prodrug linker reagent
|
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
|
US7550433B2
(en)
|
2005-06-03 |
2009-06-23 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
GB2427360A
(en)
*
|
2005-06-22 |
2006-12-27 |
Complex Biosystems Gmbh |
Aliphatic prodrug linker
|
|
WO2007140282A1
(en)
*
|
2006-05-24 |
2007-12-06 |
Peg Biosciences |
Peg linker compounds and biologically active conjugates thereof
|
|
EP2021397A4
(en)
*
|
2006-05-26 |
2012-01-04 |
Ipsen Pharma |
PROCESS FOR POTENTIAL PEGYLATION
|
|
US20090156629A1
(en)
*
|
2006-06-09 |
2009-06-18 |
Enzon Pharmaceuticals, Inc. |
Indenoisoquinoline-releasable polymer conjugates
|
|
CN101484181B
(zh)
*
|
2006-06-30 |
2012-12-26 |
希格马托罕见疾病公司 |
用于生产l-天门冬酰胺酶ⅱ的重组宿主
|
|
WO2008034120A2
(en)
*
|
2006-09-15 |
2008-03-20 |
Enzon Pharmaceuticals, Inc. |
Lysine-based polymeric linkers
|
|
MX2009002855A
(es)
*
|
2006-09-15 |
2009-03-30 |
Enzon Pharmaceuticals Inc |
Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
|
|
US20100279408A1
(en)
*
|
2006-11-27 |
2010-11-04 |
Enzon Pharmaceuticals, Inc. |
Polymeric short interfering rna conjugates
|
|
MX2009005780A
(es)
|
2006-11-30 |
2009-06-10 |
Nektar Therapeutics Al Corp |
Metodo para preparar un conjugado de polimeros.
|
|
DK2101821T3
(da)
|
2006-12-15 |
2014-10-06 |
Baxter Healthcare Sa |
Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo
|
|
JP2010514803A
(ja)
*
|
2006-12-29 |
2010-05-06 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
肺疾患を治療するためのアデノシンデアミナーゼの使用方法
|
|
US8106154B2
(en)
|
2007-01-31 |
2012-01-31 |
Affymax, Inc. |
Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
|
|
HUE027603T2
(en)
*
|
2007-04-20 |
2016-10-28 |
Sigma-Tau Rare Disease Ltd |
Stable, recombinant adenosine deaminase
|
|
PL2147122T3
(pl)
*
|
2007-04-20 |
2015-05-29 |
Leadiant Biosciences Ltd |
Enzymatyczna terapia przeciwnowotworowa
|
|
AU2008267361B2
(en)
*
|
2007-06-26 |
2012-01-19 |
Takeda Pharmaceutical Company Limited |
Method for preparing Fmoc-based hydrolysable linkers
|
|
BRPI0721948A2
(pt)
*
|
2007-08-20 |
2014-04-08 |
Enzon Pharmaceuticals Inc |
Ligantes poliméricos contendo frações dissulfeto de piridila
|
|
KR101671537B1
(ko)
*
|
2008-08-11 |
2016-11-01 |
넥타르 테라퓨틱스 |
다분지형 중합체 알카노에이트 컨쥬게이트
|
|
MX2011003063A
(es)
|
2008-09-23 |
2011-04-21 |
Nektar Therapeutics |
Composiciones y metodos para lograr concentraciones terapeuticas de farmaco sostenidas en un individuo.
|
|
JP5775820B2
(ja)
*
|
2008-10-21 |
2015-09-09 |
バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated |
遊離可能peg試薬を有するプロドラッグpegタンパク質結合体において活性成分(インビトロ脱ペグ化)を決定する方法
|
|
RU2744370C2
(ru)
|
2009-07-27 |
2021-03-05 |
Баксалта Инкорпорейтед |
Конъюгаты белков свертывания крови
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
BR112012001814A8
(pt)
|
2009-07-27 |
2018-02-06 |
Baxalta GmbH |
Conjugados de proteína de coagulação sanguínea
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
EP3081233B1
(en)
|
2009-07-27 |
2020-12-23 |
Baxalta GmbH |
Glycopolysialylation of proteins other than blood coagulation proteins
|
|
KR101831685B1
(ko)
*
|
2010-01-25 |
2018-02-23 |
롬 앤드 하스 일렉트로닉 머트어리얼즈 엘엘씨 |
질소-함유 화합물을 포함하는 포토레지스트
|
|
US20130331443A1
(en)
|
2010-12-22 |
2013-12-12 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
|
US10894087B2
(en)
|
2010-12-22 |
2021-01-19 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
|
ES2800983T3
(es)
|
2010-12-22 |
2021-01-07 |
Baxalta GmbH |
Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína
|
|
AU2012286048A1
(en)
|
2011-07-18 |
2014-02-20 |
Arts Biologics A/S |
Long acting luteinizing hormone (LH) compound
|
|
US8962577B2
(en)
*
|
2012-03-16 |
2015-02-24 |
The Johns Hopkins University |
Controlled release formulations for the delivery of HIF-1 inhibitors
|
|
CA2867203C
(en)
*
|
2012-03-16 |
2016-09-20 |
The Johns Hopkins University |
Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
|
|
EP2846822A2
(en)
|
2012-05-11 |
2015-03-18 |
Prorec Bio AB |
Method for diagnosis and treatment of prolactin associated disorders
|
|
CN103881083A
(zh)
*
|
2012-12-21 |
2014-06-25 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
CN103897176B
(zh)
*
|
2012-12-24 |
2018-08-17 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103897178A
(zh)
*
|
2012-12-24 |
2014-07-02 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
CN103910871A
(zh)
*
|
2012-12-28 |
2014-07-09 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103910870B
(zh)
*
|
2012-12-28 |
2018-08-17 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103910866B
(zh)
*
|
2012-12-31 |
2018-08-17 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
KR102384740B1
(ko)
|
2013-12-27 |
2022-04-07 |
자임워크스 인코포레이티드 |
약물 접합체를 위한 설폰아마이드-함유 연결 시스템
|
|
EP3110448B1
(en)
|
2014-02-26 |
2020-09-09 |
The Board of Regents of The University of Texas System |
Nitrobenzaldehyde proton release for manipulation of cellular acidosis
|
|
ES2905569T3
(es)
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
AU2015332533B2
(en)
|
2014-10-14 |
2018-08-30 |
Halozyme, Inc. |
Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
|
|
AU2016252864B2
(en)
|
2015-04-24 |
2021-10-14 |
Duke University |
Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents
|
|
KR102518217B1
(ko)
|
2016-01-08 |
2023-04-04 |
아센디스 파마 그로우쓰 디스오더스 에이/에스 |
낮은 npr-c 결합을 갖는 제어 방출성 cnp 작용제
|
|
CA3008015A1
(en)
|
2016-01-08 |
2017-07-13 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release c-type natriuretic peptide agonists with increased neutral endopeptidase stability
|
|
US10835578B2
(en)
|
2016-01-08 |
2020-11-17 |
Ascendis Pharma Growth Disorders A/S |
CNP prodrugs with large carrier moieties
|
|
EP4710947A3
(en)
|
2016-01-08 |
2026-06-17 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with reduced side-effects
|
|
JP6968802B2
(ja)
|
2016-01-08 |
2021-11-17 |
アセンディス ファーマ グロース ディスオーダーズ エー/エス |
環部分にキャリア結合を有するcnpプロドラッグ
|
|
AU2017205693B2
(en)
|
2016-01-08 |
2022-03-31 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release CNP agonists with low initial NPR-B activity
|
|
SI3423103T1
(sl)
|
2016-03-01 |
2024-12-31 |
Ascendis Pharma Bone Diseases A/S |
Predzdravila PTH
|
|
RU2768747C2
(ru)
|
2016-09-29 |
2022-03-24 |
Асцендис Фарма Гроус Дизордерс А/С |
Комбинаторная терапия с агонистами cnp контролируемого высвобождения
|
|
JP7039574B2
(ja)
|
2016-09-29 |
2022-03-22 |
アセンディス ファーマ ボーン ディジージズ エー/エス |
放出制御pth化合物の漸増用量設定
|
|
HUE063235T2
(hu)
|
2016-09-29 |
2024-01-28 |
Ascendis Pharma Bone Diseases As |
Adagolási rendszer szabályozott leadású PTH vegyülethez
|
|
KR102611820B1
(ko)
|
2016-09-29 |
2023-12-07 |
아센디스 파마 본 디지즈 에이/에스 |
낮은 피크 대 트로프 비를 가진 pth 화합물
|
|
CN108530637B
(zh)
*
|
2017-03-05 |
2021-03-30 |
厦门赛诺邦格生物科技股份有限公司 |
一种单一功能化支化聚乙二醇的制备方法
|
|
JP7338873B2
(ja)
|
2017-07-19 |
2023-09-05 |
ユニケリス・リミテッド |
強皮症関連血管障害を治療または改善するための組成物および方法
|
|
US12565525B2
(en)
|
2018-03-28 |
2026-03-03 |
Ascendis Pharma Oncology Division A/S |
IL-2 conjugates
|
|
CA3114056A1
(en)
|
2018-09-26 |
2020-04-02 |
Ascendis Pharma A/S |
Treatment of infections
|
|
CA3114272A1
(en)
|
2018-09-26 |
2020-04-02 |
Ascendis Pharma A/S |
Degradable hyaluronic acid hydrogels
|
|
AU2020221491B2
(en)
|
2019-02-11 |
2025-02-27 |
Ascendis Pharma Bone Diseases A/S |
Liquid pharmaceutical formulations of PTH conjugates
|
|
EP3923906A1
(en)
|
2019-02-11 |
2021-12-22 |
Ascendis Pharma Growth Disorders A/S |
Dry pharmaceutical formulations of cnp conjugates
|
|
CA3178074A1
(en)
|
2020-06-03 |
2021-12-09 |
Nina Gunnarsson |
Il-2 sequences and uses thereof
|