MX2009005780A - Metodo para preparar un conjugado de polimeros. - Google Patents

Metodo para preparar un conjugado de polimeros.

Info

Publication number
MX2009005780A
MX2009005780A MX2009005780A MX2009005780A MX2009005780A MX 2009005780 A MX2009005780 A MX 2009005780A MX 2009005780 A MX2009005780 A MX 2009005780A MX 2009005780 A MX2009005780 A MX 2009005780A MX 2009005780 A MX2009005780 A MX 2009005780A
Authority
MX
Mexico
Prior art keywords
preparing
polymer conjugate
straightforward
polyethylene glycol
active agent
Prior art date
Application number
MX2009005780A
Other languages
English (en)
Inventor
Wen Zhang
Original Assignee
Nektar Therapeutics Al Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics Al Corp filed Critical Nektar Therapeutics Al Corp
Publication of MX2009005780A publication Critical patent/MX2009005780A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33344—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carbamate group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

En la presente se provee un método directo y eficiente para el acoplamiento covalente de un polímero de polietilenglicol a un agente activo.
MX2009005780A 2006-11-30 2007-11-30 Metodo para preparar un conjugado de polimeros. MX2009005780A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86199506P 2006-11-30 2006-11-30
US316307P 2007-11-14 2007-11-14
PCT/US2007/024620 WO2008066902A2 (en) 2006-11-30 2007-11-30 Method for preparing a polymer conjugate

Publications (1)

Publication Number Publication Date
MX2009005780A true MX2009005780A (es) 2009-06-10

Family

ID=39345546

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005780A MX2009005780A (es) 2006-11-30 2007-11-30 Metodo para preparar un conjugado de polimeros.

Country Status (10)

Country Link
US (3) US8354549B2 (es)
EP (1) EP2104515B1 (es)
JP (1) JP5277417B2 (es)
KR (1) KR101441709B1 (es)
CN (1) CN101583380B (es)
AU (1) AU2007325631B9 (es)
CA (1) CA2669541C (es)
HK (1) HK1137647A1 (es)
MX (1) MX2009005780A (es)
WO (1) WO2008066902A2 (es)

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CA2732508C (en) * 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
US9059749B2 (en) * 2009-10-02 2015-06-16 Sharp Kabushiki Kaisha Antenna port mode and transmission mode transitions
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US8816099B2 (en) 2010-03-31 2014-08-26 Nof Corporation Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
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US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
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US11191843B2 (en) 2017-04-21 2021-12-07 Brightgene Bio-Medical Technology Co., Ltd. Multi-arm targeting anti-cancer conjugate
CN111346234B (zh) * 2020-03-23 2023-03-31 沈阳药科大学 去铁胺-八臂星型聚乙二醇结合物及其应用

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Also Published As

Publication number Publication date
JP5277417B2 (ja) 2013-08-28
CA2669541C (en) 2014-11-18
HK1137647A1 (en) 2010-08-06
US8937180B2 (en) 2015-01-20
KR101441709B1 (ko) 2014-09-18
US8541608B2 (en) 2013-09-24
US20100010194A1 (en) 2010-01-14
JP2010511744A (ja) 2010-04-15
WO2008066902A2 (en) 2008-06-05
CN101583380B (zh) 2013-07-10
US20130079533A1 (en) 2013-03-28
WO2008066902A3 (en) 2009-07-16
CA2669541A1 (en) 2008-06-05
KR20090085080A (ko) 2009-08-06
CN101583380A (zh) 2009-11-18
AU2007325631B2 (en) 2013-08-22
AU2007325631B9 (en) 2014-01-30
US8354549B2 (en) 2013-01-15
EP2104515B1 (en) 2018-11-14
AU2007325631A1 (en) 2008-06-05
US20140005419A1 (en) 2014-01-02
EP2104515A2 (en) 2009-09-30

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