JP2003505503A5 - - Google Patents
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- Publication number
- JP2003505503A5 JP2003505503A5 JP2001513407A JP2001513407A JP2003505503A5 JP 2003505503 A5 JP2003505503 A5 JP 2003505503A5 JP 2001513407 A JP2001513407 A JP 2001513407A JP 2001513407 A JP2001513407 A JP 2001513407A JP 2003505503 A5 JP2003505503 A5 JP 2003505503A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- inhibitor
- embedded image
- compound
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 description 31
- 229940124597 therapeutic agent Drugs 0.000 description 31
- 239000003112 inhibitor Substances 0.000 description 30
- 150000001875 compounds Chemical class 0.000 description 17
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 15
- 206010065687 Bone loss Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 210000002997 osteoclast Anatomy 0.000 description 12
- -1 3 -carboxy-4-chlorophenylamino Chemical group 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 0 COc1ccc(C(c(cc2)ccc2OC)(c(cc2)cc*2OC)Cl)cc1 Chemical compound COc1ccc(C(c(cc2)ccc2OC)(c(cc2)cc*2OC)Cl)cc1 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 125000000539 amino acid group Chemical group 0.000 description 4
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 150000001413 amino acids Chemical group 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- OBSIFIXXKXJEMM-LJSVPSOQSA-N CC(C12)[N]1(C)C21[C@H](C)CC1 Chemical compound CC(C12)[N]1(C)C21[C@H](C)CC1 OBSIFIXXKXJEMM-LJSVPSOQSA-N 0.000 description 1
- TYYDXNISHGVDGA-WIGCIBNNSA-N CC(CC1)(C(CC2)C(CC[C@H]3CC(CC4)O)C1C34C=O)C2C(CO1)=CC1=O Chemical compound CC(CC1)(C(CC2)C(CC[C@H]3CC(CC4)O)C1C34C=O)C2C(CO1)=CC1=O TYYDXNISHGVDGA-WIGCIBNNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14609499P | 1999-07-28 | 1999-07-28 | |
| US60/146,094 | 1999-07-28 | ||
| PCT/US2000/020502 WO2001008677A1 (en) | 1999-07-28 | 2000-07-28 | Methods of inhibiting osteoclast activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003505503A JP2003505503A (ja) | 2003-02-12 |
| JP2003505503A5 true JP2003505503A5 (enExample) | 2011-03-03 |
| JP4790179B2 JP4790179B2 (ja) | 2011-10-12 |
Family
ID=22515834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001513407A Expired - Fee Related JP4790179B2 (ja) | 1999-07-28 | 2000-07-28 | 破骨細胞活性を阻害する方法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1207873B1 (enExample) |
| JP (1) | JP4790179B2 (enExample) |
| AT (1) | ATE448781T1 (enExample) |
| AU (2) | AU778190B2 (enExample) |
| CA (2) | CA2647796A1 (enExample) |
| DE (1) | DE60043346D1 (enExample) |
| WO (1) | WO2001008677A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU777634B2 (en) * | 1999-07-28 | 2004-10-28 | Kazuhiro Aoki | Methods of inhibiting osteoclastogenesis |
| AU9303001A (en) | 2000-09-22 | 2002-04-02 | Immunex Corp | Screening assays for agonists or antagonists of receptor activat or of nf-kb |
| DE50212445D1 (de) | 2001-07-03 | 2008-08-14 | Febit Holding Gmbh | Zweistufige schutzgruppen für die synthese von biopolymeren |
| PT2152663E (pt) | 2007-06-04 | 2014-06-03 | Univ Ben Gurion | Compostos de triarilo e composições que compreendem os mesmos |
| WO2008150025A1 (ja) | 2007-06-05 | 2008-12-11 | Oriental Yeast Co., Ltd. | 新しい骨量増加薬 |
| CN102439026A (zh) * | 2008-05-13 | 2012-05-02 | A·R·舍拉尔 | 基于甾族惕告吉宁合成的苯甲酸腙的医学应用 |
| CN103797721B (zh) | 2011-09-09 | 2015-11-25 | 住友电气工业株式会社 | 供电系统和连接器 |
| US9556293B2 (en) | 2012-10-15 | 2017-01-31 | Iowa State University Research Foundation, Inc. | Polyisocyanates from fused bicyclic polyols and polyurethanes therefrom |
| US9828330B2 (en) | 2013-03-15 | 2017-11-28 | Pharmatrophix, Inc. | Non-peptide BDNF neurotrophin mimetics |
| CA2901839A1 (en) | 2013-03-15 | 2014-09-18 | Pharmatrophix, Inc. | Non-peptide bdnf neurotrophin mimetics |
| US9321803B2 (en) * | 2013-07-12 | 2016-04-26 | Children's Hospital Medical Center | Compositions and methods for inhibiting norovirus infection |
| EP3065723B1 (en) | 2013-11-05 | 2020-09-23 | Ben Gurion University of the Negev Research and Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
| US10077257B2 (en) | 2015-04-06 | 2018-09-18 | Iowa State University Research Foundation, Inc. | Aziridinated triglycerides and polymers formed therefrom |
| US10392471B2 (en) | 2015-05-14 | 2019-08-27 | Iowa State University Research Foundation, Inc. | Polymers and methods of making the same |
| WO2016186071A1 (ja) * | 2015-05-20 | 2016-11-24 | 国立大学法人大阪大学 | 炎症性サイトカイン分泌抑制活性を有するオリゴペプチド |
| US11833198B2 (en) | 2017-03-28 | 2023-12-05 | Children's Hospital Medical Center | Norovirus S particle based vaccines and methods of making and using same |
| CN110229118B (zh) * | 2019-06-28 | 2021-03-02 | 深圳市三启药物开发有限公司 | 腙酰胺类衍生物及其在制备抗骨质疏松药物中的应用 |
| CN111686116B (zh) * | 2020-06-08 | 2021-05-04 | 广东省微生物研究所（广东省微生物分析检测中心） | 孕甾烷衍生物在制备破骨细胞分化抑制剂中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999058674A2 (en) * | 1998-05-14 | 1999-11-18 | Immunex Corporation | Method of inhibiting osteoclast activity |
| ATE497001T1 (de) * | 1996-12-23 | 2011-02-15 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
| EP2196930B1 (en) * | 1998-07-01 | 2011-03-23 | The Trustees of The University of Pennsylvania | Cavity induced allosteric modificatin of intermolecular interactions and methods of identifiying compounds that effect the same |
| HRP20010188A2 (en) * | 1998-09-15 | 2002-04-30 | Pharmexa As | Method for down-regulating osteoprotegerin ligand activity |
| AU777634B2 (en) * | 1999-07-28 | 2004-10-28 | Kazuhiro Aoki | Methods of inhibiting osteoclastogenesis |
-
2000
- 2000-07-28 CA CA002647796A patent/CA2647796A1/en not_active Abandoned
- 2000-07-28 DE DE60043346T patent/DE60043346D1/de not_active Expired - Lifetime
- 2000-07-28 CA CA002380007A patent/CA2380007A1/en not_active Abandoned
- 2000-07-28 WO PCT/US2000/020502 patent/WO2001008677A1/en not_active Ceased
- 2000-07-28 AU AU63846/00A patent/AU778190B2/en not_active Ceased
- 2000-07-28 JP JP2001513407A patent/JP4790179B2/ja not_active Expired - Fee Related
- 2000-07-28 EP EP00950797A patent/EP1207873B1/en not_active Expired - Lifetime
- 2000-07-28 AT AT00950797T patent/ATE448781T1/de not_active IP Right Cessation
-
2005
- 2005-02-14 AU AU2005200650A patent/AU2005200650B2/en not_active Ceased
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