RU2296762C2 - Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе - Google Patents

Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2296762C2
RU2296762C2 RU2003122341/04A RU2003122341A RU2296762C2 RU 2296762 C2 RU2296762 C2 RU 2296762C2 RU 2003122341/04 A RU2003122341/04 A RU 2003122341/04A RU 2003122341 A RU2003122341 A RU 2003122341A RU 2296762 C2 RU2296762 C2 RU 2296762C2
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Russia
Prior art keywords
octane
azoniabicyclo
group
bromide
azabicyclo
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RU2003122341/04A
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English (en)
Russian (ru)
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RU2003122341A (ru
Inventor
АЛЬБЕРО Мари Антони БУИЛ (ES)
Альберо Мария Антония Буил
ФОРНЕР Мари Долорс ФЕРНАНДЕС (ES)
Форнер Мария Долорс Фернандес
КИНЬОНЕС Мари ПРАТ (ES)
Киньонес Мария Прат
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Альмиралль Продесфарма Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2003122341/04A 2000-12-22 2001-12-20 Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе RU2296762C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200003084 2000-12-22
ES200003084 2000-12-22

Publications (2)

Publication Number Publication Date
RU2003122341A RU2003122341A (ru) 2004-12-27
RU2296762C2 true RU2296762C2 (ru) 2007-04-10

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RU2003122341/04A RU2296762C2 (ru) 2000-12-22 2001-12-20 Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе

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US (3) US7208501B2 (enExample)
EP (1) EP1345937B1 (enExample)
JP (1) JP4445704B2 (enExample)
KR (1) KR100869722B1 (enExample)
CN (1) CN1298717C (enExample)
AR (1) AR035410A1 (enExample)
AT (1) ATE305468T1 (enExample)
AU (1) AU2002228015B2 (enExample)
BG (1) BG107930A (enExample)
BR (1) BR0116450A (enExample)
CA (1) CA2441896A1 (enExample)
CZ (1) CZ301323B6 (enExample)
DE (1) DE60113719T2 (enExample)
DK (1) DK1345937T3 (enExample)
EC (1) ECSP034660A (enExample)
EE (1) EE200300295A (enExample)
ES (1) ES2248409T3 (enExample)
HU (1) HUP0303529A3 (enExample)
IL (1) IL156499A0 (enExample)
MX (1) MXPA03005583A (enExample)
MY (1) MY136674A (enExample)
NO (1) NO328707B1 (enExample)
NZ (1) NZ526580A (enExample)
PE (1) PE20020719A1 (enExample)
PL (1) PL362989A1 (enExample)
RU (1) RU2296762C2 (enExample)
SI (1) SI1345937T1 (enExample)
SK (1) SK8002003A3 (enExample)
UA (1) UA76131C2 (enExample)
UY (1) UY27092A1 (enExample)
WO (1) WO2002051841A1 (enExample)
ZA (1) ZA200304769B (enExample)

Cited By (9)

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US8367696B2 (en) 2007-02-09 2013-02-05 Astellas Pharma Inc. Aza-bridged-ring compound
RU2567548C2 (ru) * 2010-06-22 2015-11-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные сложного аминоэфира алкалоида и их лекарственные композиции
RU2569846C2 (ru) * 2010-06-22 2015-11-27 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные сложных аминоэфиров и включающие их лекарственные композиции
RU2580835C2 (ru) * 2010-06-22 2016-04-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные на основе сложных аминоэфиров и композиции лекарственных средств, содержащие их
RU2585287C2 (ru) * 2011-01-28 2016-05-27 ЭсКей БАЙОФАРМАСЬЮТИКАЛЗ КО., ЛТД. Фармацевтическая композиция, содержащая производные пиридона
RU2585767C2 (ru) * 2010-11-26 2016-06-10 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные глицина и их применение в качестве антагонистов мускариновых рецепторов
RU2611627C2 (ru) * 2011-04-29 2017-02-28 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидный эфир и карбаматные производные и их медицинские композиции
RU2645675C2 (ru) * 2011-03-18 2018-02-27 Джензим Корпорейшн Ингибиторы глюкозилцерамид-синтазы
US12527776B2 (en) 2019-02-04 2026-01-20 Genzyme Corporation Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS)

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