JP2004532828A5 - - Google Patents
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- Publication number
- JP2004532828A5 JP2004532828A5 JP2002572952A JP2002572952A JP2004532828A5 JP 2004532828 A5 JP2004532828 A5 JP 2004532828A5 JP 2002572952 A JP2002572952 A JP 2002572952A JP 2002572952 A JP2002572952 A JP 2002572952A JP 2004532828 A5 JP2004532828 A5 JP 2004532828A5
- Authority
- JP
- Japan
- Prior art keywords
- tramadol
- pharmaceutical composition
- milligrams
- cis
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 229960004380 tramadol Drugs 0.000 claims 9
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 4
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229960003107 tramadol hydrochloride Drugs 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 0 COc1cc([C@@]2([C@@](CN(*)*)CCCC2)O)ccc1 Chemical compound COc1cc([C@@]2([C@@](CN(*)*)CCCC2)O)ccc1 0.000 description 3
- TVYLLZQTGLZFBW-BZSJEYESSA-N CN(C)CC(CCCC1)[C@@]1(c1cc(OC)ccc1)O Chemical compound CN(C)CC(CCCC1)[C@@]1(c1cc(OC)ccc1)O TVYLLZQTGLZFBW-BZSJEYESSA-N 0.000 description 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27680601P | 2001-03-16 | 2001-03-16 | |
| PCT/US2002/007928 WO2002074241A2 (en) | 2001-03-16 | 2002-03-15 | Method of delaying ejaculation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532828A JP2004532828A (ja) | 2004-10-28 |
| JP2004532828A5 true JP2004532828A5 (enExample) | 2006-01-05 |
| JP4377585B2 JP4377585B2 (ja) | 2009-12-02 |
Family
ID=23058139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002572952A Expired - Fee Related JP4377585B2 (ja) | 2001-03-16 | 2002-03-15 | 射精遅延の方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6974839B2 (enExample) |
| EP (1) | EP1397126B9 (enExample) |
| JP (1) | JP4377585B2 (enExample) |
| KR (1) | KR100908350B1 (enExample) |
| CN (1) | CN1289071C (enExample) |
| AT (1) | ATE326957T1 (enExample) |
| AU (1) | AU2002252361C1 (enExample) |
| CA (2) | CA2440920C (enExample) |
| CY (1) | CY1107478T1 (enExample) |
| DE (1) | DE60211689T2 (enExample) |
| DK (1) | DK1397126T5 (enExample) |
| ES (1) | ES2265495T3 (enExample) |
| MX (1) | MXPA03008372A (enExample) |
| NZ (1) | NZ528935A (enExample) |
| PT (1) | PT1397126E (enExample) |
| WO (1) | WO2002074241A2 (enExample) |
| ZA (1) | ZA200308067B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1397126B9 (en) * | 2001-03-16 | 2007-02-21 | DMI Biosciences, Inc. | Use of tramadol for delaying ejaculation |
| WO2003057223A1 (en) | 2002-01-02 | 2003-07-17 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| US7754767B2 (en) * | 2002-11-06 | 2010-07-13 | Trinity Laboratories, Inc. | Method for treatment of premature ejaculation in humans |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US8841345B2 (en) | 2003-03-21 | 2014-09-23 | Nexmed Holdings, Inc. | Compositions and methods for treatment of premature ejaculation |
| AU2003903597A0 (en) * | 2003-07-11 | 2003-07-24 | Jakov Vaisman | Treatment of premature ejaculation |
| US8604082B2 (en) * | 2005-12-13 | 2013-12-10 | Trinity Laboratories, Inc. | Method to treat premature ejaculation in humans |
| FR2907121B1 (fr) | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
| PL2114147T3 (pl) * | 2007-02-12 | 2012-10-31 | Vyrix Pharmaceuticals Inc | Zmniejszanie skutków ubocznych tramadolu |
| PL2120570T3 (pl) * | 2007-02-12 | 2012-10-31 | Vyrix Pharmaceuticals Inc | Leczenie współwystępującego przedwczesnego wytrysku i zaburzenia wzwodu prącia |
| WO2008131256A1 (en) * | 2007-04-19 | 2008-10-30 | Trinity Laboratories Inc. | Improved treatments for premature ejaculation in humans |
| US20090005319A1 (en) * | 2007-07-01 | 2009-01-01 | Barone Jr Frank V | Topical compositions for delaying ejaculation and methods of using the same |
| KR101103118B1 (ko) * | 2007-11-02 | 2012-01-04 | 동아제약주식회사 | 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물 |
| US8147848B2 (en) | 2009-08-26 | 2012-04-03 | Allergan, Inc. | Method for treating premature ejaculation with a botulinum neurotoxin |
| GR1007315B (el) * | 2010-04-19 | 2011-06-14 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, | Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
| US20180071269A1 (en) | 2015-08-12 | 2018-03-15 | Tianxin Wang | Therapeutical methods, formulations and nutraceutical formulations |
| US11000488B2 (en) | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830934A (en) | 1967-07-27 | 1974-08-20 | Gruenenthal Chemie | Analgesic and antitussive compositions and methods |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| US4507323A (en) | 1984-07-25 | 1985-03-26 | Burroughs Wellcome Co. | Treatment of psychosexual dysfunctions |
| US4940731A (en) | 1989-08-30 | 1990-07-10 | Pfizer Inc. | Method of treating premature ejaculation using sertraline |
| US5151448A (en) | 1991-07-12 | 1992-09-29 | Crenshaw Roger T | Method for treating premature ejaculation |
| NO300197B1 (no) | 1991-09-06 | 1997-04-28 | Mcneilab Inc | Preparater omfattende tramadol og et opioid |
| DE69226624T3 (de) | 1991-09-06 | 2009-11-05 | Ortho-Mcneil Pharmaceutical, Inc. | Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung |
| US5223541A (en) | 1991-09-13 | 1993-06-29 | Mcneilab, Inc. | Tramadol n-oxide material, enantiomers and compositions thereof, and their use |
| US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| US5276042A (en) | 1993-04-16 | 1994-01-04 | Crenshaw Roger T | Treatment of premature ejaculation |
| IL109460A (en) | 1993-05-10 | 1998-03-10 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
| DE4329794C2 (de) | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
| IT1264965B1 (it) | 1993-11-12 | 1996-10-17 | Giorgio Cavallini | Uso di alfa 1-bloccanti nel trattamento della eiaculazione precoce |
| US6017963A (en) | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| DE19547766A1 (de) | 1995-12-20 | 1997-06-26 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe |
| DE19601744C2 (de) | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
| DE19601745C1 (de) | 1996-01-19 | 1997-10-09 | Gruenenthal Gmbh | Verfahren zur Racematspaltung von Tramadol |
| DE19609847A1 (de) | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| IL119121A (en) | 1996-08-22 | 2000-11-21 | Chemagis Ltd | Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride |
| DE19641576C1 (de) * | 1996-10-09 | 1998-05-07 | Gruenenthal Gmbh | Kombinationspräparat enthaltend Tramadol und einen Calcium-Kanal Antagonisten |
| US5919826A (en) | 1996-10-24 | 1999-07-06 | Algos Pharmaceutical Corporation | Method of alleviating pain |
| WO1998046216A1 (fr) | 1997-04-11 | 1998-10-22 | Nippon Shinyaku Co., Ltd. | Traitements des mictions frequentes et de l'incontinence urinaire |
| US6399618B1 (en) | 1997-07-09 | 2002-06-04 | Cardiome Pharma Corp | Compositions and methods for modulating sexual activity |
| US6037360A (en) | 1997-10-28 | 2000-03-14 | Vivus, Incorporated | Administration of 5-HT3 receptor antagonists to treat premature ejaculation |
| US5922341A (en) | 1997-10-28 | 1999-07-13 | Vivus, Incorporated | Local administration of pharmacologically active agents to treat premature ejaculation |
| US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
| US6228864B1 (en) | 1997-10-28 | 2001-05-08 | Vivus, Inc. | Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation |
| US6156342A (en) | 1998-05-26 | 2000-12-05 | Andex Pharmaceuticals, Inc. | Controlled release oral dosage form |
| GB2340037A (en) | 1998-07-30 | 2000-02-16 | Glaxo Group Ltd | Compositions comprising bupropion for the treatment of premature ejaculation |
| US6337328B1 (en) | 1999-03-01 | 2002-01-08 | Sepracor, Inc. | Bupropion metabolites and methods of use |
| US6376554B1 (en) | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
| EP1180021A4 (en) | 1999-05-06 | 2005-01-19 | Pentech Pharmaceuticals Inc | TREATMENT OF THE PREMATURE EJACULATION AND ASSOCIATED KIT |
| KR100719977B1 (ko) | 1999-09-03 | 2007-05-21 | 에이피비아이 홀딩스, 엘엘씨 | 성기능 장애 치료를 위하여 효과 발현이 신속한 선택적 세로토닌 재흡수 억제제를 사용하는 방법 |
| US6339105B1 (en) | 1999-10-12 | 2002-01-15 | Ortho-Mcneil Pharmaceutical, Inc. | Analgesic regimen |
| AU1164601A (en) | 1999-11-09 | 2001-06-06 | Darwin Discovery Limited | Therapeutic use and formulation |
| US6630138B2 (en) | 2000-02-11 | 2003-10-07 | Eli Lilly And Company | Protein C derivatives |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| US6495154B1 (en) | 2000-11-21 | 2002-12-17 | Vivus Inc. | On demand administration of clomipramine and salts thereof to treat premature ejaculation |
| EP1397126B9 (en) * | 2001-03-16 | 2007-02-21 | DMI Biosciences, Inc. | Use of tramadol for delaying ejaculation |
-
2002
- 2002-03-15 EP EP02721427A patent/EP1397126B9/en not_active Expired - Lifetime
- 2002-03-15 CN CNB028099281A patent/CN1289071C/zh not_active Expired - Fee Related
- 2002-03-15 MX MXPA03008372A patent/MXPA03008372A/es active IP Right Grant
- 2002-03-15 PT PT02721427T patent/PT1397126E/pt unknown
- 2002-03-15 AU AU2002252361A patent/AU2002252361C1/en not_active Ceased
- 2002-03-15 NZ NZ528935A patent/NZ528935A/en not_active IP Right Cessation
- 2002-03-15 JP JP2002572952A patent/JP4377585B2/ja not_active Expired - Fee Related
- 2002-03-15 DE DE60211689T patent/DE60211689T2/de not_active Expired - Lifetime
- 2002-03-15 AT AT02721427T patent/ATE326957T1/de active
- 2002-03-15 CA CA2440920A patent/CA2440920C/en not_active Expired - Fee Related
- 2002-03-15 WO PCT/US2002/007928 patent/WO2002074241A2/en not_active Ceased
- 2002-03-15 DK DK02721427T patent/DK1397126T5/da active
- 2002-03-15 KR KR1020037012090A patent/KR100908350B1/ko not_active Expired - Fee Related
- 2002-03-15 ES ES02721427T patent/ES2265495T3/es not_active Expired - Lifetime
- 2002-03-15 CA CA2758923A patent/CA2758923A1/en not_active Abandoned
- 2002-03-15 US US10/098,826 patent/US6974839B2/en not_active Expired - Fee Related
-
2003
- 2003-10-16 ZA ZA2003/08067A patent/ZA200308067B/en unknown
-
2005
- 2005-09-01 US US11/219,322 patent/US20060106113A1/en not_active Abandoned
-
2006
- 2006-08-23 CY CY20061101166T patent/CY1107478T1/el unknown
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