JP2004500426A5 - - Google Patents
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- Publication number
- JP2004500426A5 JP2004500426A5 JP2001576014A JP2001576014A JP2004500426A5 JP 2004500426 A5 JP2004500426 A5 JP 2004500426A5 JP 2001576014 A JP2001576014 A JP 2001576014A JP 2001576014 A JP2001576014 A JP 2001576014A JP 2004500426 A5 JP2004500426 A5 JP 2004500426A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disease
- pharmaceutical composition
- pharmaceutically acceptable
- parkinson
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 7
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 206010019280 Heart failures Diseases 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- SYHVBRQKMHIAJQ-UHFFFAOYSA-N 3-(2-aminoethyl)benzene-1,2-diol Chemical compound NCCC1=CC=CC(O)=C1O SYHVBRQKMHIAJQ-UHFFFAOYSA-N 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001438A SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | New chemical compounds and their use in therapy |
| SE0001438-1 | 2000-04-18 | ||
| PCT/SE2001/000840 WO2001078713A1 (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500426A JP2004500426A (ja) | 2004-01-08 |
| JP2004500426A5 true JP2004500426A5 (enExample) | 2008-06-19 |
| JP4819280B2 JP4819280B2 (ja) | 2011-11-24 |
Family
ID=20279367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001576014A Expired - Fee Related JP4819280B2 (ja) | 2000-04-18 | 2001-04-17 | カテコールアミンのプロドラッグとしてのフェニルエチルアミンおよび縮合環のヴァリアント（ｖａｒｉａｎｔ）、ならびにその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6683087B2 (enExample) |
| EP (1) | EP1274411B1 (enExample) |
| JP (1) | JP4819280B2 (enExample) |
| CN (2) | CN100383126C (enExample) |
| AT (1) | ATE300290T1 (enExample) |
| AU (2) | AU4898201A (enExample) |
| CA (1) | CA2406044C (enExample) |
| CZ (1) | CZ20023455A3 (enExample) |
| DE (1) | DE60112269T2 (enExample) |
| DK (1) | DK1274411T3 (enExample) |
| ES (1) | ES2244604T3 (enExample) |
| HU (1) | HU229794B1 (enExample) |
| NZ (1) | NZ521860A (enExample) |
| PL (1) | PL204661B1 (enExample) |
| PT (1) | PT1274411E (enExample) |
| SE (1) | SE0001438D0 (enExample) |
| SI (1) | SI1274411T1 (enExample) |
| WO (1) | WO2001078713A1 (enExample) |
| ZA (1) | ZA200207919B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013965A2 (en) * | 2005-07-22 | 2007-02-01 | Sloan-Kettering Institute For Cancer Research | Synthesis of scabronines and analogues thereof |
| US7910623B2 (en) * | 2005-07-22 | 2011-03-22 | Sloan-Kettering Institute For Cancer Research | Synthesis of scabronines and analogues thereof |
| WO2007013830A1 (en) | 2005-07-26 | 2007-02-01 | Portela & Ca. S.A. | Nitrocatechol derivatives as comt inhibitors |
| EP1845097A1 (en) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| DK2481410T3 (en) | 2007-01-31 | 2016-10-24 | Bial - Portela & Ca S A | Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen |
| US20090124651A1 (en) | 2007-08-31 | 2009-05-14 | H. Lundbeck A/S | Catecholamine derivatives and prodrugs thereof |
| BRPI0908731A2 (pt) | 2008-03-17 | 2017-05-16 | Bial - Portela & C A S A | formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol |
| TW201036949A (en) * | 2009-02-27 | 2010-10-16 | Lundbeck & Co As H | Treatment of dyskinesia related disorders |
| CN102448444B (zh) | 2009-04-01 | 2016-05-25 | 巴尔-波特拉及康邦亚股份有限公司 | 包括硝基儿茶酚衍生物的药物制剂及其制备方法 |
| US8492538B1 (en) * | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| US8558016B2 (en) * | 2009-09-18 | 2013-10-15 | Kabaushiki Kaisha Riverson | Polyphenol derivative and method for producing the same |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| US9126988B2 (en) | 2011-12-13 | 2015-09-08 | Bial—Portela & Ca, S.A. | Intermediate for preparing a catechol-O-methyltransferase inhibitor |
| WO2016083863A1 (en) | 2014-11-28 | 2016-06-02 | Bial - Portela & Ca, S.A. | Medicaments for slowing parkinson's disease |
| PT3713933T (pt) | 2017-11-24 | 2026-05-19 | H Lundbeck As | Novos profrmacos de catecolamina para utilizao no tratamento de doena de parkinson |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US12391650B2 (en) | 2019-05-21 | 2025-08-19 | H. Lundbeck A/S | Catecholamine prodrugs for use in the treatment of Parkinson's disease |
| EP3972600B1 (en) | 2019-05-21 | 2026-02-18 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
| WO2020234275A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
| JP7641234B2 (ja) | 2019-05-21 | 2025-03-06 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| WO2022106352A1 (en) | 2020-11-17 | 2022-05-27 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
| JP2025514341A (ja) | 2022-04-25 | 2025-05-02 | インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー | 新規１，２，３，４，４ａ，５，６，７，８，９，１０，１０ａ－ドデカヒドロベンゾ［Ｇ］キノリン－６－オール化合物及びその使用 |
| JP2025513617A (ja) | 2022-04-25 | 2025-04-24 | インテグレーティブ リサーチ ラボラトリーズ スウェーデン アーベー | １，２，３，４，４ａ，５，６，７，８，９，１０，１０ａ－ドデカヒドロベンゾ［ｇ］キノリン－６－オール化合物の新規エステル及びその使用 |
| WO2023208867A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF |
| WO2025078574A1 (en) | 2023-10-12 | 2025-04-17 | Integrative Research Laboratories Sweden Ab | NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
| WO2025078571A1 (en) | 2023-10-12 | 2025-04-17 | Integrative Research Laboratories Sweden Ab | NOVEL CARBONATES AND CARBAMATES OF 1,2,3,4,4a,5,6,7,8,9,10,10a- DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1179954A (fr) * | 1956-02-11 | 1959-05-29 | Rhone Poulenc Sa | -1 cyclohexène-1 ones-3 nu-disubstituées, leurs dérivés et leur préparation |
| US3991207A (en) * | 1971-03-18 | 1976-11-09 | Pfizer Inc. | Combination therapy for Parkinson's disease |
| GB1593888A (en) * | 1977-12-22 | 1981-07-22 | Wyeth John & Brother Ltd | Hexahydroazepine piperidine and pyrrolidine derivatives |
| ZA805648B (en) * | 1979-09-14 | 1982-04-28 | Sandoz Ltd | Tetraline derivatives, their production and pharmaceutical compositions containing them |
| EP0026848B1 (de) * | 1979-09-14 | 1983-05-04 | Sandoz Ag | Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten |
| ATE56958T1 (de) * | 1981-10-16 | 1990-10-15 | Sandoz Ag | 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)chinolinderivate mit pharmazeutischer wirkung. |
| AU6072090A (en) * | 1989-07-05 | 1991-02-06 | Whitby Research, Inc. | Substituted 2-aminotetralins |
| DK0641320T3 (da) * | 1991-04-17 | 2001-08-20 | Upjohn Co | Substituerede (S)-3-phenylpiperidinderivater, deres fremstilling og deres anvendelse som dopaminautoreceptorantagonister |
| DE4114325A1 (de) | 1991-05-02 | 1992-11-05 | Sandoz Ag | Octahydrobenzo(g)chinolin, seine herstellung und verwendung |
| GB2260980A (en) * | 1991-10-31 | 1993-05-05 | Shell Int Research | Preparation of unsaturated cyclic ketones |
| GB9326010D0 (en) * | 1993-12-21 | 1994-02-23 | Sandoz Ltd | Improvements in or relating to organic compounds |
| EP0957080B1 (en) * | 1997-08-07 | 2006-06-21 | Fujimoto Brothers Co., Ltd. | Novel ethylamine derivatives |
| WO2000006536A1 (en) * | 1998-07-28 | 2000-02-10 | Warner-Lambert Company | Hexahydro-naphthalenone oximes and hydrazones |
| SV2001000202A (es) * | 1999-10-20 | 2001-10-16 | Warner Lambert Co | Uso de (-)-5-ceto-2-n,n-d1-n-propilamino-tetrahidrotetralina para el tratamiento del mal de parkinson |
-
2000
- 2000-04-18 SE SE0001438A patent/SE0001438D0/xx unknown
-
2001
- 2001-04-17 SI SI200130409T patent/SI1274411T1/sl unknown
- 2001-04-17 JP JP2001576014A patent/JP4819280B2/ja not_active Expired - Fee Related
- 2001-04-17 AU AU4898201A patent/AU4898201A/xx active Pending
- 2001-04-17 PL PL365113A patent/PL204661B1/pl unknown
- 2001-04-17 ES ES01922208T patent/ES2244604T3/es not_active Expired - Lifetime
- 2001-04-17 DE DE60112269T patent/DE60112269T2/de not_active Expired - Lifetime
- 2001-04-17 NZ NZ521860A patent/NZ521860A/en not_active IP Right Cessation
- 2001-04-17 HU HU0300543A patent/HU229794B1/hu not_active IP Right Cessation
- 2001-04-17 US US10/258,014 patent/US6683087B2/en not_active Expired - Fee Related
- 2001-04-17 WO PCT/SE2001/000840 patent/WO2001078713A1/en not_active Ceased
- 2001-04-17 CA CA002406044A patent/CA2406044C/en not_active Expired - Fee Related
- 2001-04-17 PT PT01922208T patent/PT1274411E/pt unknown
- 2001-04-17 EP EP01922208A patent/EP1274411B1/en not_active Expired - Lifetime
- 2001-04-17 CN CNB2005101253198A patent/CN100383126C/zh not_active Expired - Fee Related
- 2001-04-17 AT AT01922208T patent/ATE300290T1/de active
- 2001-04-17 AU AU2001248982A patent/AU2001248982B2/en not_active Ceased
- 2001-04-17 DK DK01922208T patent/DK1274411T3/da active
- 2001-04-17 CZ CZ20023455A patent/CZ20023455A3/cs unknown
- 2001-04-17 CN CNB018082858A patent/CN1234351C/zh not_active Expired - Fee Related
-
2002
- 2002-10-02 ZA ZA200207919A patent/ZA200207919B/xx unknown
-
2003
- 2003-12-18 US US10/737,782 patent/US6998405B2/en not_active Ceased
-
2007
- 2007-04-25 US US11/790,465 patent/USRE42802E1/en not_active Expired - Fee Related
-
2010
- 2010-11-12 US US12/945,057 patent/USRE43244E1/en not_active Expired - Fee Related
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