CN114401962A - 作为crbn蛋白调节剂的双并环类化合物 - Google Patents

作为crbn蛋白调节剂的双并环类化合物 Download PDF

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CN114401962A
CN114401962A CN202080064534.4A CN202080064534A CN114401962A CN 114401962 A CN114401962 A CN 114401962A CN 202080064534 A CN202080064534 A CN 202080064534A CN 114401962 A CN114401962 A CN 114401962A
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compound
reaction
reaction mixture
ethyl acetate
room temperature
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CN114401962B (zh
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罗云富
雷茂义
徐雨
栗俊苗
张国利
董井红
陈曙辉
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Medshine Discovery Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D491/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

一种式(III)所示化合物或其药学上可接受的盐，并公开了其在制备治疗与CRBN受体相关疾病药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN202080064534.4A 2019-09-12 2020-09-14 作为crbn蛋白调节剂的双并环类化合物 Active CN114401962B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN2019108657546 2019-09-12
CN201910867013 2019-09-12
CN201910865754 2019-09-12
CN2019108670131 2019-09-12
CN201910866549 2019-09-12
CN2019108665491 2019-09-12
PCT/CN2020/115126 WO2021047674A1 (zh) 2019-09-12 2020-09-14 作为crbn蛋白调节剂的双并环类化合物

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US (1) US11905276B2 (zh)
EP (1) EP4043455A4 (zh)
JP (1) JP7209897B2 (zh)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115380026A (zh) * 2020-03-17 2022-11-22 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法
CN115403544A (zh) * 2022-09-16 2022-11-29 台州永健医药科技有限公司 一种丹酚酸c的制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117751112A (zh) * 2021-07-19 2024-03-22 南京明德新药研发有限公司 杂芳-3-哌啶二酮类化合物及其应用
WO2023227696A1 (en) * 2022-05-25 2023-11-30 Katholieke Universiteit Leuven New derivatives for treating trpm3 mediated disorders
WO2024114639A1 (en) * 2022-11-28 2024-06-06 Shanghai Degron Biomedical Technology Co., Ltd. Compounds for modulating hur (elavl1)

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2010056344A1 (en) * 2008-11-14 2010-05-20 Concert Pharmaceuticals Inc. Substituted dioxopiperidinyl phthalimide derivaties
WO2014039960A1 (en) * 2012-09-10 2014-03-13 Celgene Corporation Methods for the treatment of locally advanced breast cancer
WO2017152076A1 (en) * 2016-03-04 2017-09-08 Vanderbilt University Substituted indole mcl-1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018215212B2 (en) * 2017-01-31 2022-06-02 Arvinas Operations, Inc. Cereblon ligands and bifunctional compounds comprising the same
EP3848371A4 (en) * 2018-09-07 2022-06-08 Medshine Discovery Inc. TRICYCLIC FURAN-SUBSTITUTED PIPERIDONEE COMPOUND
WO2020048546A1 (zh) * 2018-09-07 2020-03-12 南京明德新药研发有限公司 三环取代哌啶二酮类化合物
CA3111649A1 (en) * 2018-09-07 2020-03-12 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Tricyclic compounds acting on crbn proteins
CA3150653A1 (en) * 2019-09-12 2021-03-18 Yunfu Luo FUSED CYCLIC COMPOUND CAPABLE OF DEGRADING A PROTEIN AND ITS USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010056344A1 (en) * 2008-11-14 2010-05-20 Concert Pharmaceuticals Inc. Substituted dioxopiperidinyl phthalimide derivaties
WO2014039960A1 (en) * 2012-09-10 2014-03-13 Celgene Corporation Methods for the treatment of locally advanced breast cancer
WO2017152076A1 (en) * 2016-03-04 2017-09-08 Vanderbilt University Substituted indole mcl-1 inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115380026A (zh) * 2020-03-17 2022-11-22 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法
CN115403544A (zh) * 2022-09-16 2022-11-29 台州永健医药科技有限公司 一种丹酚酸c的制备方法
CN115403544B (zh) * 2022-09-16 2024-05-31 台州永健医药科技有限公司 一种丹酚酸c的制备方法

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WO2021047674A1 (zh) 2021-03-18
US11905276B2 (en) 2024-02-20
EP4043455A4 (en) 2023-09-20
EP4043455A1 (en) 2022-08-17
US20230348441A1 (en) 2023-11-02
CN114401962B (zh) 2024-05-24
JP7209897B2 (ja) 2023-01-20
JP2022537605A (ja) 2022-08-26

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