SE0001438D0 - New chemical compounds and their use in therapy - Google Patents
New chemical compounds and their use in therapyInfo
- Publication number
- SE0001438D0 SE0001438D0 SE0001438A SE0001438A SE0001438D0 SE 0001438 D0 SE0001438 D0 SE 0001438D0 SE 0001438 A SE0001438 A SE 0001438A SE 0001438 A SE0001438 A SE 0001438A SE 0001438 D0 SE0001438 D0 SE 0001438D0
- Authority
- SE
- Sweden
- Prior art keywords
- carbon atoms
- alkyl
- groups
- group
- absent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0001438A SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | New chemical compounds and their use in therapy |
PL365113A PL204661B1 (pl) | 2000-04-18 | 2001-04-17 | Fenyloetyloaminy i odmiany skondensowanych układów pierścieniowych jako proleki katecholamin, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
PT01922208T PT1274411E (pt) | 2000-04-18 | 2001-04-17 | Feniletilaminas e variantes de aneis condensados como pro-farmacos de catecolaminas, e sua utilizacao |
EP01922208A EP1274411B1 (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
CZ20023455A CZ20023455A3 (cs) | 2000-04-18 | 2001-04-17 | Fenylethylaminy a jejich varianty s anelovanými kruhy jako proléčiva katecholaminů a jejich použití |
CNB018082858A CN1234351C (zh) | 2000-04-18 | 2001-04-17 | 作为儿茶酚胺前体药物的苯乙胺和稠环变体及其用途 |
DK01922208T DK1274411T3 (da) | 2000-04-18 | 2001-04-17 | Phenylethylaminer og ringkondenserede varianter som prodrugs af catecholaminer og deres anvendelse |
CNB2005101253198A CN100383126C (zh) | 2000-04-18 | 2001-04-17 | 作为儿茶酚胺前体药物的苯乙胺和稠环变体及其用途 |
HU0300543A HU229794B1 (hu) | 2000-04-18 | 2001-04-17 | Katekolamin prodrug fenil-etil-aminok és kondenzált gyûrûs származékaik, valamint ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények |
JP2001576014A JP4819280B2 (ja) | 2000-04-18 | 2001-04-17 | カテコールアミンのプロドラッグとしてのフェニルエチルアミンおよび縮合環のヴァリアント(variant)、ならびにその使用 |
DE60112269T DE60112269T2 (de) | 2000-04-18 | 2001-04-17 | Phenylethylamine und ringkondensierte varianten als pro-drugs von katecholaminen sowie ihre verwendung |
PCT/SE2001/000840 WO2001078713A1 (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
NZ521860A NZ521860A (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as drugs of catecholamines, preparation process and their use |
SI200130409T SI1274411T1 (sl) | 2000-04-18 | 2001-04-17 | Feniletilamini in variante s kondenziranimi obroci kot predzdravila kateholaminov in njihova uporaba |
AU4898201A AU4898201A (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
ES01922208T ES2244604T3 (es) | 2000-04-18 | 2001-04-17 | Feniletilaminas y variantes de anillos condensados como profarmacos de catecolaminas y su uso. |
AU2001248982A AU2001248982B2 (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
CA002406044A CA2406044C (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
AT01922208T ATE300290T1 (de) | 2000-04-18 | 2001-04-17 | Phenylethylamine und ringkondensierte varianten als pro-drugs von katecholaminen sowie ihre verwendung |
US10/258,014 US6683087B2 (en) | 2000-04-18 | 2001-04-17 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
ZA200207919A ZA200207919B (en) | 2000-04-18 | 2002-10-02 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use. |
US10/737,782 US6998405B2 (en) | 2000-04-18 | 2003-12-18 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
HK06108406A HK1088009A1 (en) | 2000-04-18 | 2006-07-28 | Phenylethylamines and condensend rings variants asprodrugs of catecholamines and their use |
US11/790,465 USRE42802E1 (en) | 2000-04-18 | 2007-04-25 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
US12/945,057 USRE43244E1 (en) | 2000-04-18 | 2010-11-12 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0001438A SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | New chemical compounds and their use in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0001438D0 true SE0001438D0 (sv) | 2000-04-18 |
Family
ID=20279367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0001438A SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | New chemical compounds and their use in therapy |
Country Status (20)
Country | Link |
---|---|
US (4) | US6683087B2 (xx) |
EP (1) | EP1274411B1 (xx) |
JP (1) | JP4819280B2 (xx) |
CN (2) | CN1234351C (xx) |
AT (1) | ATE300290T1 (xx) |
AU (2) | AU2001248982B2 (xx) |
CA (1) | CA2406044C (xx) |
CZ (1) | CZ20023455A3 (xx) |
DE (1) | DE60112269T2 (xx) |
DK (1) | DK1274411T3 (xx) |
ES (1) | ES2244604T3 (xx) |
HK (1) | HK1088009A1 (xx) |
HU (1) | HU229794B1 (xx) |
NZ (1) | NZ521860A (xx) |
PL (1) | PL204661B1 (xx) |
PT (1) | PT1274411E (xx) |
SE (1) | SE0001438D0 (xx) |
SI (1) | SI1274411T1 (xx) |
WO (1) | WO2001078713A1 (xx) |
ZA (1) | ZA200207919B (xx) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7910623B2 (en) * | 2005-07-22 | 2011-03-22 | Sloan-Kettering Institute For Cancer Research | Synthesis of scabronines and analogues thereof |
WO2007013965A2 (en) * | 2005-07-22 | 2007-02-01 | Sloan-Kettering Institute For Cancer Research | Synthesis of scabronines and analogues thereof |
NZ565460A (en) | 2005-07-26 | 2011-06-30 | Bial Portela & Ca Sa | Nitrocatechol derivatives as COMT inhibitors |
EP1845097A1 (en) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
SI2481410T1 (sl) | 2007-01-31 | 2017-01-31 | Bial - Portela & Ca., S.A. | Derivati nitrokatehola kot COMT inhibitorji, ki se dajejo s specifičnim dozirnim režimom |
US20090124651A1 (en) | 2007-08-31 | 2009-05-14 | H. Lundbeck A/S | Catecholamine derivatives and prodrugs thereof |
TW200942531A (en) | 2008-03-17 | 2009-10-16 | Bial Portela & Companhia S A | Crystal forms of a nitrocatechol |
TW201036949A (en) * | 2009-02-27 | 2010-10-16 | Lundbeck & Co As H | Treatment of dyskinesia related disorders |
DK2413912T3 (da) | 2009-04-01 | 2019-06-17 | Bial Portela & Ca Sa | Farmaceutiske formuleringer, der omfatter nitrocatecholderivater, og metoder til fremstilling deraf |
US8492538B1 (en) * | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
CN102648284B (zh) * | 2009-09-18 | 2014-09-24 | 株式会社里维松 | 多酚衍生物及其制造方法 |
US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
WO2013089573A1 (en) | 2011-12-13 | 2013-06-20 | BIAL - PORTELA & Cª., S.A. | Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor |
JP2018500300A (ja) | 2014-11-28 | 2018-01-11 | ノヴィファーマ,エス.アー. | パーキンソン病を遅延させるための医薬 |
PE20211290A1 (es) | 2017-11-24 | 2021-07-20 | H Lundbeck As | Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
WO2020234277A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
EP3972959A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
JP2022533311A (ja) | 2019-05-21 | 2022-07-22 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
US20220213071A1 (en) | 2019-05-21 | 2022-07-07 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
US20240025857A1 (en) | 2020-11-17 | 2024-01-25 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
WO2023208865A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[G]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
WO2023208867A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF |
WO2023208869A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[G]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
Family Cites Families (14)
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FR1179954A (fr) * | 1956-02-11 | 1959-05-29 | Rhone Poulenc Sa | -1 cyclohexène-1 ones-3 nu-disubstituées, leurs dérivés et leur préparation |
US3991207A (en) * | 1971-03-18 | 1976-11-09 | Pfizer Inc. | Combination therapy for Parkinson's disease |
GB1593888A (en) | 1977-12-22 | 1981-07-22 | Wyeth John & Brother Ltd | Hexahydroazepine piperidine and pyrrolidine derivatives |
EP0026848B1 (de) | 1979-09-14 | 1983-05-04 | Sandoz Ag | Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten |
ZA805648B (en) * | 1979-09-14 | 1982-04-28 | Sandoz Ltd | Tetraline derivatives, their production and pharmaceutical compositions containing them |
DE19575006I2 (de) * | 1981-10-16 | 2003-01-09 | Novartis Ag | 1, 2, 3, 4a, 5, 10, 10a-Octahydrobenzo(g)chinolin-Derivate mit pharmazeutischer Wirkung |
CA2065450A1 (en) | 1989-07-05 | 1991-01-06 | James V. Peck | Substituted 2-aminotetralins |
EP0641320B1 (en) * | 1991-04-17 | 2001-05-30 | PHARMACIA & UPJOHN COMPANY | Substituted (s)-3-phenylpiperidine derivatives, their preparation and their use as dopamine autoreceptor antagonists |
DE4114325A1 (de) | 1991-05-02 | 1992-11-05 | Sandoz Ag | Octahydrobenzo(g)chinolin, seine herstellung und verwendung |
GB2260980A (en) * | 1991-10-31 | 1993-05-05 | Shell Int Research | Preparation of unsaturated cyclic ketones |
GB9326010D0 (en) * | 1993-12-21 | 1994-02-23 | Sandoz Ltd | Improvements in or relating to organic compounds |
PT957080E (pt) * | 1997-08-07 | 2006-10-31 | Fujimoto Brothers Co Ltd | Novos derivados de etilamina |
WO2000006536A1 (en) | 1998-07-28 | 2000-02-10 | Warner-Lambert Company | Hexahydro-naphthalenone oximes and hydrazones |
SV2001000202A (es) | 1999-10-20 | 2001-10-16 | Warner Lambert Co | Uso de (-)-5-ceto-2-n,n-d1-n-propilamino-tetrahidrotetralina para el tratamiento del mal de parkinson |
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2000
- 2000-04-18 SE SE0001438A patent/SE0001438D0/xx unknown
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2001
- 2001-04-17 JP JP2001576014A patent/JP4819280B2/ja not_active Expired - Fee Related
- 2001-04-17 CN CNB018082858A patent/CN1234351C/zh not_active Expired - Fee Related
- 2001-04-17 DE DE60112269T patent/DE60112269T2/de not_active Expired - Lifetime
- 2001-04-17 CA CA002406044A patent/CA2406044C/en not_active Expired - Fee Related
- 2001-04-17 AU AU2001248982A patent/AU2001248982B2/en not_active Ceased
- 2001-04-17 CN CNB2005101253198A patent/CN100383126C/zh not_active Expired - Fee Related
- 2001-04-17 NZ NZ521860A patent/NZ521860A/en not_active IP Right Cessation
- 2001-04-17 EP EP01922208A patent/EP1274411B1/en not_active Expired - Lifetime
- 2001-04-17 WO PCT/SE2001/000840 patent/WO2001078713A1/en active IP Right Grant
- 2001-04-17 ES ES01922208T patent/ES2244604T3/es not_active Expired - Lifetime
- 2001-04-17 CZ CZ20023455A patent/CZ20023455A3/cs unknown
- 2001-04-17 PL PL365113A patent/PL204661B1/pl unknown
- 2001-04-17 SI SI200130409T patent/SI1274411T1/sl unknown
- 2001-04-17 AT AT01922208T patent/ATE300290T1/de active
- 2001-04-17 DK DK01922208T patent/DK1274411T3/da active
- 2001-04-17 AU AU4898201A patent/AU4898201A/xx active Pending
- 2001-04-17 PT PT01922208T patent/PT1274411E/pt unknown
- 2001-04-17 US US10/258,014 patent/US6683087B2/en not_active Expired - Fee Related
- 2001-04-17 HU HU0300543A patent/HU229794B1/hu not_active IP Right Cessation
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2002
- 2002-10-02 ZA ZA200207919A patent/ZA200207919B/xx unknown
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2003
- 2003-12-18 US US10/737,782 patent/US6998405B2/en not_active Ceased
-
2006
- 2006-07-28 HK HK06108406A patent/HK1088009A1/xx not_active IP Right Cessation
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2007
- 2007-04-25 US US11/790,465 patent/USRE42802E1/en not_active Expired - Fee Related
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2010
- 2010-11-12 US US12/945,057 patent/USRE43244E1/en not_active Expired - Fee Related
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