HUP0300543A2 - Katekolamin prodrug fenil-etil-aminok és kondenzált gyűrűs származékaik, valamint ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Katekolamin prodrug fenil-etil-aminok és kondenzált gyűrűs származékaik, valamint ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0300543A2
HUP0300543A2 HU0300543A HUP0300543A HUP0300543A2 HU P0300543 A2 HUP0300543 A2 HU P0300543A2 HU 0300543 A HU0300543 A HU 0300543A HU P0300543 A HUP0300543 A HU P0300543A HU P0300543 A2 HUP0300543 A2 HU P0300543A2
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Hungary
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ring
alkyl
group
absent
methyl
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HU0300543A
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English (en)
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Durk Dijkstra
Bastiaan Johan Venhuis
Hakan Wikström
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Axon Biochemicals B.V.
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Publication of HUP0300543A2 publication Critical patent/HUP0300543A2/hu
Publication of HUP0300543A3 publication Critical patent/HUP0300543A3/hu
Publication of HU229794B1 publication Critical patent/HU229794B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Cardiology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány új (I) általános képletű vegyületekre ésgyógyszerészetileg elfogadható savakkal és bázisokkal képzett sóikravonatkozik, mely képletben B, C, D és E gyűrű jelen lehet vagyhiányozhat és ha jelen van az A gyűrűvel kombinált, mint A+C, A+E,A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D vagy A+B+C+D+E, a B, C és E gyűrűjelentése alifás, míg a D gyűrű jelentése alifás vagyaromás/heteoaromás, és amikor X jelentése -(CH2)m-, ahol m jelentése1-3 közötti egész szám, egy E gyűrűt alkot vagy, amikor E hiányzik,egy R1 csoport kötődik a nitrogénalomhoz, ahol R1 jelentésehidrogénatom, 1-3 szénatomos alkil- vagy haloalkil-, 3-5 szénatomoscikloalkil-(alkil)-csoport és amikor Y jelentése -(CH2)n-, ahol ajelentése 1-3 közötti egész szám, egy C gyűrűt alkot vagy, amikor Chiányzik, egy R2 csoport kötődik a nitrogénatomhoz, ahol R2 jelentésehidrogénatom, 1-7 szénatomos alkil- vagy haloalkil-, 3-7 szénatomoscikloalkil-(alkil)-, 3-6 szénatomos alkenil- vagy alkinil-, aril-alkil-, alkilrészében 1-3 szénatomot tartalmazó hetero-aril-alkil-csoport, míg az aril/heteroaril magok szubsztituáltak lehetnek, azzala megkötéssel, hogy amikor a B, C, D és E gyűrűk hiányoznak, NR1R2jelentése dimetil-amino-, N-metil-N-etil-amino-, N-metil-N-propinil-amino-, N-metil-N-propil-amino- és N-hidroxi-propil-N-metil-amino-csoporttól eltérő. A fenti vegyületek a katekol-aminok új prodrugjai,így a találmány az ezeket tartalmazó gyógyszerkészítményekre ésalkalmazásukra is vonatkozik. Ó
HU0300543A 2000-04-18 2001-04-17 Katekolamin prodrug fenil-etil-aminok és kondenzált gyûrûs származékaik, valamint ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények HU229794B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0001438A SE0001438D0 (sv) 2000-04-18 2000-04-18 New chemical compounds and their use in therapy
PCT/SE2001/000840 WO2001078713A1 (en) 2000-04-18 2001-04-17 Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use

Publications (3)

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HUP0300543A2 true HUP0300543A2 (hu) 2003-07-28
HUP0300543A3 HUP0300543A3 (en) 2009-04-28
HU229794B1 HU229794B1 (hu) 2014-07-28

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HU0300543A HU229794B1 (hu) 2000-04-18 2001-04-17 Katekolamin prodrug fenil-etil-aminok és kondenzált gyûrûs származékaik, valamint ezek alkalmazása és ezeket tartalmazó gyógyszerkészítmények

Country Status (20)

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US (4) US6683087B2 (hu)
EP (1) EP1274411B1 (hu)
JP (1) JP4819280B2 (hu)
CN (2) CN1234351C (hu)
AT (1) ATE300290T1 (hu)
AU (2) AU2001248982B2 (hu)
CA (1) CA2406044C (hu)
CZ (1) CZ20023455A3 (hu)
DE (1) DE60112269T2 (hu)
DK (1) DK1274411T3 (hu)
ES (1) ES2244604T3 (hu)
HK (1) HK1088009A1 (hu)
HU (1) HU229794B1 (hu)
NZ (1) NZ521860A (hu)
PL (1) PL204661B1 (hu)
PT (1) PT1274411E (hu)
SE (1) SE0001438D0 (hu)
SI (1) SI1274411T1 (hu)
WO (1) WO2001078713A1 (hu)
ZA (1) ZA200207919B (hu)

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HU229794B1 (hu) 2014-07-28
JP2004500426A (ja) 2004-01-08
ES2244604T3 (es) 2005-12-16
HUP0300543A3 (en) 2009-04-28
ZA200207919B (en) 2003-10-02
USRE42802E1 (en) 2011-10-04
DE60112269D1 (de) 2005-09-01
WO2001078713A1 (en) 2001-10-25
HK1088009A1 (en) 2006-10-27
CA2406044C (en) 2009-10-27
USRE43244E1 (en) 2012-03-13
PL204661B1 (pl) 2010-01-29
EP1274411B1 (en) 2005-07-27
CA2406044A1 (en) 2001-10-25
US6998405B2 (en) 2006-02-14
DK1274411T3 (da) 2005-11-14
US20040138281A1 (en) 2004-07-15
CN100383126C (zh) 2008-04-23
SI1274411T1 (sl) 2005-12-31
US6683087B2 (en) 2004-01-27
CN1450894A (zh) 2003-10-22
CN1781910A (zh) 2006-06-07
US20030087948A1 (en) 2003-05-08
CZ20023455A3 (cs) 2003-04-16
NZ521860A (en) 2004-03-26
PL365113A1 (en) 2004-12-27
AU2001248982B2 (en) 2005-12-15
DE60112269T2 (de) 2006-05-24
CN1234351C (zh) 2006-01-04
JP4819280B2 (ja) 2011-11-24
AU4898201A (en) 2001-10-30
SE0001438D0 (sv) 2000-04-18
ATE300290T1 (de) 2005-08-15
PT1274411E (pt) 2005-11-30

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