CY1109882T1 - Νεα αλατα ατορβαστατινης και φαρμακευτικες συνθεσεις που τα περιεχουν - Google Patents
Νεα αλατα ατορβαστατινης και φαρμακευτικες συνθεσεις που τα περιεχουνInfo
- Publication number
- CY1109882T1 CY1109882T1 CY20101100235T CY101100235T CY1109882T1 CY 1109882 T1 CY1109882 T1 CY 1109882T1 CY 20101100235 T CY20101100235 T CY 20101100235T CY 101100235 T CY101100235 T CY 101100235T CY 1109882 T1 CY1109882 T1 CY 1109882T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- atorvastatin salts
- new
- new atorvastatin
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical class C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αναφέρεται σε άλατα της ατορβαστατίνης τα οποία σχηματίζονται με ένα βασικό αμινοξύ του γενικού τύπου (I), όπου η σημασία του R είναι μια ομάδα που προέρχεται από λυσίνη, αργινίνη ή ορνιθίνη, και στις άμορφες ή πολύμορφες τροποποιήσεις τους. Η εφεύρεση αναφέρεται επίσης στη σύνθεση των ενώσεων του γενικού τύπου (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0201083A HUP0201083A2 (hu) | 2002-03-28 | 2002-03-28 | Új atorvastatinsók és az azokat tartalmazó gyógyszerkészítmények |
| EP03730380A EP1490333B1 (en) | 2002-03-28 | 2003-03-27 | New atorvastatin salts and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109882T1 true CY1109882T1 (el) | 2014-09-10 |
Family
ID=89980299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100235T CY1109882T1 (el) | 2002-03-28 | 2010-03-11 | Νεα αλατα ατορβαστατινης και φαρμακευτικες συνθεσεις που τα περιεχουν |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1490333B1 (el) |
| AT (1) | ATE455761T1 (el) |
| AU (1) | AU2003241060A1 (el) |
| CY (1) | CY1109882T1 (el) |
| DE (1) | DE60331051D1 (el) |
| DK (1) | DK1490333T3 (el) |
| ES (1) | ES2339935T3 (el) |
| HU (1) | HUP0201083A2 (el) |
| PT (1) | PT1490333E (el) |
| SI (1) | SI1490333T1 (el) |
| WO (1) | WO2003082816A1 (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227041B1 (en) * | 2003-03-24 | 2010-05-28 | Richter Gedeon Nyrt | Process for the synthesis of amorphous atorvastatin calcium |
| AU2004247023A1 (en) | 2003-05-16 | 2004-12-23 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| JP2007517028A (ja) * | 2003-12-29 | 2007-06-28 | レツク・フアーマシユーテイカルズ・デー・デー | 非晶質の（４ｒ−シス）−６−［２−［３−フェニル−４−（フェニルカルバモイル）−２−（４−フルオロフェニル）−５−（１−メチルエチル）−ピロール−１−イル］−エチル］−２，２−ジメチル−［１，３］−ジオキサン−４−イル−酢酸を調製する方法 |
| FR2869539B1 (fr) * | 2004-04-29 | 2008-08-08 | Univ Paris Descartes | Compositions pharmaceutiques pour la prevention et le traitement de l'atherosclerose |
| CA2649054A1 (en) * | 2004-05-05 | 2005-11-10 | Pfizer Products Inc. | Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid |
| CA2588216A1 (en) * | 2004-11-22 | 2006-05-26 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
| CA2613875C (en) * | 2005-07-04 | 2018-09-25 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
| US8080672B2 (en) | 2005-12-13 | 2011-12-20 | Teva Pharmaceutical Industries Ltd. | Crystal form of atorvastatin hemi-calcium and processes for preparation thereof |
| WO2011089559A1 (en) * | 2010-01-22 | 2011-07-28 | Orchid Chemicals And Pharmaceuticals Limited | A novel polymorphic form of atorvastatin salts |
| MX2010011006A (es) | 2010-10-06 | 2012-04-18 | Senosiain S A De C V Lab | Nueva sal de un derivado de pirimidina. |
| CN103274985B (zh) * | 2010-12-03 | 2016-03-09 | 上海科州药物研发有限公司 | 一种阿托伐他汀氨基酸盐 |
| WO2013083674A1 (de) * | 2011-12-08 | 2013-06-13 | Hexal Ag | Neue pharmazeutische statin-zusammensetzung |
| CN103232398B (zh) * | 2012-04-28 | 2016-04-06 | 上海科州药物研发有限公司 | 一种瑞舒伐他汀氨基酸盐及其制备方法和应用 |
| CN105246472B (zh) * | 2013-03-15 | 2018-10-12 | 武汉朗来科技发展有限公司 | 含有鸟氨酸和/或门冬氨酸的组合物及其应用 |
| WO2014139469A1 (en) * | 2013-03-15 | 2014-09-18 | Wuhan Qr Science And Technology Development Co. | Ornithine- or aspartate-containing compositions and the uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2167587T3 (es) * | 1995-07-17 | 2002-05-16 | Warner Lambert Co | Forma cristalina de la sal hemicalcica del acido (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (atorvastatina). |
| ES2401598T3 (es) * | 2000-04-10 | 2013-04-22 | Teva Pharmaceutical Industries, Ltd. | Composiciones farmacéuticas estables que contienen ácidos 7-sustituido-3,5-dihidroxiheptanoicos o ácidos 7-sustituido-3,5-dihidroxiheptenoicos |
-
2002
- 2002-03-28 HU HU0201083A patent/HUP0201083A2/hu unknown
-
2003
- 2003-03-27 EP EP03730380A patent/EP1490333B1/en not_active Expired - Lifetime
- 2003-03-27 PT PT03730380T patent/PT1490333E/pt unknown
- 2003-03-27 SI SI200331777T patent/SI1490333T1/sl unknown
- 2003-03-27 AT AT03730380T patent/ATE455761T1/de active
- 2003-03-27 ES ES03730380T patent/ES2339935T3/es not_active Expired - Lifetime
- 2003-03-27 DK DK03730380.7T patent/DK1490333T3/da active
- 2003-03-27 DE DE60331051T patent/DE60331051D1/de not_active Expired - Lifetime
- 2003-03-27 AU AU2003241060A patent/AU2003241060A1/en not_active Abandoned
- 2003-03-27 WO PCT/HU2003/000024 patent/WO2003082816A1/en not_active Application Discontinuation
-
2010
- 2010-03-11 CY CY20101100235T patent/CY1109882T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60331051D1 (de) | 2010-03-11 |
| HUP0201083A2 (hu) | 2004-06-28 |
| HU0201083D0 (el) | 2002-05-29 |
| ES2339935T3 (es) | 2010-05-27 |
| WO2003082816A1 (en) | 2003-10-09 |
| ATE455761T1 (de) | 2010-02-15 |
| AU2003241060A1 (en) | 2003-10-13 |
| EP1490333B1 (en) | 2010-01-20 |
| SI1490333T1 (sl) | 2010-04-30 |
| PT1490333E (pt) | 2010-03-04 |
| EP1490333A1 (en) | 2004-12-29 |
| DK1490333T3 (da) | 2010-05-25 |
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