DK1490333T3 - Nye atorvastatinsalte og farmaceutiske sammensætninger indeholdende dem - Google Patents
Nye atorvastatinsalte og farmaceutiske sammensætninger indeholdende demInfo
- Publication number
- DK1490333T3 DK1490333T3 DK03730380.7T DK03730380T DK1490333T3 DK 1490333 T3 DK1490333 T3 DK 1490333T3 DK 03730380 T DK03730380 T DK 03730380T DK 1490333 T3 DK1490333 T3 DK 1490333T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- salts
- atorvastatin salts
- new
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical class C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0201083A HUP0201083A2 (hu) | 2002-03-28 | 2002-03-28 | Új atorvastatinsók és az azokat tartalmazó gyógyszerkészítmények |
| PCT/HU2003/000024 WO2003082816A1 (en) | 2002-03-28 | 2003-03-27 | New atorvastatin salts and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1490333T3 true DK1490333T3 (da) | 2010-05-25 |
Family
ID=89980299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03730380.7T DK1490333T3 (da) | 2002-03-28 | 2003-03-27 | Nye atorvastatinsalte og farmaceutiske sammensætninger indeholdende dem |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1490333B1 (da) |
| AT (1) | ATE455761T1 (da) |
| AU (1) | AU2003241060A1 (da) |
| CY (1) | CY1109882T1 (da) |
| DE (1) | DE60331051D1 (da) |
| DK (1) | DK1490333T3 (da) |
| ES (1) | ES2339935T3 (da) |
| HU (1) | HUP0201083A2 (da) |
| PT (1) | PT1490333E (da) |
| SI (1) | SI1490333T1 (da) |
| WO (1) | WO2003082816A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227041B1 (en) * | 2003-03-24 | 2010-05-28 | Richter Gedeon Nyrt | Process for the synthesis of amorphous atorvastatin calcium |
| JP2007500219A (ja) | 2003-05-16 | 2007-01-11 | アンビット バイオサイエンシス コーポレーション | 複素環化合物およびその使用法 |
| AU2004309313A1 (en) * | 2003-12-29 | 2005-07-14 | Lek Pharmaceuticals D.D. | Process for preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid |
| FR2869539B1 (fr) * | 2004-04-29 | 2008-08-08 | Univ Paris Descartes | Compositions pharmaceutiques pour la prevention et le traitement de l'atherosclerose |
| US7875731B2 (en) | 2004-05-05 | 2011-01-25 | Pfizer Inc. | Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid |
| US20090208539A1 (en) * | 2004-11-22 | 2009-08-20 | Adel Penhasi | Stable atorvastatin formulations |
| EP1898922A4 (en) * | 2005-07-04 | 2012-03-14 | Ramu Krishnan | MEDICINE OR IMPROVED PHARMACEUTICAL COMPOUNDS AND PREPARATION THEREOF |
| CA2633268A1 (en) | 2005-12-13 | 2007-06-21 | Teva Pharmaceutical Industries Ltd. | Crystal form of atorvastatin hemi-calcium and processes for preparation thereof |
| WO2011089559A1 (en) * | 2010-01-22 | 2011-07-28 | Orchid Chemicals And Pharmaceuticals Limited | A novel polymorphic form of atorvastatin salts |
| MX2010011006A (es) * | 2010-10-06 | 2012-04-18 | Senosiain S A De C V Lab | Nueva sal de un derivado de pirimidina. |
| CN103288702B (zh) * | 2010-12-03 | 2015-09-16 | 上海科州药物研发有限公司 | 一种阿托伐他汀氨基酸盐的制备方法 |
| US9717707B2 (en) | 2011-12-08 | 2017-08-01 | Hexal Ag | Pharmaceutical statin composition |
| CN103232398B (zh) * | 2012-04-28 | 2016-04-06 | 上海科州药物研发有限公司 | 一种瑞舒伐他汀氨基酸盐及其制备方法和应用 |
| WO2014139469A1 (en) * | 2013-03-15 | 2014-09-18 | Wuhan Qr Science And Technology Development Co. | Ornithine- or aspartate-containing compositions and the uses thereof |
| CN105246472B (zh) * | 2013-03-15 | 2018-10-12 | 武汉朗来科技发展有限公司 | 含有鸟氨酸和/或门冬氨酸的组合物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ294108B6 (cs) * | 1995-07-17 | 2004-10-13 | Warner@Lambertácompany | Krystalická forma I hydrátu atorvastatinuŹ tj@ semivápenaté soli kyseliny [R@}RgŹRgB]@}@fluorfenylB@betaŹdelta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové |
| CA2406574C (en) * | 2000-04-10 | 2006-12-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
-
2002
- 2002-03-28 HU HU0201083A patent/HUP0201083A2/hu unknown
-
2003
- 2003-03-27 DE DE60331051T patent/DE60331051D1/de not_active Expired - Lifetime
- 2003-03-27 PT PT03730380T patent/PT1490333E/pt unknown
- 2003-03-27 AU AU2003241060A patent/AU2003241060A1/en not_active Abandoned
- 2003-03-27 DK DK03730380.7T patent/DK1490333T3/da active
- 2003-03-27 EP EP03730380A patent/EP1490333B1/en not_active Expired - Lifetime
- 2003-03-27 ES ES03730380T patent/ES2339935T3/es not_active Expired - Lifetime
- 2003-03-27 AT AT03730380T patent/ATE455761T1/de active
- 2003-03-27 SI SI200331777T patent/SI1490333T1/sl unknown
- 2003-03-27 WO PCT/HU2003/000024 patent/WO2003082816A1/en not_active Application Discontinuation
-
2010
- 2010-03-11 CY CY20101100235T patent/CY1109882T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1109882T1 (el) | 2014-09-10 |
| EP1490333A1 (en) | 2004-12-29 |
| ES2339935T3 (es) | 2010-05-27 |
| AU2003241060A1 (en) | 2003-10-13 |
| PT1490333E (pt) | 2010-03-04 |
| HUP0201083A2 (hu) | 2004-06-28 |
| SI1490333T1 (sl) | 2010-04-30 |
| DE60331051D1 (de) | 2010-03-11 |
| WO2003082816A1 (en) | 2003-10-09 |
| EP1490333B1 (en) | 2010-01-20 |
| ATE455761T1 (de) | 2010-02-15 |
| HU0201083D0 (da) | 2002-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1490333T3 (da) | Nye atorvastatinsalte og farmaceutiske sammensætninger indeholdende dem | |
| ATE440833T1 (de) | Antithrombotische diamide | |
| CA2446944A1 (en) | Anti-inflammatory and immunomodulatory amino acid derivatives, their preparation and use | |
| EA200500203A1 (ru) | Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат | |
| MX2007005694A (es) | Nuevos derivados de betulina, preparacion y uso de los mismos. | |
| ATE326453T1 (de) | Antithrombotische amide | |
| BR122016015715B8 (pt) | composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico | |
| EP2423207A3 (en) | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | |
| DE60130771D1 (de) | Substituierte heterocyclische amide | |
| DK1140918T3 (da) | Thrombininhibitorer | |
| TW200734038A (en) | Novel dispersant and compositions thereof | |
| ATE509920T1 (de) | Quadratsäurederivate als inhibitoren von histondeacetylase | |
| MX2008010884A (es) | Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1. | |
| NO20055257L (no) | Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril | |
| DK1309562T3 (da) | 4-Alkoxycyclohexan-1-aminocarboxylsyreestere og fremgangsmåde til fremstilling deraf | |
| HUP0202437A2 (hu) | Új eljárás (2S,3aS,7aS)-1-[(S)-alanil]oktahidro-1H-indol-2-karbonsav vegyületek előállítására és ezek alkalmazása perindopril előállítására | |
| ATE464043T1 (de) | Pharmazeutische zusammensetzung enthaltend l- arginin | |
| ATE373636T1 (de) | Amidderivate als inhibitoren der enzymatischen aktivität von renin | |
| BRPI0406893A (pt) | Derivados de acilaminotiazol, a respectiva preparação e a respectiva utilização como inibidores da produção do peptìdeo betaamilóide | |
| NO20061152L (no) | Ny fremgangsmate for syntese av N-(S)-1-karboksybuty)-(S)-alanin og anvendelse derav for a syntetisere perindopril | |
| DE602004009306D1 (de) | 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern | |
| HUP0401895A2 (hu) | Paroxetin N-formil származékai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| ATE382607T1 (de) | Antitrombotische aether | |
| EP1707560A4 (en) | HYDROXAMIC ACID DERIVATIVE AND THE DERIVATIVE INHIBITOR OF THE GENERATION OF AGE | |
| EA200802320A1 (ru) | Новые фармацевтические промежуточные соединения в синтезе ингибиторов ацетилхолинэстеразы (асе) и их применение |