CY1108273T1 - Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των - Google Patents

Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των

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Publication number
CY1108273T1
CY1108273T1 CY20081100885T CY081100885T CY1108273T1 CY 1108273 T1 CY1108273 T1 CY 1108273T1 CY 20081100885 T CY20081100885 T CY 20081100885T CY 081100885 T CY081100885 T CY 081100885T CY 1108273 T1 CY1108273 T1 CY 1108273T1
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CY
Cyprus
Prior art keywords
dipeptylpeptidase
pyrrolidine
cyclopropyl
fused
preparation
Prior art date
Application number
CY20081100885T
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English (en)
Inventor
Jeffrey A. Robl
Richard B. Sulsky
David J. Augeri
David R. Magnin
Lawrence G. Hamann
David A. Betebenner
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Bristol-Myers Squibb Company
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22693638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108273(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1108273T1 publication Critical patent/CY1108273T1/el

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Abstract

Παρέχονται ενώσεις που αναστέλλουν διπεπτιδυλ-πεπτιδάση-ΙV (DP-4) και έχουν τον τύπο (I) στον οποίο x είναι 0 ή 1 και y είναι 0 ή 1 (με την προϋπόθεση ότι x = 1 όταν y = 0 και x = 0 όταν y = 1), n είναι 0 ή 1, X είναι Η ή CN και στον οποίο R1, R2, R3 και R4 είναι όπως περιγράφεται στο παρόν. Παρέχεται επίσης μία μέθοδος για την θεραπευτική αγωγή του διαβήτη και σχετικών ασθενειών, ειδικά του διαβήτη τύπου II και άλλων ασθενειών, όπως αναφέρονται στο παρόν, χρησιμοποιώντας έναν τέτοιο αναστολέα DP-4 ή έναν συνδυασμό τέτοιου αναστολέα DP-4 και ενός ή περισσοτέρων από ένα άλλο αντιδιαβητικό μέσον όπως μετφορμίνη, glyburide, troglitazone, pioglitazone, rosiglitazone και/ή ινσουλίνη και/ή ένα ή περισσότερα από ένα υπολιπιδαιμικό μέσον και/ή μέσον κατά της παχυσαρκίας και/ή άλλο θεραπευτικό μέσον.
CY20081100885T 2000-03-10 2008-08-20 Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των CY1108273T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18855500P 2000-03-10 2000-03-10
PCT/US2001/007151 WO2001068603A2 (en) 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl iv, processes for their preparation, and their use

Publications (1)

Publication Number Publication Date
CY1108273T1 true CY1108273T1 (el) 2012-01-25

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CY20081100885T CY1108273T1 (el) 2000-03-10 2008-08-20 Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των
CY2010005C CY2010005I2 (el) 2000-03-10 2010-03-30 Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των
CY2012009C CY2012009I1 (el) 2000-03-10 2012-04-24 Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των

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CY2012009C CY2012009I1 (el) 2000-03-10 2012-04-24 Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των

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AU (2) AU2001245466B2 (el)
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BR (1) BRPI0109115B8 (el)
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CY (3) CY1108273T1 (el)
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