EA200600935A1 - Гетероциклические соединения бороновой кислоты - Google Patents
Гетероциклические соединения бороновой кислотыInfo
- Publication number
- EA200600935A1 EA200600935A1 EA200600935A EA200600935A EA200600935A1 EA 200600935 A1 EA200600935 A1 EA 200600935A1 EA 200600935 A EA200600935 A EA 200600935A EA 200600935 A EA200600935 A EA 200600935A EA 200600935 A1 EA200600935 A1 EA 200600935A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- phenyl
- formula
- pharmaceutical compositions
- methods
- Prior art date
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
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- C07—ORGANIC CHEMISTRY
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
Abstract
Предусмотрены соединения, ингибирующие дипептидилпептидазу-IV (DPP-IV), имеющие формулу I, где n равно 1-3, Х обозначает СН, S, О, CFили С(СН); Z означает Н, галоген, гидроксил, (C)алкокси, (C)алкил, (С)циклоалкил, фенил или гетероарил; фенильная и гетероарильные группы могут быть однократно или независимо многократно замещены R; возможно, что Х вместе с соседним атомом углерода в кольце и Z образуют конденсированный циклопропил; возможно, одна из связей в кольце, содержащем X, является двойной; CRRR, R, R, Rи Rуказаны в заявке. Описаны способы получения этих соединений и способы лечения диабета, особенно диабета II типа, и других родственных болезней с применением соединений формулы I в фармацевтических композициях, которые содержат эти соединения. Описаны также фармацевтические композиции, которые содержат комбинации этих соединений с другими антидиабетическими агентами.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51956603P | 2003-11-12 | 2003-11-12 | |
US55701104P | 2004-03-25 | 2004-03-25 | |
US59297204P | 2004-07-30 | 2004-07-30 | |
PCT/US2004/037820 WO2005047297A1 (en) | 2003-11-12 | 2004-11-12 | Heterocyclic boronic acid compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600935A1 true EA200600935A1 (ru) | 2006-10-27 |
EA013684B1 EA013684B1 (ru) | 2010-06-30 |
Family
ID=34595944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600935A EA013684B1 (ru) | 2003-11-12 | 2004-11-12 | Гетероциклические соединения бороновой кислоты |
Country Status (21)
Country | Link |
---|---|
US (3) | US7674913B2 (ru) |
EP (3) | EP1997533B8 (ru) |
JP (3) | JP5435841B2 (ru) |
KR (2) | KR20070054762A (ru) |
AR (1) | AR046778A1 (ru) |
AU (1) | AU2004288831B2 (ru) |
BR (1) | BRPI0416444B8 (ru) |
CA (1) | CA2545311C (ru) |
DK (1) | DK1689757T3 (ru) |
EA (1) | EA013684B1 (ru) |
ES (1) | ES2524916T3 (ru) |
HR (1) | HRP20141155T1 (ru) |
IL (1) | IL175550A (ru) |
NO (2) | NO337818B1 (ru) |
NZ (1) | NZ547752A (ru) |
PL (1) | PL1689757T3 (ru) |
PT (1) | PT1689757E (ru) |
SG (1) | SG134333A1 (ru) |
SI (1) | SI1689757T1 (ru) |
TW (1) | TWI337078B (ru) |
WO (1) | WO2005047297A1 (ru) |
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US7767828B2 (en) | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
US7576121B2 (en) | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
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TWI430806B (zh) * | 2006-09-13 | 2014-03-21 | Smithkline Beecham Corp | 用於投與長效降血糖藥劑之方法 |
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EA029759B1 (ru) | 2009-02-13 | 2018-05-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Антидиабетические лекарственные средства, содержащие ингибитор dpp-4 (линаглиптин) необязательно в комбинации с другими антидиабетическими средствами |
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