EA200701756A1 - Соль производного пролина, её сольват и способ её получения - Google Patents

Соль производного пролина, её сольват и способ её получения

Info

Publication number
EA200701756A1
EA200701756A1 EA200701756A EA200701756A EA200701756A1 EA 200701756 A1 EA200701756 A1 EA 200701756A1 EA 200701756 A EA200701756 A EA 200701756A EA 200701756 A EA200701756 A EA 200701756A EA 200701756 A1 EA200701756 A1 EA 200701756A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solvat
proline
derivative
salt
receiving
Prior art date
Application number
EA200701756A
Other languages
English (en)
Other versions
EA013119B1 (ru
Inventor
Томохиро Йосида
Хироси Сакасита
Наоко Уеда
Синдзи Кирихара
Сатору Уемори
Реико Цуцумиути
Фумихико Акахоси
Original Assignee
Мицубиси Фарма Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36916526&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200701756(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мицубиси Фарма Корпорейшн filed Critical Мицубиси Фарма Корпорейшн
Publication of EA200701756A1 publication Critical patent/EA200701756A1/ru
Publication of EA013119B1 publication Critical patent/EA013119B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к 3-{(2S,4S)-4-[4-(3-метил-1-фенил-1Н-пиразол-5-ил)пиперазин-1-ил]пирролидин-2-илкарбонил}тиазолидину (соединение I), который можно использовать как ингибитор дипептидилпептидазы-IV, имеет превосходные свойства стабильности и гигроскопичности, воспроизводимую структуру кристалла, и к способу его получения.
EA200701756A 2005-02-18 2006-02-17 Соль производного пролина, ее сольват и способ ее получения EA013119B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005041851 2005-02-18
PCT/JP2006/302827 WO2006088129A1 (ja) 2005-02-18 2006-02-17 プロリン誘導体の塩、またはその溶媒和物、及びその製造方法

Publications (2)

Publication Number Publication Date
EA200701756A1 true EA200701756A1 (ru) 2008-02-28
EA013119B1 EA013119B1 (ru) 2010-02-26

Family

ID=36916526

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701756A EA013119B1 (ru) 2005-02-18 2006-02-17 Соль производного пролина, ее сольват и способ ее получения

Country Status (14)

Country Link
US (2) US8003790B2 (ru)
EP (2) EP1854795B1 (ru)
JP (3) JP4208938B2 (ru)
KR (2) KR20130076903A (ru)
CN (3) CN102372705A (ru)
AU (1) AU2006215041B2 (ru)
BR (1) BRPI0607863B8 (ru)
CA (1) CA2598301C (ru)
EA (1) EA013119B1 (ru)
ES (1) ES2588164T3 (ru)
MX (1) MX2007010054A (ru)
NZ (1) NZ561489A (ru)
TW (1) TWI403511B (ru)
WO (1) WO2006088129A1 (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1854795B1 (en) * 2005-02-18 2016-06-01 Mitsubishi Tanabe Pharma Corporation Salt of a proline derivative, solvate thereof, and production method thereof
US20090088442A1 (en) * 2005-04-26 2009-04-02 Mitsubishi Tanabe Pharma Corporation Prophylactic/therapeutic agent for abnormalities of sugar/lipid metabolism
JP5616630B2 (ja) 2007-04-03 2014-10-29 田辺三菱製薬株式会社 ジペプチジルペプチダーゼ４阻害化合物と甘味料との併用
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
UY32048A (es) 2009-01-08 2010-03-26 Boehringer Ingelheim Int Derivados sustituido de 1-(sustituido)-3-metil-7-(sustituido)-8-(3-(R)-amino-piperidin-1-il)cantina y derivados sustituidos de 1-(sustituido) - 4 - fluoropirrolidin- 2 - carbonitrilo y sus sales famacéuticamente aceptables como inhibidores de DPP-4 y aplicaciones.
TWI466672B (zh) 2009-01-29 2015-01-01 Boehringer Ingelheim Int 小兒科病人糖尿病之治療
NZ619520A (en) 2009-02-13 2015-06-26 Boehringer Ingelheim Int Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CN102753161A (zh) 2009-11-27 2012-10-24 贝林格尔.英格海姆国际有限公司 基因型糖尿病患者利用dpp-iv抑制剂例如利拉利汀的治疗
TWI418370B (zh) * 2009-12-18 2013-12-11 Mitsubishi Tanabe Pharma Corp 溶出安定性製劑
WO2011113947A1 (en) 2010-03-18 2011-09-22 Boehringer Ingelheim International Gmbh Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
BR112012025592A2 (pt) 2010-04-06 2019-09-24 Arena Pharm Inc moduladores do receptor de gpr119 e o tratamento de distúrbios relacionados com os mesmos
ES2935300T3 (es) 2010-05-05 2023-03-03 Boehringer Ingelheim Int Combiterapia
CN106975074A (zh) 2010-06-24 2017-07-25 勃林格殷格翰国际有限公司 糖尿病治疗
AU2011305525B2 (en) 2010-09-22 2016-08-18 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140051714A1 (en) 2011-04-22 2014-02-20 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012165547A1 (ja) * 2011-06-01 2012-12-06 田辺三菱製薬株式会社 ピラゾール誘導体の製造方法
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
RU2014110399A (ru) 2011-08-19 2015-09-27 Мерк Шарп И Доум Корп. Кристаллические формы вгс протеазного ингибитора
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9518048B2 (en) 2012-08-31 2016-12-13 Glenmark Pharmaceuticals Limited Process for the preparation of teneligliptin
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
CN104230917B (zh) * 2013-06-24 2017-04-05 南京华威医药科技开发有限公司 一种脯氨酸衍生物盐的水合物及其生产方法
WO2015019239A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Process for the preparation of 1-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazine
WO2015019238A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one
WO2015063709A1 (en) 2013-10-31 2015-05-07 Ranbaxy Laboratories Limited Process for the preparation of 1-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazine
CN104650065A (zh) * 2013-11-22 2015-05-27 天津市汉康医药生物技术有限公司 一种替格列汀化合物
WO2015173779A1 (en) 2014-05-16 2015-11-19 Micro Labs Limited Process for the preparation of teneligliptin and its novel intermediates
CN105294673B (zh) * 2014-06-18 2018-04-13 四川科伦药物研究院有限公司 一种氢溴酸替格列汀的合成方法
CN108697707A (zh) * 2017-02-03 2018-10-23 格伦马克制药有限公司 包含特力利汀之草酸盐及其溶剂合物之配方
CN108727364A (zh) * 2017-04-18 2018-11-02 乳源东阳光药业有限公司 一种氢溴酸替格列汀无定型及其制备方法
JP2021522332A (ja) * 2018-04-25 2021-08-30 乳源▲東▼▲陽▼光▲薬▼▲業▼有限公司 テネリグリプチン臭化水素酸塩アモルファス及びその調製方法
KR102494848B1 (ko) * 2018-10-10 2023-02-02 주식회사 파마코스텍 테네리글립틴 2토실산염 2수화물의 결정형 ⅰ형 및 그 제조방법
KR20200127480A (ko) 2019-05-02 2020-11-11 연성정밀화학(주) 테네리글립틴 에디실산염 결정형 및 이의 제조방법
KR20210121421A (ko) 2020-03-30 2021-10-08 코오롱생명과학 주식회사 테네리글리프틴 2.5브롬화수소산염 무정형의 제조방법
JP2022069426A (ja) * 2020-10-23 2022-05-11 マイラン ラボラトリーズ リミテッド テネリグリプチン２．５臭化水素酸塩のアモルファスを調製する方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
US4337341A (en) * 1976-11-02 1982-06-29 Eli Lilly And Company 4a-Aryl-octahydro-1H-2-pyrindines
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
WO1995034538A2 (en) * 1994-06-10 1995-12-21 Universitaire Instelling Antwerpen Purification of serine proteases and synthetic inhibitors thereof
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
DE19823831A1 (de) * 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
JP2003520849A (ja) 2000-01-24 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 酵素ｄｐｐ−ｉｖの阻害剤であるｎ−置換２−シアノピロールおよび−ピロリン
MXPA02012272A (es) 2000-07-04 2003-04-25 Novo Nordisk As Compuestos heterociclicos que son inhibidores de la enzima dipeptidilpeptidasa-iv.
WO2002014271A1 (fr) * 2000-08-10 2002-02-21 Mitsubishi Pharma Corporation Dérivés de proline et leur utilisation comme médicaments
HUP0400058A2 (hu) 2001-02-02 2004-04-28 Takeda Chemical Industries, Ltd. Kondenzált heterogyűrűs vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
CA2460512A1 (en) * 2001-09-14 2003-03-27 Mitsubishi Pharma Corporation Thiazolidine derivatives and medicinal use thereof
US20040229848A1 (en) * 2003-05-05 2004-11-18 Hans-Ulrich Demuth Glutaminyl based DP IV-inhibitors
AU2003902946A0 (en) * 2003-06-12 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
JP4569802B2 (ja) 2003-07-23 2010-10-27 眞 八藤 ビタミンを主材とするイオン化ミネラル結合型サプリメントの製造方法
EP1854795B1 (en) * 2005-02-18 2016-06-01 Mitsubishi Tanabe Pharma Corporation Salt of a proline derivative, solvate thereof, and production method thereof
US20090088442A1 (en) 2005-04-26 2009-04-02 Mitsubishi Tanabe Pharma Corporation Prophylactic/therapeutic agent for abnormalities of sugar/lipid metabolism
EP1894567B1 (en) 2005-06-03 2012-08-15 Mitsubishi Tanabe Pharma Corporation Concomitant pharmaceutical agents and use thereof

Also Published As

Publication number Publication date
BRPI0607863B8 (pt) 2021-05-25
EP1854795B1 (en) 2016-06-01
ES2588164T3 (es) 2016-10-31
AU2006215041A1 (en) 2006-08-24
US20110282058A1 (en) 2011-11-17
JP4208938B2 (ja) 2009-01-14
KR101352650B1 (ko) 2014-01-16
KR20130076903A (ko) 2013-07-08
TW200640920A (en) 2006-12-01
CN102372705A (zh) 2012-03-14
CN101119991B (zh) 2012-01-25
US20090216016A1 (en) 2009-08-27
BRPI0607863B1 (pt) 2020-10-20
JP2013032376A (ja) 2013-02-14
CN101119991A (zh) 2008-02-06
JP2008214358A (ja) 2008-09-18
BRPI0607863A2 (pt) 2010-06-22
AU2006215041B2 (en) 2012-05-31
EP1854795A4 (en) 2009-03-25
JPWO2006088129A1 (ja) 2008-07-03
US8003790B2 (en) 2011-08-23
CA2598301C (en) 2013-05-28
EA013119B1 (ru) 2010-02-26
US8604198B2 (en) 2013-12-10
EP1854795A1 (en) 2007-11-14
MX2007010054A (es) 2007-09-21
WO2006088129A1 (ja) 2006-08-24
CA2598301A1 (en) 2006-08-24
CN102372704A (zh) 2012-03-14
EP2602259A3 (en) 2014-09-10
NZ561489A (en) 2010-10-29
CN102372704B (zh) 2014-10-08
TWI403511B (zh) 2013-08-01
EP2602259A2 (en) 2013-06-12
KR20070108247A (ko) 2007-11-08

Similar Documents

Publication Publication Date Title
EA200701756A1 (ru) Соль производного пролина, её сольват и способ её получения
EA200700720A1 (ru) Новые ингибиторы дипептидилпептидазы iv, содержащие их фармацевтические композиции и процедура их приготовления
EA201000958A1 (ru) Пептидилнитрилы и их применение в качестве ингибиторов дипептидилпептидазы i
TW201129553A (en) Dipeptidyl peptidase inhibitors
EA200702208A1 (ru) Ингибиторы дипептидилпептидазы-iv
EA200970050A1 (ru) Ингибиторы пролилгидроксилаз
RU2012103851A (ru) Би-арил-мета-пиримидиновые ингибиторы киназ
EA200600935A1 (ru) Гетероциклические соединения бороновой кислоты
ATE554085T1 (de) Neue inhibitoren von glutaminylcyclase
RS51106B (sr) Derivati prolina i njihova upotreba kao inhibitora dipeptidil peptidaze iv
ATE527259T1 (de) Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
WO2007079199A3 (en) Substituted bis-amide metalloprotease inhibitors
NO20071242L (no) Triazolpyridinylsulfanylderivater som P38-MAP-kinaseinhibitorer
EA201001359A1 (ru) Гетероциклические соединения в качестве ингибиторов cxcr2
NO20075809L (no) DNA-PK inhibitorer
PE20130239A1 (es) Compuestos heteroaril-aril-ureas como inhibidores de la quinasa
MX2008012490A (es) Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes.
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
ATE549926T1 (de) Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes
TW200714589A (en) Phenylacetamides suitable as protein kinase inhibitors
EA200970149A1 (ru) Производные n-(аминогетероарил)-1h-индол-2-карбоксамидов, их получение и их применение в терапии
EP1794120A4 (en) peptidase
EA201270630A1 (ru) Гетероциклические сетр ингибиторы
EA200500312A1 (ru) Новые спироконденсированные хиназолиноны и их применение в качестве ингибиторов фосфодиэстераз
NO20063944L (no) Piperidinylkarbonyl-pyrrolidiner og deres anvendelse som melanokortinagonister

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM