JP2005539088A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005539088A5 JP2005539088A5 JP2004559025A JP2004559025A JP2005539088A5 JP 2005539088 A5 JP2005539088 A5 JP 2005539088A5 JP 2004559025 A JP2004559025 A JP 2004559025A JP 2004559025 A JP2004559025 A JP 2004559025A JP 2005539088 A5 JP2005539088 A5 JP 2005539088A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- benzo
- formula
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 230000003205 diastolic effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 0 CC**1*(C)CC(*C)C([C@@](C(*)(CC)C(CCC(*)CC2)CC*(C)*2N)C2=CCCC(C)(*)CC(C)(*)CCC2*C)=CCCC1 Chemical compound CC**1*(C)CC(*C)C([C@@](C(*)(CC)C(CCC(*)CC2)CC*(C)*2N)C2=CCCC(C)(*)CC(C)(*)CCC2*C)=CCCC1 0.000 description 2
- DWAWUJTUMDEWBR-UHFFFAOYSA-N CC(C)(C)c(cc1)cc2c1[nH]cn2 Chemical compound CC(C)(C)c(cc1)cc2c1[nH]cn2 DWAWUJTUMDEWBR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39199202P | 2002-06-26 | 2002-06-26 | |
| PCT/US2003/016213 WO2004052847A2 (en) | 2002-06-26 | 2003-06-13 | Tricyclic steroid hormone nuclear receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005539088A JP2005539088A (ja) | 2005-12-22 |
| JP2005539088A5 true JP2005539088A5 (enExample) | 2006-07-27 |
| JP4395076B2 JP4395076B2 (ja) | 2010-01-06 |
Family
ID=32507560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559025A Expired - Fee Related JP4395076B2 (ja) | 2002-06-26 | 2003-06-13 | 三環式ステロイドホルモン核内受容体モジュレーター |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7411072B2 (enExample) |
| EP (1) | EP1519915B1 (enExample) |
| JP (1) | JP4395076B2 (enExample) |
| KR (1) | KR20050013255A (enExample) |
| CN (2) | CN1331848C (enExample) |
| AR (1) | AR044526A1 (enExample) |
| AT (1) | ATE432257T1 (enExample) |
| AU (1) | AU2003302220B2 (enExample) |
| BR (1) | BR0312095A (enExample) |
| CA (1) | CA2489276C (enExample) |
| CO (1) | CO5650160A2 (enExample) |
| CY (1) | CY1109490T1 (enExample) |
| DE (1) | DE60327767D1 (enExample) |
| DK (1) | DK1519915T3 (enExample) |
| EA (1) | EA200500088A1 (enExample) |
| EC (1) | ECSP045501A (enExample) |
| ES (1) | ES2325861T3 (enExample) |
| HR (1) | HRP20041187A2 (enExample) |
| MX (1) | MXPA04012998A (enExample) |
| NO (1) | NO20050397L (enExample) |
| PE (1) | PE20040587A1 (enExample) |
| PL (1) | PL374708A1 (enExample) |
| PT (1) | PT1519915E (enExample) |
| SI (1) | SI1519915T1 (enExample) |
| TW (1) | TW200400816A (enExample) |
| WO (1) | WO2004052847A2 (enExample) |
| ZA (1) | ZA200410293B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066153A1 (en) * | 2003-12-19 | 2005-07-21 | Eli Lilly And Company | Tricyclic steroid hormone nuclear receptor modulators |
| DE602004014640D1 (de) * | 2003-12-19 | 2008-08-07 | Lilly Co Eli | Tricyclische modulatoren von nuklearen steroidhormonrezeptoren |
| EP1781300A1 (en) * | 2004-07-16 | 2007-05-09 | ProteoSys AG | Muscarinic antagonists with parp and sir modulatng activity as agents for inflammatory diseases |
| RU2007107177A (ru) * | 2004-07-28 | 2008-09-10 | Айрм Ллк (Bm) | Соединения и композиции, как модуляторы ядерных рецепторов стероидных гормонов |
| JP2008531564A (ja) | 2005-02-25 | 2008-08-14 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ステロイドホルモン核受容体のモジュレーターとしてのスピロ含有化合物および組成物 |
| DE102005022020A1 (de) * | 2005-05-12 | 2006-11-23 | Merckle Gmbh | Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten |
| PE20070335A1 (es) * | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
| AU2006306499A1 (en) * | 2005-10-21 | 2007-05-03 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| EA014695B1 (ru) * | 2006-07-14 | 2010-12-30 | Эли Лилли Энд Компани | Модулятор рецепторов глюкокортикостероидов и его применение |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| ES2375877T3 (es) | 2006-10-31 | 2012-03-07 | Pfizer Products Inc. | Compuestos de pirazolina como antagonistas de receptores de mineralocorticoides. |
| JP4866901B2 (ja) | 2007-02-07 | 2012-02-01 | 協和発酵キリン株式会社 | ３環系化合物 |
| TWI431010B (zh) | 2007-12-19 | 2014-03-21 | Lilly Co Eli | 礦皮質素受體拮抗劑及使用方法 |
| ES2370148T3 (es) | 2008-01-11 | 2011-12-13 | Eli Lilly & Company | (e)-n-{3-[fluoro-11h-10-oxa-1-aza-dibenzo-[a,d]-ciclohepten-5-iliden)-propil]-fenil}-metilsulfonamida como modulador del receptor de glucocorticoides para el tratamiento de artritis reumatoide. |
| JPWO2010001990A1 (ja) * | 2008-07-03 | 2011-12-22 | 協和発酵キリン株式会社 | 四環系化合物 |
| EP2313091A4 (en) * | 2008-07-14 | 2012-04-04 | Univ Kingston | PHARMACEUTICAL COMPOSITIONS WITH RET-HEMMERN AND METHOD FOR THE TREATMENT OF CANCER |
| US20110190201A1 (en) * | 2008-07-24 | 2011-08-04 | Searete Llc | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
| US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
| US20100022991A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and device for maintaining physiological levels of steroid hormone in a subject |
| US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| EP3081213B1 (en) | 2008-08-06 | 2020-04-01 | Kyowa Kirin Co., Ltd. | Tricyclic compound |
| WO2010104721A1 (en) | 2009-03-12 | 2010-09-16 | Eli Lilly And Company | Mineralocorticoid receptor antagonist and methods of use |
| WO2011081173A1 (ja) * | 2009-12-29 | 2011-07-07 | 協和発酵キリン株式会社 | 四環系化合物 |
| EP2568986B1 (en) | 2010-05-10 | 2016-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| EP2569310A1 (en) | 2010-05-11 | 2013-03-20 | Pfizer Inc | Morpholine compounds as mineralocorticoid receptor antagonists |
| EP2582365B1 (en) | 2010-06-16 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for stimulating reepithelialisation during wound healing |
| BR112013033777A2 (pt) * | 2011-03-15 | 2016-09-13 | Abbvie Inc | moduladores de receptor de hormônio nuclear |
| BR112014003567A2 (pt) * | 2011-08-16 | 2018-08-14 | Mt Sinai School Of Medicine | composto, uso de um composto, e, composição farmacêutica |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| GEP201706623B (en) | 2012-10-16 | 2017-02-10 | Almirall Sa | Pyrrolotriazinone derivatives as pi3k inhibitors |
| EP2935284A4 (en) | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
| RU2015139700A (ru) | 2013-02-19 | 2017-03-27 | Икан Скул Оф Медсин Эт Маунт Синай | Трициклические гетероциклические соединения в качестве противораковых средств |
| CN106458916A (zh) | 2014-03-11 | 2017-02-22 | 西奈山伊坎医学院 | 受限制的三环磺酰胺 |
| CN106458936A (zh) | 2014-03-11 | 2017-02-22 | 西奈山伊坎医学院 | 作为抗癌药的三环‑2‑氨基环烷醇衍生的磺酰胺 |
| CN104402920B (zh) * | 2014-11-27 | 2018-04-03 | 河南科技学院 | 一种合成2‑卤代‑3‑频那醇硼酸酯‑5‑氯苯胺的方法 |
| JP6955485B2 (ja) | 2015-09-09 | 2021-10-27 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| JP6966425B2 (ja) | 2015-09-09 | 2021-11-17 | アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| US20180280414A1 (en) | 2015-10-13 | 2018-10-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation |
| EP3490606B8 (en) | 2016-07-26 | 2024-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
| AR117951A1 (es) | 2018-07-20 | 2021-09-08 | Gruenenthal Gmbh | Derivados de triazolquinoxalina adicionalmente sustituidos |
| EP4118235B1 (en) | 2020-03-11 | 2026-08-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy |
| CN113101291A (zh) * | 2021-04-14 | 2021-07-13 | 浙江大学 | 磺酰胺类化合物在制备治疗自身免疫性疾病药物中的应用 |
| CN113264917B (zh) * | 2021-05-28 | 2022-07-01 | 华南理工大学 | 一种抗乙肝病毒化合物及其制备方法和应用 |
| WO2023031277A1 (en) | 2021-08-31 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of ocular rosacea |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1001822A (en) | 1960-08-26 | 1965-08-18 | Sandoz Ag | Improvements in or relating to homothiaxanthenes |
| GB1043158A (en) | 1962-06-07 | 1966-09-21 | Sandoz Ag | Improvements in or relating to piperidylalkidene-5h-dibenzo(a,d)cycloheptenes |
| US3205264A (en) | 1962-06-15 | 1965-09-07 | Merck & Co Inc | Process for the preparation of 10, 11-dihydro-5-(gamma-methyl-and dimethyl-amino propylidene)-5h-dibenzo[a, d] cycloheptene |
| US3351588A (en) | 1965-09-14 | 1967-11-07 | American Home Prod | Dibenz [b, e] azepine derivative |
| US3519621A (en) | 1967-10-16 | 1970-07-07 | American Home Prod | 5h-dibenzo(a,d)cycloheptene derivatives |
| GB1242096A (en) | 1968-12-20 | 1971-08-11 | Labaz | Benzobenzofuranooxepine compounds and process for preparing the same |
| US3859356A (en) | 1972-07-24 | 1975-01-07 | Sandoz Ag | Benzylidene substituted bicyclic and tricyclic compounds |
| FI753701A7 (enExample) | 1975-01-06 | 1976-07-07 | Sumitomo Chemical Co | |
| US4282233B1 (en) | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
| FR2603713B1 (fr) | 1986-09-10 | 1992-07-24 | Canon Kk | Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant |
| WO1989003212A1 (en) | 1987-10-13 | 1989-04-20 | Pfizer Inc. | 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents |
| JPH01161245A (ja) | 1987-12-18 | 1989-06-23 | Canon Inc | 電子写真感光体 |
| JPH01183663A (ja) | 1988-01-14 | 1989-07-21 | Canon Inc | 電子写真感光体 |
| US4999363A (en) | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| JPH0232358A (ja) | 1988-07-21 | 1990-02-02 | Canon Inc | 電子写真感光体 |
| JPH02113258A (ja) | 1988-10-21 | 1990-04-25 | Canon Inc | 電子写真感光体 |
| US5093210A (en) | 1989-06-30 | 1992-03-03 | Ricoh Company, Ltd. | Electroluminescent device |
| JPH0446352A (ja) | 1990-06-14 | 1992-02-17 | Minolta Camera Co Ltd | 感光体 |
| JPH052278A (ja) | 1991-06-24 | 1993-01-08 | Konica Corp | 電子写真感光体 |
| DE69230721T2 (de) | 1991-12-27 | 2000-08-31 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclische Verbindungen als Angiotensin-II-Antagonisten |
| US5378701A (en) | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
| JPH05281765A (ja) | 1992-03-30 | 1993-10-29 | Kao Corp | 電子写真感光体 |
| RU2178790C2 (ru) | 1995-09-19 | 2002-01-27 | Ново Нордиск А/С | Производные дибензо[d, g][1,3]диоксоцина и дибензо-[d,g][1,3,6]диоксазоцина, способ их получения, фармацевтическая композиция на их основе и способ лечения нейрогенного воспаления, нейропатии и ревматоидного артрита |
| JPH09101200A (ja) | 1995-10-05 | 1997-04-15 | Canon Inc | イメ−ジセンサ− |
| AU700386B2 (en) | 1995-10-16 | 1999-01-07 | Kyowa Hakko Kogyo Co. Ltd. | Triciclic compounds |
| US6372779B1 (en) | 1997-12-29 | 2002-04-16 | Ortho Pharmaceutical Corporation | Anti-inflammatory compounds |
| JP4676061B2 (ja) | 1998-07-30 | 2011-04-27 | アボット・ラボラトリーズ | グルココルチコイド選択性薬剤 |
| DE69922306T2 (de) | 1998-09-04 | 2005-11-24 | Canon K.K. | Elektrophotographische Vorrichtung und Verarbeitungskartusche |
| US6362188B1 (en) | 1998-12-18 | 2002-03-26 | Schering Corporation | Farnesyl protein transferase inhibitors |
| EP1154997A4 (en) | 1999-01-26 | 2002-11-04 | Dana Farber Cancer Inst Inc | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE |
| JP2001089680A (ja) | 1999-09-22 | 2001-04-03 | Fuji Photo Film Co Ltd | トリアリールアミン構造を有する新規な三置換エチレン系化合物 |
| AU1604001A (en) | 2000-06-13 | 2001-12-24 | Pharmacia Corp | Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects |
| JP2004505060A (ja) | 2000-07-27 | 2004-02-19 | ファルマシア・コーポレーション | 炎症関連心臓血管障害を防止するかまたは治療するためのアルドステロンアンタゴニストおよびシクロオキシゲナーゼ−２阻害剤併用療法 |
| DK1313485T3 (da) | 2000-08-28 | 2005-12-27 | Pharmacia Corp | Anvendelse af en aldosteronreceptorantagonist til forbedring af kognitiv funktion |
| GB0113232D0 (en) | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical process |
| DE602004014640D1 (de) * | 2003-12-19 | 2008-08-07 | Lilly Co Eli | Tricyclische modulatoren von nuklearen steroidhormonrezeptoren |
-
2003
- 2003-05-30 TW TW092114743A patent/TW200400816A/zh unknown
- 2003-06-13 AU AU2003302220A patent/AU2003302220B2/en not_active Expired - Fee Related
- 2003-06-13 KR KR10-2004-7021263A patent/KR20050013255A/ko not_active Withdrawn
- 2003-06-13 JP JP2004559025A patent/JP4395076B2/ja not_active Expired - Fee Related
- 2003-06-13 SI SI200331630T patent/SI1519915T1/sl unknown
- 2003-06-13 WO PCT/US2003/016213 patent/WO2004052847A2/en not_active Ceased
- 2003-06-13 BR BR0312095-3A patent/BR0312095A/pt not_active IP Right Cessation
- 2003-06-13 DE DE60327767T patent/DE60327767D1/de not_active Expired - Lifetime
- 2003-06-13 ES ES03810038T patent/ES2325861T3/es not_active Expired - Lifetime
- 2003-06-13 PT PT03810038T patent/PT1519915E/pt unknown
- 2003-06-13 AT AT03810038T patent/ATE432257T1/de active
- 2003-06-13 CN CNB038150980A patent/CN1331848C/zh not_active Expired - Fee Related
- 2003-06-13 CN CNA2007101121728A patent/CN101161641A/zh active Pending
- 2003-06-13 CA CA2489276A patent/CA2489276C/en not_active Expired - Fee Related
- 2003-06-13 DK DK03810038T patent/DK1519915T3/da active
- 2003-06-13 MX MXPA04012998A patent/MXPA04012998A/es not_active Application Discontinuation
- 2003-06-13 EA EA200500088A patent/EA200500088A1/ru unknown
- 2003-06-13 US US10/517,010 patent/US7411072B2/en not_active Expired - Fee Related
- 2003-06-13 HR HR20041187A patent/HRP20041187A2/hr not_active Application Discontinuation
- 2003-06-13 EP EP03810038A patent/EP1519915B1/en not_active Expired - Lifetime
- 2003-06-13 PL PL03374708A patent/PL374708A1/xx not_active Application Discontinuation
- 2003-06-25 AR ARP030102283A patent/AR044526A1/es unknown
- 2003-06-26 PE PE2003000645A patent/PE20040587A1/es not_active Application Discontinuation
-
2004
- 2004-12-21 ZA ZA200410293A patent/ZA200410293B/xx unknown
- 2004-12-21 EC EC2004005501A patent/ECSP045501A/es unknown
- 2004-12-23 CO CO04128011A patent/CO5650160A2/es not_active Application Discontinuation
-
2005
- 2005-01-25 NO NO20050397A patent/NO20050397L/no not_active Application Discontinuation
-
2008
- 2008-07-15 US US12/173,059 patent/US20090149445A1/en not_active Abandoned
-
2009
- 2009-07-28 CY CY20091100806T patent/CY1109490T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005112864A5 (enExample) | ||
| RU2002123350A (ru) | Дипептиднитрильные ингибиторы катепсина К | |
| JP2009500423A5 (enExample) | ||
| JP2005053931A5 (enExample) | ||
| JP2011502958A5 (enExample) | ||
| JP2003531118A5 (enExample) | ||
| JP2010530372A5 (enExample) | ||
| JP2005523922A5 (enExample) | ||
| JP2008508303A5 (enExample) | ||
| JP2006524660A5 (enExample) | ||
| JP2008523126A5 (enExample) | ||
| JP2005507872A5 (enExample) | ||
| WO2006098918A3 (en) | Substituted gamma lactams as therapeutic agents | |
| JP2006520397A5 (enExample) | ||
| JP2003502367A5 (enExample) | ||
| JP2003503449A5 (enExample) | ||
| NO20055655L (no) | Anvendelse av azetidinkarboksamidderivater i terapi | |
| JP2006504738A5 (enExample) | ||
| JPWO2023195529A5 (enExample) | ||
| JP2005517677A5 (enExample) | ||
| JP2008517020A5 (enExample) | ||
| JP2001525394A5 (enExample) | ||
| JP2005526773A5 (enExample) | ||
| JP2005517008A5 (enExample) | ||
| JP2003507380A5 (enExample) |