JP2005517677A5 - - Google Patents
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- Publication number
- JP2005517677A5 JP2005517677A5 JP2003556413A JP2003556413A JP2005517677A5 JP 2005517677 A5 JP2005517677 A5 JP 2005517677A5 JP 2003556413 A JP2003556413 A JP 2003556413A JP 2003556413 A JP2003556413 A JP 2003556413A JP 2005517677 A5 JP2005517677 A5 JP 2005517677A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- lower alkyl
- lower alkoxy
- cycloalkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- 125000001624 naphthyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000002877 alkyl aryl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YQHZTGWSLGCDMD-UHFFFAOYSA-N 3-(diethylaminomethyl)pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound N1=C(N)N=C(N)C2=NC(CN(CC)CC)=NN=C21 YQHZTGWSLGCDMD-UHFFFAOYSA-N 0.000 claims 1
- IDGWYMMARYUEBB-UHFFFAOYSA-N 3-[(4-benzylpiperazin-1-yl)methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound N1=NC2=NC(N)=NC(N)=C2N=C1CN(CC1)CCN1CC1=CC=CC=C1 IDGWYMMARYUEBB-UHFFFAOYSA-N 0.000 claims 1
- WKSHXOLOZIUZTA-UHFFFAOYSA-N 3-[[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound C1=CC=C2C(CN3CCN(CC3)CC3=NC4=C(N)N=C(N=C4N=N3)N)=CC=CC2=C1 WKSHXOLOZIUZTA-UHFFFAOYSA-N 0.000 claims 1
- SATYBAVYGUXQNB-UHFFFAOYSA-N 3-[[4-(naphthalen-2-ylmethyl)piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound C1=CC=CC2=CC(CN3CCN(CC3)CC3=NC4=C(N)N=C(N=C4N=N3)N)=CC=C21 SATYBAVYGUXQNB-UHFFFAOYSA-N 0.000 claims 1
- CZGQQXSRCSHFLV-UHFFFAOYSA-N 3-[[4-[(2,4-dimethylphenyl)methyl]piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound CC1=CC(C)=CC=C1CN1CCN(CC=2N=C3C(N)=NC(N)=NC3=NN=2)CC1 CZGQQXSRCSHFLV-UHFFFAOYSA-N 0.000 claims 1
- RHNCKNUQEQIGCV-UHFFFAOYSA-N 3-[[4-[(4-ethyl-2-methylnaphthalen-1-yl)methyl]piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound C12=CC=CC=C2C(CC)=CC(C)=C1CN1CCN(CC=2N=C3C(N)=NC(N)=NC3=NN=2)CC1 RHNCKNUQEQIGCV-UHFFFAOYSA-N 0.000 claims 1
- HTWLUYGORXTUSF-UHFFFAOYSA-N 3-[[4-[(4-phenylmethoxyphenyl)methyl]piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound N1=NC2=NC(N)=NC(N)=C2N=C1CN(CC1)CCN1CC(C=C1)=CC=C1OCC1=CC=CC=C1 HTWLUYGORXTUSF-UHFFFAOYSA-N 0.000 claims 1
- DZEQIAGNCDPNJU-UHFFFAOYSA-N 3-[[4-[(4-phenylphenyl)methyl]piperazin-1-yl]methyl]pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical compound N1=NC2=NC(N)=NC(N)=C2N=C1CN(CC1)CCN1CC(C=C1)=CC=C1C1=CC=CC=C1 DZEQIAGNCDPNJU-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- -1 di-substituted naphthyl Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34393701P | 2001-12-27 | 2001-12-27 | |
| US39911002P | 2002-07-26 | 2002-07-26 | |
| PCT/EP2002/014771 WO2003055883A1 (en) | 2001-12-27 | 2002-12-27 | Pyrimidotriazines as phosphatase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005517677A JP2005517677A (ja) | 2005-06-16 |
| JP2005517677A5 true JP2005517677A5 (enExample) | 2005-12-22 |
| JP4188839B2 JP4188839B2 (ja) | 2008-12-03 |
Family
ID=26993696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556413A Expired - Fee Related JP4188839B2 (ja) | 2001-12-27 | 2002-12-27 | ホスファターゼインヒビーターとしてのピリミドトリアジン |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6642381B2 (enExample) |
| EP (1) | EP1467996B1 (enExample) |
| JP (1) | JP4188839B2 (enExample) |
| KR (1) | KR100601769B1 (enExample) |
| CN (1) | CN100402530C (enExample) |
| AT (1) | ATE311388T1 (enExample) |
| AU (1) | AU2002367190B2 (enExample) |
| BR (1) | BR0215395A (enExample) |
| CA (1) | CA2471265C (enExample) |
| DE (1) | DE60207759T2 (enExample) |
| ES (1) | ES2252554T3 (enExample) |
| JO (1) | JO2242B1 (enExample) |
| MX (1) | MXPA04006266A (enExample) |
| PA (1) | PA8562901A1 (enExample) |
| PE (1) | PE20030896A1 (enExample) |
| PL (1) | PL371180A1 (enExample) |
| TW (1) | TW200306313A (enExample) |
| UY (1) | UY27606A1 (enExample) |
| WO (1) | WO2003055883A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002342859B2 (en) * | 2001-10-30 | 2007-07-26 | Merck Serono Sa | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPS) |
| EP1565475B1 (en) | 2002-11-18 | 2009-04-08 | F. Hoffmann-La Roche Ag | Diazinopyrimidines and their use as protein kinase inhibitors |
| EP1594847A2 (en) * | 2003-02-12 | 2005-11-16 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| US20040186151A1 (en) * | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| AU2005214349B2 (en) * | 2004-02-12 | 2011-11-03 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| BRPI0707338A2 (pt) | 2006-01-30 | 2011-05-03 | Transtech Pharma Inc | derivados de imidazol, composições, e métodos substituìdos de uso como inibidores de ptpase |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| WO2010083645A1 (en) * | 2009-01-21 | 2010-07-29 | Shanghai Targetdrug Co., Ltd | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2014057522A1 (en) | 2012-10-12 | 2014-04-17 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| JP6442412B2 (ja) | 2013-03-15 | 2018-12-19 | 持田製薬株式会社 | 非アルコール性脂肪性肝炎治療のための組成物および方法 |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| GB0022079D0 (en) | 2000-09-08 | 2000-10-25 | Inst Of Molecul & Cell Biology | Novel protein tyrosine phosphatase inhibitor |
-
2002
- 2002-12-10 US US10/315,769 patent/US6642381B2/en not_active Expired - Fee Related
- 2002-12-24 PA PA20028562901A patent/PA8562901A1/es unknown
- 2002-12-25 TW TW091137302A patent/TW200306313A/zh unknown
- 2002-12-26 JO JO2002137A patent/JO2242B1/en active
- 2002-12-26 UY UY27606A patent/UY27606A1/es not_active Application Discontinuation
- 2002-12-27 CN CNB028264223A patent/CN100402530C/zh not_active Expired - Fee Related
- 2002-12-27 EP EP02805774A patent/EP1467996B1/en not_active Expired - Lifetime
- 2002-12-27 CA CA2471265A patent/CA2471265C/en not_active Expired - Fee Related
- 2002-12-27 DE DE60207759T patent/DE60207759T2/de not_active Expired - Lifetime
- 2002-12-27 AU AU2002367190A patent/AU2002367190B2/en not_active Ceased
- 2002-12-27 JP JP2003556413A patent/JP4188839B2/ja not_active Expired - Fee Related
- 2002-12-27 PL PL02371180A patent/PL371180A1/xx not_active Application Discontinuation
- 2002-12-27 WO PCT/EP2002/014771 patent/WO2003055883A1/en not_active Ceased
- 2002-12-27 KR KR1020047010017A patent/KR100601769B1/ko not_active Expired - Fee Related
- 2002-12-27 AT AT02805774T patent/ATE311388T1/de not_active IP Right Cessation
- 2002-12-27 MX MXPA04006266A patent/MXPA04006266A/es active IP Right Grant
- 2002-12-27 BR BR0215395-5A patent/BR0215395A/pt not_active IP Right Cessation
- 2002-12-27 ES ES02805774T patent/ES2252554T3/es not_active Expired - Lifetime
-
2003
- 2003-01-06 PE PE2003000022A patent/PE20030896A1/es not_active Application Discontinuation