JP2005519908A5 - - Google Patents

Info

Publication number

JP2005519908A5

JP2005519908A5 JP2003562099A JP2003562099A JP2005519908A5 JP 2005519908 A5 JP2005519908 A5 JP 2005519908A5 JP 2003562099 A JP2003562099 A JP 2003562099A JP 2003562099 A JP2003562099 A JP 2003562099A JP 2005519908 A5 JP2005519908 A5 JP 2005519908A5

Authority

JP

Japan

Prior art keywords

compound

methyl

formula

pharmaceutically acceptable

acceptable salt

Prior art date

2003-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 34
• 150000003839 salts Chemical class 0.000 claims 27
• 239000001257 hydrogen Substances 0.000 claims 12
• 229910052739 hydrogen Inorganic materials 0.000 claims 12
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 11
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
• 125000004430 oxygen atom Chemical group O* 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 9
• 229910052757 nitrogen Inorganic materials 0.000 claims 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 6
• 125000002947 alkylene group Chemical group 0.000 claims 6
• -1 pyrrolidino, piperidyl Chemical group 0.000 claims 6
• 150000001204 N-oxides Chemical class 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 150000002431 hydrogen Chemical class 0.000 claims 5
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 5
• 241001465754 Metazoa Species 0.000 claims 4
• 125000004432 carbon atom Chemical group C* 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 125000004043 oxo group Chemical group O=* 0.000 claims 4
• 230000002062 proliferating effect Effects 0.000 claims 4
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 claims 1
• 125000002883 imidazolyl group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
• HWZPPDMBLZOREF-UHFFFAOYSA-N n-[4-(hydroxymethyl)-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(CO)=CC=2)C=C1 HWZPPDMBLZOREF-UHFFFAOYSA-N 0.000 claims 1
• PIHXYGAKULHFPS-UHFFFAOYSA-N n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-[(3-oxopiperazin-1-yl)methyl]benzamide Chemical compound C1=C(NC=2N=C(C=CN=2)C=2C=NC=CC=2)C(C)=CC=C1NC(=O)C(C=C1)=CC=C1CN1CCNC(=O)C1 PIHXYGAKULHFPS-UHFFFAOYSA-N 0.000 claims 1
• 239000007800 oxidant agent Substances 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 125000006239 protecting group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1