GB0201508D0 - Organic compounds - Google Patents

Organic compounds

Info

Publication number
GB0201508D0
GB0201508D0 GBGB0201508.9A GB0201508A GB0201508D0 GB 0201508 D0 GB0201508 D0 GB 0201508D0 GB 0201508 A GB0201508 A GB 0201508A GB 0201508 D0 GB0201508 D0 GB 0201508D0
Authority
GB
United Kingdom
Prior art keywords
organic compounds
preparation
pharmaceutical compositions
derivatives
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0201508.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9929594&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0201508(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Priority to GBGB0201508.9A priority Critical patent/GB0201508D0/en
Publication of GB0201508D0 publication Critical patent/GB0201508D0/en
Priority to CA2474104A priority patent/CA2474104C/en
Priority to EP03731700A priority patent/EP1470120B1/en
Priority to CNB038027089A priority patent/CN100467461C/zh
Priority to PT03731700T priority patent/PT1470120E/pt
Priority to MXPA04007130A priority patent/MXPA04007130A/es
Priority to PCT/EP2003/000613 priority patent/WO2003062220A1/en
Priority to ES03731700T priority patent/ES2294293T3/es
Priority to ES10150442.1T priority patent/ES2503734T3/es
Priority to EP10150442.1A priority patent/EP2194049B1/en
Priority to KR1020047011382A priority patent/KR100778163B1/ko
Priority to US10/502,291 priority patent/US7557105B2/en
Priority to DE60318013T priority patent/DE60318013T2/de
Priority to BR0307058-1A priority patent/BR0307058A/pt
Priority to CNA200910002666XA priority patent/CN101468984A/zh
Priority to KR1020077011065A priority patent/KR20070058019A/ko
Priority to EP07101787A priority patent/EP1783126A3/en
Priority to JP2003562099A priority patent/JP4213595B2/ja
Priority to AT03731700T priority patent/ATE380807T1/de
Priority to PT101504421T priority patent/PT2194049E/pt
Priority to IL162979A priority patent/IL162979A/en
Priority to JP2008208640A priority patent/JP5027076B2/ja
Priority to US12/478,082 priority patent/US20090239879A1/en
Priority to US12/781,430 priority patent/US20100222362A1/en
Priority to IL208399A priority patent/IL208399A/en
Priority to US13/176,289 priority patent/US20110294820A1/en
Priority to US14/330,404 priority patent/US20140323494A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
GBGB0201508.9A 2002-01-23 2002-01-23 Organic compounds Ceased GB0201508D0 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GBGB0201508.9A GB0201508D0 (en) 2002-01-23 2002-01-23 Organic compounds
AT03731700T ATE380807T1 (de) 2002-01-23 2003-01-22 N-oxid von n-phenyl-2-pyrimidinaminderivaten
PT101504421T PT2194049E (pt) 2002-01-23 2003-01-22 N-óxidos de derivados de n-fenil-2-pirimidina-amina
US10/502,291 US7557105B2 (en) 2002-01-23 2003-01-22 N-oxides of N-phenyl-2-pyrimidine-amine derivatives
CNA200910002666XA CN101468984A (zh) 2002-01-23 2003-01-22 N-苯基-2-嘧啶-胺衍生物的n-氧化物
CNB038027089A CN100467461C (zh) 2002-01-23 2003-01-22 N-苯基-2-嘧啶-胺衍生物的n-氧化物
PT03731700T PT1470120E (pt) 2002-01-23 2003-01-22 Derivados n-óxidos de n-fenil-2-pirimidino-amina
MXPA04007130A MXPA04007130A (es) 2002-01-23 2003-01-22 N-oxido de derivados de n-fenil-2-pirimidin-amina.
PCT/EP2003/000613 WO2003062220A1 (en) 2002-01-23 2003-01-22 N-oxyde of n-phenyl-2-pyrimidine-amine derivatives
ES03731700T ES2294293T3 (es) 2002-01-23 2003-01-22 N-oxido de derivados de n-fenil-2-pirimidinamina.
ES10150442.1T ES2503734T3 (es) 2002-01-23 2003-01-22 N-Óxidos de derivados de n-fenil-2-pirimidinamina
EP10150442.1A EP2194049B1 (en) 2002-01-23 2003-01-22 N-oxides of N-phenyl-2-pyrimidine-amine derivatives
KR1020047011382A KR100778163B1 (ko) 2002-01-23 2003-01-22 Ｎ-페닐-2-피리미딘-아민의 ｎ-옥사이드 유도체
CA2474104A CA2474104C (en) 2002-01-23 2003-01-22 N-oxides of n-phenyl-2-pyrimidine-amine derivatives
DE60318013T DE60318013T2 (de) 2002-01-23 2003-01-22 N-oxid von n-phenyl-2-pyrimidinaminderivaten
BR0307058-1A BR0307058A (pt) 2002-01-23 2003-01-22 N-óxidos de derivados de n-fenil-2-pirimidina-amina
EP03731700A EP1470120B1 (en) 2002-01-23 2003-01-22 N-oxyde of n-phenyl-2-pyrimidine-amine derivatives
KR1020077011065A KR20070058019A (ko) 2002-01-23 2003-01-22 Ｎ-페닐-2-피리미딘-아민의 ｎ-옥사이드 유도체
EP07101787A EP1783126A3 (en) 2002-01-23 2003-01-22 N-oxides of N-phenyl-2-pyrimidine-amine derivatives
JP2003562099A JP4213595B2 (ja) 2002-01-23 2003-01-22 Ｎ−フェニル−２−ピリミジン−アミン誘導体のｎ−オキシド
IL162979A IL162979A (en) 2002-01-23 2004-07-12 4-[(4-methyl-4-oxido-1-piperazinyl)-methyl]-n-{4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide, pharmaceutical compositions comprising it and use thereof for the preparation of medicaments for the treatment of a proliferative disorder
JP2008208640A JP5027076B2 (ja) 2002-01-23 2008-08-13 Ｎ−フェニル−２−ピリミジン−アミン誘導体のｎ−オキシド
US12/478,082 US20090239879A1 (en) 2002-01-23 2009-06-04 N-oxides of n-phenyl-2-pyrimidine-amine derivatives
US12/781,430 US20100222362A1 (en) 2002-01-23 2010-05-17 N-oxides of n-phenyl-2-pyramidine-amine derivatives
IL208399A IL208399A (en) 2002-01-23 2010-10-03 4-[(4-methyl-1-piperazinyl)-methyl]-n-{4-methyl-3[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide,pharmaceutical compositions comprising it and use thereof for the preparation of a pharmaceutical composition for the treatment of a proliferative disorder
US13/176,289 US20110294820A1 (en) 2002-01-23 2011-07-05 N-Oxides of n-Phenyl-2-pyrimidine-amine Derivatives
US14/330,404 US20140323494A1 (en) 2002-01-23 2014-07-14 N-oxides of n-phenyl-2-pyrimidine-amine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0201508.9A GB0201508D0 (en) 2002-01-23 2002-01-23 Organic compounds

Publications (1)

Publication Number Publication Date
GB0201508D0 true GB0201508D0 (en) 2002-03-13

Family

ID=9929594

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0201508.9A Ceased GB0201508D0 (en) 2002-01-23 2002-01-23 Organic compounds

Country Status (15)

Country Link
US (5) US7557105B2 (enExample)
EP (3) EP2194049B1 (enExample)
JP (2) JP4213595B2 (enExample)
KR (2) KR20070058019A (enExample)
CN (2) CN100467461C (enExample)
AT (1) ATE380807T1 (enExample)
BR (1) BR0307058A (enExample)
CA (1) CA2474104C (enExample)
DE (1) DE60318013T2 (enExample)
ES (2) ES2294293T3 (enExample)
GB (1) GB0201508D0 (enExample)
IL (2) IL162979A (enExample)
MX (1) MXPA04007130A (enExample)
PT (2) PT2194049E (enExample)
WO (1) WO2003062220A1 (enExample)

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GB0201508D0 (en) * 2002-01-23 2002-03-13 Novartis Ag Organic compounds
AU2004246800B2 (en) * 2003-06-13 2008-12-04 Novartis Ag 2-aminopyrimidine derivatives as Raf kinase inhibitors
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GB0512091D0 (en) * 2005-06-14 2005-07-20 Novartis Ag Organic compounds
JP5066446B2 (ja) * 2005-08-01 2012-11-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を予測する方法
JP4989476B2 (ja) * 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
KR101353763B1 (ko) * 2005-11-07 2014-01-21 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 ｃ―ｋｉｔ 키나아제 저해 물질의병용
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CN101225085B (zh) * 2007-01-17 2011-09-21 天津天士力集团有限公司 苯基呋咱氮类一氧化氮供体型2-苯胺嘧啶衍生物、其制备方法、含有该化合物的组合物及其用途
WO2008093855A1 (ja) 2007-01-29 2008-08-07 Eisai R & D Management Co., Ltd. 未分化型胃癌治療用組成物
CN101245061B (zh) * 2007-02-13 2012-09-19 天津天士力集团有限公司 N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶胺类一氧化氮供体型衍生物，制备方法及其用途
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JP5559043B2 (ja) 2007-06-07 2014-07-23 イントラ−セルラー・セラピーズ・インコーポレイテッド 新規ヘテロ環化合物およびその使用
MX2010003200A (es) * 2007-09-25 2010-04-30 Teva Pharma Composiciones de imatibnib estables.
CA2704000C (en) * 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
WO2009096377A1 (ja) * 2008-01-29 2009-08-06 Eisai R & D Management Co., Ltd. 血管阻害物質とタキサンとの併用
EP2255192A1 (en) * 2008-03-26 2010-12-01 Merck Patent GmbH Method of long term storage of substrate-coupled beads
CN101417995B (zh) * 2008-11-21 2012-06-06 陈依军 苯氧基嘧啶衍生物及其制备方法和用途
CA2771403C (en) 2009-08-19 2015-02-24 Eisai R&D Management Co. Ltd. Quinoline derivative-containing pharmaceutical composition
CN102958523B (zh) 2010-06-25 2014-11-19 卫材R&D管理有限公司 使用具有激酶抑制作用的组合的抗肿瘤剂
AU2012246490B2 (en) 2011-04-18 2016-08-04 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
JPWO2014098176A1 (ja) 2012-12-21 2017-01-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体のアモルファス及びその製造方法
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103588754B (zh) * 2013-11-04 2015-05-27 遵义医学院 伊马替尼的制备方法
EP3187491A4 (en) 2014-08-28 2018-08-01 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
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CN110072528B (zh) 2017-02-08 2022-04-26 卫材R&D管理有限公司 治疗肿瘤的药物组合物
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Also Published As

Publication number Publication date
KR20040081467A (ko) 2004-09-21
JP5027076B2 (ja) 2012-09-19
IL208399A0 (en) 2010-12-30
EP2194049B1 (en) 2014-08-13
CN100467461C (zh) 2009-03-11
EP1470120A1 (en) 2004-10-27
JP4213595B2 (ja) 2009-01-21
JP2005519908A (ja) 2005-07-07
CA2474104C (en) 2012-04-17
US20090239879A1 (en) 2009-09-24
DE60318013D1 (de) 2008-01-24
US20140323494A1 (en) 2014-10-30
DE60318013T2 (de) 2008-11-13
KR100778163B1 (ko) 2007-11-28
WO2003062220A1 (en) 2003-07-31
JP2009051837A (ja) 2009-03-12
ATE380807T1 (de) 2007-12-15
EP1783126A3 (en) 2008-11-26
EP1783126A2 (en) 2007-05-09
IL208399A (en) 2013-02-28
US20050209452A1 (en) 2005-09-22
ES2503734T3 (es) 2014-10-07
MXPA04007130A (es) 2004-10-29
EP2194049A1 (en) 2010-06-09
US20100222362A1 (en) 2010-09-02
ES2294293T3 (es) 2008-04-01
CN101468984A (zh) 2009-07-01
BR0307058A (pt) 2004-12-28
PT1470120E (pt) 2008-03-03
EP1470120B1 (en) 2007-12-12
US7557105B2 (en) 2009-07-07
KR20070058019A (ko) 2007-06-07
IL162979A (en) 2010-12-30
CN1646519A (zh) 2005-07-27
CA2474104A1 (en) 2003-07-31
US20110294820A1 (en) 2011-12-01
PT2194049E (pt) 2014-11-10

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