DE60318013T2 - N-oxid von n-phenyl-2-pyrimidinaminderivaten - Google Patents
N-oxid von n-phenyl-2-pyrimidinaminderivaten Download PDFInfo
- Publication number
- DE60318013T2 DE60318013T2 DE60318013T DE60318013T DE60318013T2 DE 60318013 T2 DE60318013 T2 DE 60318013T2 DE 60318013 T DE60318013 T DE 60318013T DE 60318013 T DE60318013 T DE 60318013T DE 60318013 T2 DE60318013 T2 DE 60318013T2
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- phenyl
- pyridinyl
- piperazinyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
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- Diabetes (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0201508.9A GB0201508D0 (en) | 2002-01-23 | 2002-01-23 | Organic compounds |
| GB0201508 | 2002-01-23 | ||
| PCT/EP2003/000613 WO2003062220A1 (en) | 2002-01-23 | 2003-01-22 | N-oxyde of n-phenyl-2-pyrimidine-amine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60318013D1 DE60318013D1 (de) | 2008-01-24 |
| DE60318013T2 true DE60318013T2 (de) | 2008-11-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318013T Expired - Lifetime DE60318013T2 (de) | 2002-01-23 | 2003-01-22 | N-oxid von n-phenyl-2-pyrimidinaminderivaten |
Country Status (15)
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|---|---|
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| EP (3) | EP2194049B1 (enExample) |
| JP (2) | JP4213595B2 (enExample) |
| KR (2) | KR100778163B1 (enExample) |
| CN (2) | CN100467461C (enExample) |
| AT (1) | ATE380807T1 (enExample) |
| BR (1) | BR0307058A (enExample) |
| CA (1) | CA2474104C (enExample) |
| DE (1) | DE60318013T2 (enExample) |
| ES (2) | ES2294293T3 (enExample) |
| GB (1) | GB0201508D0 (enExample) |
| IL (2) | IL162979A (enExample) |
| MX (1) | MXPA04007130A (enExample) |
| PT (2) | PT2194049E (enExample) |
| WO (1) | WO2003062220A1 (enExample) |
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| DE60126997T2 (de) * | 2000-10-20 | 2007-10-25 | Eisai R&D Management Co., Ltd. | Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen |
| GB0201508D0 (en) * | 2002-01-23 | 2002-03-13 | Novartis Ag | Organic compounds |
| WO2004110452A1 (en) * | 2003-06-13 | 2004-12-23 | Novartis Ag | 2-aminopyrimidine derivatives as raf kinase inhibitors |
| US8969379B2 (en) * | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| GB0512091D0 (en) * | 2005-06-14 | 2005-07-20 | Novartis Ag | Organic compounds |
| JP5066446B2 (ja) * | 2005-08-01 | 2012-11-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を予測する方法 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| WO2007052849A1 (ja) * | 2005-11-07 | 2007-05-10 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質とc-kitキナーゼ阻害物質との併用 |
| GEP20105074B (en) * | 2005-12-21 | 2010-09-10 | Novartis Ag | Pyrimidinyl aryl urea derivatives being fgf inhibitors |
| JP5190361B2 (ja) * | 2006-05-18 | 2013-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 甲状腺癌に対する抗腫瘍剤 |
| EP2068835A2 (en) * | 2006-09-01 | 2009-06-17 | Teva Pharmaceutical Industries Ltd. | Imatinib compositions |
| KR20090061055A (ko) * | 2006-10-26 | 2009-06-15 | 시코르, 인크. | 결정질 및 비결정질 이매티닙 염기, 이매티닙 메실레이트 및 이들의 제조 방법 |
| EP1988089A1 (en) * | 2006-10-26 | 2008-11-05 | Sicor, Inc. | Imatinib base, and imatinib mesylate and processes for preparation thereof |
| CN101225085B (zh) * | 2007-01-17 | 2011-09-21 | 天津天士力集团有限公司 | 苯基呋咱氮类一氧化氮供体型2-苯胺嘧啶衍生物、其制备方法、含有该化合物的组合物及其用途 |
| WO2008093855A1 (ja) | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
| CN101245061B (zh) * | 2007-02-13 | 2012-09-19 | 天津天士力集团有限公司 | N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-嘧啶胺类一氧化氮供体型衍生物，制备方法及其用途 |
| US7550591B2 (en) | 2007-05-02 | 2009-06-23 | Chemagis Ltd. | Imatinib production process |
| TWI433677B (zh) * | 2007-06-04 | 2014-04-11 | Avila Therapeutics Inc | 雜環化合物及其用途 |
| EP2166860B1 (en) | 2007-06-07 | 2016-09-21 | Intra-Cellular Therapies, Inc. | Novel heterocycle compounds and uses thereof |
| US8367686B2 (en) | 2007-06-07 | 2013-02-05 | Intra-Cellular Therapies, Inc. | Heterocycle compounds and uses thereof |
| EP2081556A1 (en) * | 2007-09-25 | 2009-07-29 | Teva Pharmaceutical Industries Ltd. | Stable imatinib compositions |
| EP2218712B1 (en) * | 2007-11-09 | 2015-07-01 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| JP5399926B2 (ja) * | 2008-01-29 | 2014-01-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管阻害物質とタキサンとの併用 |
| JP2011515685A (ja) * | 2008-03-26 | 2011-05-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 基質結合ビーズを長期間保存する方法 |
| CN101417995B (zh) * | 2008-11-21 | 2012-06-06 | 陈依军 | 苯氧基嘧啶衍生物及其制备方法和用途 |
| WO2011021597A1 (ja) | 2009-08-19 | 2011-02-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体含有医薬組成物 |
| BR112012032462A2 (pt) | 2010-06-25 | 2016-11-08 | Eisai R&D Man Co Ltd | agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase. |
| US8962650B2 (en) | 2011-04-18 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| ES2705950T3 (es) | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
| CN104755463A (zh) | 2012-12-21 | 2015-07-01 | 卫材R&D管理有限公司 | 非晶态形式的喹啉衍生物及其生产方法 |
| JP6411379B2 (ja) | 2013-05-14 | 2018-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ化合物に対する子宮内膜がん対象の応答性を予測及び評価するためのバイオマーカー |
| CN103588754B (zh) * | 2013-11-04 | 2015-05-27 | 遵义医学院 | 伊马替尼的制备方法 |
| DK3524595T3 (da) | 2014-08-28 | 2022-09-19 | Eisai R&D Man Co Ltd | Quinolinderivat af høj renhed og fremgangsmåde til fremstilling deraf |
| DK3263106T3 (da) | 2015-02-25 | 2024-01-08 | Eisai R&D Man Co Ltd | Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat |
| WO2016140717A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer |
| US11369623B2 (en) | 2015-06-16 | 2022-06-28 | Prism Pharma Co., Ltd. | Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor |
| MX381976B (es) | 2015-08-20 | 2025-03-13 | Eisai R&D Man Co Ltd | Agente terapéutico contra tumores. |
| WO2018147275A1 (ja) | 2017-02-08 | 2018-08-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
| CA3061888A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| CN107573322A (zh) * | 2017-09-06 | 2018-01-12 | 南京优科生物医药研究有限公司 | 伊马替尼双氮氧化物、其制备方法和用途 |
| CN109761970B (zh) * | 2019-01-26 | 2020-06-09 | 中国药科大学 | 一种蛋白靶向降解嵌合分子、制备方法及应用 |
Family Cites Families (11)
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|---|---|---|---|---|
| US4607041A (en) * | 1983-04-27 | 1986-08-19 | Fisons Plc | Antihypertensive 2-phenyl Hantzsch dihydropyridines |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (enExample) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| DE4444288A1 (de) * | 1994-12-13 | 1996-06-20 | Rainer Dr Med Etzel | Verwendung von Weihrauch zur Behandlung der Alzheimer-Krankheit |
| NZ302926A (en) * | 1995-02-28 | 1998-10-28 | Hoechst Marion Roussel Inc | Composition for use as antihistamines comprising piperidinoalkanol derivatives and inert ingredients |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
| GB0201508D0 (en) * | 2002-01-23 | 2002-03-13 | Novartis Ag | Organic compounds |
| US7279576B2 (en) * | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
-
2002
- 2002-01-23 GB GBGB0201508.9A patent/GB0201508D0/en not_active Ceased
-
2003
- 2003-01-22 CN CNB038027089A patent/CN100467461C/zh not_active Expired - Fee Related
- 2003-01-22 PT PT101504421T patent/PT2194049E/pt unknown
- 2003-01-22 CA CA2474104A patent/CA2474104C/en not_active Expired - Fee Related
- 2003-01-22 AT AT03731700T patent/ATE380807T1/de active
- 2003-01-22 ES ES03731700T patent/ES2294293T3/es not_active Expired - Lifetime
- 2003-01-22 MX MXPA04007130A patent/MXPA04007130A/es active IP Right Grant
- 2003-01-22 PT PT03731700T patent/PT1470120E/pt unknown
- 2003-01-22 WO PCT/EP2003/000613 patent/WO2003062220A1/en not_active Ceased
- 2003-01-22 EP EP10150442.1A patent/EP2194049B1/en not_active Expired - Lifetime
- 2003-01-22 EP EP07101787A patent/EP1783126A3/en not_active Withdrawn
- 2003-01-22 ES ES10150442.1T patent/ES2503734T3/es not_active Expired - Lifetime
- 2003-01-22 BR BR0307058-1A patent/BR0307058A/pt not_active IP Right Cessation
- 2003-01-22 JP JP2003562099A patent/JP4213595B2/ja not_active Expired - Fee Related
- 2003-01-22 KR KR1020047011382A patent/KR100778163B1/ko not_active Expired - Fee Related
- 2003-01-22 DE DE60318013T patent/DE60318013T2/de not_active Expired - Lifetime
- 2003-01-22 EP EP03731700A patent/EP1470120B1/en not_active Expired - Lifetime
- 2003-01-22 US US10/502,291 patent/US7557105B2/en not_active Expired - Fee Related
- 2003-01-22 KR KR1020077011065A patent/KR20070058019A/ko not_active Withdrawn
- 2003-01-22 CN CNA200910002666XA patent/CN101468984A/zh active Pending
-
2004
- 2004-07-12 IL IL162979A patent/IL162979A/en unknown
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2008
- 2008-08-13 JP JP2008208640A patent/JP5027076B2/ja not_active Expired - Fee Related
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2009
- 2009-06-04 US US12/478,082 patent/US20090239879A1/en not_active Abandoned
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2010
- 2010-05-17 US US12/781,430 patent/US20100222362A1/en not_active Abandoned
- 2010-10-03 IL IL208399A patent/IL208399A/en unknown
-
2011
- 2011-07-05 US US13/176,289 patent/US20110294820A1/en not_active Abandoned
-
2014
- 2014-07-14 US US14/330,404 patent/US20140323494A1/en not_active Abandoned
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