JP2007502295A5 - - Google Patents
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- Publication number
- JP2007502295A5 JP2007502295A5 JP2006523384A JP2006523384A JP2007502295A5 JP 2007502295 A5 JP2007502295 A5 JP 2007502295A5 JP 2006523384 A JP2006523384 A JP 2006523384A JP 2006523384 A JP2006523384 A JP 2006523384A JP 2007502295 A5 JP2007502295 A5 JP 2007502295A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- heterocyclyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000623 heterocyclic group Chemical group 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 23
- 125000003710 aryl alkyl group Chemical group 0.000 claims 22
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 16
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 15
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 15
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 12
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 12
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 12
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000004434 sulfur atom Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- -1 resolved enantiomers Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- FOVAPSHEBWJWGL-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)-1-[3-(dimethylamino)propyl]piperidin-4-yl]propan-1-one;dihydrochloride Chemical compound Cl.Cl.C=1C=CC(Cl)=CC=1C1(C(=O)CC)CCN(CCCN(C)C)CC1 FOVAPSHEBWJWGL-UHFFFAOYSA-N 0.000 claims 1
- IVJNVMJPCBIFTA-UHFFFAOYSA-N 2-methylquinazoline-4,6-diamine Chemical compound C1=C(N)C=CC2=NC(C)=NC(N)=C21 IVJNVMJPCBIFTA-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 0 CCC(C)(*)N=*(NC)N(*)*(C)=N Chemical compound CCC(C)(*)N=*(NC)N(*)*(C)=N 0.000 description 11
- LNNFFEQNOYDBLO-UHFFFAOYSA-N C(c1ncccc1)Oc(cc1)c(C2[IH]C2)cc1Nc(c1c2)ncnc1ccc2NC1=NC(CNC2)C2O1 Chemical compound C(c1ncccc1)Oc(cc1)c(C2[IH]C2)cc1Nc(c1c2)ncnc1ccc2NC1=NC(CNC2)C2O1 LNNFFEQNOYDBLO-UHFFFAOYSA-N 0.000 description 1
- NTOIUWIFSFVQJQ-IPPBACCNSA-N CC(C1)C(Oc2ccccc2)=CC=C1Nc1ncnc2c1cc(/C=N/NC(COC)=N)cc2 Chemical compound CC(C1)C(Oc2ccccc2)=CC=C1Nc1ncnc2c1cc(/C=N/NC(COC)=N)cc2 NTOIUWIFSFVQJQ-IPPBACCNSA-N 0.000 description 1
- PXFBJRJPCQFUQY-UHFFFAOYSA-N CC(N)OCC(CO)(CO)N Chemical compound CC(N)OCC(CO)(CO)N PXFBJRJPCQFUQY-UHFFFAOYSA-N 0.000 description 1
- RVDBLABCOYZBMV-UHFFFAOYSA-N CC1(CO)N=C(Nc(cc23)ccc2ncnc3Nc(cc2)cc(Cl)c2OCc2cccc(F)c2)OC1 Chemical compound CC1(CO)N=C(Nc(cc23)ccc2ncnc3Nc(cc2)cc(Cl)c2OCc2cccc(F)c2)OC1 RVDBLABCOYZBMV-UHFFFAOYSA-N 0.000 description 1
- GUXJXWKCUUWCLX-UHFFFAOYSA-N CC1=NCCO1 Chemical compound CC1=NCCO1 GUXJXWKCUUWCLX-UHFFFAOYSA-N 0.000 description 1
- KLRJZHCELLGMCB-KLPHOBTLSA-N CC1C=C(/C=N/NC(C)=N)C=C2C(Nc(cc3Cl)ccc3OCc3cccc(F)c3)=NC=NC12 Chemical compound CC1C=C(/C=N/NC(C)=N)C=C2C(Nc(cc3Cl)ccc3OCc3cccc(F)c3)=NC=NC12 KLRJZHCELLGMCB-KLPHOBTLSA-N 0.000 description 1
- DKGHBASAZOGTAB-UHFFFAOYSA-N CC1N=C(Nc(cc2)cc3c2ncnc3Nc(cc2)cc(Cl)c2OCc2ccccn2)OC1 Chemical compound CC1N=C(Nc(cc2)cc3c2ncnc3Nc(cc2)cc(Cl)c2OCc2ccccn2)OC1 DKGHBASAZOGTAB-UHFFFAOYSA-N 0.000 description 1
- RUBJWKNIOKHRAC-UHFFFAOYSA-N CC1OC(Nc(cc2)cc3c2ncnc3Nc(cc2Cl)ccc2OCc2ccccn2)=NC1 Chemical compound CC1OC(Nc(cc2)cc3c2ncnc3Nc(cc2Cl)ccc2OCc2ccccn2)=NC1 RUBJWKNIOKHRAC-UHFFFAOYSA-N 0.000 description 1
- ZOQVYYINLXDVAA-UHFFFAOYSA-N CC1OC(Nc(cc23)ccc2N=CNC3Nc(cc2)cc(C)c2OC2=CNC(C)C=C2)=NC1 Chemical compound CC1OC(Nc(cc23)ccc2N=CNC3Nc(cc2)cc(C)c2OC2=CNC(C)C=C2)=NC1 ZOQVYYINLXDVAA-UHFFFAOYSA-N 0.000 description 1
- GIVFIMJOKVOQDT-UHFFFAOYSA-N CC1OC(Nc(cc23)ccc2ncnc3Nc(cc2)cc(Cl)c2OCc2ncc[s]2)NC1 Chemical compound CC1OC(Nc(cc23)ccc2ncnc3Nc(cc2)cc(Cl)c2OCc2ncc[s]2)NC1 GIVFIMJOKVOQDT-UHFFFAOYSA-N 0.000 description 1
- VTSUMCFFGMUODS-KLPHOBTLSA-N COCC(N/N=C/c(cc1)cc2c1ncnc2Nc(cc1Cl)ccc1OCc1cccc(F)c1)=N Chemical compound COCC(N/N=C/c(cc1)cc2c1ncnc2Nc(cc1Cl)ccc1OCc1cccc(F)c1)=N VTSUMCFFGMUODS-KLPHOBTLSA-N 0.000 description 1
- QZGIWJNNXZVDII-UHFFFAOYSA-N Cc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCCO2)c1Oc1ccc(C)nc1 Chemical compound Cc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCCO2)c1Oc1ccc(C)nc1 QZGIWJNNXZVDII-UHFFFAOYSA-N 0.000 description 1
- LFKSHLJVZXWZBV-UHFFFAOYSA-N Cc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(COC3)C3O2)c1OCc1ncc[s]1 Chemical compound Cc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(COC3)C3O2)c1OCc1ncc[s]1 LFKSHLJVZXWZBV-UHFFFAOYSA-N 0.000 description 1
- YQTHNULRNIAONX-UHFFFAOYSA-N Cc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(COC3)C3O2)c1Oc1cnc(C)cc1 Chemical compound Cc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(COC3)C3O2)c1Oc1cnc(C)cc1 YQTHNULRNIAONX-UHFFFAOYSA-N 0.000 description 1
- QIQNYHYMERTSPD-UHFFFAOYSA-N Cc1cc(NC2=NC=NC3C=CC(NC4=NCC5(CCOCC5)O4)=CC23)ccc1Oc1ccc(C)nc1 Chemical compound Cc1cc(NC2=NC=NC3C=CC(NC4=NCC5(CCOCC5)O4)=CC23)ccc1Oc1ccc(C)nc1 QIQNYHYMERTSPD-UHFFFAOYSA-N 0.000 description 1
- PVFIWCZYIRQZSL-UHFFFAOYSA-N Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NC(COC3)C3O2)c1OCc1ncc[s]1 Chemical compound Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NC(COC3)C3O2)c1OCc1ncc[s]1 PVFIWCZYIRQZSL-UHFFFAOYSA-N 0.000 description 1
- CWZISLULKPYASC-UHFFFAOYSA-N Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCC3(CCOCC3)O2)c1OCc1ncc[s]1 Chemical compound Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCC3(CCOCC3)O2)c1OCc1ncc[s]1 CWZISLULKPYASC-UHFFFAOYSA-N 0.000 description 1
- UDCKLYWMFGBYSA-UHFFFAOYSA-N Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCCO2)c1OCc1ncc[s]1 Chemical compound Clc(cc(cc1)Nc(c2c3)ncnc2ccc3NC2=NCCO2)c1OCc1ncc[s]1 UDCKLYWMFGBYSA-UHFFFAOYSA-N 0.000 description 1
- GINSUBFDDIACIY-UHFFFAOYSA-N Clc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(CNC3)C3O2)c1OCc1ncc[s]1 Chemical compound Clc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NC(CNC3)C3O2)c1OCc1ncc[s]1 GINSUBFDDIACIY-UHFFFAOYSA-N 0.000 description 1
- WJTSFUSWESMJEP-UHFFFAOYSA-N Clc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NCCO2)c1OCc1ccccn1 Chemical compound Clc(cc(cc1)Nc2ncnc(cc3)c2cc3NC2=NCCO2)c1OCc1ccccn1 WJTSFUSWESMJEP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/642,440 US7501427B2 (en) | 2003-08-14 | 2003-08-14 | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| US10/642,440 | 2003-08-14 | ||
| US55171804P | 2004-03-10 | 2004-03-10 | |
| US60/551,718 | 2004-03-10 | ||
| PCT/US2004/026235 WO2005016346A1 (en) | 2003-08-14 | 2004-08-10 | Quinazoline analogs as receptor tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502295A JP2007502295A (ja) | 2007-02-08 |
| JP2007502295A5 true JP2007502295A5 (enExample) | 2007-09-27 |
| JP4828421B2 JP4828421B2 (ja) | 2011-11-30 |
Family
ID=34198338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523384A Expired - Lifetime JP4828421B2 (ja) | 2003-08-14 | 2004-08-10 | 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7452895B2 (enExample) |
| EP (1) | EP1660090B1 (enExample) |
| JP (1) | JP4828421B2 (enExample) |
| KR (2) | KR101028952B1 (enExample) |
| CN (3) | CN102432552B (enExample) |
| AR (1) | AR045378A1 (enExample) |
| AU (1) | AU2004264937B2 (enExample) |
| BR (1) | BRPI0413565B8 (enExample) |
| CA (1) | CA2535614C (enExample) |
| CL (1) | CL2004002066A1 (enExample) |
| CY (1) | CY1113992T1 (enExample) |
| DK (1) | DK1660090T3 (enExample) |
| ES (1) | ES2399427T3 (enExample) |
| IL (1) | IL173593A (enExample) |
| IS (1) | IS8288A (enExample) |
| MX (1) | MXPA06001767A (enExample) |
| NO (1) | NO336275B1 (enExample) |
| NZ (1) | NZ545459A (enExample) |
| PL (1) | PL1660090T3 (enExample) |
| PT (1) | PT1660090E (enExample) |
| RU (1) | RU2350605C2 (enExample) |
| TW (1) | TWI353982B (enExample) |
| WO (1) | WO2005016346A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7488823B2 (en) * | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
| JP4828421B2 (ja) * | 2003-08-14 | 2011-11-30 | アレイ バイオファーマ、インコーポレイテッド | 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
| US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| CA2755268C (en) | 2005-11-15 | 2013-12-31 | Array Biopharma, Inc. | Erbb inhibitors |
| DK2765990T3 (da) | 2011-10-14 | 2017-11-13 | Array Biopharma Inc | Faststofdispersion |
| RU2629116C2 (ru) | 2011-10-14 | 2017-08-24 | Эррэй Биофарма Инк. | Полиморфы arry-380, селективного ингибитора erbb2, и фармацевтические составы, содержащие их |
| KR102317166B1 (ko) | 2012-03-23 | 2021-10-26 | 어레이 바이오파마 인크. | 뇌암의 치료 |
| JP2018526382A (ja) * | 2015-09-04 | 2018-09-13 | アスラン ファーマシューティカルズ ピーティーイー リミテッド | 耐性癌または難治性癌の治療用バルリチニブ |
| JP2019514864A (ja) * | 2016-04-21 | 2019-06-06 | アスラン ファーマシューティカルズ ピーティーイー リミテッド | 肝癌の治療方法 |
| GB201611580D0 (en) * | 2016-07-01 | 2016-08-17 | Aslan Pharmaceuticals Pte Ltd | Method |
| CN106317040A (zh) * | 2016-08-09 | 2017-01-11 | 浙江医药高等专科学校 | 含噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途 |
| CN106317039A (zh) * | 2016-08-09 | 2017-01-11 | 浙江医药高等专科学校 | 一种含噻吩磺酰胺结构的乙氧苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途 |
| CN106349230A (zh) * | 2016-08-09 | 2017-01-25 | 浙江医药高等专科学校 | 一种含硝基噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂及用途 |
| CN106349231A (zh) * | 2016-08-09 | 2017-01-25 | 浙江医药高等专科学校 | 一类含卤代噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂 |
| CN106279135A (zh) * | 2016-08-09 | 2017-01-04 | 浙江医药高等专科学校 | 一种噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂 |
| SG10201913858WA (en) | 2016-08-26 | 2020-03-30 | Agency Science Tech & Res | Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof |
| TW201834649A (zh) | 2017-03-02 | 2018-10-01 | 新加坡商亞獅康私人有限公司 | 癌症療法 |
| WO2018201016A1 (en) | 2017-04-28 | 2018-11-01 | Cascadian Therapeutics, Inc. | Treatment of her2 positive cancers |
| WO2018222134A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
| WO2018222135A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
| HUE065578T2 (hu) | 2018-09-18 | 2024-06-28 | Hoffmann La Roche | Kinazolin-származékok, mint daganatellenes szerek |
| KR20210090625A (ko) | 2018-10-09 | 2021-07-20 | 아슬란 파마슈티컬스 피티이 엘티디 | 바를리티닙의 말론산 염 |
| ES2989387T3 (es) | 2019-05-31 | 2024-11-26 | Janssen Pharmaceutica Nv | Pequeñas moléculas inhibidoras de la quinasa inductora de nf-kb |
| CN111499622B (zh) * | 2019-07-08 | 2023-06-06 | 山东省科学院菏泽分院 | 一种治疗胆管癌的药物的制备方法 |
| TW202214641A (zh) | 2020-06-30 | 2022-04-16 | 美商艾瑞生藥股份有限公司 | Ｈｅｒ２突變抑制劑 |
| JP7511097B1 (ja) | 2021-06-26 | 2024-07-04 | アレイ バイオファーマ インコーポレイテッド | Ｈｅｒ２変異阻害薬 |
| WO2023081637A1 (en) * | 2021-11-02 | 2023-05-11 | Enliven Therapeutics, Inc. | Fused tetracyclic quinazoline derivatives as inhibitors of erbb2 |
| JP2025509995A (ja) * | 2022-03-28 | 2025-04-11 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 含窒素複素環系化合物、その調製方法及びその医薬的使用 |
| AU2024353411A1 (en) * | 2023-09-27 | 2026-05-07 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutically acceptable salt and crystalline form of quinazoline derivative, and use thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2583774A (en) * | 1948-04-30 | 1952-01-29 | Merck & Co Inc | Vitamin b6 derivatives |
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US5204348A (en) | 1988-10-06 | 1993-04-20 | Mitsui Toatsu Chemicals Inc. | Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components |
| CA1340821C (en) | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (enExample) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| DE69536015D1 (de) * | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| AR004010A1 (es) * | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| JP3370340B2 (ja) * | 1996-04-12 | 2003-01-27 | ワーナー―ランバート・コンパニー | チロシンキナーゼの不可逆的阻害剤 |
| DE69716916T2 (de) | 1996-07-13 | 2003-07-03 | Glaxo Group Ltd., Greenford | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| WO1999024440A1 (en) | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| WO1999044612A1 (en) * | 1998-03-02 | 1999-09-10 | Cocensys, Inc. | Substituted quinazolines and analogs and the use thereof |
| US6017922A (en) * | 1998-05-18 | 2000-01-25 | U.S. Bioscience, Inc. | Thermally stable trimetrexates and processes for producing the same |
| ES2188254T3 (es) | 1998-11-19 | 2003-06-16 | Warner Lambert Co | N-(4-(3-chloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quin azolin-6-il)-acrilamada, un inhibidor irreversible de tirosina quinasas. |
| IL144214A0 (en) | 1999-01-13 | 2002-05-23 | Warner Lambert Co | Benzoheterocycles and their use as mek inhibitors |
| BRPI0017548B8 (pt) * | 1999-02-10 | 2023-05-02 | Astrazeneca Ab | Composto |
| JP2003509497A (ja) | 1999-09-21 | 2003-03-11 | アストラゼネカ アクチボラグ | キナゾリン化合物とそれらを含有する医薬組成物 |
| GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| ATE295348T1 (de) * | 2000-02-17 | 2005-05-15 | Bristol Myers Squibb Co | Thyroid-rezeptorliganden, die von anilin ableitbar sind |
| AU2001252463A1 (en) * | 2000-06-06 | 2001-12-17 | Pfizer Products Inc. | Thiophene derivatives useful as anticancer agents |
| NZ522568A (en) | 2000-06-22 | 2004-12-24 | Pfizer Prod Inc | Substituted bicyclic derivatives for the treatment of abnormal cell growth |
| BR0111947A (pt) * | 2000-06-30 | 2003-05-06 | Glaxo Group Ltd | Composto, composição farmacêutica, método para o tratamento de um distúrbio em um mamìfero, uso de um composto e processo para preparar, um composto |
| US7265134B2 (en) | 2001-08-17 | 2007-09-04 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US7169788B2 (en) | 2001-10-30 | 2007-01-30 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP2005515176A (ja) | 2001-11-03 | 2005-05-26 | アストラゼネカ アクチボラグ | 抗腫瘍剤としてのキナゾリン誘導体 |
| KR101029281B1 (ko) * | 2001-12-24 | 2011-04-18 | 아스트라제네카 아베 | 오로라 키나제의 억제제로서 치환된 퀴나졸린 유도체 |
| US7488823B2 (en) | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
| KR20050122199A (ko) | 2003-01-23 | 2005-12-28 | 티.케이. 시그널 리미티드 | 표피성장인자 수용체 티로신 키나제의 비가역성 억제제 및 그의 용도 |
| PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| MXPA05012839A (es) * | 2003-05-27 | 2006-05-17 | Pfizer Prod Inc | Quinazolinas y pirido[3,4-d] pirimidinas como inhibidores de receptores tirosina quinasa. |
| JP4828421B2 (ja) | 2003-08-14 | 2011-11-30 | アレイ バイオファーマ、インコーポレイテッド | 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
| US7501427B2 (en) * | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| KR20080014144A (ko) | 2003-08-18 | 2008-02-13 | 화이자 프로덕츠 인크. | ｅｒｂＢ２ 항암제에 대한 투약 스케쥴 |
| JP2007510708A (ja) | 2003-11-06 | 2007-04-26 | ファイザー・プロダクツ・インク | 癌の治療における選択的ｅｒｂＢ２阻害剤／抗ｅｒｂＢ抗体の組合せ |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| CA2755268C (en) | 2005-11-15 | 2013-12-31 | Array Biopharma, Inc. | Erbb inhibitors |
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