JP2009519249A5 - - Google Patents
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- Publication number
- JP2009519249A5 JP2009519249A5 JP2008544521A JP2008544521A JP2009519249A5 JP 2009519249 A5 JP2009519249 A5 JP 2009519249A5 JP 2008544521 A JP2008544521 A JP 2008544521A JP 2008544521 A JP2008544521 A JP 2008544521A JP 2009519249 A5 JP2009519249 A5 JP 2009519249A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- lower alkyl
- alkyl
- alkoxy
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000005103 alkyl silyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 5
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 5
- 125000000547 substituted alkyl group Chemical group 0.000 claims 5
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 208000007502 anemia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74857705P | 2005-12-09 | 2005-12-09 | |
| US60/748,577 | 2005-12-09 | ||
| US78535806P | 2006-03-24 | 2006-03-24 | |
| US60/785,358 | 2006-03-24 | ||
| PCT/US2006/046785 WO2007070359A2 (en) | 2005-12-09 | 2006-12-08 | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519249A JP2009519249A (ja) | 2009-05-14 |
| JP2009519249A5 true JP2009519249A5 (enExample) | 2010-02-04 |
| JP5202327B2 JP5202327B2 (ja) | 2013-06-05 |
Family
ID=38163416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544521A Expired - Fee Related JP5202327B2 (ja) | 2005-12-09 | 2006-12-08 | プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7728130B2 (enExample) |
| EP (1) | EP1960363B1 (enExample) |
| JP (1) | JP5202327B2 (enExample) |
| AU (1) | AU2006326662B2 (enExample) |
| CA (1) | CA2634168C (enExample) |
| ES (1) | ES2446416T3 (enExample) |
| WO (1) | WO2007070359A2 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855510B2 (en) * | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
| US7728130B2 (en) * | 2005-12-09 | 2010-06-01 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity |
| US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| MX2009000286A (es) | 2006-06-26 | 2009-03-20 | Procter & Gamble | Inhibidores de prolil hidroxilasa y metodos de uso. |
| AU2007334321B2 (en) | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| EP2111399A2 (en) * | 2006-12-18 | 2009-10-28 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| AU2008241577B2 (en) * | 2007-04-18 | 2011-04-07 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
| CA2683758A1 (en) * | 2007-04-18 | 2008-10-30 | Merck & Co., Inc. | Novel 1,8-naphthyridine compounds |
| CA2683956C (en) * | 2007-04-18 | 2012-12-18 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| US8097620B2 (en) * | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| AU2008248234B2 (en) | 2007-05-04 | 2011-02-03 | Amgen Inc. | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
| EP2222305A1 (en) * | 2007-11-02 | 2010-09-01 | Fibrogen, Inc. | Methods for reducing blood pressure |
| US8952160B2 (en) | 2008-01-11 | 2015-02-10 | Fibrogen, Inc. | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity |
| US8324405B2 (en) | 2008-02-05 | 2012-12-04 | Fibrogen, Inc. | Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors |
| CA2716798A1 (en) * | 2008-02-25 | 2009-09-03 | Merck Sharp & Dohme Corp. | Tetrahydrofuropyridones |
| PL2294066T3 (pl) | 2008-04-28 | 2015-02-27 | Janssen Pharmaceutica Nv | Benzimidazole jako inhibitory hydroksylazy prolilowej |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| GB0809262D0 (en) * | 2008-05-21 | 2008-06-25 | Isis Innovation | Assay |
| US8217043B2 (en) | 2008-08-20 | 2012-07-10 | Fibrogen, Inc. | Compounds and methods for their use |
| CN102272117B (zh) | 2008-11-14 | 2015-06-17 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| AU2015249140C1 (en) * | 2009-02-10 | 2017-12-14 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
| CN102388037B (zh) * | 2009-02-10 | 2014-12-03 | 詹森药业有限公司 | 作为脯氨酰羟化酶抑制剂的喹唑啉酮 |
| CA2767911C (en) | 2009-07-15 | 2016-03-29 | Zhejiang Beta Pharma Inc. | Compounds as hypoxia mimetics, and compositions, and uses thereof |
| MY160066A (en) | 2009-11-06 | 2017-02-15 | Aerpio Therapeutics Inc | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| EP2536709A4 (en) | 2010-02-17 | 2013-11-27 | Univ Cornell | PROLYL HYDROXYLASE HEMMER AND USE METHOD THEREFOR |
| CN103068821B (zh) | 2010-08-13 | 2015-02-25 | 詹森药业有限公司 | 作为脯氨酰羟化酶抑制剂的4-氨基喹唑啉-2-基-1-吡唑-4-羧酸化合物 |
| WO2012025237A1 (en) | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| CA2804824A1 (en) | 2010-08-27 | 2012-03-01 | Gruenenthal Gmbh | Substituted quinoline-3-carboxamides as kcnq2/3 modulators |
| AR082732A1 (es) | 2010-08-27 | 2012-12-26 | Gruenenthal Gmbh | 2-oxiquinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3 |
| WO2012025239A1 (en) * | 2010-08-27 | 2012-03-01 | Grünenthal GmbH | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
| CA2807886A1 (en) | 2010-09-01 | 2012-03-08 | Gruenenthal Gmbh | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| US8962598B2 (en) | 2010-10-14 | 2015-02-24 | Immunahr Ab | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators |
| CN103608346B (zh) | 2011-02-02 | 2016-06-15 | 菲布罗根有限公司 | 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物 |
| GB201102659D0 (en) | 2011-02-15 | 2011-03-30 | Isis Innovation | Assay |
| NO2686520T3 (enExample) | 2011-06-06 | 2018-03-17 | ||
| MX2013014310A (es) | 2011-06-06 | 2014-01-23 | Akebia Therapeutics Inc | Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer. |
| CN104024227B8 (zh) | 2011-07-22 | 2025-07-29 | 北京贝美拓新药研发有限公司 | 抑制脯氨酸羟化酶活性的化合物的晶型及其应用 |
| GB201113101D0 (en) | 2011-07-28 | 2011-09-14 | Isis Innovation | Assay |
| MX2014001680A (es) | 2011-08-11 | 2014-05-27 | Actelion Pharmaceuticals Ltd | Derivados de quinazolina-2, 4-diona. |
| US8512586B2 (en) * | 2011-09-01 | 2013-08-20 | Tel Epion Inc. | Gas cluster ion beam etching process for achieving target etch process metrics for multiple materials |
| US9353081B2 (en) | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
| ES2574262T3 (es) | 2011-10-25 | 2016-06-16 | Janssen Pharmaceutica, N.V. | Formulaciones de sal de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico |
| WO2013070908A1 (en) * | 2011-11-09 | 2013-05-16 | Fibrogen, Inc. | Therapeutic method |
| NZ708605A (en) * | 2012-12-24 | 2016-07-29 | Cadila Healthcare Ltd | Novel quinolone derivatives |
| CN114404414A (zh) | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
| KR102495018B1 (ko) | 2013-11-15 | 2023-02-06 | 아케비아 테라퓨틱스 인코포레이티드 | {[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노}아세트산의 고체형, 이의 조성물 및 용도 |
| EP3079697B1 (en) | 2013-12-12 | 2021-02-03 | Cornell University | Prolylhydroxylase/atf4 inhibitors for treating neural cell injury |
| CN107001316A (zh) * | 2014-08-06 | 2017-08-01 | 诺华股份有限公司 | 作为抗菌剂的喹诺酮衍生物 |
| WO2016034108A1 (zh) * | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| EP3247355A4 (en) | 2015-01-23 | 2018-06-13 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| EA036920B1 (ru) | 2015-04-01 | 2021-01-15 | Экебиа Терапьютикс, Инк. | Композиции и способы для лечения анемии |
| WO2018108704A1 (en) * | 2016-12-13 | 2018-06-21 | Boehringer Ingelheim International Gmbh | New 6-amino-quinolinone compounds and derivatives as bcl6 inhibitors |
| CN108484598B (zh) | 2017-05-09 | 2021-03-02 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| CN107739378A (zh) * | 2017-11-14 | 2018-02-27 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| TW202406895A (zh) | 2018-05-09 | 2024-02-16 | 美商阿克比治療有限公司 | 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| CN115010662B (zh) * | 2021-03-05 | 2023-12-08 | 广东东阳光药业股份有限公司 | 喹啉酮类化合物的晶型及其用途 |
| BR112023018949A2 (pt) | 2021-03-19 | 2023-10-17 | Zydus Lifesciences Ltd | Composto, uso do mesmo para tratar anemia falciforme e composição farmacêutica compreendendo o referido composto |
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| JPS587637B2 (ja) * | 1973-12-27 | 1983-02-10 | 住友化学工業株式会社 | シンキペニシリンノ セイホウ |
| AT328085B (de) | 1974-04-23 | 1976-03-10 | Sumitomo Chemical Co | Verfahren zur herstellung neuer penicilline |
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
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| US4404201A (en) * | 1981-11-13 | 1983-09-13 | Warner-Lambert Company | Cephalosporins |
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| IL100917A0 (en) | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
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| US5726605A (en) * | 1996-04-14 | 1998-03-10 | Northrop Grumman Corporation | Silicon carbide RF power module |
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| AU2003286594A1 (en) | 2002-10-21 | 2004-05-13 | Irm Llc | Quinolones with anti-hiv activity |
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| WO2007038571A2 (en) | 2005-09-26 | 2007-04-05 | Smithkline Beecham Corporation | Prolyl hydroxylase antagonists |
| US7728130B2 (en) * | 2005-12-09 | 2010-06-01 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity |
-
2006
- 2006-12-08 US US11/635,683 patent/US7728130B2/en active Active
- 2006-12-08 EP EP06844992.5A patent/EP1960363B1/en active Active
- 2006-12-08 ES ES06844992.5T patent/ES2446416T3/es active Active
- 2006-12-08 AU AU2006326662A patent/AU2006326662B2/en not_active Ceased
- 2006-12-08 WO PCT/US2006/046785 patent/WO2007070359A2/en not_active Ceased
- 2006-12-08 JP JP2008544521A patent/JP5202327B2/ja not_active Expired - Fee Related
- 2006-12-08 CA CA2634168A patent/CA2634168C/en not_active Expired - Fee Related
-
2010
- 2010-02-10 US US12/703,716 patent/US8012968B2/en active Active
- 2010-02-10 US US12/703,496 patent/US8017626B2/en active Active
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