JP2009519249A5 - - Google Patents

Download PDF

Info

Publication number
JP2009519249A5
JP2009519249A5 JP2008544521A JP2008544521A JP2009519249A5 JP 2009519249 A5 JP2009519249 A5 JP 2009519249A5 JP 2008544521 A JP2008544521 A JP 2008544521A JP 2008544521 A JP2008544521 A JP 2008544521A JP 2009519249 A5 JP2009519249 A5 JP 2009519249A5
Authority
JP
Japan
Prior art keywords
substituted
lower alkyl
alkyl
alkoxy
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008544521A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009519249A (ja
JP5202327B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/046785 external-priority patent/WO2007070359A2/en
Publication of JP2009519249A publication Critical patent/JP2009519249A/ja
Publication of JP2009519249A5 publication Critical patent/JP2009519249A5/ja
Application granted granted Critical
Publication of JP5202327B2 publication Critical patent/JP5202327B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008544521A 2005-12-09 2006-12-08 プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 Expired - Fee Related JP5202327B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74857705P 2005-12-09 2005-12-09
US60/748,577 2005-12-09
US78535806P 2006-03-24 2006-03-24
US60/785,358 2006-03-24
PCT/US2006/046785 WO2007070359A2 (en) 2005-12-09 2006-12-08 Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof

Publications (3)

Publication Number Publication Date
JP2009519249A JP2009519249A (ja) 2009-05-14
JP2009519249A5 true JP2009519249A5 (enExample) 2010-02-04
JP5202327B2 JP5202327B2 (ja) 2013-06-05

Family

ID=38163416

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008544521A Expired - Fee Related JP5202327B2 (ja) 2005-12-09 2006-12-08 プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用

Country Status (7)

Country Link
US (3) US7728130B2 (enExample)
EP (1) EP1960363B1 (enExample)
JP (1) JP5202327B2 (enExample)
AU (1) AU2006326662B2 (enExample)
CA (1) CA2634168C (enExample)
ES (1) ES2446416T3 (enExample)
WO (1) WO2007070359A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855510B2 (en) * 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
JP5202327B2 (ja) * 2005-12-09 2013-06-05 アムジエン・インコーポレーテツド プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PL3357911T3 (pl) 2006-06-26 2022-09-05 Akebia Therapeutics Inc. Inhibitory prolilohydroksylazy i sposoby ich użycia
WO2008076425A1 (en) 2006-12-18 2008-06-26 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
AU2007334323B2 (en) * 2006-12-18 2011-03-10 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US7569726B2 (en) * 2007-04-18 2009-08-04 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
EP2136810A4 (en) * 2007-04-18 2012-01-04 Merck Sharp & Dohme NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS
ES2442847T3 (es) * 2007-04-18 2014-02-13 Amgen, Inc Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa
AU2008248234B2 (en) * 2007-05-04 2011-02-03 Amgen Inc. Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
AU2008248165B2 (en) 2007-05-04 2011-12-08 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
US20110039878A1 (en) * 2007-11-02 2011-02-17 Volkmar Guenzler-Pukall Methods for reducing blood pressure
EP2252619B1 (en) 2008-01-11 2013-10-09 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
WO2009100250A1 (en) 2008-02-05 2009-08-13 Fibrogen, Inc. Chromene derivatives and use thereof as hif hydroxylase activity inhibitors
CN101951777A (zh) * 2008-02-25 2011-01-19 默沙东公司 四氢呋喃并吡啶酮
WO2009134750A1 (en) 2008-04-28 2009-11-05 Janssen Pharmaceutica Nv Benzoimidazoles as prolyl hydroxylase inhibitors
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
GB0809262D0 (en) * 2008-05-21 2008-06-25 Isis Innovation Assay
EP2334682B1 (en) 2008-08-20 2017-10-04 Fibrogen, Inc. Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
EP2370422B1 (en) 2008-11-14 2019-06-05 Fibrogen, Inc. Thiochromene derivatives as hif hydroxylase inhibitors
ES2548250T3 (es) * 2009-02-10 2015-10-15 Janssen Pharmaceutica, N.V. Quinazolinonas como inhibidores de prolilhidroxilasa
AU2015249140C1 (en) * 2009-02-10 2017-12-14 Janssen Pharmaceutica Nv Quinazolinones as prolyl hydroxylase inhibitors
KR20120065311A (ko) 2009-07-15 2012-06-20 씬산 강 저산소증 모방체인 화합물, 및 그의 조성물 및 용도
CN102638983B (zh) 2009-11-06 2014-11-26 阿尔皮奥治疗学股份有限公司 用于治疗结肠炎的组合物和方法
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
EP2536709A4 (en) 2010-02-17 2013-11-27 Univ Cornell PROLYL HYDROXYLASE HEMMER AND USE METHOD THEREFOR
JP5755741B2 (ja) 2010-08-13 2015-07-29 ヤンセン ファーマシューティカ エヌ.ベー. プロリルヒドロキシラーゼインヒビタとしての4−アミノキナゾリン−2−イル−1−ピラゾール−4−カルボン酸化合物
CA2809287C (en) * 2010-08-27 2018-05-22 Gruenenthal Gmbh Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators
AR082734A1 (es) 2010-08-27 2012-12-26 Gruenenthal Gmbh Quinolino-3-carboxamidas sustituidas como moduladores de kcnq2/3
WO2012025237A1 (en) 2010-08-27 2012-03-01 Grünenthal GmbH Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators
PT2609083E (pt) 2010-08-27 2015-07-01 Gruenenthal Gmbh 2-oxi-quinolina-3-carboxamidas substituídas como moduladores de kcnq2/3
EP2611780A1 (en) 2010-09-01 2013-07-10 Grünenthal GmbH Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators
RU2013120556A (ru) 2010-10-14 2014-11-20 Иммунар Аб 1,2-гидрокси-2-оксо-хинолин-3-карбоксанилиды в качестве активаторов ahr
EP2670750B1 (en) 2011-02-02 2016-09-14 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
NO2686520T3 (enExample) 2011-06-06 2018-03-17
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
KR102029951B1 (ko) 2011-07-22 2019-11-08 베이징 베타 파머수티컬 컴퍼니 리미티드 프로릴 히드록실라제 억제제로서 화합물의 다형체형, 및 이의 용도
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
BR112014003200A2 (pt) 2011-08-11 2017-04-04 Actelion Pharmaceuticals Ltd derivados de quinazolina-2,4-diona
US8512586B2 (en) * 2011-09-01 2013-08-20 Tel Epion Inc. Gas cluster ion beam etching process for achieving target etch process metrics for multiple materials
US9353081B2 (en) 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
ES2818977T3 (es) 2011-10-25 2021-04-14 Janssen Pharmaceutica Nv Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico
US20140309256A1 (en) * 2011-11-09 2014-10-16 Fibrogen, Inc. Therapeutic Method
AU2013368843B2 (en) * 2012-12-24 2016-02-25 Zydus Lifesciences Limited Novel quinolone derivatives
PE20160194A1 (es) 2013-06-13 2016-04-20 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
TW201946625A (zh) 2013-11-15 2019-12-16 美商阿克比治療有限公司 {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途
US10716783B2 (en) 2013-12-12 2020-07-21 Cornell University Prolylhydroxylase/ATF4 inhibitors and methods of use for treating neural cell injury or death and conditions resulting therefrom
EP3177593A1 (en) * 2014-08-06 2017-06-14 Novartis AG Quinolone derivatives as antibacterials
WO2016034108A1 (zh) * 2014-09-02 2016-03-10 广东东阳光药业有限公司 喹啉酮类化合物及其应用
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
SG11201707994UA (en) 2015-04-01 2017-10-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
US11001570B2 (en) 2016-12-13 2021-05-11 Boehringer Ingelheim International Gmbh 6-amino-quinolinone compounds and derivatives as BCL6 inhibitors
CA3062972C (en) 2017-05-09 2021-09-14 Kind Pharmaceutical Indolizine derivatives and their application in medicine
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
AU2019265629B2 (en) 2018-05-09 2024-09-12 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
CN115010662B (zh) * 2021-03-05 2023-12-08 广东东阳光药业股份有限公司 喹啉酮类化合物的晶型及其用途

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4935392A (enExample) 1972-08-02 1974-04-01
JPS5417754B2 (enExample) * 1972-12-15 1979-07-02
CA1022544A (en) 1972-12-21 1977-12-13 Yukiyasu Murakami Process of preparing a heterocyclic acyl group-substituted cephalosporin derivative
JPS587637B2 (ja) * 1973-12-27 1983-02-10 住友化学工業株式会社 シンキペニシリンノ セイホウ
AT328085B (de) 1974-04-23 1976-03-10 Sumitomo Chemical Co Verfahren zur herstellung neuer penicilline
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
US4468394A (en) * 1981-04-02 1984-08-28 Eisai Co., Ltd. Cephalosporin compounds
US4404201A (en) * 1981-11-13 1983-09-13 Warner-Lambert Company Cephalosporins
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
US4382089A (en) * 1982-03-02 1983-05-03 Warner-Lambert Company Antibacterial amide compounds, compositions thereof and methods of using them
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
SU1735288A1 (ru) 1990-03-05 1992-05-23 Харьковский государственный фармацевтический институт Способ получени N-R-замещенных амидов 4-гидроксихинолон-2 карбоновой -3-кислоты
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
DE4138820A1 (de) * 1991-11-26 1993-05-27 Basf Ag Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
JPH07224040A (ja) * 1994-02-07 1995-08-22 Fujisawa Pharmaceut Co Ltd キノリン誘導体
US5485717A (en) * 1994-06-29 1996-01-23 Williams International Corporation Multi-spool by-pass turbofan engine
IL135495A (en) * 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
US5726605A (en) * 1996-04-14 1998-03-10 Northrop Grumman Corporation Silicon carbide RF power module
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2260499A1 (en) 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Pharmaceutical compositions for the treatment of ischemic brain damage
US6133285A (en) * 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
GB9911047D0 (en) * 1999-05-12 1999-07-14 Isis Innovation Assay method and means
TWI287004B (en) * 2000-12-28 2007-09-21 Shionogi & Co A pyridone derivative having an affinity effect for cannabinoid 2 type receptor
EP1487472B1 (en) * 2001-12-06 2019-06-26 Fibrogen, Inc. Treatment of ischemic or hypoxic conditions using heterocyclic carboxamides
US7019141B2 (en) 2002-10-21 2006-03-28 Irm Llc Quinolones with anti-HIV activity
WO2004103974A1 (ja) * 2003-05-23 2004-12-02 Japan Tobacco Inc. 置換2-オキソキノリン化合物およびその医薬用途
WO2004104000A1 (ja) 2003-05-23 2004-12-02 Japan Tobacco Inc. トリサイクリック縮合環化合物およびその医薬用途
PL1644336T3 (pl) 2003-06-06 2011-07-29 Fibrogen Inc Związki heteroarylowe zawierające azot i ich zastosowanie w zwiększaniu poziomu endogennej erytropoetyny
WO2006088246A1 (ja) * 2005-02-18 2006-08-24 Takeda Pharmaceutical Company Limited Gpr34受容体機能調節剤
WO2007038571A2 (en) * 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
JP5202327B2 (ja) * 2005-12-09 2013-06-05 アムジエン・インコーポレーテツド プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用

Similar Documents

Publication Publication Date Title
JP2009519249A5 (enExample)
CA2672652A1 (en) Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
JPWO2022177917A5 (enExample)
CA2683738A1 (en) Indanone derivatives that inhibit prolyl hydroxylase
JP2007502295A5 (enExample)
JP2013544276A5 (enExample)
JP2003520195A5 (enExample)
JP2020527175A5 (enExample)
JP2004535466A5 (enExample)
JP2006501295A5 (enExample)
JP2016503786A5 (enExample)
JP2007505931A5 (enExample)
JP2007502804A5 (enExample)
RU2003134376A (ru) Производные хинолина и производные хиназолина, которые содержат азолильную группу
JP2006524222A5 (enExample)
JP2006515858A5 (enExample)
JP2018502101A5 (enExample)
JPWO2020123827A5 (enExample)
JP2007524683A5 (enExample)
JP2019500387A5 (enExample)
JP2008534453A5 (enExample)
JPWO2023099623A5 (enExample)
JP2007532627A5 (enExample)
JP2005503435A5 (enExample)
JP2009501234A5 (enExample)