JP2005532397A5 - - Google Patents
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- Publication number
- JP2005532397A5 JP2005532397A5 JP2004519888A JP2004519888A JP2005532397A5 JP 2005532397 A5 JP2005532397 A5 JP 2005532397A5 JP 2004519888 A JP2004519888 A JP 2004519888A JP 2004519888 A JP2004519888 A JP 2004519888A JP 2005532397 A5 JP2005532397 A5 JP 2005532397A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- compound
- benzodiazepin
- aryl
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 68
- 150000003839 salts Chemical class 0.000 claims 11
- -1 pyrrolidino, piperidino, morpholino Chemical group 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 125000001589 carboacyl group Chemical group 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical compound N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- TYGXBDDJEVLSTB-UHFFFAOYSA-N 1-[2-[4-(7-bromoquinolin-2-yl)oxyphenoxy]propanoylamino]ethanesulfonic acid Chemical compound C1=CC(OC(C)C(=O)NC(C)S(O)(=O)=O)=CC=C1OC1=CC=C(C=CC(Br)=C2)C2=N1 TYGXBDDJEVLSTB-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 claims 1
- ZEAOOTYTERCBMG-UHFFFAOYSA-N 2-[2-[4-(7-bromoquinolin-2-yl)oxyphenoxy]propanoylamino]acetic acid Chemical compound C1=CC(OC(C)C(=O)NCC(O)=O)=CC=C1OC1=CC=C(C=CC(Br)=C2)C2=N1 ZEAOOTYTERCBMG-UHFFFAOYSA-N 0.000 claims 1
- FOCANWDIFCZHRU-UHFFFAOYSA-N 2-[2-[4-(7-chloroquinoxalin-2-yl)oxyphenoxy]propanoylamino]acetic acid Chemical compound C1=CC(OC(C)C(=O)NCC(O)=O)=CC=C1OC1=CN=C(C=CC(Cl)=C2)C2=N1 FOCANWDIFCZHRU-UHFFFAOYSA-N 0.000 claims 1
- ZEAOOTYTERCBMG-GFCCVEGCSA-N 2-[[(2r)-2-[4-(7-bromoquinolin-2-yl)oxyphenoxy]propanoyl]amino]acetic acid Chemical compound C1=CC(O[C@H](C)C(=O)NCC(O)=O)=CC=C1OC1=CC=C(C=CC(Br)=C2)C2=N1 ZEAOOTYTERCBMG-GFCCVEGCSA-N 0.000 claims 1
- FOCANWDIFCZHRU-LLVKDONJSA-N 2-[[(2r)-2-[4-(7-chloroquinoxalin-2-yl)oxyphenoxy]propanoyl]amino]acetic acid Chemical compound C1=CC(O[C@H](C)C(=O)NCC(O)=O)=CC=C1OC1=CN=C(C=CC(Cl)=C2)C2=N1 FOCANWDIFCZHRU-LLVKDONJSA-N 0.000 claims 1
- DPRRUXWWUMTBRO-UHFFFAOYSA-N C1=CC(OC(C)C(=O)NC(C)S(O)(=O)=O)=CC=C1OC1=CN=C(C=CC(Cl)=C2)C2=N1 Chemical compound C1=CC(OC(C)C(=O)NC(C)S(O)(=O)=O)=CC=C1OC1=CN=C(C=CC(Cl)=C2)C2=N1 DPRRUXWWUMTBRO-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 0 CN*(*N)Oc(cc1)ccc1OC1C=*C2=CC=C(*)C(*)[C@@]2*1 Chemical compound CN*(*N)Oc(cc1)ccc1OC1C=*C2=CC=C(*)C(*)[C@@]2*1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39385802P | 2002-07-03 | 2002-07-03 | |
| PCT/US2003/021062 WO2004005260A1 (en) | 2002-07-03 | 2003-07-03 | A-`7-halo-2-quino (xa-) linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532397A JP2005532397A (ja) | 2005-10-27 |
| JP2005532397A5 true JP2005532397A5 (enExample) | 2006-08-17 |
Family
ID=30115656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519888A Pending JP2005532397A (ja) | 2002-07-03 | 2003-07-03 | 抗新生物薬剤としての４−‘７−ハロ−２−キノ（ｘａ−）リニロキシフェノキシ−プロピオン酸誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7109341B2 (enExample) |
| EP (1) | EP1539699A1 (enExample) |
| JP (1) | JP2005532397A (enExample) |
| CN (1) | CN1688547A (enExample) |
| AU (2) | AU2003249722A1 (enExample) |
| BR (1) | BR0311491A (enExample) |
| CA (1) | CA2491612C (enExample) |
| EA (1) | EA009679B1 (enExample) |
| GE (1) | GEP20074058B (enExample) |
| IL (1) | IL164555A0 (enExample) |
| MX (1) | MXPA05000233A (enExample) |
| NO (1) | NO20050573L (enExample) |
| NZ (1) | NZ535887A (enExample) |
| PL (1) | PL373624A1 (enExample) |
| SG (1) | SG145570A1 (enExample) |
| UA (1) | UA79293C2 (enExample) |
| WO (2) | WO2004005260A1 (enExample) |
| ZA (1) | ZA200408191B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL367340A1 (en) * | 2001-07-31 | 2005-02-21 | Wayne State University | Quinoline derivatives and use thereof as antitumor agents |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| WO2004024149A1 (de) * | 2002-08-24 | 2004-03-25 | Zentaris Gmbh | Arzneimittel enthaltend disorale und ihre derivate und deren anwendung zur behandlung gutartiger und bosärtiger tumorerkrankungen |
| CN100427482C (zh) * | 2005-08-01 | 2008-10-22 | 复旦大学 | N,n-二甲胺酰基-2,3-二呋喃基-6-氨基喹噁啉,其制备方法与应用 |
| US7470788B2 (en) * | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
| US20070054938A1 (en) * | 2005-09-07 | 2007-03-08 | Horwitz Jerome P | Antitumor agents |
| US8183379B2 (en) * | 2005-09-07 | 2012-05-22 | Wayne State University | Antitumor agents |
| EP1897542A1 (en) * | 2006-09-07 | 2008-03-12 | Sanofi-Aventis | Aqueous formulation comprising an antitumor agent |
| CN101686983A (zh) * | 2007-05-10 | 2010-03-31 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并-1,4-二氮杂䓬及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
| US9096544B2 (en) | 2009-12-23 | 2015-08-04 | Wayne State University | Therapeutic compounds |
| CN103127112A (zh) * | 2013-02-27 | 2013-06-05 | 江苏先声药物研究有限公司 | 一类喹啉酮衍生物在肿瘤治疗中的应用 |
| CN105085506B (zh) * | 2014-05-16 | 2018-01-19 | 湖南大学 | 2‑[4‑(苯并噁唑‑2‑氧基)苯氧基]脂肪酰吡啶胺的医药用途 |
| CN105085480B (zh) * | 2014-05-16 | 2017-12-29 | 湖南大学 | 2‑[4‑（喹喔啉‑2‑氧基）苯氧基]脂肪酰吡啶胺的医药用途 |
| CN107827828B (zh) * | 2017-11-21 | 2021-03-30 | 南京华漫新材料科技有限公司 | 含苯酰肼骨架的喹喔啉衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
| CN110698418B (zh) * | 2019-09-11 | 2022-07-01 | 广西师范大学 | 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用 |
| TWI826034B (zh) * | 2022-10-07 | 2023-12-11 | 宏碁股份有限公司 | 影像過曝改善方法及電子裝置 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54112628A (en) | 1978-02-23 | 1979-09-03 | Canon Inc | Electromagnetic driving device |
| JPS6033389B2 (ja) * | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤 |
| US6197728B1 (en) * | 1980-08-06 | 2001-03-06 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US5364831A (en) * | 1980-08-06 | 1994-11-15 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US4760066A (en) * | 1982-09-21 | 1988-07-26 | Wayne State University | Method for treating human tumor cell metastasis |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| US5250690A (en) * | 1985-05-02 | 1993-10-05 | Dowelanco | Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides |
| JPS62190172A (ja) * | 1986-02-14 | 1987-08-20 | Teijin Ltd | フエノキシ脂肪族カルボン酸誘導体および除草剤 |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1994013647A1 (en) * | 1992-12-15 | 1994-06-23 | The Du Pont Merck Pharmaceutical Company | (2-quinoxalinyloxy)phenoxypropanoic acids and related derivatives as anticancer agents |
| US6680311B1 (en) * | 1996-08-30 | 2004-01-20 | Eli Lilly And Company | Cryptophycin compounds |
| EP0932601A4 (en) * | 1996-08-30 | 2000-02-02 | Lilly Co Eli | METHOD FOR PRODUCING PHARMACEUTICALS |
| BR9712805A (pt) * | 1996-09-06 | 1999-11-23 | Lilly Co Eli | Processo para a preparação de compostos farmecêuticos |
| US6160006A (en) * | 1996-10-18 | 2000-12-12 | Wayne State University | 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit |
| US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| US6238644B1 (en) * | 1997-09-03 | 2001-05-29 | Wayne State University | Method for treating and/or imaging breast cancer using radioactive iodide |
| US6586461B1 (en) * | 1998-06-16 | 2003-07-01 | Wayne State University | Prenyl transferase inhibitors |
| US6103913A (en) * | 1998-10-16 | 2000-08-15 | Eli Lilly And Company | Process for preparing enollactone derivatives |
| WO2001092244A1 (en) * | 2000-05-30 | 2001-12-06 | Wayne State University | Inhibitors of matrix metalloproteinases |
| US6747021B2 (en) * | 2000-10-02 | 2004-06-08 | Eli Lilly And Company | Cryptophycin compound |
| PL367340A1 (en) * | 2001-07-31 | 2005-02-21 | Wayne State University | Quinoline derivatives and use thereof as antitumor agents |
| UA79293C2 (en) | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
-
2003
- 2003-03-07 UA UAA200500921A patent/UA79293C2/uk unknown
- 2003-07-03 EA EA200500095A patent/EA009679B1/ru not_active IP Right Cessation
- 2003-07-03 EP EP03763213A patent/EP1539699A1/en not_active Withdrawn
- 2003-07-03 US US10/613,914 patent/US7109341B2/en not_active Expired - Fee Related
- 2003-07-03 GE GEAP8611A patent/GEP20074058B/en unknown
- 2003-07-03 PL PL03373624A patent/PL373624A1/xx unknown
- 2003-07-03 SG SG200700010-2A patent/SG145570A1/en unknown
- 2003-07-03 MX MXPA05000233A patent/MXPA05000233A/es active IP Right Grant
- 2003-07-03 WO PCT/US2003/021062 patent/WO2004005260A1/en not_active Ceased
- 2003-07-03 AU AU2003249722A patent/AU2003249722A1/en not_active Abandoned
- 2003-07-03 BR BR0311491-0A patent/BR0311491A/pt not_active IP Right Cessation
- 2003-07-03 CA CA2491612A patent/CA2491612C/en not_active Expired - Fee Related
- 2003-07-03 JP JP2004519888A patent/JP2005532397A/ja active Pending
- 2003-07-03 NZ NZ535887A patent/NZ535887A/en unknown
- 2003-07-03 AU AU2003249704A patent/AU2003249704B2/en not_active Ceased
- 2003-07-03 WO PCT/US2003/021126 patent/WO2004004651A2/en not_active Ceased
- 2003-07-03 CN CNA038158809A patent/CN1688547A/zh active Pending
-
2004
- 2004-10-11 ZA ZA200408191A patent/ZA200408191B/en unknown
- 2004-10-13 IL IL16455504A patent/IL164555A0/xx unknown
-
2005
- 2005-02-02 NO NO20050573A patent/NO20050573L/no not_active Application Discontinuation
-
2006
- 2006-08-31 US US11/469,205 patent/US7585863B2/en not_active Expired - Fee Related
-
2008
- 2008-10-29 US US12/260,296 patent/US7728007B2/en not_active Expired - Fee Related