JP2020527175A5 - - Google Patents
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- JP2020527175A5 JP2020527175A5 JP2020524667A JP2020524667A JP2020527175A5 JP 2020527175 A5 JP2020527175 A5 JP 2020527175A5 JP 2020524667 A JP2020524667 A JP 2020524667A JP 2020524667 A JP2020524667 A JP 2020524667A JP 2020527175 A5 JP2020527175 A5 JP 2020527175A5
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- Prior art keywords
- compound according
- alkyl
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- 150000001875 compounds Chemical class 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000001188 haloalkyl group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- -1 2-oxazolyl Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/093106 | 2017-07-17 | ||
| CNPCT/CN2017/093106 | 2017-07-17 | ||
| PCT/CN2018/095973 WO2019015583A1 (en) | 2017-07-17 | 2018-07-17 | NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527175A JP2020527175A (ja) | 2020-09-03 |
| JP2020527175A5 true JP2020527175A5 (enExample) | 2021-07-26 |
| JP7067725B2 JP7067725B2 (ja) | 2022-05-16 |
Family
ID=65014996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524667A Active JP7067725B2 (ja) | 2017-07-17 | 2018-07-17 | Ａｃｃ阻害剤としての新規な化合物およびそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10995099B2 (enExample) |
| EP (1) | EP3655409B1 (enExample) |
| JP (1) | JP7067725B2 (enExample) |
| CN (1) | CN111201234A (enExample) |
| WO (2) | WO2019015583A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3660023B1 (en) * | 2017-07-26 | 2023-03-08 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Thienopyrimidinedione compounds as acc inhibitors and use thereof |
| CN113924303B (zh) | 2019-07-02 | 2023-10-20 | 广东东阳光药业股份有限公司 | 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用 |
| AR119594A1 (es) * | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| WO2021074198A1 (en) | 2019-10-15 | 2021-04-22 | Boehringer Ingelheim International Gmbh | Novel tetrazoles |
| CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
| TW202229292A (zh) * | 2020-10-14 | 2022-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為trpa1抑制劑之四唑衍生物 |
| CN116348471B (zh) * | 2020-10-14 | 2025-10-31 | 勃林格殷格翰国际有限公司 | 作为trpa1抑制剂的四唑衍生物 |
| TW202233632A (zh) * | 2021-02-07 | 2022-09-01 | 大陸商正大天晴藥業集團股份有限公司 | 噻吩并嘧啶衍生物 |
| CA3210965A1 (en) | 2021-04-14 | 2022-10-20 | Boehringer Ingelheim International Gmbh | 3h,4h-thieno[2,3-d]pyrimidin-4-one derivatives as trpa1 inhibitors |
| CN114409664B (zh) * | 2021-12-24 | 2023-07-18 | 河北威远生物化工有限公司 | 一种螺杂环四氢吡喃化合物及其制备方法和应用 |
| CN114815020B (zh) * | 2022-04-21 | 2023-09-22 | 岭南师范学院 | 一种高品质因数折射率传感器的设计方法及折射率传感器 |
| CN116747321B (zh) * | 2023-06-14 | 2025-09-05 | 厦门君德医药科技有限公司 | 一种接枝改性的介孔二氧化硅及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102033806B1 (ko) * | 2011-11-11 | 2019-10-17 | 길리어드 아폴로, 엘엘씨 | Ａｃｃ 억제제 및 이의 용도 |
| IN2014DN09358A (enExample) * | 2012-05-30 | 2015-07-17 | Bayer Cropscience Ag | |
| KR20160005365A (ko) * | 2013-05-10 | 2016-01-14 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
| WO2015003879A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicylic derivatives |
| CN106008516A (zh) * | 2014-01-29 | 2016-10-12 | 苏州晶云药物科技有限公司 | 依鲁替尼的新晶型及其制备方法 |
| GB201419102D0 (en) * | 2014-10-27 | 2014-12-10 | Imp Innovations Ltd | Novel compounds |
| BR112017014341A2 (pt) * | 2015-01-09 | 2018-03-27 | Gilead Apollo, Llc | método e sistema para tratamento, estabilização, ou redução da gravidade ou progressão de uma doença de fígado gorduroso não alcoólica, e, composição. |
| CN205115664U (zh) * | 2015-10-15 | 2016-03-30 | 阳光能源（青海）有限公司 | 一种用于单晶炉的二次填料装置 |
| CN106137971A (zh) * | 2015-11-17 | 2016-11-23 | 南京瑞捷医药科技有限公司 | 一种他克莫司分散体及其缓释组合物及制备方法 |
| EA201890913A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | Пиразоловые соединения в качестве ингибиторов акк и их применение |
| BR112018010453B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Compostos triazólicos inibindores de acetil coa carboxilase (acc) |
| AU2017226267B2 (en) | 2016-03-02 | 2021-06-24 | Gilead Apollo, Llc | Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof |
| PL3589636T3 (pl) * | 2017-03-03 | 2024-02-19 | Gilead Sciences, Inc. | Sposoby wytwarzania inhibitorów acc i ich form stałych |
| WO2018228369A1 (zh) * | 2017-06-15 | 2018-12-20 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| EP3660023B1 (en) * | 2017-07-26 | 2023-03-08 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Thienopyrimidinedione compounds as acc inhibitors and use thereof |
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2018
- 2018-07-17 US US16/631,800 patent/US10995099B2/en active Active
- 2018-07-17 WO PCT/CN2018/095973 patent/WO2019015583A1/en not_active Ceased
- 2018-07-17 EP EP18835671.1A patent/EP3655409B1/en active Active
- 2018-07-17 CN CN201880053983.1A patent/CN111201234A/zh active Pending
- 2018-07-17 JP JP2020524667A patent/JP7067725B2/ja active Active
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2019
- 2019-01-14 WO PCT/CN2019/071630 patent/WO2020015343A1/en not_active Ceased