JP2021523169A5 - - Google Patents
Info
- Publication number
- JP2021523169A5 JP2021523169A5 JP2020563505A JP2020563505A JP2021523169A5 JP 2021523169 A5 JP2021523169 A5 JP 2021523169A5 JP 2020563505 A JP2020563505 A JP 2020563505A JP 2020563505 A JP2020563505 A JP 2020563505A JP 2021523169 A5 JP2021523169 A5 JP 2021523169A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- ch2oc
- och3
- sch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862667540P | 2018-05-06 | 2018-05-06 | |
| US62/667,540 | 2018-05-06 | ||
| PCT/US2019/030771 WO2019217250A1 (en) | 2018-05-06 | 2019-05-05 | Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523169A JP2021523169A (ja) | 2021-09-02 |
| JP2021523169A5 true JP2021523169A5 (enExample) | 2022-04-19 |
| JP7522661B2 JP7522661B2 (ja) | 2024-07-25 |
Family
ID=68468208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563505A Active JP7522661B2 (ja) | 2018-05-06 | 2019-05-05 | ビスフルオロアルキル－１，４－ベンゾジアゼピノン化合物を含む組み合わせ組成物およびその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20210244745A1 (enExample) |
| EP (1) | EP3790552A4 (enExample) |
| JP (1) | JP7522661B2 (enExample) |
| KR (1) | KR20210005714A (enExample) |
| CN (1) | CN112218639A (enExample) |
| AU (2) | AU2019266150A1 (enExample) |
| BR (1) | BR112020022654A2 (enExample) |
| CA (1) | CA3099479A1 (enExample) |
| IL (1) | IL278492B2 (enExample) |
| MX (1) | MX2020011826A (enExample) |
| SG (1) | SG11202011041YA (enExample) |
| WO (1) | WO2019217250A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210379079A1 (en) * | 2018-05-06 | 2021-12-09 | Ayala Pharmaceuticals Inc. | Compositions comprising cd20 inhibitors and bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof |
| US20220339162A1 (en) * | 2018-05-06 | 2022-10-27 | Ayala Pharmaceuticals Inc. | Bisfluoroalkyl-1,4-benzodiazepinone compounds for treating desmoid tumors |
| EP3793564A4 (en) | 2018-05-15 | 2022-03-30 | Ayala Pharmaceuticals Inc. | COMPOSITIONS CONTAINING BISFLUOROALKYL-L,4-BENZODIAZEPINONE COMPOUNDS FOR THE TREATMENT OF ADENOCARCINOMA |
| BR112020023975A2 (pt) * | 2018-05-24 | 2021-02-23 | Ayala Pharmaceuticals Inc. | composições que compreendem os compostos de bisfluoroalquil-1,4-benzodiazepinona e imunoterapêuticos e métodos de uso das mesmas |
| JP2022533100A (ja) * | 2019-05-15 | 2022-07-21 | アヤラ ファーマシューティカルズ インコーポレイテッド | Ｎｏｔｃｈ活性化乳がんを治療するためのビスフルオロアルキル－１，４－ベンゾジアゼピノン化合物 |
| US20240299411A1 (en) * | 2021-05-13 | 2024-09-12 | Ayala Pharmaceuticals Inc. | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds for treating cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8852901A1 (es) * | 2008-12-22 | 2010-07-27 | Lilly Co Eli | Inhibidores de proteina cinasa |
| TWI530489B (zh) * | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| US20140357605A1 (en) * | 2012-03-22 | 2014-12-04 | Bristol-Myers Squibb Company | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
| AR087107A1 (es) * | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
| EP2861255B1 (en) | 2012-06-19 | 2019-10-09 | The Broad Institute, Inc. | Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy |
| TWI614238B (zh) * | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| JP2015531792A (ja) * | 2012-09-21 | 2015-11-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | １，４−ベンゾジアゼピノン化合物のプロドラッグ |
| CN105101968A (zh) * | 2013-04-04 | 2015-11-25 | 百时美施贵宝公司 | 治疗增殖性疾病的组合疗法 |
| CN105793251B (zh) | 2013-12-05 | 2018-10-12 | 豪夫迈·罗氏有限公司 | 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物 |
| EP3212233B1 (en) * | 2014-10-31 | 2020-06-24 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| CN120661674A (zh) * | 2016-03-15 | 2025-09-19 | 奥莱松基因组股份有限公司 | 用于治疗实体瘤的lsd1抑制剂的组合 |
| MX380779B (es) | 2016-04-12 | 2025-03-12 | Lilly Co Eli | Terapia combinatoria con inhibidores notch y cdk4/6 |
| US20190185559A1 (en) * | 2016-09-02 | 2019-06-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating neoplasias |
| IL268349B2 (en) * | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| EP3615055A1 (en) * | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3615068A1 (en) * | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US11970542B2 (en) * | 2017-11-08 | 2024-04-30 | Fred Hutchinson Cancer Center | Bispecific antibodies specific for treating hematological malignancies |
-
2019
- 2019-05-05 EP EP19800442.6A patent/EP3790552A4/en not_active Withdrawn
- 2019-05-05 WO PCT/US2019/030771 patent/WO2019217250A1/en not_active Ceased
- 2019-05-05 CA CA3099479A patent/CA3099479A1/en active Pending
- 2019-05-05 JP JP2020563505A patent/JP7522661B2/ja active Active
- 2019-05-05 IL IL278492A patent/IL278492B2/en unknown
- 2019-05-05 BR BR112020022654-8A patent/BR112020022654A2/pt not_active Application Discontinuation
- 2019-05-05 KR KR1020207034548A patent/KR20210005714A/ko not_active Ceased
- 2019-05-05 AU AU2019266150A patent/AU2019266150A1/en not_active Abandoned
- 2019-05-05 US US17/052,812 patent/US20210244745A1/en not_active Abandoned
- 2019-05-05 CN CN201980036073.7A patent/CN112218639A/zh active Pending
- 2019-05-05 SG SG11202011041YA patent/SG11202011041YA/en unknown
- 2019-05-05 MX MX2020011826A patent/MX2020011826A/es unknown
-
2020
- 2020-10-22 US US17/077,857 patent/US12281085B2/en active Active
-
2025
- 2025-03-07 AU AU2025201674A patent/AU2025201674A1/en active Pending
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