JP2020007311A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020007311A5 JP2020007311A5 JP2019135624A JP2019135624A JP2020007311A5 JP 2020007311 A5 JP2020007311 A5 JP 2020007311A5 JP 2019135624 A JP2019135624 A JP 2019135624A JP 2019135624 A JP2019135624 A JP 2019135624A JP 2020007311 A5 JP2020007311 A5 JP 2020007311A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- pharmaceutically acceptable
- compound according
- acceptable salt
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 43
- 150000003839 salts Chemical class 0.000 claims 40
- 239000012453 solvate Substances 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 6
- -1 heterocyclo Chemical group 0.000 claims 5
- 230000003463 hyperproliferative effect Effects 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 3
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000012868 Overgrowth Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662371504P | 2016-08-05 | 2016-08-05 | |
| US62/371,504 | 2016-08-05 | ||
| US201762454101P | 2017-02-03 | 2017-02-03 | |
| US62/454,101 | 2017-02-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506191A Division JP6651180B2 (ja) | 2016-08-05 | 2017-08-04 | Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020007311A JP2020007311A (ja) | 2020-01-16 |
| JP2020007311A5 true JP2020007311A5 (enExample) | 2020-09-03 |
| JP7205903B2 JP7205903B2 (ja) | 2023-01-17 |
Family
ID=59677319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506191A Active JP6651180B2 (ja) | 2016-08-05 | 2017-08-04 | Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 |
| JP2019135624A Active JP7205903B2 (ja) | 2016-08-05 | 2019-07-23 | Ｂｃｌ－２阻害剤としてのｎ－（フェニルスルホニル）ベンズアミドおよび関連化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506191A Active JP6651180B2 (ja) | 2016-08-05 | 2017-08-04 | Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10829488B2 (enExample) |
| EP (3) | EP4129999A1 (enExample) |
| JP (2) | JP6651180B2 (enExample) |
| KR (2) | KR102429704B1 (enExample) |
| CN (2) | CN110483501B (enExample) |
| AU (2) | AU2017305508B2 (enExample) |
| CA (1) | CA3031419C (enExample) |
| CY (1) | CY1123859T1 (enExample) |
| DK (1) | DK3494115T3 (enExample) |
| ES (1) | ES2849959T3 (enExample) |
| HR (1) | HRP20202073T1 (enExample) |
| HU (1) | HUE053414T2 (enExample) |
| IL (2) | IL264059B (enExample) |
| LT (1) | LT3494115T (enExample) |
| MX (2) | MX381588B (enExample) |
| MY (1) | MY199409A (enExample) |
| PE (1) | PE20190711A1 (enExample) |
| PH (1) | PH12019500231A1 (enExample) |
| PT (1) | PT3494115T (enExample) |
| RS (1) | RS61821B1 (enExample) |
| RU (2) | RU2722560C1 (enExample) |
| SA (1) | SA519401020B1 (enExample) |
| SG (2) | SG11201900135YA (enExample) |
| SI (1) | SI3494115T1 (enExample) |
| SM (1) | SMT202100025T1 (enExample) |
| WO (1) | WO2018027097A1 (enExample) |
| ZA (2) | ZA201900240B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11001582B2 (en) * | 2016-03-10 | 2021-05-11 | Assia Chemical Industries Ltd. | Solid state forms of Venetoclax and processes for preparation of Venetoclax |
| MX381588B (es) * | 2016-08-05 | 2025-03-12 | Univ Michigan Regents | N-(fenilsulfonil)benzamidas y compuestos relacionados como inhibidores de bcl-2. |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| AU2018255621B2 (en) * | 2017-04-18 | 2022-03-10 | Fochon Pharmaceuticals, Ltd. | Apoptosis-inducing agents |
| PL3788042T3 (pl) | 2018-04-29 | 2025-06-02 | Beigene Switzerland Gmbh | Inhibitory bcl-2 |
| CN114522167A (zh) * | 2018-07-31 | 2022-05-24 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| CN110772639B (zh) * | 2018-07-31 | 2021-04-13 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途 |
| CA3095699A1 (en) * | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| AU2019315466B2 (en) * | 2018-07-31 | 2022-05-19 | Ascentage Pharma (Suzhou) Co., Ltd. | Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP |
| EP3706741A4 (en) * | 2018-11-23 | 2022-03-30 | Ascentage Pharma (Suzhou) Co., Ltd. | PHARMACEUTICAL COMPOSITION AND USE THEREOF |
| TWI770503B (zh) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物 |
| CN112168830B (zh) * | 2019-07-02 | 2022-01-25 | 苏州亚盛药业有限公司 | 一种含有mTOR抑制剂的药物组合及其应用 |
| CN112294966B (zh) * | 2019-07-31 | 2021-12-17 | 苏州亚盛药业有限公司 | Bcl-2/Bcl-xL抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途 |
| CN112852959A (zh) | 2019-11-27 | 2021-05-28 | 苏州亚盛药业有限公司 | 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物 |
| CN119097631A (zh) * | 2019-12-03 | 2024-12-10 | 苏州亚盛药业有限公司 | 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 |
| CN112891353B (zh) * | 2019-12-04 | 2024-01-30 | 苏州亚盛药业有限公司 | 药物组合及其用途 |
| IL292882A (en) | 2019-12-06 | 2022-07-01 | Loxo Oncology Inc | Dosage of Bruton's tyrosine kinase inhibitor |
| CN113354636B (zh) * | 2020-03-06 | 2022-08-09 | 苏州亚盛药业有限公司 | N-(苯基磺酰基)苯甲酰胺类化合物或其盐、溶剂合物的结晶形式或无定形形式 |
| WO2021180040A1 (zh) * | 2020-03-12 | 2021-09-16 | 南京明德新药研发有限公司 | 苯并五元环类化合物 |
| JP2023520843A (ja) | 2020-04-15 | 2023-05-22 | ベイジーン リミテッド | Ｂｃｌ－２阻害剤 |
| WO2021227763A1 (en) * | 2020-05-14 | 2021-11-18 | Ascentage Pharma (Suzhou) Co., Ltd. | Hplc analysis method for n- (phenylsulfonyl) benzamide compound |
| WO2022002178A1 (en) * | 2020-07-01 | 2022-01-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof |
| CN111537654B (zh) * | 2020-07-07 | 2020-11-10 | 上海亚盛医药科技有限公司 | N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法 |
| WO2022007940A1 (zh) * | 2020-07-10 | 2022-01-13 | 江苏恒瑞医药股份有限公司 | 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用 |
| CN114057728A (zh) * | 2020-08-06 | 2022-02-18 | 北京诺诚健华医药科技有限公司 | 作为bcl-2抑制剂的杂环化合物 |
| CN114073707A (zh) * | 2020-08-21 | 2022-02-22 | 苏州亚盛药业有限公司 | 治疗系统性红斑狼疮的组合物和方法 |
| CN114073703B (zh) * | 2020-08-21 | 2022-12-30 | 苏州亚盛药业有限公司 | 用于治疗非酒精性脂肪肝炎的组合物和方法 |
| CN114533677A (zh) * | 2020-11-25 | 2022-05-27 | 苏州亚盛药业有限公司 | 固体分散体、制剂、其制备方法及其应用 |
| US20240316069A1 (en) * | 2020-12-28 | 2024-09-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods of treating multiple sclerosis |
| WO2022161496A1 (en) * | 2021-02-01 | 2022-08-04 | Ascentage Pharma (Suzhou) Co., Ltd. | Sulfonyl benzamide derivatives as bcl-2 inhibitors |
| US20250319183A1 (en) | 2021-04-07 | 2025-10-16 | David Avigan | Compositions and methods for the treatment of cancer |
| JP2024528174A (ja) | 2021-08-02 | 2024-07-26 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | 医薬組合せおよびその使用 |
| EP4442685A4 (en) * | 2021-12-06 | 2025-11-19 | Hangzhou Healzen Therapeutics Co Ltd | BCL-2 PROTEIN ANTI-APOPTOTIC INHIBITOR: PHARMACEUTICAL COMPOSITION AND USES |
| CN115260191B (zh) * | 2022-09-29 | 2022-12-27 | 上海睿跃生物科技有限公司 | 哌啶类化合物及其制备方法和应用 |
| EP4421075A1 (en) * | 2023-02-27 | 2024-08-28 | KRKA, d.d., Novo mesto | Process for the preparation of venetoclax and intermediates used therein |
| EP4676478A1 (en) | 2023-03-03 | 2026-01-14 | iOnctura SA | Combination of roginolisib and bcl-2 inhibitor in the treatment of haematological malignancy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1021343A (en) | 1912-01-17 | 1912-03-26 | M A N Mfg Company | Locking-clamp. |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US7767684B2 (en) * | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| US7842681B2 (en) | 2006-09-05 | 2010-11-30 | Abbott Laboratories | Treatment of myeoproliferative diseases |
| BRPI0719563A2 (pt) | 2006-12-04 | 2013-12-10 | Abbott Lab | Ensaios diagnósticos amigáveis para terapia de câncer |
| UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| TWI600642B (zh) | 2008-12-05 | 2017-10-01 | 艾伯維有限公司 | 用於治療癌症及免疫疾病之ｂｃｌ-２-選擇性細胞凋亡誘發劑 |
| CN104945311A (zh) | 2009-01-19 | 2015-09-30 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| CA2751293A1 (en) | 2009-02-11 | 2010-08-19 | Abbott Laboratories | Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| AR076705A1 (es) * | 2009-05-26 | 2011-06-29 | Abbott Lab | Agentes inductores de la apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes |
| TWI520960B (zh) * | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| MX349533B (es) | 2010-10-29 | 2017-08-02 | Abbvie Inc | Dispersiones solidas que contienen un agente inductor de apoptosis. |
| MY191300A (en) * | 2010-11-23 | 2022-06-14 | Abbvie Ireland Unlimited Co | Methods of treatment using selective bcl-2 inhibitors |
| NZ610151A (en) * | 2010-11-23 | 2015-06-26 | Abbvie Inc | Salts and crystalline forms of an apoptosis-inducing agent |
| US10362975B2 (en) | 2015-12-30 | 2019-07-30 | Dexcom, Inc. | System and method for factory calibration or reduced calibration of an indwelling sensor based on sensitivity profile and baseline model of sensors |
| MX381588B (es) * | 2016-08-05 | 2025-03-12 | Univ Michigan Regents | N-(fenilsulfonil)benzamidas y compuestos relacionados como inhibidores de bcl-2. |
-
2017
- 2017-08-04 MX MX2019001391A patent/MX381588B/es unknown
- 2017-08-04 US US16/317,056 patent/US10829488B2/en active Active
- 2017-08-04 MY MYPI2019000239A patent/MY199409A/en unknown
- 2017-08-04 EP EP22179906.7A patent/EP4129999A1/en active Pending
- 2017-08-04 SG SG11201900135YA patent/SG11201900135YA/en unknown
- 2017-08-04 SG SG10201913643YA patent/SG10201913643YA/en unknown
- 2017-08-04 CN CN201910626474.XA patent/CN110483501B/zh active Active
- 2017-08-04 WO PCT/US2017/045428 patent/WO2018027097A1/en not_active Ceased
- 2017-08-04 AU AU2017305508A patent/AU2017305508B2/en active Active
- 2017-08-04 DK DK17754889.8T patent/DK3494115T3/da active
- 2017-08-04 PE PE2019000335A patent/PE20190711A1/es unknown
- 2017-08-04 SI SI201730535T patent/SI3494115T1/sl unknown
- 2017-08-04 EP EP19184604.7A patent/EP3569601B1/en active Active
- 2017-08-04 CN CN201780035965.6A patent/CN109311871B/zh active Active
- 2017-08-04 JP JP2019506191A patent/JP6651180B2/ja active Active
- 2017-08-04 SM SM20210025T patent/SMT202100025T1/it unknown
- 2017-08-04 ES ES17754889T patent/ES2849959T3/es active Active
- 2017-08-04 KR KR1020217026744A patent/KR102429704B1/ko active Active
- 2017-08-04 KR KR1020197002744A patent/KR102376764B1/ko active Active
- 2017-08-04 LT LTEP17754889.8T patent/LT3494115T/lt unknown
- 2017-08-04 CA CA3031419A patent/CA3031419C/en active Active
- 2017-08-04 RU RU2019105721A patent/RU2722560C1/ru active
- 2017-08-04 RU RU2020114660A patent/RU2744358C2/ru active
- 2017-08-04 HU HUE17754889A patent/HUE053414T2/hu unknown
- 2017-08-04 RS RS20201599A patent/RS61821B1/sr unknown
- 2017-08-04 HR HRP20202073TT patent/HRP20202073T1/hr unknown
- 2017-08-04 PT PT177548898T patent/PT3494115T/pt unknown
- 2017-08-04 EP EP17754889.8A patent/EP3494115B1/en active Active
-
2018
- 2018-08-01 US US16/051,816 patent/US10221174B2/en active Active
-
2019
- 2019-01-02 IL IL264059A patent/IL264059B/en active IP Right Grant
- 2019-01-14 ZA ZA2019/00240A patent/ZA201900240B/en unknown
- 2019-01-31 MX MX2020013014A patent/MX2020013014A/es unknown
- 2019-01-31 PH PH12019500231A patent/PH12019500231A1/en unknown
- 2019-02-04 SA SA519401020A patent/SA519401020B1/ar unknown
- 2019-07-23 JP JP2019135624A patent/JP7205903B2/ja active Active
- 2019-12-19 ZA ZA2019/08466A patent/ZA201908466B/en unknown
-
2020
- 2020-09-17 US US17/023,426 patent/US11718613B2/en active Active
-
2021
- 2021-01-15 CY CY20211100032T patent/CY1123859T1/el unknown
- 2021-04-06 IL IL282099A patent/IL282099B/en unknown
- 2021-04-06 AU AU2021202113A patent/AU2021202113B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020007311A5 (enExample) | ||
| CN115244058A (zh) | 嘧啶并二环类衍生物、其制备方法及其在医药上的应用 | |
| RU2350605C2 (ru) | Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ | |
| CN114430739A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| JP2019511528A5 (enExample) | ||
| JP2018516917A5 (enExample) | ||
| JPWO2021168193A5 (enExample) | ||
| JP2019535746A5 (enExample) | ||
| JP2019510798A5 (enExample) | ||
| JP2020532532A5 (enExample) | ||
| JP2018517686A5 (enExample) | ||
| JP2014193925A5 (enExample) | ||
| JP2019527230A5 (enExample) | ||
| JP2018526413A5 (enExample) | ||
| JP2003522163A5 (enExample) | ||
| JP2007529421A5 (enExample) | ||
| JP2019507114A5 (enExample) | ||
| JPWO2021060453A5 (enExample) | ||
| JP2011509302A5 (enExample) | ||
| JP2020531414A5 (enExample) | ||
| JPWO2020023560A5 (enExample) | ||
| JP2020514344A5 (enExample) | ||
| RU2011134283A (ru) | Имидазотиазольные производные, имеющие пролиновую циклическую структуру | |
| JPWO2020163823A5 (enExample) | ||
| RU2426539C2 (ru) | Способы лечения устойчивого к лекарственным средствам рака |